Thomas Frielle

4.2k total citations · 4 hit papers
24 papers, 3.5k citations indexed

About

Thomas Frielle is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Animal Science and Zoology. According to data from OpenAlex, Thomas Frielle has authored 24 papers receiving a total of 3.5k indexed citations (citations by other indexed papers that have themselves been cited), including 19 papers in Molecular Biology, 8 papers in Cellular and Molecular Neuroscience and 6 papers in Animal Science and Zoology. Recurrent topics in Thomas Frielle's work include Receptor Mechanisms and Signaling (15 papers), Pharmacological Effects and Assays (6 papers) and Amino Acid Enzymes and Metabolism (4 papers). Thomas Frielle is often cited by papers focused on Receptor Mechanisms and Signaling (15 papers), Pharmacological Effects and Assays (6 papers) and Amino Acid Enzymes and Metabolism (4 papers). Thomas Frielle collaborates with scholars based in United States, Russia and Switzerland. Thomas Frielle's co-authors include Robert J. Lefkowitz, Marc G. Caron, Brian K. Kobilka, Henrik Dohlman, M A Bolanowski, Richard A. F. Dixon, Sheila Collins, Uta Francke, Irving S. Sigal and Kiefer W. Daniel and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Thomas Frielle

23 papers receiving 3.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 981 citations Richard A. F. Dixon, Brian K. Kobilka et al. Nature profile →
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 554 citations Brian K. Kobilka, Richard A. F. Dixon et al. Proceedings of the National Academy of Sciences profile →
Cloning of the cDNA for the human beta 1-adrenergic receptor.

1987 492 citations Thomas Frielle, Sheila Collins et al. Proceedings of the National Academy of Sciences profile →
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 425 citations Brian K. Kobilka, Thomas Frielle et al. Nature profile →

Peers

Thomas Frielle

CMN

PHYSI

ASZ

CCM

R J Lefkowitz United States

L E Limbird United States

T L Yang-Feng United States

R.J. Lefkowitz United States

Mari R. Candelore United States

C C Malbon United States

M G Caron United States

Antonio De Blasi Italy

Stephen M. Lanier United States

Tommaso Costa Italy

R J Lefkowitz United States

Thomas Frielle

3.1k ×1.1

1.9k ×1.2

CMN

589 ×1.0

PHYSI

292 ×0.5

ASZ

318 ×1.4

CCM

Citations per year, relative to Thomas Frielle Thomas Frielle (= 1×) peers R J Lefkowitz

Countries citing papers authored by Thomas Frielle

Since Specialization

Citations

This map shows the geographic impact of Thomas Frielle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas Frielle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas Frielle more than expected).

Fields of papers citing papers by Thomas Frielle

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas Frielle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas Frielle. The network helps show where Thomas Frielle may publish in the future.

Co-authorship network of co-authors of Thomas Frielle

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas Frielle. A scholar is included among the top collaborators of Thomas Frielle based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas Frielle. Thomas Frielle is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Frielle, Thomas, et al.. (2015). Changes in Rat Renal Glutaminase Activity Studied in vivo and in Primary Cultures of Proximal Convoluted Tubular Cells. Contributions to nephrology. 47. 150–156.

Yue, Jianbo, Melanie T. Hartsough, Randall S. Frey, Thomas Frielle, & Kathleen M. Mulder. (1999). Cloning and expression of a rat Smad1: Regulation by TGF� and modulation by the ras/MEK pathway. Journal of Cellular Physiology. 178(3). 387–396. 28 indexed citations

Ellis, Christopher E. & Thomas Frielle. (1999). Characterization of Two Human β1-Adrenergic Receptor Transcripts: Cloning and Alterations in the Failing Heart. Biochemical and Biophysical Research Communications. 258(3). 552–558. 3 indexed citations

Evanko, Daniel, et al.. (1998). Preliminary Analysis of the Transcriptional Regulation of the Human β1-Adrenergic Receptor Gene. Biochemical and Biophysical Research Communications. 244(2). 395–402. 5 indexed citations

