Standout Papers

Direct conversion of fibroblasts to functional n... 1995 2026 2005 2015 2.2k
  1. Direct conversion of fibroblasts to functional neurons by defined factors (2010)
    Thomas Vierbuchen, Austin Ostermeier et al. Nature
  2. THE SYNAPTIC VESICLE CYCLE (2004)
    Thomas C. Südhof Annual Review of Neuroscience
  3. The synaptic vesicle cycle: a cascade of protein–protein interactions (1995)
    Thomas C. Südhof Nature
  4. Membrane Fusion: Grappling with SNARE and SM Proteins (2009)
    Thomas C. Südhof, James E. Rothman Science
  5. α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro (2010)
    Jacqueline Burré, Manu Sharma et al. Science
  6. Neuroligins and neurexins link synaptic function to cognitive disease (2008)
    Thomas C. Südhof Nature
  7. Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse (1994)
    Martin Geppert, Yukiko Goda et al. Cell
  8. Membrane Fusion (2003)
    Reinhard Jahn, Thorsten Lang et al. Cell
  9. Membrane Fusion and Exocytosis (1999)
    Reinhard Jahn, Thomas C. Südhof Annual Review of Biochemistry
  10. Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion (2000)
    Matthijs Verhage, Ascanio S. Maia et al. Science
  11. Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells (2013)
    Yingsha Zhang, Henrik Ahlenius et al. Neuron
  12. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25 (1993)
    Juan Blasi, Edwin R. Chapman et al. Nature
  13. Induction of human neuronal cells by defined transcription factors (2011)
    Zhiping P. Pang, Nan Yang et al. Nature
  14. Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013)
    Thomas C. Südhof Neuron
  15. Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface (1992)
    Nils Brose, Alexander G. Petrenko et al. Science
  16. α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration (2005)
    Sreeganga S. Chandra, Gilbert Gallardo et al. Cell
  17. A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice (2007)
    Katsuhiko Tabuchi, Jacqueline Blundell et al. Science
  18. Synaptotagmin I functions as a calcium regulator of release probability (2001)
    Rafael Fernández‐Chacón, Andreas Königstorfer et al. Nature
  19. The Presynaptic Active Zone (2012)
    Thomas C. Südhof Neuron
  20. The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins (1985)
    Thomas C. Südhof, Joseph L. Goldstein et al. Science
  21. C2-domains, Structure and Function of a Universal Ca2+-binding Domain (1998)
    Josep Rizo, Thomas C. Südhof Journal of Biological Chemistry
  22. Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. (1994)
    Tetsuya Hayashi, Harvey T. McMahon et al. The EMBO Journal
  23. Essential functions of synapsins I and II in synaptic vesicle regulation (1995)
    Thomas W. Rosahl, Markus Missler et al. Nature
  24. Neuroligins Determine Synapse Maturation and Function (2006)
    Frédérique Varoqueaux, Gayane Aramuni et al. Neuron
  25. SynCAM, a Synaptic Adhesion Molecule That Drives Synapse Assembly (2002)
    Thomas Biederer, Yıldırım Sara et al. Science
  26. Binding of Neuroligins to PSD-95 (1997)
    Y. Hata, Masami Takeuchi et al. Science
  27. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin (1993)
    Yutaka Hata, Clive A. Slaughter et al. Nature
  28. Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold (1995)
    R. Bryan Sutton, Bazbek Davletov et al. Cell
  29. Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses (1999)
    Ji‐Ying Song, Konstantin Ichtchenko et al. Proceedings of the National Academy of Sciences
  30. Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin (1992)
    Yuri A. Ushkaryov, Alexander G. Petrenko et al. Science
  31. Neuroligin 1: A splice site-specific ligand for β-neurexins (1995)
    Konstantin Ichtchenko, Yutaka Hata et al. Cell
  32. α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis (2003)
    Markus Missler, Weiqi Zhang et al. Nature
  33. Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins (1995)
    Cai Li, B. Ullrich et al. Nature
  34. Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits (2017)
    Thomas C. Südhof Cell
  35. SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice (2001)
    Susanne Schoch, F. Deák et al. Science
  36. A Neural Circuit for Memory Specificity and Generalization (2013)
    Wei Xu, Thomas C. Südhof Science
  37. Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins (1989)
    Thomas C. Südhof, Andrew J. Czernik et al. Science
  38. RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone (2002)
    Susanne Schoch, Pablo E. Castillo et al. Nature
  39. Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons (2013)
    Orly L. Wapinski, Thomas Vierbuchen et al. Cell
  40. Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor (1989)
    Gregory A. Mignery, Thomas C. Südhof et al. Nature
  41. Common circuit defect of excitatory-inhibitory balance in mouse models of autism (2009)
    Nadine Gogolla, Jocelyn J. LeBlanc et al. Journal of Neurodevelopmental Disorders
  42. Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2 (2007)
    Alexander A. Chubykin, Deniz Atasoy et al. Neuron
  43. A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain (1998)
    Stefan Butz, Masaya Okamoto et al. Cell
  44. RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction (2011)
    Pascal S. Kaeser, Lunbin Deng et al. Cell
  45. rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. (1990)
    Gabriele Fischer von Mollard, Gregory A. Mignery et al. Proceedings of the National Academy of Sciences
  46. Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein (1993)
