Yasuhide Hirota

1.8k total citations · 1 hit paper
21 papers, 1.5k citations indexed

About

Yasuhide Hirota is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, Yasuhide Hirota has authored 21 papers receiving a total of 1.5k indexed citations (citations by other indexed papers that have themselves been cited), including 14 papers in Molecular Biology, 11 papers in Oncology and 4 papers in Cancer Research. Recurrent topics in Yasuhide Hirota's work include Cancer therapeutics and mechanisms (6 papers), Cancer Treatment and Pharmacology (4 papers) and Bioactive Compounds and Antitumor Agents (3 papers). Yasuhide Hirota is often cited by papers focused on Cancer therapeutics and mechanisms (6 papers), Cancer Treatment and Pharmacology (4 papers) and Bioactive Compounds and Antitumor Agents (3 papers). Yasuhide Hirota collaborates with scholars based in Japan, Germany and Italy. Yasuhide Hirota's co-authors include Keiki Sato, Masashi Aonuma, Yasuyoshi Kawato, Hiroshi Kuga, Yusuke Wataya, Akiko Yoshioka, Osamu Hiraoka, Kouichi Uoto, Ikuo Mitsui and S Tanaka and has published in prestigious journals such as Journal of Biological Chemistry, Cancer Research and Biochemical and Biophysical Research Communications.

In The Last Decade

Yasuhide Hirota

20 papers receiving 1.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 762 citations Yasuyoshi Kawato, Masashi Aonuma et al. PubMed profile →

Peers

Yasuhide Hirota

ONCOL

TOXIC

Marie-Christine Bissery France

Masashi Aonuma Japan

Hiroshi Kuga Japan

Paul Nimmer United States

Fernando C. Giuliani Italy

Hans R. Hendriks Netherlands

Stella Tinelli Italy

Benjamin Winograd Netherlands

Dale Grabowski United States

Donald J. Dykes United States

Marie-Christine Bissery France

Yasuhide Hirota

641 ×0.6

641 ×0.8

ONCOL

180 ×0.9

66 ×0.5

TOXIC

184 ×1.5

Citations per year, relative to Yasuhide Hirota Yasuhide Hirota (= 1×) peers Marie-Christine Bissery

Countries citing papers authored by Yasuhide Hirota

Since Specialization

Citations

This map shows the geographic impact of Yasuhide Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yasuhide Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yasuhide Hirota more than expected).

Fields of papers citing papers by Yasuhide Hirota

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yasuhide Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yasuhide Hirota. The network helps show where Yasuhide Hirota may publish in the future.

Co-authorship network of co-authors of Yasuhide Hirota

This figure shows the co-authorship network connecting the top 25 collaborators of Yasuhide Hirota. A scholar is included among the top collaborators of Yasuhide Hirota based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Yasuhide Hirota. Yasuhide Hirota is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kang, Yumei, et al.. (2024). Separation and Measurement of Microplastics in Paddy Soil. Journal of Environmental Protection. 15(12). 1016–1021. 2 indexed citations

Yoshihama, Yohei, Sachiko Takaishi, Tomoko Shibutani, et al.. (2022). Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion. Cancer Research. 82(21). 4031–4043. 15 indexed citations

Koizumi, Makoto, et al.. (2021). RNA interference activity of single-stranded oligonucleotides linked between the passenger strand and the guide strand with an aryl phosphate linker. Nucleosides Nucleotides & Nucleic Acids. 40(6). 647–664. 1 indexed citations

Kawai, Junya, Masahiro Ota, Hidekazu Inoue, et al.. (2019). Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity. Journal of Medicinal Chemistry. 62(22). 10204–10220. 56 indexed citations

Koizumi, Makoto, Yasuhide Hirota, Masakazu Tamura, et al.. (2019). Design of 2'-O-methyl RNA and DNA double-stranded oligonucleotides: naturally-occurring nucleotide components with strong RNA interference gene expression inhibitory activity. Nucleosides Nucleotides & Nucleic Acids. 39(1-3). 292–309. 3 indexed citations

Koul, Dimpy, Shuzhen Wang, Shaofang Wu, et al.. (2017). Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma. Oncotarget. 8(13). 21741–21753. 16 indexed citations

