Standout Papers

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function 1996 2026 2006 2016 2.5k
  1. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function (1996)
    Chin Chiang, Ying Litingtung et al. Nature
  2. Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened (2002)
    James Chen, Jussi Taipale et al. Genes & Development
  3. The Hedgehog and Wnt signalling pathways in cancer (2001)
    Jussi Taipale, Philip A. Beachy Nature
  4. Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development (1996)
    Jeffery A. Porter, Keith E. Young et al. Science
  5. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine (2000)
    Jussi Taipale, James Chen et al. Nature
  6. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours (2003)
    David M. Berman, Sunil Karhadkar et al. Nature
  7. Tissue repair and stem cell renewal in carcinogenesis (2004)
    Philip A. Beachy, Sunil Karhadkar et al. Nature
  8. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer (2003)
    D. Neil Watkins, David M. Berman et al. Nature
  9. Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb (2000)
    Baolin Wang, John F. Fallon et al. Cell
  10. Small molecule modulation of Smoothened activity (2002)
    James Chen, Jussi Taipale et al. Proceedings of the National Academy of Sciences
  11. Hedgehog signalling in prostate regeneration, neoplasia and metastasis (2004)
    Sunil Karhadkar, G. Steven Bova et al. Nature
  12. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis (1995)
    Henk Roelink, Jeffery A. Porter et al. Cell
  13. Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling (1998)
    Michael K. Cooper, Jeffery A. Porter et al. Science
  14. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia (2009)
    Alan Chen, Catriona Jamieson et al. Nature
  15. The Hedgehog Response Network: Sensors, Switches, and Routers (2004)
    Lawrence Lum, Philip A. Beachy Science
  16. Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade (2002)
    David M. Berman, Sunil Karhadkar et al. Science
  17. Patched acts catalytically to suppress the activity of Smoothened (2002)
    Jussi Taipale, Michael K. Cooper et al. Nature
  18. Molecular Genetics of the Bithorax Complex in Drosophila melanogaster (1983)
    Welcome Bender, Michael Akam et al. Science
  19. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog (1992)
    John J. Lee, Doris P. von Kessler et al. Cell
  20. Stromal response to Hedgehog signaling restrains pancreatic cancer progression (2014)
    John J. Lee, Rushika M. Perera et al. Proceedings of the National Academy of Sciences
  21. Cellular and molecular mechanisms of Hedgehog signalling (2023)
    Yunxiao Zhang, Philip A. Beachy Nature Reviews Molecular Cell Biology

Immediate Impact

9 by Nobel laureates 78 from Science/Nature 119 standout
Sub-graph 1 of 18

Citing Papers

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
2014 StandoutScience
Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain
2014 StandoutScience

Works of Philip A. Beachy being referenced

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
2011
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
2011 Nature

Author Peers

Author Last Decade Papers Cites
Philip A. Beachy 29322 8367 5001 131 33.1k
Mario R. Capecchi 20219 7373 3165 236 27.9k
Randall T. Moon 37811 6057 3847 295 44.7k
Roel Nusse 43096 7953 7708 206 54.4k
Frank Costantini 17357 5490 1797 143 24.3k
Peter Gruß 34126 11805 3389 314 43.5k
Matthew P. Scott 17705 5760 1999 139 21.0k
Harold Weintraub 25720 5496 2259 96 30.0k
Argiris Efstratiadis 19826 8397 2203 118 28.5k
Philippe Soriano 17947 4543 3082 148 26.4k
Austin Smith 41877 5913 3686 219 49.3k

All Works

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2026