Standout Papers

Click Chemistry: Diverse Chemical Function from a Few Good Reactions 1994 2026 2004 2015 11.1k
  1. Click Chemistry: Diverse Chemical Function from a Few Good Reactions (2001)
    Hartmuth C. Kolb, M. G. Finn et al. Angewandte Chemie International Edition
  2. A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes (2002)
    Vsevolod V. Rostovtsev, Luke G. Green et al. Angewandte Chemie International Edition
  3. Click Chemistry: Diverse Chemical Function from a Few Good Reactions (2001)
    Hartmuth C. Kolb, M. G. Finn et al. Angewandte Chemie International Edition
  4. Catalytic Asymmetric Dihydroxylation (1994)
    Hartmuth C. Kolb, Michael S. VanNieuwenhze et al. Chemical Reviews
  5. The growing impact of click chemistry on drug discovery (2003)
    Hartmuth C. Kolb, K. Barry Sharpless Drug Discovery Today
  6. (2002)
    Vsevolod V. Rostovtsev, Luke G. Green et al. Angewandte Chemie
  7. The first practical method for asymmetric epoxidation (1980)
    Tsutomu Katsuki, K. Barry Sharpless Journal of the American Chemical Society
  8. Catalytic asymmetric epoxidation and kinetic resolution: modified procedures including in situ derivatization (1987)
    Yun Gao, Janice M. Klunder et al. Journal of the American Chemical Society
  9. Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen (2001)
    Hartmuth C. Kolb, M. G. Finn et al. Angewandte Chemie
  10. “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension (2005)
    Sridhar Narayan, John Muldoon et al. Angewandte Chemie International Edition
  11. Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates (2004)
    Fahmi Himo, Timothy Lovell et al. Journal of the American Chemical Society
  12. Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition (2003)
    Qian Wang, Timothy R. Chan et al. Journal of the American Chemical Society
  13. Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis (2004)
    Timothy R. Chan, Robert Hilgraf et al. Organic Letters
  14. The osmium-catalyzed asymmetric dihydroxylation: a new ligand class and a process improvement (1992)
    K. Barry Sharpless, Willi M. Amberg et al. The Journal of Organic Chemistry
  15. Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry (2014)
    Jiajia Dong, Larissa B. Krasnova et al. Angewandte Chemie International Edition
  16. Efficiency and Fidelity in a Click‐Chemistry Route to Triazole Dendrimers by the Copper(I)‐Catalyzed Ligation of Azides and Alkynes (2004)
    Peng Wu, Alina K. Feldman et al. Angewandte Chemie International Edition
  17. Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides (2005)
    Li Zhang, Xinguo Chen et al. Journal of the American Chemical Society
  18. Kinetic resolution of racemic allylic alcohols by enantioselective epoxidation. A route to substances of absolute enantiomeric purity? (1981)
    Victor S. Martı́n, Scott S. Woodard et al. Journal of the American Chemical Society
  19. Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks (2002)
    Warren G. Lewis, Luke G. Green et al. Angewandte Chemie International Edition
  20. High stereo- and regioselectivities in the transition metal catalyzed epoxidations of olefinic alcohols by tert-butyl hydroperoxide (1973)
    K. Barry Sharpless, Robert Michaelson Journal of the American Chemical Society
  21. Asymmetric dihydroxylation via ligand-accelerated catalysis (1988)
    Eric N. Jacobsen, István E. Markó et al. Journal of the American Chemical Society
  22. Catalytic Asymmetric Aminohydroxylation (AA) of Olefins (1996)
    Guigen Li, Han‐Ting Chang et al. Angewandte Chemie International Edition in English
  23. Ligand‐Accelerated Catalysis (1995)
    David J. Berrisford, Carsten Bolm et al. Angewandte Chemie International Edition in English
  24. Searching for New Reactivity (Nobel Lecture) Copyright© The Nobel Foundation 2002. We thank the Nobel Foundation, Stockholm, for permission to print this lecture. Adapted with the permission of the editors from “Coelacanths and Catalysis”: K. B. Sharpless, Tetrahedron 1994, 50, 4235. (2002)
    K. Barry Sharpless Angewandte Chemie International Edition
  25. Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry (2006)
    Matthew Whiting, John Muldoon et al. Angewandte Chemie International Edition
  26. Vicinal diol cyclic sulfates. Like epoxides only more reactive (1988)
    Yun Gao, K. Barry Sharpless Journal of the American Chemical Society
  27. Mild procedure for the conversion of epoxides to allylic alcohols. First organoselenium reagent (1973)
    K. Barry Sharpless, R. F. LAUER Journal of the American Chemical Society
  28. Searching for new reactivity (Nobel lecture). (2002)
