Timothy P. Heffernan

18.2k citations

38 papers · 1.3k indexed · h-index 18

Cancer Research top 5%
- Cancer, Hypoxia, and Metabolism 5
- Cancer Genomics and Diagnostics 4
- Carcinogens and Genotoxicity Assessment 4
Hematology top 5%
Oncology top 5%
- Cancer-related Molecular Pathways 10
- Colorectal Cancer Treatments and Studies 3
Genetics top 5%
- Chronic Lymphocytic Leukemia Research 2
Molecular Biology top 10%
- DNA Repair Mechanisms 9
- Melanoma and MAPK Pathways 5

Co-authors: William K. Kaufmann Marila Cordeiro‐Stone Dennis A. Simpson Richard S. Paules Alexandra N. Heinloth Christopher A. Bristow P. Andrew Futreal Scott Kopetz
Cited by: Cancer Research Hematology Oncology
Journals: Proceedings of the National Academy of Sciences (1 paper)Journal of Biological Chemistry (1 paper)Journal of Clinical Oncology (4 papers)
Partner nations: United States Austria United Kingdom

In The Last Decade

Timothy P. Heffernan

34 papers receiving 1.3k citations

Peers

Countries citing papers authored by Timothy P. Heffernan

Since Specialization

Citations

This map shows the geographic impact of Timothy P. Heffernan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Timothy P. Heffernan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Timothy P. Heffernan more than expected).

