Standout Papers

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes thro... 1997 2026 2006 2016 3.3k
  1. An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements (1997)
    Ken Itoh, Tomoki Chiba et al. Biochemical and Biophysical Research Communications
  2. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain (1999)
    Ken Itoh, Nobunao Wakabayashi et al. Genes & Development
  3. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants (2002)
    Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. Proceedings of the National Academy of Sciences
  4. Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages (2000)
    Tetsuro Ishii, Ken Itoh et al. Journal of Biological Chemistry
  5. Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression (2003)
    Michael McMahon, Ken Itoh et al. Journal of Biological Chemistry
  6. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice (2001)
    Minerva Ramos‐Gómez, Mi-Kyoung Kwak et al. Proceedings of the National Academy of Sciences
  7. Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles (2004)
    Ken Itoh, Kit I. Tong et al. Free Radical Biology and Medicine
  8. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation (2003)
    Nobunao Wakabayashi, Ken Itoh et al. Nature Genetics
  9. Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles (2003)
    Ken Itoh, Nobunao Wakabayashi et al. Genes to Cells
  10. Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model (2006)
    Kit I. Tong, Yasutake Katoh et al. Molecular and Cellular Biology
  11. Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway (2003)
    Nobunao Wakabayashi, Ken Itoh et al. Journal of Biological Chemistry
  12. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. (2001)
    Michael McMahon, Ken Itoh et al. PubMed
  13. Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site (1996)
    Ken Itoh, Hozumi Motohashi et al. Molecular and Cellular Biology
  14. Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter (2002)
    Mi-Kyoung Kwak, Ken Itoh et al. Molecular and Cellular Biology
  15. Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology (2020)
    Shuya Kasai, Sunao Shimizu et al. Biomolecules

Immediate Impact

11 by Nobel laureates 8 from Science/Nature 161 standout
Sub-graph 1 of 14

Citing Papers

Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
59 intermediate papers

Works of Ken Itoh being referenced

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
2009
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
1997 Standout
and 58 more

Author Peers

Author Last Decade Papers Cites
Ken Itoh 26508 2610 2838 244 33.4k
John D. Hayes 27547 2200 1681 255 36.4k
Albena T. Dinkova‐Kostova 18531 2466 1809 188 25.6k
Thomas W. Kensler 28371 3048 3536 400 41.4k
Henry Jay Forman 13172 3791 2785 282 26.5k
Young‐Joon Surh 14409 1830 2330 406 27.0k
Paul Talalay 28424 1444 1953 253 39.4k
Sten Orrenius 28265 4693 5074 448 50.8k
Rodney L. Levine 13010 4666 1475 201 26.6k
Hozumi Motohashi 16166 1755 2287 174 22.4k
Lawrence J. Marnett 13104 3170 1629 515 34.4k

All Works

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