T.E. Roche

2.3k citations

37 papers · 1.9k indexed · h-index 27

Impact in

Biochemistry top 0.2%
- Biochemical Acid Research Studies
- Amino Acid Enzymes and Metabolism
Clinical Biochemistry top 0.5%
- Metabolism and Genetic Disorders

Papers in ⓘ

Biochemistry 25
- Biochemical Acid Research Studies 25
Clinical Biochemistry 17
- Metabolism and Genetic Disorders 17

Co-authors: Mohammed Rahmatullah (10 shared papers)Yasuaki Hiromasa (1 shared paper)Richard L. Cate (3 shared papers)Gary A. Radke (8 shared papers)Ross L. Coppel (5 shared papers)Judy Van de Water (3 shared papers)Aftab A. Ansari (3 shared papers)Bruce A. McFadden (3 shared papers)
Journals: Journal of Biological Chemistry (18 papers)The Journal of Immunology (2 papers)Biochemistry (2 papers)Biochemical and Biophysical Research Communications (2 papers)Tourism Management (1 paper)
Partner nations: United States Australia United Kingdom

In The Last Decade

T.E. Roche

36 papers receiving 1.9k citations

Peers

Countries citing papers authored by T.E. Roche

Since Specialization

Citations

This map shows the geographic impact of T.E. Roche's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by T.E. Roche with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites T.E. Roche more than expected).

Fields of papers citing papers by T.E. Roche

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by T.E. Roche. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by T.E. Roche. The network helps show where T.E. Roche may publish in the future.

