Sigal Saphier

1.5k total citations · 2 hit papers
22 papers, 1.1k citations indexed

About

Sigal Saphier is a scholar working on Pharmaceutical Science, Organic Chemistry and Molecular Biology. According to data from OpenAlex, Sigal Saphier has authored 22 papers receiving a total of 1.1k indexed citations (citations by other indexed papers that have themselves been cited), including 12 papers in Pharmaceutical Science, 10 papers in Organic Chemistry and 6 papers in Molecular Biology. Recurrent topics in Sigal Saphier's work include Fluorine in Organic Chemistry (8 papers), Drug Solubulity and Delivery Systems (4 papers) and Chemical Synthesis and Analysis (3 papers). Sigal Saphier is often cited by papers focused on Fluorine in Organic Chemistry (8 papers), Drug Solubulity and Delivery Systems (4 papers) and Chemical Synthesis and Analysis (3 papers). Sigal Saphier collaborates with scholars based in Israel, United States and United Kingdom. Sigal Saphier's co-authors include Yossi Zafrani, Eytan Gershonov, Dafna Amir, Daniele Marciano, Gali Sod‐Moriah, Dina Yeffet, Shlomi Elias, Shahaf Katalan, Moran Madmon and Nissan Ashkenazi and has published in prestigious journals such as Journal of the American Chemical Society, Angewandte Chemie International Edition and Environmental Science & Technology.

In The Last Decade

Sigal Saphier

21 papers receiving 1.1k citations

Hit Papers

Difluoromethyl Bioisostere: Examining the “Lipophilic Hyd... 2017 2026 2020 2023 2017 2019 100 200 300 400 500
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
    2017 529 citations Yossi Zafrani, Dina Yeffet et al. Journal of Medicinal Chemistry profile →
  2. CF 2 H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH 3 ?
    2019 270 citations Yossi Zafrani, Gali Sod‐Moriah et al. Journal of Medicinal Chemistry profile →

Peers

Sigal Saphier
Mark E. Rerek United States
Teresa Martínez del Campo Spain
Nissan Ashkenazi Israel
Richard Plantier‐Royon France
Beatríz Lantaño Argentina
Shijun Huang China
Yoshihiro Nishimoto Japan
Ze Tan China
Mark E. Rerek United States
Sigal Saphier
Citations per year, relative to Sigal Saphier Sigal Saphier (= 1×) peers Mark E. Rerek

Countries citing papers authored by Sigal Saphier

Since Specialization
Citations

This map shows the geographic impact of Sigal Saphier's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sigal Saphier with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sigal Saphier more than expected).

Fields of papers citing papers by Sigal Saphier

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sigal Saphier. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sigal Saphier. The network helps show where Sigal Saphier may publish in the future.

