Zhen Cai

9.7k citations

308 papers · 5.8k indexed · 2 hit papers · h-index 40

Impact in

Hematology top 0.5%
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
Immunology top 2%
- Immune Cell Function and Interaction
- Immune cells in cancer

Papers in ⓘ

Hematology 119
- Multiple Myeloma Research and Treatments 72
- Acute Myeloid Leukemia Research 25
- Hematopoietic Stem Cell Transplantation 24
Oncology 91
- Peptidase Inhibition and Analysis 24
- CAR-T cell therapy research 17

Co-authors: Jingsong He (91 shared papers)Yin Li (20 shared papers)Enfan Zhang (38 shared papers)Haimeng Yan (18 shared papers)Qing Yi (20 shared papers)Jianwei Qu (12 shared papers)He Huang (71 shared papers)Wen Cao (8 shared papers)
Journals: Blood (48 papers)Annals of Hematology (5 papers)Frontiers in Oncology (5 papers)International Journal of Hematology (5 papers)Journal of Hematology & Oncology (4 papers)
Partner nations: China United States Hong Kong

In The Last Decade

Zhen Cai

272 papers receiving 5.7k citations

Hit Papers

align trajectories log scale

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential 2022 · 159 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2022 Journal of Hematology & Oncology
2021 Biomarker Research

Peers

Countries citing papers authored by Zhen Cai

Since Specialization

Citations

This map shows the geographic impact of Zhen Cai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Zhen Cai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Zhen Cai more than expected).

Fields of papers citing papers by Zhen Cai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Zhen Cai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Zhen Cai. The network helps show where Zhen Cai may publish in the future.

