Standout Papers

Restoring function in exhausted CD8 T cells during chronic viral infection 2005 2026 2012 2019 3.1k
  1. Restoring function in exhausted CD8 T cells during chronic viral infection (2005)
    Daniel L. Barber, E. John Wherry et al. Nature
  2. Molecular and cellular insights into T cell exhaustion (2015)
    E. John Wherry, Makoto Kurachi Nature reviews. Immunology
  3. T cell exhaustion (2011)
    E. John Wherry Nature Immunology
  4. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection (2008)
    Shawn D. Blackburn, Haina Shin et al. Nature Immunology
  5. Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection (2007)
    E. John Wherry, Sang‐Jun Ha et al. Immunity
  6. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells (2003)
    Susan M. Kaech, Joyce T. Tan et al. Nature Immunology
  7. Lineage relationship and protective immunity of memory CD8 T cell subsets (2003)
    E. John Wherry, Volker Teichgräber et al. Nature Immunology
  8. Effector and memory T-cell differentiation: implications for vaccine development (2002)
    Susan M. Kaech, E. John Wherry et al. Nature reviews. Immunology
  9. Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment (2003)
    E. John Wherry, Joseph N. Blattman et al. Journal of Virology
  10. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection (2007)
    Arlene H. Sharpe, E. John Wherry et al. Nature Immunology
  11. CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer (2019)
    Laura M. McLane, Mohamed S. Abdel-Hakeem et al. Annual Review of Immunology
  12. Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection (2007)
    E. John Wherry, Sang‐Jun Ha et al. Immunity
  13. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. (2011)
    Laurel A. Monticelli, Gregory F. Sonnenberg et al. Nature Immunology
  14. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus (2011)
    Laurel A. Monticelli, Gregory F. Sonnenberg et al. Nature Immunology
  15. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin (2005)
    Andrew M. Intlekofer, Naofumi Takemoto et al. Nature Immunology
  16. Defining ‘T cell exhaustion’ (2019)
    Christian U. Blank, W. Nicholas Haining et al. Nature reviews. Immunology
  17. Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade (2016)
    Kristen E. Pauken, Morgan A. Sammons et al. Science
  18. Overcoming T cell exhaustion in infection and cancer (2015)
    Kristen E. Pauken, E. John Wherry Trends in Immunology
  19. Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity (2012)
    Michael C. Abt, Lisa C. Osborne et al. Immunity
  20. Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade (2016)
    Joseph L. Benci, Bihui Xu et al. Cell
  21. Redefining Chronic Viral Infection (2009)
    Herbert W. Virgin, E. John Wherry et al. Cell
  22. Memory CD8 T-Cell Differentiation during Viral Infection (2004)
    E. John Wherry, Rafi Ahmed Journal of Virology
  23. Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection (2012)
    Michael Paley, Daniela C. Kroy et al. Science
  24. The epigenetic landscape of T cell exhaustion (2016)
    Debattama R. Sen, James J. Kaminski et al. Science
  25. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria (2013)
    Matthew R. Hepworth, Laurel A. Monticelli et al. Nature
  26. Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells (2002)
    Todd C. Becker, E. John Wherry et al. The Journal of Experimental Medicine
  27. Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms (2020)
    Jean‐Christophe Beltra, Sasikanth Manne et al. Immunity
  28. Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion (2016)
    Bertram Bengsch, Andrew L. Johnson et al. Immunity
  29. Antigen-Independent Differentiation and Maintenance of Effector-like Resident Memory T Cells in Tissues (2012)
    Kerry A. Casey, Kathryn Fraser et al. The Journal of Immunology
  30. T cell responses in patients with COVID-19 (2020)
    Zeyu Chen, E. John Wherry Nature reviews. Immunology
  31. The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs (2019)
    Anthony Virtue, Sam J. McCright et al. Science Translational Medicine
  32. CD8+ T cells in the cancer-immunity cycle (2023)
    Josephine R. Giles, Anna-Maria Globig et al. Immunity
  33. T cell immunity to COVID-19 vaccines (2022)
    E. John Wherry, Dan H. Barouch Science
  34. LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity (2024)
    Lawrence P. Andrews, Jian Cui et al. Cell

Immediate Impact

11 by Nobel laureates 69 from Science/Nature 190 standout
Sub-graph 1 of 13

Citing Papers

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
2022 StandoutScienceNobel
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
1 intermediate paper

Works of E. John Wherry being referenced

Molecular and cellular insights into T cell exhaustion
2015 Standout
Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity
2013

Author Peers

Author Last Decade Papers Cites
E. John Wherry 42913 20172 8951 270 57.6k
Giorgio Trinchieri 46473 11447 12816 431 66.6k
Antonio Lanzavecchia 57125 12823 12884 346 76.1k
Jacques Banchereau 61797 14797 16129 475 79.5k
Rafi Ahmed 54620 17073 11964 463 74.6k
Andrew D. Luster 28770 14079 10559 337 50.1k
Arlene H. Sharpe 47078 28206 16005 406 74.3k
Robert D. Schreiber 47711 33142 20381 378 78.3k
Gordon J. Freeman 53470 37868 14403 418 81.0k
Federica Sallusto 40897 10043 8833 239 54.6k
Robert L. Coffman 39139 6530 8691 254 60.2k

All Works

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2026