Yasuhide Hirota

1.8k citations

21 papers · 1.5k indexed · 1 hit paper · h-index 13

Co-authors: Keiki Sato Masashi Aonuma Yasuyoshi Kawato Hiroshi Kuga Yusuke Wataya Akiko Yoshioka Osamu Hiraoka Kouichi Uoto
Topics: Cancer therapeutics and mechanisms (6 papers)Cancer Treatment and Pharmacology (4 papers)Bioactive Compounds and Antitumor Agents (3 papers)
Cited by: Toxicology Oncology Molecular Biology
Journals: Journal of Biological Chemistry Cancer Research Biochemical and Biophysical Research Communications
Partner nations: Japan Germany Italy

In The Last Decade

Yasuhide Hirota

20 papers receiving 1.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 762 citations Yasuyoshi Kawato, Masashi Aonuma et al. PubMed profile →

Peers

Countries citing papers authored by Yasuhide Hirota

Since Specialization

Citations

This map shows the geographic impact of Yasuhide Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yasuhide Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yasuhide Hirota more than expected).

Fields of papers citing papers by Yasuhide Hirota

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yasuhide Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yasuhide Hirota. The network helps show where Yasuhide Hirota may publish in the future.

Co-authorship network of co-authors of Yasuhide Hirota

This figure shows the co-authorship network connecting the top 25 collaborators of Yasuhide Hirota. A scholar is included among the top collaborators of Yasuhide Hirota based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Yasuhide Hirota. Yasuhide Hirota is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Separation and Measurement of Microplastics in Paddy Soil 2024 ·Journal of Environmental Protection ·Yumei Kang,Yasuhide Hirota,(unknown),Kou Ikejima,Katsutoshi Sakurai	2
2	Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion 2022 ·Cancer Research ·Yohei Yoshihama,(unknown),(unknown),(unknown),Sachiko Takaishi,(unknown),(unknown),(unknown),Tomoko Shibutani,Kazunori Fujimoto,(unknown),Hiroki Goto,Naoya Wada,Shinji Tsutsumi,Yasuhide Hirota,T. Ishikawa,S Yamamoto	15
3	RNA interference activity of single-stranded oligonucleotides linked between the passenger strand and the guide strand with an aryl phosphate linker 2021 ·Nucleosides Nucleotides & Nucleic Acids ·Makoto Koizumi,Yasuhide Hirota,(unknown),Masakazu Tamura,Wataru Obuchi	1
4	Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity 2019 ·Journal of Medicinal Chemistry ·Junya Kawai,(unknown),Masahiro Ota,Hidekazu Inoue,Yoshimi Takata,(unknown),Makoto Suzuki,Takashi Shimada,Kaori Ono,Kanae Suzuki,Sachiko Takaishi,Hitoshi Ohki,Satoshi Matsui,Shinji Tsutsumi,Yasuhide Hirota,Kiyoshi Nakayama	56
5	Design of 2'-O-methyl RNA and DNA double-stranded oligonucleotides: naturally-occurring nucleotide components with strong RNA interference gene expression inhibitory activity 2019 ·Nucleosides Nucleotides & Nucleic Acids ·Makoto Koizumi,Yasuhide Hirota,(unknown),Masakazu Tamura,Wataru Obuchi,Akiko Kurimoto,Hiroshi Tsuchida,Hiroaki Maeda	3
6	Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma 2017 ·Oncotarget ·Dimpy Koul,Shuzhen Wang,Shaofang Wu,Norihiko Saito,Siyuan Zheng,Feng Gao,(unknown),(unknown),Kiyoshi Nakayama,Kumiko Koyama,Yoshinobu Shiose,Erik P. Sulman,Yasuhide Hirota,W.K. Alfred Yung	16
7	Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogs of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position. 1998 ·Chemical and Pharmaceutical Bulletin ·Kouichi Uoto,(unknown),Teruo Yoshino,Yasuhide Hirota,Shin Ando,Ikuo Mitsui,Hiroaki Terasawa,Takatoshi Soga	14
8	Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues 1998 ·Journal of Medicinal Chemistry ·Masamichi Sugimori,Akio Ejima,Satoru Ohsuki,Kouichi Uoto,Ikuo Mitsui,Yasuyoshi Kawato,Yasuhide Hirota,Keiki Sato,Hirofumi Terasawa	29
