William J. Hoekstra

2.7k citations

70 papers · 2.2k indexed · 1 hit paper · h-index 27

Co-authors: Robert J. Schotzinger Edward P. Garvey Bruce E. Maryanoff Christopher M. Yates Barry G. Shearer Patricia Andrade‐Gordon Galina I. Lepesheva Tatiana Y. Hargrove
Topics: Antifungal resistance and susceptibility (18 papers)Fungal Infections and Studies (12 papers)Chemical Synthesis and Analysis (10 papers)
Cited by: Infectious Diseases Hematology Organic Chemistry
Journals: Proceedings of the National Academy of Sciences Journal of Biological Chemistry Journal of Clinical Oncology
Partner nations: United States United Kingdom Germany

In The Last Decade

William J. Hoekstra

69 papers receiving 2.1k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

2017 317 citations William J. Hoekstra, Robert J. Schotzinger et al. profile →

Peers

Countries citing papers authored by William J. Hoekstra

Since Specialization

Citations

This map shows the geographic impact of William J. Hoekstra's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William J. Hoekstra with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William J. Hoekstra more than expected).

Fields of papers citing papers by William J. Hoekstra

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William J. Hoekstra. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William J. Hoekstra. The network helps show where William J. Hoekstra may publish in the future.

Co-authorship network of co-authors of William J. Hoekstra

This figure shows the co-authorship network connecting the top 25 collaborators of William J. Hoekstra. A scholar is included among the top collaborators of William J. Hoekstra based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William J. Hoekstra. William J. Hoekstra is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Abstract P233: Inhibition Of Aldosterone Synthesis In Non-human Primates By PB6440, The Novel Highly Selective And Potent CYP11B2 Inhibitor 2020 ·Hypertension ·Bertram Pitt,Deepak L. Bhatt,(unknown),J. David Becherer,William J. Hoekstra,(unknown),Steven M. Sparks,John S. Lee	1
2	Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors 2017 ·Bioorganic & Medicinal Chemistry Letters ·Christopher M. Yates,Edward P. Garvey,Sammy R. Shaver,Robert J. Schotzinger,William J. Hoekstra	71
3	Activity of VT-1129 againstCryptococcus neoformansclinical isolates with high fluconazole MICs 2016 ·Medical Mycology ·Kirsten Nielsen,(unknown),Kyle D. Smith,David B. Meya,Edward P. Garvey,William J. Hoekstra,Robert J. Schotzinger,David R. Boulware	23
4	Design and optimization of highly-selective fungal CYP51 inhibitors 2014 ·Bioorganic & Medicinal Chemistry Letters ·William J. Hoekstra,Edward P. Garvey,William R. Moore,(unknown),Christopher M. Yates,Robert J. Schotzinger	152
5	Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors 2014 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Joel R. Eisner,William R. Moore,Robert J. Schotzinger,William J. Hoekstra	45
6	Co-crystal structure guided array synthesis of PPARγ inverse agonists 2007 ·Bioorganic & Medicinal Chemistry Letters ·Ryan P. Trump,(unknown),Barry G. Shearer,Millard H. Lambert,Robert T. Nolte,Timothy M. Willson,Richard G. Buckholz,Sumin Zhao,Lisa M. Leesnitzer,Marie A. Iannone,Kenneth H. Pearce,Andrew N. Billin,William J. Hoekstra	15
7	Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines 2006 ·Bioorganic & Medicinal Chemistry Letters ·Robert W. Wiethe,Eugene L. Stewart,David H. Drewry,David W. Gray,(unknown),William J. Hoekstra	14
8	Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonists 2005 ·Bioorganic & Medicinal Chemistry Letters ·David G. Jones,Xi Liang,Eugene L. Stewart,Robert A. Noe,Lara S. Kallander,Kevin P. Madauss,Shawn P. Williams,Scott K. Thompson,David W. Gray,William J. Hoekstra	26
9	Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins 2004 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),William A. Kinney,Li Liu,Shyamali Ghosh,Livia Brunner,William J. Hoekstra,Rosemary J. Santulli,Robert W. Tuman,Judith F. Baker,(unknown),(unknown),Brett A. Tounge,Bruce P. Damiano,Bruce E. Maryanoff,Dana L. Johnson,Robert A. Galemmo	17
