Mario R. Capecchi

37.2k total citations · 21 hit papers
239 papers, 28.3k citations indexed

About

Mario R. Capecchi is a scholar working on Molecular Biology, Genetics and Cellular and Molecular Neuroscience. According to data from OpenAlex, Mario R. Capecchi has authored 239 papers receiving a total of 28.3k indexed citations (citations by other indexed papers that have themselves been cited), including 186 papers in Molecular Biology, 73 papers in Genetics and 24 papers in Cellular and Molecular Neuroscience. Recurrent topics in Mario R. Capecchi's work include Developmental Biology and Gene Regulation (48 papers), CRISPR and Genetic Engineering (42 papers) and Animal Genetics and Reproduction (37 papers). Mario R. Capecchi is often cited by papers focused on Developmental Biology and Gene Regulation (48 papers), CRISPR and Genetic Engineering (42 papers) and Animal Genetics and Reproduction (37 papers). Mario R. Capecchi collaborates with scholars based in United States, Belgium and China. Mario R. Capecchi's co-authors include Kirk R. Thomas, Eugenio Sangiorgi, Suzanne L. Mansour, Nancy R. Manley, Judy M. Goddard, Deneen M. Wellik, Chu‐Xia Deng, Anne M. Boulet, Anne Moon and Brian G. Condie and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Mario R. Capecchi

238 papers receiving 27.4k citations

Hit Papers

Altering the Genome by Homologous Recombination 1965 2026 1985 2005 1989 1988 2008 1980 2009 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Altering the Genome by Homologous Recombination
    1989 1.5k citations Mario R. Capecchi profile →
  2. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
    1988 1.4k citations Kirk R. Thomas, Mario R. Capecchi et al. profile →
  3. Bmi1 is expressed in vivo in intestinal stem cells
    2008 947 citations Eugenio Sangiorgi, Mario R. Capecchi profile →
  4. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells
    1980 754 citations Mario R. Capecchi profile →
  5. Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
    2009 684 citations Akifumi Ootani, Xingnan Li et al. profile →
  6. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
    2011 634 citations Kelley S. Yan, Xingnan Li et al. Proceedings of the National Academy of Sciences profile →
  7. Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
    1995 483 citations Mario R. Capecchi et al. profile →
  8. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
    2005 479 citations Mario R. Capecchi profile →
  9. Retinopathy induced in mice by targeted disruption of the rhodopsin gene
    1997 451 citations Mario R. Capecchi et al. profile →
  10. Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6
    1992 443 citations Teresa S. Musci, Mario R. Capecchi et al. profile →
  11. Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton
    2003 441 citations Mario R. Capecchi et al. profile →
  12. The new mouse genetics: Altering the genome by gene targeting
    1989 414 citations Mario R. Capecchi profile →
  13. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
    1993 382 citations Mario R. Capecchi et al. Development profile →
  14. Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.
    1996 380 citations Mario R. Capecchi et al. profile →
  15. Patterns of Integration of DNA Microinjected into Cultured Mammalian Cells: Evidence for Homologous Recombination Between Injected Plasmid DNA Molecules
    1982 350 citations Kim R. Folger, Mario R. Capecchi et al. Molecular and Cellular Biology profile →
  16. The role of Hoxa-3 in mouse thymus and thyroid development
    1995 344 citations Mario R. Capecchi et al. Development profile →
  17. A mouse model for the delta F508 allele of cystic fibrosis.
    1995 249 citations Bernhardt Zeiher, E. J. Eichwald et al. Journal of Clinical Investigation profile →
  18. N-formylmethionyl-sRNA as the initiator of protein synthesis.
    1966 241 citations Mario R. Capecchi et al. Proceedings of the National Academy of Sciences profile →
  19. Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules.
    1982 222 citations Kim R. Folger, Mario R. Capecchi et al. Molecular and Cellular Biology profile →
  20. Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA
    1983 213 citations Mario R. Capecchi et al. profile →
  21. Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor
    1965 185 citations Mario R. Capecchi et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Mario R. Capecchi United States 95 20.4k 7.5k 3.2k 2.2k 2.1k 239 28.3k
Stylianos E. Antonarakis Switzerland 102 21.9k 1.1× 13.3k 1.8× 1.9k 0.6× 2.5k 1.1× 1.8k 0.8× 602 40.8k
D.N. Cooper United Kingdom 90 19.9k 1.0× 10.5k 1.4× 2.1k 0.7× 2.5k 1.1× 1.2k 0.6× 568 34.9k
Jonathan A. Epstein United States 92 17.1k 0.8× 3.1k 0.4× 2.3k 0.7× 2.7k 1.2× 1.9k 0.9× 263 23.9k
Marie‐Geneviève Mattéi France 95 15.9k 0.8× 7.0k 0.9× 3.6k 1.1× 1.3k 0.6× 2.2k 1.0× 507 29.2k
Philippe Soriano United States 82 18.1k 0.9× 4.6k 0.6× 3.1k 1.0× 1.3k 0.6× 4.3k 2.1× 150 26.7k
Heiner Westphal United States 73 14.9k 0.7× 5.8k 0.8× 1.7k 0.5× 904 0.4× 3.0k 1.4× 153 22.5k
Nobuyoshi Shimizu Japan 70 12.5k 0.6× 5.2k 0.7× 3.8k 1.2× 4.0k 1.8× 3.5k 1.6× 541 27.6k
András Nagy Canada 90 30.1k 1.5× 7.2k 1.0× 2.9k 0.9× 2.0k 0.9× 3.2k 1.5× 396 42.2k
Frank Grosveld Netherlands 105 27.5k 1.3× 7.1k 1.0× 2.3k 0.7× 1.8k 0.8× 1.9k 0.9× 391 38.5k
Frank Costantini United States 69 17.6k 0.9× 5.6k 0.7× 1.8k 0.6× 2.1k 1.0× 1.9k 0.9× 145 24.6k

Countries citing papers authored by Mario R. Capecchi

Since Specialization
Citations

This map shows the geographic impact of Mario R. Capecchi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mario R. Capecchi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mario R. Capecchi more than expected).