Co-authors

The 25 scholars most cited alongside T.E. Roche, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with T.E. Roche Line = papers co-authored together T.E. Roche links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 37 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis. Journal of Clinical Investigation ·Shinji Shimoda, Judy Van de Water, Aftab A. Ansari, Motoki Nakamura, Hiromi Ishibashi, Ross L. Coppel, John R. Lake, E B Keeffe, T.E. Roche, M. Eric Gershwin	1998	212
2	Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer Cellular and Molecular Life Sciences ·T.E. Roche, Yasuaki Hiromasa	2007	209
3	Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex. Journal of Biological Chemistry ·Joseph M. Jilka, Mohammed Rahmatullah, Mohammad Kazemi, T.E. Roche	1986	113
4	Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis The Journal of Immunology ·Judy Van de Water, Aftab A. Ansari, Charles D. Surh, Ross L. Coppel, T.E. Roche, Herbert L. Bonkovsky, M. Kaplan, M. Eric Gershwin	1991	106
5	Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. The Journal of Experimental Medicine ·Judy Van de Water, Aftab A. Ansari, Thomas Prindiville, Ross L. Coppel, Nancy S. Ricalton, Brian L. Kotzin, S Liu, T.E. Roche, Sheri M. Krams, Sara Muñoz, M. Eric Gershwin	1995	97
6	Mechanism of pyruvate inhibition of kidney pyruvate dehydrogenasea kinase and synergistic inhibition by pyruvate and ADP. Journal of Biological Chemistry ·Mary L. Pratt, T.E. Roche	1979	97
7	Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme. The Journal of Immunology ·David R. Fregeau, T.E. Roche, Paul A. Davis, Ross L. Coppel, M. Eric Gershwin	1990	88
8	A unifying mechanism for stimulation of mammalian pyruvate dehydrogenase(a) kinase by reduced nicotinamide adenine dinucleotide, dihydrolipoamide, acetyl coenzyme A, or pyruvate. Journal of Biological Chemistry ·Richard L. Cate, T.E. Roche	1978	79
9	Rapid intersite transfer of acetyl groups and movement of pyruvate dehydrogenase component in the kidney pyruvate dehydrogenase complex. Journal of Biological Chemistry ·Richard L. Cate, T.E. Roche, Lawrence C. Davis	1980	69
10	Subunit Associations in the Mammalian Pyruvate Dehydrogenase Complex Journal of Biological Chemistry ·Mohammed Rahmatullah, Subramaniam Gopalakrishnan, Philip Andrews, Cecile Chang, Gary A. Radke, T.E. Roche	1989	65
11	AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2 Biochemical Society Transactions ·Jenny Morrell, Jon P. Orme, Roger J. Butlin, T.E. Roche, R.M. Mayers, Elaine Kilgour	2003	64
12	Effect of pH and buffer upon and inhibition by phosphoenolpyruvate of isocitrate lyase from Pseudomonas indigofera Biochimica et Biophysica Acta (BBA) - Enzymology ·T.E. Roche, Judith O. Williams, Bruce A. McFadden	1970	51
13	Separation of Protein X from the Dihydrolipoyl Transacetylase Component of the Mammalian Pyruvate Dehydrogenase Complex and Function of Protein X Journal of Biological Chemistry ·SUSAN L. POWERS‐GREENWOOD, Mohammed Rahmatullah, Gary A. Radke, T.E. Roche	1989	50
14	Domain Structures of the Dihydrolipoyl Transacetylase and the Protein X Components of Mammalian Pyruvate Dehydrogenase Complex Journal of Biological Chemistry ·Mohammed Rahmatullah, Subramaniam Gopalakrishnan, Gary A. Radke, T.E. Roche	1989	50
15	Changes in the core of the mammalian-pyruvate dehydrogenase complex upon selective removal of the lipoyl domain from the transacetylase component but not from the protein X component. Journal of Biological Chemistry ·Mohammed Rahmatullah, Gary A. Radke, Philip Andrews, T.E. Roche	1990	48
16	Function and regulation of mammalian pyruvate dehydrogenase complex. Acetylation, interlipoyl acetyl transfer, and migration of the pyruvate dehydrogenase component. Journal of Biological Chemistry ·Richard L. Cate, T.E. Roche	1979	46
17	A kinetic study of dihydrolipoyl transacetylase from bovine kidney. Journal of Biological Chemistry ·Peter Butterworth, Chun-Chien Tsai, Michael H. Eley, T.E. Roche, Lester J. Reed	1975	44
18	Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action. Journal of Biological Chemistry ·Mohammed Rahmatullah, T.E. Roche	1985	43
19	The catalytic requirements for reduction and acetylation of protein×and the related regulation of various forms of resolved pyruvate dehydrogenase kinase. Journal of Biological Chemistry ·Mohammed Rahmatullah, T.E. Roche	1987	43
20	Isocitrate lyase from Pseudomonas indigofera. V. Subunits and terminal residues and the relation to catalytic activity Biochemistry ·Bruce A. McFadden, G. Ramananda Rao, Amikam Cohen, T.E. Roche	1968	39

About T.E. Roche

T.E. Roche is a scholar working on Biochemistry, Clinical Biochemistry, Hepatology, Molecular Biology and Cancer Research, having authored 37 papers that have together received 1.9k indexed citations. Recurring topics across this work include Biochemical Acid Research Studies (25 papers), Metabolism and Genetic Disorders (17 papers), Biochemical and Molecular Research (8 papers), Cancer, Hypoxia, and Metabolism (4 papers), Enzyme Structure and Function (4 papers), Pancreatic function and diabetes (3 papers), Microbial Metabolic Engineering and Bioproduction (3 papers) and Liver Disease Diagnosis and Treatment (3 papers). The work is most often cited by research in Biochemistry (1.0k citations), Clinical Biochemistry (676 citations), Hepatology (456 citations), Molecular Biology (826 citations) and Cancer Research (149 citations). T.E. Roche has collaborated with scholars based in United States, Australia and United Kingdom. Frequent co-authors include Mohammed Rahmatullah, Yasuaki Hiromasa, Richard L. Cate, Gary A. Radke, Ross L. Coppel, Judy Van de Water, Aftab A. Ansari, Bruce A. McFadden, M. Eric Gershwin and Joseph M. Jilka. Their work appears in journals such as Journal of Biological Chemistry, The Journal of Immunology, Biochemistry, Biochemical and Biophysical Research Communications and Tourism Management.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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