Thomas Ryckmans

1.3k citations

29 papers · 877 indexed · 1 hit paper · h-index 15

Impact in

Organic Chemistry top 10%
- Carbohydrate Chemistry and Synthesis
Sensory Systems top 10%

Papers in ⓘ

Sensory Systems 3
- Ion Channels and Receptors 3
Cellular and Molecular Neuroscience 9
- Neuropeptides and Animal Physiology 6
- Neurotransmitter Receptor Influence on Behavior 4

Co-authors: Dafydd R. Owen (2 shared papers)Lisa R. Thompson (1 shared paper)Martin P. Edwards (1 shared paper)Tim Young (1 shared paper)Nicolas H. Thomä (1 shared paper)Vladimiras Oleinikovas (1 shared paper)Pablo Gaínza (1 shared paper)Bernhard Fasching (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (11 papers)Tetrahedron Letters (2 papers)Tetrahedron (2 papers)MedChemComm (2 papers)Journal of Medicinal Chemistry (2 papers)
Partner nations: United Kingdom United States Belgium

In The Last Decade

Thomas Ryckmans

28 papers receiving 855 citations

Hit Papers

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From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation 2023 · 89 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2023 The Annual Review of Pharmacology and Toxicology

Peers

Countries citing papers authored by Thomas Ryckmans

Since Specialization

Citations

This map shows the geographic impact of Thomas Ryckmans's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas Ryckmans with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas Ryckmans more than expected).

Fields of papers citing papers by Thomas Ryckmans

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas Ryckmans. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas Ryckmans. The network helps show where Thomas Ryckmans may publish in the future.