    Harvey T. McMahon, Yuri A. Ushkaryov et al. Nature
  47. A Broken α-Helix in Folded α-Synuclein (2003)
    Sreeganga S. Chandra, Xiaocheng Chen et al. Journal of Biological Chemistry
  48. Structure and expression of the rat inositol 1,4,5-trisphosphate receptor. (1990)
    Gregory A. Mignery, C. Newton et al. Journal of Biological Chemistry
  49. RIBEYE, a Component of Synaptic Ribbons (2000)
    Frank Schmitz, Andreas Königstorfer et al. Neuron
  50. A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. (1993)
    Bazbek Davletov, Thomas C. Südhof Journal of Biological Chemistry
  51. Towards an Understanding of Synapse Formation (2018)
    Thomas C. Südhof Neuron
  52. Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein (2005)
    Francesco Fornai, Oliver M. Schlüter et al. Proceedings of the National Academy of Sciences
  53. Snares and munc18 in synaptic vesicle fusion (2002)
    Josep Rizo, Thomas C. Südhof Nature reviews. Neuroscience
  54. β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs (2002)
    Jeong-Seop Rhee, Andrea Betz et al. Cell
  55. The role of Rab3A in neurotransmitter release (1994)
    Martin Geppert, Vadim Y. Bolshakov et al. Nature
  56. Cell Biology and Pathophysiology of α-Synuclein (2017)
    Jacqueline Burré, Manu Sharma et al. Cold Spring Harbor Perspectives in Medicine
  57. ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion (2017)
    Yu‐Wen Alvin Huang, Bo Zhou et al. Cell
  58. Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains (1985)
    Mark A. Lehrman, Wolfgang J. Schneider et al. Science
  59. Synaptotagmins: Why So Many? (2002)
    Thomas C. Südhof Journal of Biological Chemistry
  60. α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation (2014)
    Jacqueline Burré, Manu Sharma et al. Proceedings of the National Academy of Sciences
  61. Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release (2001)
    Kerstin Reim, Michael Mansour et al. Cell
  62. A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins (2005)
    Antony A. Boucard, Alexander A. Chubykin et al. Neuron
  63. Structures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins (1996)
    Konstantin Ichtchenko, Thai Nguyen et al. Journal of Biological Chemistry
  64. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion (1997)
    Martin Geppert, Yukiko Goda et al. Nature
  65. Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior (2010)
    Jacqueline Blundell, Cory A. Blaiss et al. Journal of Neuroscience
  66. A stoichiometric complex of neurexins and dystroglycan in brain (2001)
    Shuzo Sugita, Fumiaki Saito et al. The Journal of Cell Biology
  67. Proteolysis of SNAP-25 by types E and A botulinal neurotoxins. (1994)
    Thomas Binz, Juan Blasi et al. Journal of Biological Chemistry
  68. Cartography of neurexins: More than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons (1995)
    B. Ullrich, Yuri A. Ushkaryov et al. Neuron
  69. Nicastrin Functions as a γ-Secretase-Substrate Receptor (2005)
    Sanjiv Shah, Katsuhiko Tabuchi et al. Cell
  70. Structure of a novel InsP3 receptor. (1991)
    Thomas C. Südhof, C. Newton et al. The EMBO Journal
  71. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells (2012)
    Ernesto Lujan, Soham Chanda et al. Proceedings of the National Academy of Sciences
  72. A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis (2006)
    Jiong Tang, Anton Maximov et al. Cell
  73. Synapses and Alzheimer's Disease (2012)
    Morgan Sheng, Bernardo L. Sabatini et al. Cold Spring Harbor Perspectives in Biology
  74. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region (1987)
    Claire Davis, Joseph L. Goldstein et al. Nature
  75. Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments (2009)
    Mark R. Etherton, Cory A. Blaiss et al. Proceedings of the National Academy of Sciences
  76. Double-knockout mice for α- and β-synucleins: Effect on synaptic functions (2004)
    Sreeganga S. Chandra, Francesco Fornai et al. Proceedings of the National Academy of Sciences
  77. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis (2012)
    Demet Araç, Antony A. Boucard et al. The EMBO Journal
  78. The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged? (2012)
    Josep Rizo, Thomas C. Südhof Annual Review of Cell and Developmental Biology
  79. The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor. (1990)
    Gregory A. Mignery, Thomas C. Südhof The EMBO Journal
  80. Cell biology of Ca2+-triggered exocytosis (2010)
    Zhiping P. Pang, Thomas C. Südhof Current Opinion in Cell Biology

Immediate Impact

65 by Nobel laureates 95 from Science/Nature 107 standout
Sub-graph 1 of 18

Citing Papers

Deep learning
2015 StandoutNatureNobel
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
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1 intermediate paper

Works of Thomas C. Südhof being referenced

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
2013 Standout
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNature

Author Peers

Author Last Decade Papers Cites
Thomas C. Südhof 64289 43373 40299 584 96.5k
Paul Greengard 69535 22267 51642 956 111.1k
Solomon H. Snyder 73879 10112 57757 976 140.4k
Michael E. Greenberg 57907 7303 26130 249 87.5k
Roger Y. Tsien 70492 11828 28180 315 110.3k
Fred H. Gage 61065 6640 53643 742 143.0k
Pietro De Camilli 35221 31102 13663 379 51.9k
Reinhard Jahn 32687 28390 15727 375 47.5k
Marc G. Caron 54404 5197 45350 592 79.2k
George D. Yancopoulos 54500 9824 18351 425 101.4k
Morgan Sheng 32635 9975 29588 254 55.2k

All Works

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