Co-authors

The 25 scholars most cited alongside Zhen Cai, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Zhen Cai Line = papers co-authored together Zhen Cai links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 308 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Metabolic reprogramming in macrophage responses Biomarker Research ·Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Zhen Cai Hit paper breakdown →	2021	386
2	Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug–induced apoptosis Blood ·Yuhuan Zheng, Zhen Cai, Siqing Wang, Xiang Zhang, Jianfei Qian, Sungyoul Hong, Haiyan Li, Michael Wang, Jing Yang, Qing Yi	2009	247
3	Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4 Blood ·Yuzhen Wang, Taoyong Chen, Chaofeng Han, Donghua He, Haibo Liu, Huazhang An, Zhen Cai, Xuetao Cao	2007	171
4	RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential Journal of Hematology & Oncology ·Jianwei Qu, Haimeng Yan, Yifan Hou, Wen Cao, Yang Liu, Enfan Zhang, Jingsong He, Zhen Cai Hit paper breakdown →	2022	159
5	T-cell-replete haploidentical HSCT with low-dose anti-T-lymphocyte globulin compared with matched sibling HSCT and unrelated HSCT Blood ·Yi Luo, Haowen Xiao, Xiaoyu Lai, Jimin Shi, Yamin Tan, Jingsong He, Wanzhuo Xie, Weiyan Zheng, Yuanyuan Zhu, Xiujin Ye, Xiaohong Yu, Zhen Cai, Maofang Lin, He Huang	2014	139
6	Metformin and cancer: An existing drug for cancer prevention and therapy (Review) Oncology Letters ·Fuming Zi, Huapu Zi, Yi Li, Jingsong He, Qingzhi Shi, Zhen Cai	2017	129
7	PSGL-1/selectin and ICAM-1/CD18 interactions are involved in macrophage-induced drug resistance in myeloma Leukemia ·Yuhuan Zheng, Jing Yang, Junyan Qian, Peiju Qiu, Shino Hanabuchi, Yong Lu, Z Wang, Zhiqiang Liu, Heng Li, Jie He, Pei Lin, D. Weber, R. Eric Davis, Larry W. Kwak, Zhen Cai, Qing Yi	2012	125
8	Synergistic antitumor effects of lenalidomide and rituximab on mantle cell lymphoma in vitro and in vivo American Journal of Hematology ·Liang Zhang, Zhengzi Qian, Zhen Cai, Luhong Sun, Huaqing Wang, J. Blake Bartlett, Qing Yi, Michael Wang	2009	120
9	Fibroblast activation protein α in tumor microenvironment: Recent progression and implications (Review) Molecular Medicine Reports ·Fuming Zi, Jingsong He, Donghua He, Yi Li, Yang Li, Zhen Cai	2015	107
10	Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors. Proceedings of the National Academy of Sciences ·M. Kawaguchi, Masanobu Nanno, Yoshinori Umesaki, Satoshi Matsumoto, Yasushi Okada, Zhen Cai, Takahiro Shimamura, Yoshiaki Matsuoka, Makoto Ohwaki, Hiromichi Ishikawa	1993	103
11	Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress Molecular Cell ·Szu-Wei Lee, Chien‐Feng Li, Guoxiang Jin, Zhen Cai, Fei Han, Chia‐Hsin Chan, Wei-Lei Yang, Binkui Li, Abdol Hossein Rezaeian, Hongyu Li, Hsuan-Ying Huang, Hui‐Kuan Lin	2015	93
12	Harnessing accurate non-homologous end joining for efficient precise deletion in CRISPR/Cas9-mediated genome editing Genome biology ·Tao Guo, Yi-Li Feng, Jingjing Xiao, Qian Liu, Xiuna Sun, Ji-Feng Xiang, Na Kong, Sicheng Liu, Guoqiao Chen, Yue Wang, Mengmeng Dong, Zhen Cai, Hui Lin, Xiujun Cai, Anyong Xie	2018	93
13	Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma BMC Cancer ·Xiaoyan Han, Lijuan Wang, Hongfei Shi, Gaofeng Zheng, Jingsong He, Wenjun Wu, Jimin Shi, Guoqing Wei, Weiyan Zheng, Jie Sun, He Huang, Zhen Cai	2017	91
14	Identification of prognostic genes in the acute myeloid leukemia immune microenvironment based on TCGA data analysis Cancer Immunology Immunotherapy ·Haimeng Yan, Jianwei Qu, Wen Cao, Yang Liu, Gaofeng Zheng, Enfan Zhang, Zhen Cai	2019	85
15	A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome Journal of Hematology & Oncology ·Guoqing Wei, Wanmao Ni, Jen-wei Chiao, Zhen Cai, He Huang, Delong Liu	2011	72
16	Quantitative analysis of an engineered CO2-fixing Escherichia coli reveals great potential of heterotrophic CO2 fixation Biotechnology for Biofuels ·Fuyu Gong, Guoxia Liu, Xiaoyun Zhai, Jie Zhou, Zhen Cai, Yin Li	2015	70
17	p38 MAPK in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction Cancer Research ·Jin He, Zhiqiang Liu, Yuhuan Zheng, Jianfei Qian, Haiyan Li, Yong Lu, Jingda Xu, Bangxing Hong, Mingjun Zhang, Pei Lin, Zhen Cai, Robert Z. Orlowski, Larry W. Kwak, Qing Yi, Jing Yang	2012	69
18	Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1 Molecular Cell ·Guoxiang Jin, Szu-Wei Lee, Xian Zhang, Zhen Cai, Yuan Gao, Ping‐Chieh Chou, Abdol Hossein Rezaeian, Fei Han, Chi‐Yun Wang, Juo-Chin Yao, Zhaohui Gong, Chia‐Hsin Chan, Chih‐Yang Huang, Fuu‐Jen Tsai, Chang‐Hai Tsai, Shih‐Hsin Tu, Chih‐Hsiung Wu, Dos D. Sarbassov, Yuan‐Soon Ho, Hui‐Kuan Lin	2015	67
19	Engineering Saccharomyces cerevisiae for efficient anaerobic xylose fermentation: Reflections and perspectives Biotechnology Journal ·Zhen Cai, Bo Zhang, Yin Li	2011	67
20	In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-κB activity Leukemia ·Christian Wuchter, Daniel Krappmann, Zhen Cai, V Ruppert, Claus Scheidereit, Bernd Dörken, W-D Ludwig, Leonid Karawajew	2001	63

About Zhen Cai

Zhen Cai is a scholar working on Hematology, Oncology, Genetics, Immunology and Molecular Biology, having authored 308 papers that have together received 5.8k indexed citations. Recurring topics across this work include Multiple Myeloma Research and Treatments (72 papers), Protein Degradation and Inhibitors (28 papers), Acute Myeloid Leukemia Research (25 papers), Hematopoietic Stem Cell Transplantation (24 papers), Peptidase Inhibition and Analysis (24 papers), Ubiquitin and proteasome pathways (18 papers), CAR-T cell therapy research (17 papers) and Chronic Lymphocytic Leukemia Research (17 papers). The work is most often cited by research in Hematology (1.3k citations), Immunology (1.3k citations), Oncology (1.4k citations), Cancer Research (664 citations) and Molecular Biology (2.9k citations). Zhen Cai has collaborated with scholars based in China, United States and Hong Kong. Frequent co-authors include Jingsong He, Yin Li, Enfan Zhang, Haimeng Yan, Qing Yi, Jianwei Qu, He Huang, Wen Cao, Donghua He and Huiyao Gu. Their work appears in journals such as Blood, Annals of Hematology, Frontiers in Oncology, International Journal of Hematology and Journal of Hematology & Oncology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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