Co-authors

The 25 scholars most cited alongside Thomas Ryckmans, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas Ryckmans Line = papers co-authored together Thomas Ryckmans links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 29 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis Bioorganic & Medicinal Chemistry Letters ·Thomas Ryckmans, Martin P. Edwards, Val A. Horne, Ana Monica Correia, Dafydd R. Owen, Lisa R. Thompson, Isabelle Tran, Michelle F. Tutt, Tim Young	2009	191
2	Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa Journal of the American Chemical Society ·Roman Sommer, Stefanie Wagner, Katharina Rox, Annabelle Varrot, Dirk Hauck, Eike‐Christian Wamhoff, Janine Schreiber, Thomas Ryckmans, Thomas Brunner, Christoph Rademacher, Rolf W. Hartmann, Mark Brönstrup, Anne Imberty, Alexander Titz	2017	103
3	From Thalidomide to Rational Molecular Glue Design for Targeted Protein Degradation The Annual Review of Pharmacology and Toxicology ·Vladimiras Oleinikovas, Pablo Gaínza, Thomas Ryckmans, Bernhard Fasching, Nicolas H. Thomä Hit paper breakdown →	2023	89
4	Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure–Activity Relationship Study of C-Glycosidic LecB Inhibitors Journal of Medicinal Chemistry ·Roman Sommer, Katharina Rox, Stefanie Wagner, Dirk Hauck, Sarah S. Henrikus, Shelby Newsad, Tatjana Arnold, Thomas Ryckmans, Mark Brönstrup, Anne Imberty, Annabelle Varrot, Rolf W. Hartmann, Alexander Titz	2019	59
5	The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain Journal of Medicinal Chemistry ·S. Skerratt, Mark D. Andrews, Sharan K. Bagal, James Bilsland, David Brown, Peter J. Bungay, Susan Cole, Karl R. Gibson, Russell M. Jones, Iñaki Morao, Angus Nedderman, Kiyoyuki Omoto, Colin M. Robinson, Thomas Ryckmans, Kimberly Skinner, Paul A. Stupple, Gareth Waldron	2016	58
6	First dual NK1 antagonists–serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants Bioorganic & Medicinal Chemistry Letters ·Thomas Ryckmans, Laurent Balançon, Olivier Berton, Christophe Génicot, Yves Lamberty, Bénédicte Lallemand, Patrick Pasau, Nathalie Pirlot, Luc Quéré, Patrice Talaga	2002	52
7	Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel Bioorganic & Medicinal Chemistry Letters ·Thomas Ryckmans, Aisah A. Aubdool, Jennifer V. Bodkin, Peter J. Cox, Susan D. Brain, Thomas Dupont, Emma Fairman, Yoshinobu Hashizume, Naoko Ishii, Teruhisa Kato, Linda Kitching, Julie Newman, Kiyoyuki Omoto, David J. Rawson, Jade Strover	2011	35
8	Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug‐like and Drug Fragment‐like Molecules ChemMedChem ·Shoko Nakagawa, Katie A. Bainbridge, Ken J. Butcher, Dave Ellis, Wolfgang Klute, Thomas Ryckmans	2011	34
9	Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study Analytical Methods ·Anisha Wijeyesekera, Philip A. Clarke, Magda Bictash, Ian Brown, Mark Fidock, Thomas Ryckmans, Ivan Kok Seng Yap, Queenie Chan, Jeremiah Stamler, Paul Elliott, Elaine Holmes, Jeremy K. Nicholson	2011	28
10	Dual NK1 antagonists—serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives Bioorganic & Medicinal Chemistry Letters ·Thomas Ryckmans, Olivier Berton, R. Grimée, Thierry Kogej, Yves Lamberty, Patrick Pasau, Patrice Talaga, Christophe Génicot	2002	28
11	Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition Bioorganic & Medicinal Chemistry Letters ·Paul V. Fish, Christopher Deur, Xinmin Gan, Keri L. Greene, D. W. T. HOOPLE, Malcolm MacKenny, Kimberly S. Para, Keith A. Reeves, Thomas Ryckmans, Cory M. Stiff, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock	2008	26
12	A Concise Total Synthesis of the Lichen Macrolide (+)-Aspicilin Organic Letters ·Christophe Dubost, István E. Markó, Thomas Ryckmans	2006	22
13	Identification of novel scaffolds targeting Mycobacterium tuberculosis Journal of Molecular Medicine ·Michael Dal Molin, Petra Selchow, Daniel Schäfle, Andreas Tschumi, Thomas Ryckmans, Stephan Laage-Witt, Peter Sander	2019	21
14	TAK1 Inhibition in the DFG‐Out Conformation Chemical Biology & Drug Design ·Iain Kilty, Martin P. Green, Andrew Bell, David G. Brown, Peter G. Dodd, Christopher A. Hewson, Samantha Jane Hughes, Christopher Phillips, Thomas Ryckmans, R T Smith, Willem P. van Hoorn, Philip Cohen, Lyn H. Jones	2013	17
15	SAR mining and its application to the design of TRPA1 antagonists MedChemComm ·James E. Mills, Alan D. Brown, Thomas Ryckmans, Duncan C. Miller, S. Skerratt, Carolyn M. Barker, Mark E. Bunnage	2011	15
16	Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability Bioorganic & Medicinal Chemistry Letters ·Patrick S. Johnson, Thomas Ryckmans, Justin S. Bryans, David M. Beal, Kevin N. Dack, N. Feeder, Anthony Harrison, Mark L. Lewis, Helen J. Mason, James E. Mills, Julie Newman, Christelle Pasquinet, Dave J. Rawson, Lee R. Roberts, Rachel Russell, D. Spark, Alan Stobie, Toby J. Underwood, Robyn L. Ward, Simon Wheeler	2011	13
17	Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity Bioorganic & Medicinal Chemistry Letters ·Paul V. Fish, Nancy S. Barta, David Gray, Thomas Ryckmans, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock	2008	11
18	Modulation of the vasopressin system for the treatment of CNS diseases. PubMed ·Thomas Ryckmans	2010	11
19	Enantioselective synthesis of (R)- and (S)-N-Boc-morpholine-2-carboxylic acids by enzyme-catalyzed kinetic resolution: application to the synthesis of reboxetine analogs Tetrahedron Letters ·Paul V. Fish, Malcolm MacKenny, Gerwyn Bish, Timothy Buxton, Russell Cave, David Drouard, D. W. T. HOOPLE, Alan S. Jessiman, Duncan C. Miller, Christelle Pasquinet, Bhairavi Patel, Keith A. Reeves, Thomas Ryckmans, Melanie Skerten, Florian Wakenhut	2008	10
20	[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors Bioorganic & Medicinal Chemistry Letters ·Paul V. Fish, Thomas Ryckmans, Alan Stobie, Florian Wakenhut	2008	9

About Thomas Ryckmans

Thomas Ryckmans is a scholar working on Sensory Systems, Cellular and Molecular Neuroscience, Biochemistry, Microbiology and Organic Chemistry, having authored 29 papers that have together received 877 indexed citations. Recurring topics across this work include Neuropeptides and Animal Physiology (6 papers), Receptor Mechanisms and Signaling (6 papers), Pharmacological Receptor Mechanisms and Effects (6 papers), Neurotransmitter Receptor Influence on Behavior (4 papers), Chemical synthesis and alkaloids (3 papers), Neuroendocrine regulation and behavior (3 papers), Ion Channels and Receptors (3 papers) and Asymmetric Synthesis and Catalysis (2 papers). The work is most often cited by research in Organic Chemistry (305 citations), Sensory Systems (43 citations), Microbiology (45 citations), Molecular Biology (499 citations) and Computational Theory and Mathematics (104 citations). Thomas Ryckmans has collaborated with scholars based in United Kingdom, United States and Belgium. Frequent co-authors include Dafydd R. Owen, Lisa R. Thompson, Martin P. Edwards, Tim Young, Nicolas H. Thomä, Vladimiras Oleinikovas, Pablo Gaínza, Bernhard Fasching, Katharina Rox and Anne Imberty. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Tetrahedron, MedChemComm and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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