9	Synthesis and Structure-Activity Relationships of Novel 2',2'-Difluoro Analogues of Docetaxel. 1997 ·Chemical and Pharmaceutical Bulletin ·Kouichi Uoto,Satoru Ohsuki,(unknown),Takashi Ishiyama,Shin Iimura,Yasuhide Hirota,Ikuo Mitsui,Hirofumi Terasawa,Tsunehiko Soga	72
10	p53 Antisense Oligonucleotide Inhibits Growth of Human Colon Tumor and Normal Cell Lines 1996 ·Japanese Journal of Cancer Research ·Yasuhide Hirota,Tadashi Horiuchi,Kouichi Akahane	21
11	A New Water‐soluble Camptothecin Derivative, DX‐8951f, Exhibits Potent Antitumor Activity against Human Tumors in vitro and in vivo 1995 ·PubMed ·Ikuo Mitsui,Eiji Kumazawa,Yasuhide Hirota,Masashi Aonuma,Masamichi Sugimori,Satoru Ohsuki,Kouichi Uoto,Akio Ejima,Hirofumi Terasawa,Keiki Sato	134
12	Different Mechanisms of Inhibition of DNA Synthesis by (E)-5-(2-Bromovinyl)-2′-deoxyuridine in Cells Transfected with Gene for Thymidine Kinase of Herpes Simplex Virus Type 1 and in Cells Infected with the Virus 1995 ·Nucleosides and Nucleotides ·Yasuhide Hirota,(unknown),Akiko Matsumoto,Shiro Nii,Yusuke Wataya	2
13	Inhibitory Activity of Camptothecin Derivatives Against Acetylcholinesterase in Dogs and Their Binding Activity to Acetylcholine Receptors in Rats 1993 ·Journal of Pharmacy and Pharmacology ·Yasuyoshi Kawato,Masayasu Sekiguchi,Kouichi Akahane,Yumi Tsutomi,Yasuhide Hirota,Hiroshi Kuga,(unknown),Hideo Hakusui,(unknown)	38
14	Imbalance of Deoxyribonucleoside Triphosphates and DNA Double‐strand Breaks in Mouse Mammary Tumor FM3A Cells Treated in vitro with an Antineoplastic Tropolone Derivative 1992 ·Japanese Journal of Cancer Research ·Masatoshi Yamato,Yasuhide Hirota,Sei Yoshida,Shouhei Tanaka,Tetsuo Morita,(unknown),Kuniko Hashigaki,Hikoya Hayatsu,Yusuke Wataya	7
15	Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.breakdown → 1991 ·PubMed ·Yasuyoshi Kawato,Masashi Aonuma,Yasuhide Hirota,Hiroshi Kuga,Keiki Sato	762
16	The Mechanism of 2-Chlorodeoxyadenosine-Induced Cell Death 1989 ·Advances in experimental medicine and biology ·Yusuke Wataya,Yasuhide Hirota,(unknown),S Tanaka,Takeshi Otani,Jun Minowada,Akira Matsuda,Takuya Ueda	6
17	Imbalance of deoxyribonucleoside triphosphates, DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells. 1989 ·PubMed ·Yasuhide Hirota,Akiko Yoshioka,Shohei Tanaka,Kenichi Watanabe,Takeshi Otani,Jun Minowada,Akira Matsuda,Takuya Ueda,Yusuke Wataya	79
18	Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. 1987 ·Journal of Biological Chemistry ·Akiko Yoshioka,S Tanaka,Osamu Hiraoka,(unknown),Yasuhide Hirota,Dai Ayusawa,Tetsuzo Seno,Charles Garrett,Yusuke Wataya	219
19	Deoxyribonucleoside-triphosphate imbalance death: Deoxyadenosine-induced dNTP imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death 1987 ·Biochemical and Biophysical Research Communications ·Akiko Yoshioka,Shohei Tanaka,Osamu Hiraoka,(unknown),Yasuhide Hirota,Yusuke Wataya	34
20	The mechanism of dNTP-unbalanced cell death induced by 5-fluorouracil and its derivatives. 1985 ·PubMed ·Akira Yoshioka,(unknown),Osamu Hiraoka,(unknown),Yasuhide Hirota,(unknown)	4

About Yasuhide Hirota

Yasuhide Hirota is a scholar working on Toxicology, Oncology and Cancer Research, having authored 21 papers that have together received 1.5k indexed citations. Recurring topics across this work include Cancer therapeutics and mechanisms (6 papers), Cancer Treatment and Pharmacology (4 papers) and Bioactive Compounds and Antitumor Agents (3 papers). The work is most often cited by research in Toxicology (127 citations), Oncology (766 citations) and Molecular Biology (1.1k citations). Yasuhide Hirota has collaborated with scholars based in Japan, Germany and Italy. Frequent co-authors include Keiki Sato, Masashi Aonuma, Yasuyoshi Kawato, Hiroshi Kuga, Yusuke Wataya, Akiko Yoshioka, Osamu Hiraoka, Kouichi Uoto, Ikuo Mitsui and S Tanaka. Their work appears in journals such as Journal of Biological Chemistry, Cancer Research and Biochemical and Biophysical Research Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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