Fields of papers citing papers by Timothy P. Heffernan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Timothy P. Heffernan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Timothy P. Heffernan. The network helps show where Timothy P. Heffernan may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Timothy P. Heffernan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Timothy P. Heffernan Line = papers co-authored together Timothy P. Heffernan links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	CBX250 Is a Novel Cathepsin G Peptide-HLA-Targeting T Cell Engager That Exhibits High Tumor Antigen Selectivity and Potent Antileukemic Activity In Vivo Blood ·Benjamin H. Lee,Geraldine L. C. Paulus,Jennifer D. Helble,Preethi Sankaran,Tanzila Rahman,Delainey O’Connor,Melissa J. Bikowitz,Sarah Jaffe,Alona Kulesha,Bhupal Ban,N Mak,Michael F. Princiotta,Chunhua Shi,Jun Yan,Hong He,Ningping Feng,Jeffrey J. Molldrem,Timothy P. Heffernan,Gheath Alatrash,Dmitri Wiederschain	2024	0
2	Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL Leukemia ·Ze Tian,Chunhua Shi,Guojun Yang,Jason Allen,Qing Shi,Amin Al-Shami,Jill Olson,Melinda Smith,Qing Chang,Jasbir Kaur,Junping You,Timothy Lofton,Michelle A. González,Qi Zhang,Dongxing Zha,Sarah K. Tasian,Nitin Jain,Marina Konopleva,Timothy P. Heffernan,Jeffrey J. Molldrem	2023	6
3	Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma Clinical Cancer Research ·Abdullah A. Osman,Emre Arslan,Mason Bartels,Chieko Michikawa,Antje Lindemann,Katarzyna Tomczak,Wangjie Yu,Vlad C. Sandulache,Wencai Ma,Li Shen,Jing Wang,Anand K. Singh,Mitchell J. Frederick,Nakia D. Spencer,Jeffery Kovacs,Timothy P. Heffernan,W. Fraser Symmans,Kunal Rai,Jeffrey N. Myers	2023	32
4	Anti‐MS4A4A Antibody Modulates Myeloid Cell Biology and TREM2 Signaling Alzheimer s & Dementia ·Yaíma L. Lightfoot,Alexandra Botté,Ronnie The Pong Trinh,Grant S. Ding,Morgan McReynolds,Jason Allen,Michelle A Gonzalez,Chunchua Shi,Jeffrey J. Molldrem,Timothy P. Heffernan,Timothy Lofton,Alexandra Münch,Edoardo Marcora,Alison Goate,William J. Ray	2023	0
5	Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition Cancer Research ·Yan Liang,Bo Tu,Jun Yao,Jing Gong,Alessandro Carugo,Christopher A. Bristow,Qiuyun Wang,Cihui Zhu,Bingbing Dai,Ya’an Kang,Leng Han,Ningping Feng,Yanqing Jin,Jason B. Fleming,Timothy P. Heffernan,Wantong Yao,Haoqiang Ying	2021	30
6	Combined inhibition of DDR1 and CDK4/6 induces synergistic effects in ER-positive, HER2-negative breast cancer with PIK3CA/AKT1 mutations Oncogene ·Maryam Shariati,Kurt W. Evans,Xiaofeng Zheng,Christopher A. Bristow,Patrick Kwok‐Shing Ng,Yasmeen Q. Rizvi,Coya Tapia,Fei Yang,Alessandro Carugo,Timothy P. Heffernan,Michael Peoples,Debu Tripathy,Funda Meric‐Bernstam	2021	17
7	The cytosolic iron–sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors npj Breast Cancer ·Abena B. Redwood,Xiaomei Zhang,Sahil Seth,Zhongqi Ge,Wendy Bindeman,Xinhui Zhou,Vidya C. Sinha,Timothy P. Heffernan,Helen Piwnica‐Worms	2021	9
8	First-in-human biomarker-driven phase I trial of the potent and selective glutaminase-1 (GLS1) inhibitor IACS-6274 (IPN60090) in patients (pts) with molecularly selected advanced solid tumors. Journal of Clinical Oncology ·Timothy A. Yap,Ecaterina E. Dumbrava,Jordi Rodón,David S. Hong,Shubham Pant,Daniel D. Karp,Sarina A. Piha‐Paul,Vivek Subbiah,Apostolia M. Tsimberidou,Siqing Fu,Filip Jankú,Sandra Montez,Majd T Ahmad-Taha,Darlene Guerrero,Natalya Nazarenko,Yan Moore,Michael Soth,Jeff Kovacs,Timothy P. Heffernan,Philip Jones	2021	11
9	Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints International Journal of Radiation Biology ·Jessica M. Molkentine,David Molkentine,Kathleen A. Bridges,Tongxin Xie,Liangpeng Yang,Aakash Sheth,Timothy P. Heffernan,D.A. Clump,Alma Z. Faust,Robert L. Ferris,Jeffrey N. Myers,Mitchell J. Frederick,Kathryn A. Mason,Raymond E. Meyn,Curtis R. Pickering,Heath D. Skinner	2020	29
10	Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models UNC Libraries ·Ji Yuan Wu,Garth Powis,Feng Tian,Timothy P. Heffernan,Ningping Feng,Jason Gay,Qing Chang,Carlo Toniatti,Lawrence N. Kwong,Timothy L. Helms,Michael S. Lee,Scott Kopetz	2020	5
11	A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis npj Breast Cancer ·Emily Powell,Jiansu Shao,Hector Picon,Christopher A. Bristow,Zhongqi Ge,Michael Peoples,Frederick S. Robinson,Sabrina L. Jeter-Jones,Christopher Schlosberg,Caitlin L. Grzeskowiak,Fei Yang,Yun Wu,Ignacio I. Wistuba,Stacy Moulder,W. Fraser Symmans,Kenneth L. Scott,John R. Edwards,Han Liang,Timothy P. Heffernan,Helen Piwnica‐Worms	2018	39
12	PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy Cell stem cell ·Joanne I. Hsu,Tajhal Dayaram,Ayala Tovy,Étienne De Braekeleer,Mira Jeong,Feng Wang,Jianhua Zhang,Timothy P. Heffernan,Sonal Gera,Jeffrey J. Kovacs,Joseph R. Marszalek,Christopher A. Bristow,Yuanqing Yan,Guillermo Garcia‐Manero,Hagop M. Kantarjian,George S. Vassiliou,P. Andrew Futreal,Lawrence A. Donehower,Koichi Takahashi,Margaret A. Goodell	2018	268
13	HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome Oncogene ·Joanna Wardwell‐Ozgo,Turgut Dogruluk,Armel Gifford,Y. Zhang,Timothy P. Heffernan,Remco van Doorn,Chad J. Creighton,Lih‐Shen Chin,K L Scott	2013	53
14	ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine Journal of Investigative Dermatology ·Timothy P. Heffernan,Masaoki Kawasumi,Alessandra Blasina,Kenna Anderes,Allan H. Conney,Paul Nghiem	2009	66
15	Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development Cancer Cell ·Ruprecht Wiedemeyer,Cameron Brennan,Timothy P. Heffernan,Yonghong Xiao,John E. Mahoney,Alexei Protopopov,Hongwu Zheng,Graham R. Bignell,Frank B. Furnari,Webster K. Cavenee,William C. Hahn,Koichi Ichimura,V. Peter Collins,Gerald C. Chu,Michael R. Stratton,Keith L. Ligon,P. Andrew Futreal,Lynda Chin	2008	93
16	Cdc7-Dbf4 and the Human S Checkpoint Response to UVC Journal of Biological Chemistry ·Timothy P. Heffernan,Keziban Ünsal-Kaçmaz,Alexandra N. Heinloth,Dennis A. Simpson,Richard S. Paules,Aziz Sancar,Marila Cordeiro‐Stone,William K. Kaufmann	2007	56
17	Checkpoint Regulation of Replication Dynamics in UV-Irradiated Human Cells Cell Cycle ·Paul D. Chastain,Timothy P. Heffernan,Kathleen R. Nevis,Lin Li,William K. Kaufmann,David G. Kaufman,Marila Cordeiro‐Stone	2006	47
18	Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function. Journal of Carcinogenesis ·Dennis A. Simpson,Elizabeth Livanos,Timothy P. Heffernan,William K. Kaufmann	2005	16
19	Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts DNA repair ·Nicole M. King,Nana Nikolaishvili‐Feinberg,Miriam F. Bryant,Douglas D. Luche,Timothy P. Heffernan,Dennis A. Simpson,Fumio Hanaoka,William K. Kaufmann,Marila Cordeiro‐Stone	2005	24
20	Spine-Board Transfer Techniques and the Unstable Cervical Spine Spine ·Gianluca Del Rossi,MaryBeth Horodyski,Timothy P. Heffernan,Michael E. Powers,Ronald Siders,Denis Brunt,Glenn R. Rechtine	2004	49

About Timothy P. Heffernan

Timothy P. Heffernan is a scholar working on Cancer Research, Oncology and Genetics, having authored 38 papers that have together received 1.3k indexed citations. Recurring topics across this work include Cancer-related Molecular Pathways (10 papers), DNA Repair Mechanisms (9 papers), Melanoma and MAPK Pathways (5 papers), Cancer, Hypoxia, and Metabolism (5 papers), Cancer Genomics and Diagnostics (4 papers), Carcinogens and Genotoxicity Assessment (4 papers), Colorectal Cancer Treatments and Studies (3 papers) and Chronic Lymphocytic Leukemia Research (2 papers). The work is most often cited by research in Cancer Research (378 citations), Hematology (210 citations) and Oncology (476 citations). Timothy P. Heffernan has collaborated with scholars based in United States, Austria and United Kingdom. Frequent co-authors include William K. Kaufmann, Marila Cordeiro‐Stone, Dennis A. Simpson, Richard S. Paules, Alexandra N. Heinloth, Christopher A. Bristow, P. Andrew Futreal, Scott Kopetz, Jeffrey J. Kovacs and Joseph R. Marszalek. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Oncology.

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