Uoto, Kouichi, Teruo Yoshino, Yasuhide Hirota, et al.. (1998). Synthesis and Evaluation of Water-Soluble Non-Prodrug Analogs of Docetaxel Bearing sec-Aminoethyl Group at the C-10 Position.. Chemical and Pharmaceutical Bulletin. 46(5). 770–776. 14 indexed citations

Sugimori, Masamichi, Akio Ejima, Satoru Ohsuki, et al.. (1998). Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues. Journal of Medicinal Chemistry. 41(13). 2308–2318. 29 indexed citations

Uoto, Kouichi, Satoru Ohsuki, Takashi Ishiyama, et al.. (1997). Synthesis and Structure-Activity Relationships of Novel 2',2'-Difluoro Analogues of Docetaxel.. Chemical and Pharmaceutical Bulletin. 45(11). 1793–1804. 72 indexed citations

10.

Hirota, Yasuhide, Tadashi Horiuchi, & Kouichi Akahane. (1996). p53 Antisense Oligonucleotide Inhibits Growth of Human Colon Tumor and Normal Cell Lines. Japanese Journal of Cancer Research. 87(7). 735–742. 21 indexed citations

11.

Mitsui, Ikuo, Eiji Kumazawa, Yasuhide Hirota, et al.. (1995). A New Water‐soluble Camptothecin Derivative, DX‐8951f, Exhibits Potent Antitumor Activity against Human Tumors in vitro and in vivo. Japanese Journal of Cancer Research. 86(8). 776–782. 134 indexed citations

12.

Hirota, Yasuhide, et al.. (1995). Different Mechanisms of Inhibition of DNA Synthesis by (E)-5-(2-Bromovinyl)-2′-deoxyuridine in Cells Transfected with Gene for Thymidine Kinase of Herpes Simplex Virus Type 1 and in Cells Infected with the Virus. Nucleosides and Nucleotides. 14(9-10). 2079–2087. 2 indexed citations

13.

Kawato, Yasuyoshi, Masayasu Sekiguchi, Kouichi Akahane, et al.. (1993). Inhibitory Activity of Camptothecin Derivatives Against Acetylcholinesterase in Dogs and Their Binding Activity to Acetylcholine Receptors in Rats. Journal of Pharmacy and Pharmacology. 45(5). 444–448. 38 indexed citations

14.

Yamato, Masatoshi, Yasuhide Hirota, Sei Yoshida, et al.. (1992). Imbalance of Deoxyribonucleoside Triphosphates and DNA Double‐strand Breaks in Mouse Mammary Tumor FM3A Cells Treated in vitro with an Antineoplastic Tropolone Derivative. Japanese Journal of Cancer Research. 83(6). 661–668. 7 indexed citations

15.

Kawato, Yasuyoshi, Masashi Aonuma, Yasuhide Hirota, Hiroshi Kuga, & Keiki Sato. (1991). Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.. PubMed. 51(16). 4187–91. 762 indexed citations breakdown →

16.

Wataya, Yusuke, Yasuhide Hirota, S Tanaka, et al.. (1989). The Mechanism of 2-Chlorodeoxyadenosine-Induced Cell Death. Advances in experimental medicine and biology. 253B. 227–234. 6 indexed citations

17.

Hirota, Yasuhide, Akiko Yoshioka, Shohei Tanaka, et al.. (1989). Imbalance of deoxyribonucleoside triphosphates, DNA double-strand breaks, and cell death caused by 2-chlorodeoxyadenosine in mouse FM3A cells.. PubMed. 49(4). 915–9. 79 indexed citations

18.

Yoshioka, Akiko, S Tanaka, Osamu Hiraoka, et al.. (1987). Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.. Journal of Biological Chemistry. 262(17). 8235–8241. 219 indexed citations

19.

Yoshioka, Akiko, et al.. (1987). Deoxyribonucleoside-triphosphate imbalance death: Deoxyadenosine-induced dNTP imbalance and DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. Biochemical and Biophysical Research Communications. 146(1). 258–264. 34 indexed citations

20.

Yoshioka, Akira, et al.. (1985). The mechanism of dNTP-unbalanced cell death induced by 5-fluorouracil and its derivatives.. PubMed. 245–8. 4 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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