Standout Papers

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely... 2001 2026 2009 2017 1.7k
  1. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice (2005)
    Sunil R. Hingorani, Lifu Wang et al. Cancer Cell
  2. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse (2003)
    Sunil R. Hingorani, Emanuel F. Petricoin et al. Cancer Cell
  3. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis (2011)
    Gina M. DeNicola, Florian A. Karreth et al. Nature
  4. Transcriptional Regulation by Nrf2 (2017)
    Claudia Tonelli, Iok In Christine Chio et al. Antioxidants and Redox Signaling
  5. Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor (2001)
    Heikki Joensuu, Peter Roberts‎ et al. New England Journal of Medicine
  6. Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer (2013)
    Christine Feig, James O. Jones et al. Proceedings of the National Academy of Sciences
  7. Restoration of p53 function leads to tumour regression in vivo (2007)
    Andrea Ventura, David G. Kirsch et al. Nature
  8. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras (2001)
    Erica L. Jackson, Nicholas A. Willis et al. Genes & Development
  9. Pancreatic cancer (2016)
    Jörg Kleeff, Murray Korc et al. Nature Reviews Disease Primers
  10. The Pancreas Cancer Microenvironment (2012)
    Christine Feig, Aarthi Gopinathan et al. Clinical Cancer Research
  11. Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome (2004)
    Kenneth P. Olive, David A. Tuveson et al. Cell
  12. Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein–α (2010)
    Matthew Kraman, James N. Arnold et al. Science
  13. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice (2001)
    Leisa Johnson, Kim L. Mercer et al. Nature
  14. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma (2018)
    Giulia Biffi, Tobiloba E. Oni et al. Cancer Discovery
  15. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer (2012)
    Michael A. Jacobetz, Derek Chan et al. Gut
  16. ATP citrate lyase inhibition can suppress tumor cell growth (2005)
    Georgia Hatzivassiliou, Fangping Zhao et al. Cancer Cell
  17. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. (2001)
    Brian P. Rubin, Samuel Singer et al. PubMed
  18. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma (2003)
    Andrew J. Aguirre, Nabeel Bardeesy et al. Genes & Development
  19. Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion (2007)
    Carolyn E. Clark, Sunil R. Hingorani et al. Cancer Research
  20. Diversity and Biology of Cancer-Associated Fibroblasts (2020)
    Giulia Biffi, David A. Tuveson Physiological Reviews
  21. Fibroblast heterogeneity in the cancer wound (2014)
    Daniel Öhlund, Ela Elyada et al. The Journal of Experimental Medicine
  22. Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects (2004)
    David A. Tuveson, Alice T. Shaw et al. Cancer Cell
  23. Stromal biology and therapy in pancreatic cancer (2010)
    Albrecht Neeße, Patrick Michl et al. Gut
  24. Cancer modeling meets human organoid technology (2019)
    David A. Tuveson, Hans Clevers Science
  25. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications (2001)
    David A. Tuveson, Nicholas A. Willis et al. Oncogene
  26. In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma (2011)
    Florian A. Karreth, Yvonne Tay et al. Cell
  27. Stromal biology and therapy in pancreatic cancer: a changing paradigm (2015)
    Albrecht Neeße, Hana Algül et al. Gut
  28. ROS in Cancer: The Burning Question (2017)
    Iok In Christine Chio, David A. Tuveson Trends in Molecular Medicine
  29. Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis (2016)
    Sebastian R. Nielsen, Valeria Quaranta et al. Nature Cell Biology
  30. Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells (2019)
    Chenxi Tian, Karl R. Clauser et al. Proceedings of the National Academy of Sciences
  31. Activated fibroblasts in cancer: Perspectives and challenges (2023)
    Giuseppina Caligiuri, David A. Tuveson Cancer Cell
  32. Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction (2024)
    Corina Amor, Yu-Jui Ho et al. Nature Aging

Immediate Impact

3 by Nobel laureates 65 from Science/Nature 137 standout
Sub-graph 1 of 16

Citing Papers

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
2018 StandoutNature
1 intermediate paper

Works of David A. Tuveson being referenced

Pancreatic cancer
2016 Standout
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
2001 Standout

Author Peers

Author Last Decade Papers Cites
David A. Tuveson 20810 19285 9180 200 40.1k
Lisa M. Coussens 26884 23229 12264 195 59.8k
Anirban Maitra 25265 26073 14142 557 50.0k
Christine A. Iacobuzio–Donahue 17019 13029 8900 280 28.8k
Robert J. Coffey 7775 16389 6236 412 33.3k
Frances R. Balkwill 22155 13853 9511 291 46.0k
Daniel J. Hicklin 13904 20563 8709 184 34.9k
Axel Ullrich 22787 31993 6681 256 55.1k
Eric R. Fearon 20584 23614 12408 190 45.4k
Victor E. Velculescu 20138 34053 16698 182 53.4k
Isaiah J. Fidler 20990 21725 13490 496 47.8k

All Works

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2026