Standout Papers

Geometric Control of Cell Life and Death 1997 2026 2006 2016 3.7k
  1. Geometric Control of Cell Life and Death (1997)
    Christopher S. Chen, Milan Mrksich et al. Science
  2. Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment (2004)
    Rowena McBeath, Dana M. Pirone et al. Developmental Cell
  3. Cells lying on a bed of microneedles: An approach to isolate mechanical force (2003)
    John L. Tan, Joe Tien et al. Proceedings of the National Academy of Sciences
  4. Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix (2009)
    Farshid Guilak, Daniel M. Cohen et al. Cell stem cell
  5. Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues (2012)
    Jordan S. Miller, Kelly R. Stevens et al. Nature Materials
  6. Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012)
    Brendon M. Baker, Christopher S. Chen Journal of Cell Science
  7. Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure (1997)
    Andrew J. Maniotis, Christopher S. Chen et al. Proceedings of the National Academy of Sciences
  8. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics (2010)
    Carsten Grashoff, Brenton D. Hoffman et al. Nature
  9. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels (2013)
    Sudhir Khetan, Murat Güvendiren et al. Nature Materials
  10. Mechanical regulation of cell function with geometrically modulated elastomeric substrates (2010)
    Jianping Fu, Yang-Kao Wang et al. Nature Methods
  11. Emergent patterns of growth controlled by multicellular form and mechanics (2005)
    Celeste M. Nelson, Ronald P. Jean et al. Proceedings of the National Academy of Sciences
  12. Mechanotransduction in development: a growing role for contractility (2008)
    Michele A. Wozniak, Christopher S. Chen Nature Reviews Molecular Cell Biology
  13. Micropatterned Surfaces for Control of Cell Shape, Position, and Function (1998)
    Christopher S. Chen, Milan Mrksich et al. Biotechnology Progress
  14. Mechanical tugging force regulates the size of cell–cell junctions (2010)
    Zhijun Liu, John L. Tan et al. Proceedings of the National Academy of Sciences
  15. Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments (2015)
    Brendon M. Baker, Britta Trappmann et al. Nature Materials
  16. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy (2015)
    J. Travis Hinson, Anant Chopra et al. Science
  17. Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1 (2013)
    Daniel E. Conway, Mark T. Breckenridge et al. Current Biology
  18. Mechanical regulation of glycolysis via cytoskeleton architecture (2020)
    Jin Suk Park, Christoph J. Burckhardt et al. Nature
  19. Measuring cell-generated forces: a guide to the available tools (2016)
    William J. Polacheck, Christopher S. Chen Nature Methods
  20. Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise (2018)
    Haixin Song, Rowza T. Rumma et al. Cell stem cell
  21. MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools (2019)
    Madeleine Ernst, Kyo Bin Kang et al. Metabolites
  22. Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions (2012)
    Wesley R. Legant, Colin K. Choi et al. Proceedings of the National Academy of Sciences

Immediate Impact

4 by Nobel laureates 93 from Science/Nature 318 standout
Sub-graph 1 of 16

Citing Papers

Infrared nanosensors of piconewton to micronewton forces
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Additive manufacturing of highly entangled polymer networks
2024 StandoutScience
95 intermediate papers

Works of Christopher S. Chen being referenced

Microfabricated blood vessels for modeling the vascular transport barrier
2019
A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues
2011
and 59 more

Author Peers

Author Last Decade Papers Cites
Christopher S. Chen 21588 26873 13482 388 50.3k
Dennis E. Discher 17939 20619 17923 303 57.4k
Paul A. Janmey 24019 13903 13903 429 46.1k
Donald E. Ingber 26197 39217 28515 435 86.3k
Roger D. Kamm 7289 15905 9562 447 34.6k
Benjamin Geiger 23608 7328 18621 336 42.9k
Adam J. Engler 11335 14074 6470 139 26.7k
Valerie M. Weaver 15256 10694 12112 180 35.5k
Kenneth M. Yamada 25185 9856 28634 694 70.7k
Shu Chien 9528 9017 15813 632 46.2k
H. Lee Sweeney 10451 9040 17961 279 34.1k

All Works

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2026