Co-authorship network of co-authors of Sigal Saphier

This figure shows the co-authorship network connecting the top 25 collaborators of Sigal Saphier. A scholar is included among the top collaborators of Sigal Saphier based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sigal Saphier. Sigal Saphier is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Yeffet, Dina, Ishay Columbus, Shlomi Elias, et al.. (2025). Intramolecular hydrogen-bonding motifs in the 14-oxymorphinan opioids: An experimental and computational study. European Journal of Medicinal Chemistry. 300. 118133–118133.
2.
Saphier, Sigal & Yossi Zafrani. (2024). CF 2 H: a fascinating group for application in drug development enabling modulation of many molecular properties. Future Medicinal Chemistry. 16(12). 1181–1184. 6 indexed citations
3.
Yeffet, Dina, Ishay Columbus, Galit Parvari, et al.. (2024). Addressing the Opioids Lipophilicity Challenge via a Straightforward and Simultaneous 1H NMR-Based logP/D Determination, Both Separately and in Mixtures. Journal of Medicinal Chemistry. 67(14). 12399–12409. 1 indexed citations
4.
Columbus, Ishay, Ido M. Herzog, Galit Parvari, et al.. (2023). Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads. Communications Chemistry. 6(1). 197–197. 7 indexed citations
5.
Columbus, Ishay, G. Fridkin, Dafna Amir, et al.. (2022). Studying Lipophilicity Trends of Phosphorus Compounds by 31P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs. Journal of Medicinal Chemistry. 65(12). 8511–8524. 11 indexed citations
6.
Saphier, Sigal, Shahaf Katalan, G. Fridkin, et al.. (2022). Placing CF2 in the Center: Major Physicochemical Changes Upon a Minor Structural Alteration in Gem‐Difunctional Compounds. Chemistry - A European Journal. 29(7). e202202939–e202202939. 18 indexed citations
7.
Zafrani, Yossi, Galit Parvari, Dafna Amir, et al.. (2021). Modulation of the H-Bond Basicity of Functional Groups by α-Fluorine-Containing Functions and its Implications for Lipophilicity and Bioisosterism. Journal of Medicinal Chemistry. 64(8). 4516–4531. 42 indexed citations
8.
Saphier, Sigal, et al.. (2020). The Effect of Anesthetic Regimens on Intestinal Absorption of Passively Absorbed Drugs in Rats. Pharmaceutical Research. 37(5). 87–87. 2 indexed citations
9.
Zafrani, Yossi, Gali Sod‐Moriah, Dina Yeffet, et al.. (2019). CF 2 H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH 3 ?. Journal of Medicinal Chemistry. 62(11). 5628–5637. 270 indexed citations breakdown →
10.
Kumari, Pallavi, et al.. (2019). A biomimetic platform for studying root-environment interaction. Plant and Soil. 447(1-2). 157–168. 8 indexed citations
11.
Zafrani, Yossi, Dafna Amir, Moran Madmon, et al.. (2016). Chemoselective N-Difluoromethylation of Functionalized Tertiary Amines. The Journal of Organic Chemistry. 81(19). 9180–9187. 26 indexed citations
12.
Fridkin, G., Ishay Columbus, Sigal Saphier, et al.. (2015). Component Mobility by a Minute Quantity of the Appropriate Solvent as a Principal Motif in the Acceleration of Solid-Supported Reactions. The Journal of Organic Chemistry. 80(10). 5176–5188. 6 indexed citations
13.
Elias, Shlomi, Sigal Saphier, Ishay Columbus, & Yossi Zafrani. (2014). Polysaccharide-Thickened Aqueous Fluoride Solutions for Rapid Destruction of the Nerve Agent VX. Introducing the Opportunity for Extensive Decontamination Scenarios. Environmental Science & Technology. 48(5). 2893–2900. 9 indexed citations
14.
Saphier, Sigal, et al.. (2012). Bacterial Reduction as Means for Colonic Drug Delivery: Can Other Chemical Groups Provide an Alternative to the Azo Bond?. Journal of Medicinal Chemistry. 55(23). 10781–10785. 19 indexed citations
15.
Mizrahi, Dana M., Sigal Saphier, & Ishay Columbus. (2010). Efficient heterogeneous and environmentally friendly degradation of nerve agents on a tungsten-based POM. Journal of Hazardous Materials. 179(1-3). 495–499. 40 indexed citations
16.
Saphier, Sigal, et al.. (2010). Gastro intestinal tracking and gastric emptying of solid dosage forms in rats using X-ray imagining. International Journal of Pharmaceutics. 388(1-2). 190–195. 48 indexed citations
17.
Saphier, Sigal & Yishai Karton. (2009). Novel salicylazo polymers for colon drug delivery: Dissolving polymers by means of bacterial degradation. Journal of Pharmaceutical Sciences. 99(2). 804–815. 11 indexed citations
18.
Saphier, Sigal, Yunfeng Hu, Subhash C. Sinha, K. N. Houk, & Ehud Keinan. (2004). Origin of Selectivity in the Antibody 20F10-Catalyzed Yang Cyclization. Journal of the American Chemical Society. 127(1). 132–145. 7 indexed citations
19.
Saphier, Sigal, Subhash C. Sinha, & Ehud Keinan. (2003). Antibody‐Catalyzed Enantioselective Norrish Type II Cyclization. Angewandte Chemie International Edition. 42(12). 1378–1381. 13 indexed citations
20.
Shabat, Doron, et al.. (1997). An Efficient Sol−Gel Reactor for Antibody-Catalyzed Transformations. Chemistry of Materials. 9(11). 2258–2260. 56 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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