    K. Barry Sharpless PubMed
  29. A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-acyltetrazoles from azides and acyl cyanides. (2002)
    Zachary Demko, K. Barry Sharpless PubMed
  30. Copper(I)‐Catalyzed Cycloaddition of Organic Azides and 1‐Iodoalkynes (2009)
    Jason E. Hein, Jonathan C. Tripp et al. Angewandte Chemie International Edition
  31. Titanium isopropoxide-mediated nucleophilic openings of 2,3-epoxy alcohols. A mild procedure for regioselective ring-opening (1985)
    Maurice Caron, K. Barry Sharpless The Journal of Organic Chemistry
  32. A Potent and Highly Selective Inhibitor of Human α-1,3-Fucosyltransferase via Click Chemistry (2003)
    Lac V. Lee, Michael L. Mitchell et al. Journal of the American Chemical Society
  33. Highly Efficient Epoxidation of Olefins Using Aqueous H2O2 and Catalytic Methyltrioxorhenium/Pyridine:  Pyridine-Mediated Ligand Acceleration (1997)
    Joachim Rudolph, K. Laxma Reddy et al. Journal of the American Chemical Society
  34. Multivalent, bifunctional dendrimers prepared by click chemistry (2005)
    Peng Wu, Michael Malkoch et al. Chemical Communications
  35. A Click Chemistry Approach to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis of 5-Sulfonyl Tetrazoles from Azides and Sulfonyl Cyanides We thank the National Institute of General Medical Sciences, National Institutes of Health (GM-28384), the National Science Foundation (CHE-9985553), the Skaggs Institute for Chemical Biology for a Predoctoral Fellowship (Z.D.), and the W. M. Keck Foundation for financial support. Dedicated to Professor Rolf Huisgen, the pioneer of this large and extremely useful family of reactions. (2002)
    Zachary Demko, K. Barry Sharpless Angewandte Chemie International Edition
  36. Click chemistry in materials synthesis. 1. Adhesive polymers from copper‐catalyzed azide‐alkyne cycloaddition (2004)
    David Díaz Díaz, Sreenivas Punna et al. Journal of Polymer Science Part A Polymer Chemistry
  37. In Situ Click Chemistry:  Enzyme Inhibitors Made to Their Own Specifications (2004)
    Roman Manetsch, Antoni Krasiński et al. Journal of the American Chemical Society
  38. Why Is Tetrazole Formation by Addition of Azide to Organic Nitriles Catalyzed by Zinc(II) Salts? (2003)
    Fahmi Himo, Zachary Demko et al. Journal of the American Chemical Society
  39. Chromyl chloride oxidations of olefins. Possible role of organometallic intermediates in the oxidations of olefins by oxo transition metal species (1977)
    K. Barry Sharpless, Jan E. Bäckvall et al. Journal of the American Chemical Society
  40. Mechanisms of Tetrazole Formation by Addition of Azide to Nitriles (2002)
    Fahmi Himo, Zachary Demko et al. Journal of the American Chemical Society
  41. In Situ Selection of Lead Compounds by Click Chemistry:  Target-Guided Optimization of Acetylcholinesterase Inhibitors (2005)
    Antoni Krasiński, Zoran Radić et al. Journal of the American Chemical Society
  42. “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension (2005)
    Sridhar Narayan, John Muldoon et al. Angewandte Chemie
  43. Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation (2004)
    Yves Bourne, Hartmuth C. Kolb et al. Proceedings of the National Academy of Sciences
  44. Copper‐Catalyzed Synthesis of N‐Sulfonyl‐1,2,3‐triazoles: Controlling Selectivity (2007)
    Eun Jeong Yoo, Mårten S. G. Ahlquist et al. Angewandte Chemie International Edition
  45. Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates (2017)
    Bing Gao, Linda Zhang et al. Nature Chemistry
  46. Mechanism of asymmetric epoxidation. 2. Catalyst structure (1991)
    M. G. Finn, K. Barry Sharpless Journal of the American Chemical Society
  47. SuFEx‐Based Synthesis of Polysulfates (2014)
    Jiajia Dong, K. Barry Sharpless et al. Angewandte Chemie International Edition
  48. Modular click chemistry libraries for functional screens using a diazotizing reagent (2019)
    Genyi Meng, Taijie Guo et al. Nature
  49. Bromine-Catalyzed Aziridination of Olefins. A Rare Example of Atom-Transfer Redox Catalysis by a Main Group Element (1998)
    Jae Uk Jeong, Beata Tao et al. Journal of the American Chemical Society
  50. A New Ligand Class for the Asymmetric Dihydroxylation of Olefins (1996)
    Heinrich Becker, K. Barry Sharpless Angewandte Chemie International Edition in English
  51. An Intramolecular [2 + 3] Cycloaddition Route to Fused 5-Heterosubstituted Tetrazoles (2001)
    Zachary Demko, K. Barry Sharpless Organic Letters
  52. A simplified procedure for the stereospecific transformation of 1,2-diols into epoxides (1992)