10	Aza-bicyclic amino acid sulfonamides as α4β1/α4β7 integrin antagonists 2003 ·Bioorganic & Medicinal Chemistry Letters ·Alexey B. Dyatkin,William J. Hoekstra,William A. Kinney,Maria Kontoyianni,Rosemary J. Santulli,Edward S. Kimball,(unknown),Stephen M. Prouty,William M. Abraham,Patricia Andrade‐Gordon,Dennis J. Hlasta,Wei He,Pamela J. Hornby,Bruce P. Damiano,Bruce E. Maryanoff	7
11	Recent Advances in Peroxisome Proliferator-Activated Receptor Science 2003 ·Current Medicinal Chemistry ·Barry G. Shearer,William J. Hoekstra	86
12	Bridged bicyclic vasopressin receptor antagonists with V2-Selective or dual V1a/V2 activity 2002 ·Bioorganic & Medicinal Chemistry Letters ·Alexey B. Dyatkin,William J. Hoekstra,Dennis J. Hlasta,Patricia Andrade‐Gordon,Lawrence de Garavilla,Keith T. Demarest,Joseph W. Gunnet,William Hageman,Richard Look,Bruce E. Maryanoff	10
13	Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist 2001 ·Thrombosis Research ·Bruce P. Damiano,John A. Mitchell,Edward C. Giardino,(unknown),Barbara J. Haertlein,Lawrence de Garavilla,Jack A. Kauffman,William J. Hoekstra,Bruce E. Maryanoff,Patricia Andrade‐Gordon	26
14	Protease-Activated Receptor-2 (PAR-2): Structure-Function Study of Receptor Activation by Diverse Peptides Related to Tethered-Ligand Epitopes 2001 ·Archives of Biochemistry and Biophysics ·Bruce E. Maryanoff,Rosemary J. Santulli,David F. McComsey,William J. Hoekstra,Kenway Hoey,Charles E. Smith,Marylyn M. Addo,Andrew L. Darrow,Patricia Andrade‐Gordon	47
15	1,2,4-Triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists 2001 ·Bioorganic & Medicinal Chemistry Letters ·Edward C. Lawson,William J. Hoekstra,Marylyn M. Addo,Patricia Andrade‐Gordon,Bruce P. Damiano,Jack A. Kauffman,John A. Mitchell,Bruce E. Maryanoff	47
16	An Expedient Method for Resolution of 3-Amino-3-(3‘-pyridyl)propionic Acid and Related Compounds 2000 ·Organic Process Research & Development ·(unknown),(unknown),Leonard R. Hecker,William J. Hoekstra,(unknown),Cynthia A. Maryanoff,(unknown),Rekha D. Shah,(unknown),Kirk L. Sorgi,(unknown),(unknown),Frank J. Villani,Donald G. Walker	10
17	Photoactivatable peptides based on BMS-197525: A potent antagonist of the human thrombin receptor (PAR-1) 1999 ·Bioorganic & Medicinal Chemistry Letters ·John T. Elliott,William J. Hoekstra,Bruce E. Maryanoff,Glenn D. Prestwich	12
18	Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif 1998 ·Bioorganic & Medicinal Chemistry Letters ·William J. Hoekstra,(unknown),David F. McComsey,Patricia Andrade‐Gordon,Jack A. Kauffman,Marylyn M. Addo,Donna Oksenberg,Robert M. Scarborough,Bruce E. Maryanoff	29
19	Integrin Receptor GPIIb/IIIa Bound State Conformation of the Fibrinogen γ-Chain C-Terminal Peptide 400−411: NMR and Transfer NOE Studies 1996 ·Biochemistry ·Kevin H. Mayo,(unknown),Mary Pat Beavers,Annette Eckardt,Patricia M. Keane,William J. Hoekstra,Patricia Andrade‐Gordon	16
20	Design and Evaluation of Nonpeptide Fibrinogen .gamma. Chain-Based GPIIB/IIIA Antagonists 1995 ·Journal of Medicinal Chemistry ·William J. Hoekstra,Mary Pat Beavers,Patricia Andrade‐Gordon,(unknown),Patricia M. Keane,Jeffery B. Press,Karen Tomko,(unknown),Marek Kloczewiak	27

About William J. Hoekstra

William J. Hoekstra is a scholar working on Hematology, Immunology and Allergy and Infectious Diseases, having authored 70 papers that have together received 2.2k indexed citations. Recurring topics across this work include Antifungal resistance and susceptibility (18 papers), Fungal Infections and Studies (12 papers) and Chemical Synthesis and Analysis (10 papers). The work is most often cited by research in Infectious Diseases (701 citations), Hematology (310 citations) and Organic Chemistry (728 citations). William J. Hoekstra has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Robert J. Schotzinger, Edward P. Garvey, Bruce E. Maryanoff, Christopher M. Yates, Barry G. Shearer, Patricia Andrade‐Gordon, Galina I. Lepesheva, Tatiana Y. Hargrove, Z. Wawrzak and Aidong Qi. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Oncology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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