Standout Papers

The Enzymes, Regulation, ... 1984 2026 1998 2012 2003 1985 2005 1984 1989 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation benchmark for papers published in the same subfield and year, or reaches the top citation threshold in at least one of its specific research topics.

  1. The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
    2003 1.6k citations David W. Russell Annual Review of Biochemistry profile →
  2. Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
    1985 1.4k citations Joseph L. Goldstein, Michael S. Brown et al. PubMed profile →
  3. A comprehensive classification system for lipids
    2005 1.3k citations Eoin Fahy, Shankar Subramaniam et al. Journal of Lipid Research profile →
  4. The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
    1984 1.2k citations Tokuo Yamamoto, Christopher G. Davis et al. Cell profile →
  5. Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
    1989 1.2k citations S Andersson, Daphne L. Davis et al. Journal of Biological Chemistry profile →
  6. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
    1997 1.1k citations Hui-Qiao Tian, Steven L. McKnight et al. Genes & Development profile →
  7. Clinical importance of the cytochromes P450
    2002 1.1k citations Daniel W. Nebert, David W. Russell The Lancet profile →
  8. LMSD: LIPID MAPS structure database
    2006 989 citations Manish Sud, Eoin Fahy et al. Nucleic Acids Research profile →
  9. Transplanted bone marrow regenerates liver by cell fusion
    2003 982 citations George Vassilopoulos, Pei-Rong Wang et al. Nature profile →
  10. STEROID 5α-REDUCTASE: TWO GENES/TWO ENZYMES
    1994 876 citations David W. Russell, Jean D. Wilson Annual Review of Biochemistry profile →
  11. Purification of Nucleic Acids by Extraction with Phenol:Chloroform
    2006 721 citations Joseph Sambrook, David W. Russell Cold Spring Harbor Protocols profile →
  12. The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
    1985 714 citations Thomas C. Südhof, Joseph L. Goldstein et al. Science profile →
  13. Bile acid biosynthesis
    1992 676 citations David W. Russell, Kenneth D.R. Setchell Biochemistry profile →
  14. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.
    1993 563 citations Anice E. Thigpen, Richard I. Silver et al. Journal of Clinical Investigation profile →
  15. THE LDL RECEPTOR LOCUS IN FAMILIAL HYPERCHOLESTEROLEMIA: Mutational Analysis of a Membrane Protein
    1990 544 citations Helen H. Hobbs, David W. Russell et al. Annual Review of Genetics profile →
  16. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    1999 540 citations Erik Lund, Joseph M. Guileyardo et al. Proceedings of the National Academy of Sciences profile →
  17. Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
    2004 524 citations Jeffrey B. Cheng, Michael A. Levine et al. Proceedings of the National Academy of Sciences profile →
  18. Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
    1991 523 citations Stefan Andersson, David M. Berman et al. Nature profile →
  19. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    1998 518 citations Hui Tian, Robert E. Hammer et al. Genes & Development profile →
  20. Systemic delivery of genes to striated muscles using adeno-associated viral vectors
    2004 502 citations Paul Gregorevic, Michael J. Blankinship et al. Nature Medicine profile →
  21. HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells
    2017 438 citations Germán G. Gornalusse, Roli K. Hirata et al. Nature Biotechnology profile →
  22. Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains
    1985 379 citations Mark A. Lehrman, Wolfgang J. Schneider et al. Science profile →
  23. 25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon
    2014 338 citations Andrea Reboldi, Eric V. Dang et al. Science profile →
  24. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
    1987 335 citations Claire Davis, Joseph L. Goldstein et al. Nature profile →
  25. Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor
    1984 324 citations David W. Russell, Wolfgang J. Schneider et al. Cell profile →
  26. Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain
    1985 252 citations Mark A. Lehrman, Joseph L. Goldstein et al. Cell profile →

Immediate Impact

55 by Nobel laureates 48 from Science/Nature 102 hit
Sub-graph 1 of 16

Citing Papers

CAR T cell immunotherapy for human cancer
2018 HitScience
Diet–microbiota interactions as moderators of human metabolism
2016 HitNature
3 intermediate papers

Works of David W. Russell being referenced

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
2003 Hit
Bile acid biosynthesis
1992 Hit
and 7 more

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
David W. Russell 29.5k 12.4k 11.1k 8.0k 7.2k 541 52.5k
Charis Eng 23.9k 0.8× 7.8k 0.6× 7.6k 0.7× 9.8k 1.2× 8.4k 1.2× 646 44.7k
Michael B. Sporn 44.7k 1.5× 5.3k 0.4× 8.0k 0.7× 12.8k 1.6× 3.9k 0.6× 512 73.4k
Aldons J. Lusis 30.6k 1.0× 11.3k 0.9× 9.0k 0.8× 3.4k 0.4× 6.5k 0.9× 616 63.5k
Bert W. O’Malley 40.6k 1.4× 6.3k 0.5× 35.6k 3.2× 11.0k 1.4× 9.9k 1.4× 962 77.8k
Nabil G. Seidah 17.2k 0.6× 11.3k 0.9× 2.7k 0.2× 4.0k 0.5× 3.8k 0.5× 706 41.5k
M Kellis 28.9k 1.0× 9.7k 0.8× 19.9k 1.8× 5.1k 0.6× 8.8k 1.2× 1.3k 81.0k
Francis S. Collins 30.8k 1.0× 3.4k 0.3× 13.2k 1.2× 6.9k 0.9× 1.4k 0.2× 422 60.8k
Eric Boerwinkle 13.9k 0.5× 11.1k 0.9× 13.2k 1.2× 1.4k 0.2× 10.4k 1.5× 812 47.5k
Oliver Smithies 26.6k 0.9× 2.8k 0.2× 11.4k 1.0× 3.3k 0.4× 5.5k 0.8× 331 55.5k
Stephen B. Baylin 60.3k 2.0× 5.1k 0.4× 8.9k 0.8× 16.0k 2.0× 2.2k 0.3× 445 76.9k

All Works

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Rankless by CCL
2026