    Hartmuth C. Kolb, K. Barry Sharpless Tetrahedron
  53. SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization (2018)
    Zilei Liu, Jie Li et al. Journal of the American Chemical Society
  54. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue (2016)
    Wentao Chen, Jiajia Dong et al. Journal of the American Chemical Society
  55. Conformational study of cinchona alkaloids. A combined NMR, molecular mechanics and x-ray approach (1989)
    Gerard Dijkstra, Richard M. Kellogg et al. Journal of the American Chemical Society
  56. Asymmetric epoxidation provides shortest routes to four chiral epoxy alcohols which are key intermediates in syntheses of methymycin, erythromycin, leukotriene C-1, and disparlure (1981)
    Bryant E. Rossiter, Tsutomu Katsuki et al. Journal of the American Chemical Society
  57. Olefin synthesis. Rate enhancement of the elimination of alkyl aryl selenoxides by electron-withdrawing substituents (1975)
    K. Barry Sharpless, Michael W. Young The Journal of Organic Chemistry
  58. “Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates (2017)
    D.E. Mortenson, Lars Plate et al. Journal of the American Chemical Society
  59. Asymmetric induction in the reaction of osmium tetroxide with olefins (1980)
    Steven G. Hentges, K. Barry Sharpless Journal of the American Chemical Society
  60. Selenium dioxide oxidation of olefins. Evidence for the intermediacy of allylseleninic acids (1972)
    K. Barry Sharpless, R. F. LAUER Journal of the American Chemical Society
  61. Schwefel(VI)‐fluorid‐Austausch (SuFEx): Eine weitere gute Anwendung für die Click‐Chemie (2014)
    Jiajia Dong, Larissa B. Krasnova et al. Angewandte Chemie
  62. Improved enantioselectivity in asymmetric dihydroxylations of terminal olefins using pyrimidine ligands (1993)
    Gerard A. Crispino, Kyu‐Sung Jeong et al. The Journal of Organic Chemistry
  63. Synthetic applications of arylselenenic and arylseleninic acids. Conversion of olefins to allylic alcohols and epoxides (1978)
    K. Barry Sharpless et al. The Journal of Organic Chemistry
  64. Mechanism of epoxidation of olefins by covalent peroxides of molybdenum(VI) (1972)
    K. Barry Sharpless, Donald R. Williams et al. Journal of the American Chemical Society
  65. New ligands double the scope of the catalytic asymmetric dihydroxylation of olefins (1991)
    K. Barry Sharpless, Willi M. Amberg et al. The Journal of Organic Chemistry
  66. A mechanistic insight leads to a greatly improved osmium-catalyzed asymmetric dihydroxylation process (1989)
    John Wai, István E. Markó et al. Journal of the American Chemical Society
  67. A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope (2017)
    Taijie Guo, Genyi Meng et al. Angewandte Chemie International Edition
  68. Synthesis of dioxobis(tert-alkylimido)osmium(VIII) and oxotris(tert-alkylimido)osmium(VIII) complexes. Stereospecific vicinal diamination of olefins (1977)
    A. O. CHONG, Koichiro Oshima et al. Journal of the American Chemical Society
  69. Stereoselective epoxidation of acyclic allylic alcohols. A correction of our previous work. (1979)
    Bryant E. Rossiter, Thomas R. Verhoeven et al. Tetrahedron Letters
  70. Stereo and regioselective openings of chiral 2,3-epoxy alcohols. Versatile routes to optically pure natural products and drugs. Unusual kinetic resolutions (1983)
    K. Barry Sharpless, Carl H. Behrens et al. Pure and Applied Chemistry
  71. SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase (2019)
    Qinheng Zheng, Jordan L. Woehl et al. Proceedings of the National Academy of Sciences
  72. Osmium-catalyzed vicinal oxyamination of olefins by Chloramine-T (1976)
    K. Barry Sharpless, A. O. CHONG et al. The Journal of Organic Chemistry
  73. Lower valent tungsten halides. New class of reagents for deoxygenation of organic molecules (1972)
    K. Barry Sharpless, Martha A. Umbreit et al. Journal of the American Chemical Society
  74. Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry (2020)
    Seiya Kitamura, Qinheng Zheng et al. Journal of the American Chemical Society
  75. Chiral hydroxamic acids as ligands in the vanadium catalyzed asymmetric epoxidation of allylic alcohols by tert-butyl hydroperoxide (1977)
    Robert Michaelson, Robert E. Palermo et al. Journal of the American Chemical Society
  76. SuFExable polymers with helical structures derived from thionyl tetrafluoride (2021)
    Suhua Li, Gencheng Li et al. Nature Chemistry
  77. Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis (2021)
    Qinheng Zheng, Hongtao Xu et al. Journal of the American Chemical Society

