Thomas D. Penning

7.3k total citations · 1 hit paper
52 papers, 3.4k citations indexed

About

Thomas D. Penning is a scholar working on Oncology, Molecular Biology and Organic Chemistry. According to data from OpenAlex, Thomas D. Penning has authored 52 papers receiving a total of 3.4k indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Oncology, 20 papers in Molecular Biology and 12 papers in Organic Chemistry. Recurrent topics in Thomas D. Penning's work include PARP inhibition in cancer therapy (14 papers), Asthma and respiratory diseases (12 papers) and Inflammatory mediators and NSAID effects (9 papers). Thomas D. Penning is often cited by papers focused on PARP inhibition in cancer therapy (14 papers), Asthma and respiratory diseases (12 papers) and Inflammatory mediators and NSAID effects (9 papers). Thomas D. Penning collaborates with scholars based in United States, United Kingdom and Canada. Thomas D. Penning's co-authors include Karen Seibert, James K. Gierse, Peter C. Isakson, Ravi G. Kurumbail, Joseph J. McDonald, Anna M. Stevens, William C. Stallings, Roderick A. Stegeman, Carl R. Johnson and Eric F. Johnson and has published in prestigious journals such as Nature, Journal of the American Chemical Society and Journal of Clinical Oncology.

In The Last Decade

Thomas D. Penning

51 papers receiving 3.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1996 1.6k citations Ravi G. Kurumbail, Anna M. Stevens et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Thomas D. Penning United States	24	1.5k	1.2k	1.2k	843	346	52	3.4k
Joseph J. McDonald United States	20	1.1k 0.7×	911 0.7×	1.4k 1.2×	336 0.4×	385 1.1×	38	2.9k
Curtis Hose United States	22	1.6k 1.0×	2.3k 1.9×	511 0.4×	1.2k 1.4×	131 0.4×	31	4.7k
M. David Percival Canada	36	638 0.4×	1.4k 1.1×	796 0.7×	520 0.6×	316 0.9×	68	3.1k
Ravi G. Kurumbail United States	28	1.8k 1.1×	1.8k 1.5×	1.9k 1.6×	431 0.5×	508 1.5×	54	4.9k
Concettina La Motta Italy	36	1.3k 0.8×	1.5k 1.2×	387 0.3×	595 0.7×	135 0.4×	138	3.7k
Adriano Martinelli Italy	36	1.2k 0.8×	1.9k 1.6×	667 0.6×	414 0.5×	112 0.3×	163	3.7k
Aaron B. Miller United States	26	543 0.4×	1.5k 1.2×	521 0.4×	485 0.6×	640 1.8×	47	2.8k
Anna M. Stevens United States	16	1.0k 0.7×	617 0.5×	1.2k 1.0×	219 0.3×	320 0.9×	26	2.5k
Mary K. Danks United States	39	503 0.3×	3.4k 2.7×	837 0.7×	2.0k 2.4×	420 1.2×	99	5.0k
Brian K. Hubbard United States	35	595 0.4×	2.4k 2.0×	1.1k 0.9×	225 0.3×	188 0.5×	78	4.5k

Countries citing papers authored by Thomas D. Penning

Since Specialization

Citations

This map shows the geographic impact of Thomas D. Penning's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas D. Penning with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas D. Penning more than expected).

Fields of papers citing papers by Thomas D. Penning

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas D. Penning. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas D. Penning. The network helps show where Thomas D. Penning may publish in the future.

Co-authorship network of co-authors of Thomas D. Penning

This figure shows the co-authorship network connecting the top 25 collaborators of Thomas D. Penning. A scholar is included among the top collaborators of Thomas D. Penning based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Thomas D. Penning. Thomas D. Penning is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Mastracchio, Anthony, Chunqiu Lai, Maricel Torrent, et al.. (2019). Investigation of biaryl heterocycles as inhibitors of Wee1 kinase. Bioorganic & Medicinal Chemistry Letters. 29(12). 1481–1486. 5 indexed citations

Brederson, Jill‐Desiree, Shailen K. Joshi, Kaitlin E. Browman, et al.. (2012). PARP inhibitors attenuate chemotherapy‐induced painful neuropathy. Journal of the Peripheral Nervous System. 17(3). 324–330. 26 indexed citations

