Standout Papers

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases 1993 2026 2004 2015 4.9k
  1. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases (1993)
    J. Wade Harper Cell
  2. Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control (1995)
    Chu‐Xia Deng, Pumin Zhang et al. Cell
  3. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy (2014)
    Joseph D. Mancias, Xiaoxu Wang et al. Nature
  4. The DNA Damage Response: Ten Years After (2007)
    J. Wade Harper, Stephen J. Elledge Molecular Cell
  5. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest (1994)
    Vjekoslav Dulić, William K. Kaufmann et al. Cell
  6. Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome (2011)
    Woong Kim, Eric J. Bennett et al. Molecular Cell
  7. Network organization of the human autophagy system (2010)
    Christian Behrends, Mathew E. Sowa et al. Nature
  8. Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex (2002)
    Ning Zheng, Brenda A. Schulman et al. Nature
  9. Defining the Human Deubiquitinating Enzyme Interaction Landscape (2009)
    Mathew E. Sowa, Eric J. Bennett et al. Cell
  10. SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box (1996)
    Chang Bai, Partha Sen et al. Cell
  11. F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex (1997)
    Dorota Skowyra, Karen Craig et al. Cell
  12. p53-Independent Expression of p21 Cip1 in Muscle and Other Terminally Differentiating Cells (1995)
    Susan B. Parker, Gregor Eichele et al. Science
  13. Formation and Activation of a Cyclin E-cdk2 Complex During the G 1 Phase of the Human Cell Cycle (1992)
    Andrew Koff, Antonio Giordano et al. Science
  14. Inhibition of cyclin-dependent kinases by p21. (1995)
    J. Wade Harper, Stephen J. Elledge et al. Molecular Biology of the Cell
  15. The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase (2004)
    Sara B. Cullinan, John D. Gordan et al. Molecular and Cellular Biology
  16. Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization (2013)
    Shireen A. Sarraf, Malavika Raman et al. Nature
  17. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. (1995)
    Satomi Matsuoka, Michael C. Edwards et al. Genes & Development
  18. The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro (1999)
    Jeffrey Winston, Peter R. Strack et al. Genes & Development
  19. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation (2004)
    Markus Welcker, Amir Orian et al. Proceedings of the National Academy of Sciences
  20. Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways (2009)
    Brenda A. Schulman, J. Wade Harper Nature Reviews Molecular Cell Biology
  21. The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy (2015)
    Jin‐Mi Heo, Alban Ordureau et al. Molecular Cell
  22. Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase (1999)
    Takumi Kamura, Deanna M. Koepp et al. Science
  23. Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF Fbw7 Ubiquitin Ligase (2001)
    Deanna M. Koepp, Laura Schaefer et al. Science
  24. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome (1997)
    Pumin Zhang, Nanette J. Liégeois et al. Nature
  25. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway (2016)
    Lynne Chantranupong, Sonia M. Scaria et al. Cell
  26. Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis (2014)
    Alban Ordureau, Shireen A. Sarraf et al. Molecular Cell
  27. Structure of a β-TrCP1-Skp1-β-Catenin Complex (2003)
    Geng Wu, Guozhou Xu et al. Molecular Cell
  28. A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1 (2006)
    Jianping Jin, Jing Chen et al. Molecular Cell
  29. Building and decoding ubiquitin chains for mitophagy (2018)
    J. Wade Harper, Alban Ordureau et al. Nature Reviews Molecular Cell Biology
  30. SAMTOR is an S -adenosylmethionine sensor for the mTORC1 pathway (2017)
    Xin Gu, Jose M. Orozco et al. Science
  31. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis (2015)
    Joseph D. Mancias, Laura Pontano Vaites et al. eLife
  32. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase (2005)
    Wenyi Wei, Jianping Jin et al. Cancer Cell
  33. Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence (2019)
    Gabriel E. Neurohr, Rachel Terry et al. Cell

Immediate Impact

44 by Nobel laureates 97 from Science/Nature 216 standout
Sub-graph 1 of 15

Citing Papers

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6 intermediate papers

Works of J. Wade Harper being referenced

Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers
2012
The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase
2004 Standout
and 4 more

Author Peers

Author Last Decade Papers Cites
J. Wade Harper 48175 19357 11582 303 61.5k
Stephen J. Elledge 75009 27392 14866 360 91.4k
Stanley J. Korsmeyer 59060 15203 6419 230 83.2k
Aaron Ciechanover 35060 10209 9134 289 43.2k
David Beach 34200 20131 9114 241 46.9k
Dario R. Alessi 50134 7625 10045 308 64.7k
Jiří Bártek 40971 22942 8164 378 52.8k
Charles J. Sherr 38985 30272 7513 270 57.5k
Hediye Erdjument‐Bromage 52815 7276 7633 283 67.2k
Stephen P. Jackson 55777 20612 5513 346 65.3k
Paul Tempst 61550 8205 8629 320 79.9k

All Works

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