Frielle, Thomas, et al.. (1996). Comparison ofR-, S-, andRS-albuterol interaction with human β1 and β2-adrenergic receptors. Clinical Reviews in Allergy & Immunology. 14(1). 37–45. 96 indexed citations

Saito, Mariko, Thomas Frielle, Jeffrey Benovic, & Robert W. Ledeen. (1995). Modulation by GM1 ganglioside of β1-adrenergic receptor-induced cyclic AMP formation in Sf9 cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1267(1). 1–5. 18 indexed citations

Suzuki, Takayuki, F. Nantel, H Bonin, et al.. (1992). Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.. Molecular Pharmacology. 41(3). 542–548. 102 indexed citations

Dohlman, Henrik, Marc G. Caron, Antonio DeBlasi, Thomas Frielle, & Robert J. Lefkowitz. (1990). Role of extracellular disulfide-bonded cysteines in the ligand binding function of the .beta.2-adrenergic receptor. Biochemistry. 29(9). 2335–2342. 194 indexed citations

Yang‐Feng, Teresa L., Fei Xue, Wuning Zhong, et al.. (1990). Chromosomal organization of adrenergic receptor genes.. Proceedings of the National Academy of Sciences. 87(4). 1516–1520. 103 indexed citations

10.

Caron, Marc G., Brian K. Kobilka, Thomas Frielle, et al.. (1988). Cloning of the cDNA and Genes for the Hamster and Human β₂-Adrenergic Receptors. Journal of Receptor Research. 8(1-4). 7–21. 8 indexed citations

11.

Frielle, Thomas, Brian K. Kobilka, Robert J. Lefkowitz, & Marc G. Caron. (1988). Human β1- and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. Trends in Neurosciences. 11(7). 321–324. 29 indexed citations

12.

Frielle, Thomas, Sheila Collins, Kiefer W. Daniel, et al.. (1987). Cloning of the cDNA for the human beta 1-adrenergic receptor.. Proceedings of the National Academy of Sciences. 84(22). 7920–7924. 492 indexed citations breakdown →

13.

Kobilka, Brian K., Richard A. F. Dixon, Thomas Frielle, et al.. (1987). cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.. Proceedings of the National Academy of Sciences. 84(1). 46–50. 554 indexed citations breakdown →

14.

Kobilka, Brian K., Thomas Frielle, Sheila Collins, et al.. (1987). An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature. 329(6134). 75–79. 425 indexed citations breakdown →

15.

Dixon, Richard A. F., Brian K. Kobilka, Jeffrey Benovic, et al.. (1986). Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin. Nature. 321(6065). 75–79. 981 indexed citations breakdown →

16.

Frielle, Thomas & Norman P. Curthoys. (1983). Characterization of the membrane binding domain of .gamma.-glutamyl transpeptidase by specific labeling techniques. Biochemistry. 22(25). 5709–5714. 12 indexed citations

17.

Frielle, Thomas & Norman P. Curthoys. (1983). Specific Labelling of the Hydrophobic Domain of Rat Renal γ‐Glutamyltransferase. Novartis Foundation symposium. 95. 73–91. 3 indexed citations

18.

Frielle, Thomas, Josef Brunner, & Norman P. Curthoys. (1982). Isolation of the hydrophobic membrane binding domain of rat renal gamma-glutamyl transpeptidase selectively labeled with 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine.. Journal of Biological Chemistry. 257(24). 14979–14982. 29 indexed citations

19.

Frielle, Thomas, et al.. (1979). A continuous spectrophotometric assay for cyclic 3′,5′-nucleotide phosphodiesterase. Analytical Biochemistry. 97(1). 239–247. 3 indexed citations

20.

Niehaus, Walter G., et al.. (1978). Purification and characterization of a secondary alcohol dehydrogenase from a pseudomonad. Journal of Bacteriology. 134(1). 177–183. 22 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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