Fields of papers citing papers by Mario R. Capecchi

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mario R. Capecchi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mario R. Capecchi. The network helps show where Mario R. Capecchi may publish in the future.

Co-authorship network of co-authors of Mario R. Capecchi

This figure shows the co-authorship network connecting the top 25 collaborators of Mario R. Capecchi. A scholar is included among the top collaborators of Mario R. Capecchi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mario R. Capecchi. Mario R. Capecchi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Branca, Caterina, Teresa S. Musci, Ignazio S. Piras, et al.. (2025). Tic-related behaviors in Celsr3 mutant mice are contributed by alterations of striatal D3 dopamine receptors. Molecular Psychiatry. 30(9). 3912–3924. 1 indexed citations
2.
3.
Capecchi, Mario R.. (2021). The origin and evolution of gene targeting. Developmental Biology. 481. 179–187. 5 indexed citations
4.
Titen, Simon, et al.. (2020). Site-Specific Recombination with Inverted Target Sites: A Cautionary Tale of Dicentric and Acentric Chromosomes. Genetics. 215(4). 923–930. 3 indexed citations
5.
Wang, Haoyi, Sen Wu, Mario R. Capecchi, & Rudolf Jaenisch. (2020). A brief review of genome editing technology for generating animal models. Frontiers of Agricultural Science and Engineering. 7(2). 123–123. 6 indexed citations
6.
Capecchi, Mario R. & Amir Pozner. (2015). ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination. Nature Communications. 6(1). 8763–8763. 71 indexed citations
7.
Barham, Whitney, Andrea L. Frump, Taylor P. Sherrill, et al.. (2013). Targeting the Wnt Pathway in Synovial Sarcoma Models. Cancer Discovery. 3(11). 1286–1301. 57 indexed citations
8.
Yan, Kelley S., Xingnan Li, Akifumi Ootani, et al.. (2011). The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proceedings of the National Academy of Sciences. 109(2). 466–471. 634 indexed citations breakdown →
9.
Makki, Nadja & Mario R. Capecchi. (2011). Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Developmental Biology. 357(2). 295–304. 43 indexed citations
10.
Xue, Haipeng, Sen Wu, Sophia T. Papadeas, et al.. (2009). A Targeted Neuroglial Reporter Line Generated by Homologous Recombination in Human Embryonic Stem Cells. Stem Cells. 27(8). 1836–1846. 58 indexed citations
11.
Haldar, Malay, R. Lor Randall, & Mario R. Capecchi. (2008). Synovial Sarcoma: From Genetics to Genetic-based Animal Modeling. Clinical Orthopaedics and Related Research. 466(9). 2156–2167. 62 indexed citations
12.
Wu, Sen, Yuanyuan Wu, & Mario R. Capecchi. (2006). Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo. Development. 133(4). 581–590. 156 indexed citations
13.
Makki, Nadja, Benjamin R. Arenkiel, & Mario R. Capecchi. (2006). Hoxa1-lineage analysis suggests novel domains of Hoxa1 function. Developmental Biology. 295(1). 448–448. 1 indexed citations
14.
Boulet, Anne M., Anne Moon, Benjamin R. Arenkiel, & Mario R. Capecchi. (2004). The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Developmental Biology. 273(2). 361–372. 164 indexed citations
15.
Capecchi, Mario R., et al.. (2002). The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. Genes & Development. 16(24). 3223–3235. 166 indexed citations
16.
Wilder, Phillip J., David L. Kelly, Cynthia L. Peterson, et al.. (1997). Inactivation of the FGF-4 Gene in Embryonic Stem Cells Alters the Growth and/or the Survival of Their Early Differentiated Progeny. Developmental Biology. 192(2). 614–629. 103 indexed citations
17.
Zeiher, Bernhardt, E. J. Eichwald, Joseph Zabner, et al.. (1995). A mouse model for the delta F508 allele of cystic fibrosis.. Journal of Clinical Investigation. 96(4). 2051–2064. 249 indexed citations breakdown →
18.
Capecchi, Mario R.. (1989). Molecular genetics of early Drosophila and mouse development. 5 indexed citations
19.
Folger, Kim R., Kirk R. Thomas, & Mario R. Capecchi. (1985). Nonreciprocal Exchanges of Information Between DNA Duplexes Coinjected into Mammalian Cell Nuclei. Molecular and Cellular Biology. 5(1). 59–69. 22 indexed citations
20.
Capecchi, Mario R. & Robert E. Webster. (1975). 10 Bacteriophage RNA as Template for In Vitro Protein Synthesis. Cold Spring Harbor Monograph Archive. 5. 279–299. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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