Immediate Impact

136 by Nobel laureates 39 from Science/Nature 190 standout
Sub-graph 1 of 15

Citing Papers

Covalent targeted radioligands potentiate radionuclide therapy
2024 StandoutNature
Papers and patents are becoming less disruptive over time
2023 StandoutNature

Works of K. Barry Sharpless being referenced

Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 Standout
The first practical method for asymmetric epoxidation
1980 Standout
and 4 more

Author Peers

Author Last Decade Papers Cites
K. Barry Sharpless 71156 37116 8694 10062 447 91.0k
K. N. Houk 67861 20278 13466 13464 1.7k 96.6k
M. G. Finn 28175 21954 1423 5668 274 46.0k
Robert H. Grubbs 70053 23448 9590 7955 719 80.2k
Stephen L. Buchwald 80004 12723 21482 4826 677 88.7k
Hartmuth C. Kolb 24305 15318 1750 4404 132 37.4k
Valery V. Fokin 32657 18212 1551 3366 183 39.9k
François Diederich 38962 9405 5706 23865 843 60.0k
George M. Sheldrick 82608 21106 86062 50153 832 172.3k
David N. Reinhoudt 19576 9349 5545 16482 962 49.1k
Jean‐Maríe Lehn 24329 10703 9904 18314 594 48.7k

All Works

Loading papers...

Rankless by CCL
2026