Woods, Keith W., Chunqiu Lai, Julie M. Miyashiro, et al.. (2012). Aminopyrimidinone Cdc7 Kinase Inhibitors. Bioorganic & Medicinal Chemistry Letters. 22(5). 1940–1943. 18 indexed citations

Zhu, Gui‐Dong, Jianchun Gong, Viraj B. Gandhi, et al.. (2012). Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. Bioorganic & Medicinal Chemistry. 20(15). 4635–4645. 24 indexed citations

Zhang, Qingwei, Michael J. Mitten, Loren Lasko, et al.. (2012). Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors. Bioorganic & Medicinal Chemistry Letters. 22(24). 7615–7622. 12 indexed citations

Liu, Xuesong, Yan Shi, David Maag, et al.. (2011). Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor. Clinical Cancer Research. 18(2). 510–523. 139 indexed citations

Palma, Joann P., Yichun Wang, Luis E. Rodrı́guez, et al.. (2009). ABT-888 Confers Broad In vivo Activity in Combination with Temozolomide in Diverse Tumors. Clinical Cancer Research. 15(23). 7277–7290. 111 indexed citations

Liu, Xuesong, Edward K. Han, Mark G. Anderson, et al.. (2009). Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways. Molecular Cancer Research. 7(10). 1686–1692. 77 indexed citations

Gandhi, Viraj B., Yan Luo, Xuesong Liu, et al.. (2009). Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters. 20(3). 1023–1026. 29 indexed citations

10.

Liu, Xuesong, Xu Luo, Yan Shi, et al.. (2008). Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. Cancer Biology & Therapy. 7(6). 934–941. 10 indexed citations

11.

Penning, Thomas D., Nizal S. Chandrakumar, B.N. Desai, et al.. (2003). Synthesis of Imidazopyridines and Purines as Potent Inhibitors of Leukotriene A4 Hydrolase. Bioorganic & Medicinal Chemistry Letters. 13(6). 1137–1139. 26 indexed citations

12.

Penning, Thomas D., Nizal S. Chandrakumar, B.N. Desai, et al.. (2002). Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A4 hydrolase. Bioorganic & Medicinal Chemistry Letters. 12(23). 3383–3386. 11 indexed citations

13.

Penning, Thomas D.. (2001). Inhibitors of Leukotriene A4 (LTA4) Hydrolase as Potential Anti-Inflammatory Agents>. Current Pharmaceutical Design. 7(3). 163–179. 42 indexed citations

14.

Kurumbail, Ravi G., Anna M. Stevens, James K. Gierse, et al.. (1996). Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature. 384(6610). 644–648. 1559 indexed citations breakdown →

15.

Fretland, D. J., Meire Bremer, Peter C. Isakson, et al.. (1995). Antiinflammatory effects of second-generation leukotriene B4 receptor antagonist, SC-53228: Impact upon Leukotriene B4- and 12(R)-HETE- mediated events. Inflammation. 19(2). 193–205. 15 indexed citations

16.

Bertenshaw, Stephen R., D. Joseph Rogier, Matthew J. Graneto, et al.. (1995). 3,4-diarylthiophenes are selective COX-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 5(23). 2919–2922. 1 indexed citations

17.

Penning, Thomas D., Stevan W. Djurić, Stella S. Yu, et al.. (1993). The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930. Inflammation Research. 39(S1). C11–C13. 3 indexed citations

18.

Fretland, D. J., et al.. (1993). Leukotriene B4-induced granulocyte trafficking in guinea pig dermis. Inflammation. 17(3). 353–360. 9 indexed citations

19.

Adams, Joseph P., Adam Gołȩbiowski, Thomas D. Penning, et al.. (1992). Applications of enzymes in the synthesis of bioactive polyols. Pure and Applied Chemistry. 64(8). 1115–1120.

20.

Johnson, Carl R. & Thomas D. Penning. (1988). Triply convergent synthesis of (-)-prostaglandin E2 methyl ester. Journal of the American Chemical Society. 110(14). 4726–4735. 80 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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