Robert I. Higuchi

903 citations

18 papers · 446 indexed · h-index 11

Impact in

Endocrinology, Diabetes and Metabolism top 10%
- Hormonal and reproductive studies
Organic Chemistry top 10%
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Catalytic C–H Functionalization Methods
- Synthetic Organic Chemistry Methods

Papers in

Genetics 14
- Estrogen and related hormone effects 13
Endocrinology, Diabetes and Metabolism 8
- Hormonal and reproductive studies 7

Co-authors: Keith B. Marschke Todd K. Jones James P. Edwards Lawrence G. Hamann Lin Zhi Barry M. Trost Luc J. Farmer Andrew R. Hudson
Journals: Bioorganic & Medicinal Chemistry Letters (11 papers)Journal of Medicinal Chemistry (3 papers)Current Topics in Medicinal Chemistry (1 paper)Tetrahedron Letters (1 paper)ACS Medicinal Chemistry Letters (1 paper)
Partner nations: United States China

In The Last Decade

Robert I. Higuchi

17 papers receiving 429 citations

Peers

Countries citing papers authored by Robert I. Higuchi

Since Specialization

Citations

This map shows the geographic impact of Robert I. Higuchi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Robert I. Higuchi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Robert I. Higuchi more than expected).

Fields of papers citing papers by Robert I. Higuchi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Robert I. Higuchi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Robert I. Higuchi. The network helps show where Robert I. Higuchi may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Robert I. Higuchi, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Robert I. Higuchi Line = papers co-authored together Robert I. Higuchi links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

18 of 18 papers shown

#	Work
1	Lipid Tales: Optimizing Arylomycin Membrane Anchors ACS Medicinal Chemistry Letters ·Michael F. T. Koehler, Оксана Ларсен, Yongsheng Chen, Yuan Chen, James J. Crawford, Matthew R. Durk, Cassandra Y. Owen, Emily J. Hanan, Robert I. Higuchi, Huiyong Hu, Cuong Q. Ly, ศรัญญา โรจนวงศ์ชัย, Tucker C. Roberts, Jacob B. Schwarz, Peter A. Smith, Jorge Messias Leal do Nascimento, Christopher E. Heise	2023	4
2	Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation Bioorganic & Medicinal Chemistry Letters ·Andrew R. Hudson, Robert I. Higuchi, Steven L. Roach, Prof. Dr. Johannes Ibrahim Kosasih, Mark E. Adams, N. Tsopelas, Deepa Rungta, Peter M. Syka, Dale E. Mais, Keith B. Marschke, Zhi Lin	2011	3
3	Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation Bioorganic & Medicinal Chemistry Letters ·Steven L. Roach, Robert I. Higuchi, Andrew R. Hudson, N. Tsopelas, Victor M Angulo, Tz-Yen Cheng, J Duruge, Deepa Rungta, Peter M. Syka, Dale E. Mais, Keith B. Marschke, Lin Zhi	2011	1
4	Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists Bioorganic & Medicinal Chemistry Letters ·Andrew R. Hudson, Robert I. Higuchi, Steven L. Roach, Mark E. Adams, Ondoa Otieno, Peter M. Syka, Dale E. Mais, Jeffrey N. Miner, Keith B. Marschke, Zhi Lin	2011	6
5	Tetrahydroquinoline glucocorticoid receptor agonists: Discovery of a 3-hydroxyl for improving receptor selectivity Bioorganic & Medicinal Chemistry Letters ·Steven L. Roach, Robert I. Higuchi, Andrew R. Hudson, Mark E. Adams, Peter M. Syka, Dale E. Mais, Jeffrey N. Miner, Keith B. Marschke, Zhi Lin	2010	9
6	Recent Developments in the Discovery of Selective Glucocorticoid Receptor Modulators (SGRMs) Current Topics in Medicinal Chemistry ·Andrew R. Hudson, Elberth Moraes, Robert I. Higuchi	2008	27
7	Efficient synthesis of an androgen receptor modulator Tetrahedron Letters ·Neelakandha S. Mani, Howard Hua, James P. Edwards, Min Wu, Penghui Chen, Robert I. Higuchi	2008	2
8	Selective androgen receptor modulators based on a series of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in vivo activity Bioorganic & Medicinal Chemistry Letters ·Yun Oliver Long, Robert I. Higuchi, Thomas R. Caferro, Jose R. Reyna, Min Wu, H. Schr�der, Esther Martinborough, Keith B. Marschke, William Y. Chang, Francisco J. López, Donald S. Karanewsky, Zhi Lin	2008	14
9	Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines Bioorganic & Medicinal Chemistry Letters ·Steven L. Roach, Robert I. Higuchi, Mark E. Adams, Yan Liu, Donald S. Karanewsky, Keith B. Marschke, Dale E. Mais, Jeffrey N. Miner, Lin Zhi	2008	25
10	Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones Bioorganic & Medicinal Chemistry Letters ·Robert I. Higuchi, Anthony W. Thompson, Howard Hua, Thomas R. Caferro, H. Schr�der, Primitivo III Cabanes Ragandang, Mark E. Adams, Christopher M. Tegley, James P. Edwards, M. S. Sunitha, E. Adam Kallel, Donald S. Karanewsky, William T. Schrader, Keith B. Marschke, Lin Zhi	2007	13
11	Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones Bioorganic & Medicinal Chemistry Letters ·Arjan van Oeveren, Barbara Pio, Christopher M. Tegley, Robert I. Higuchi, Min Wu, Todd K. Jones, Keith B. Marschke, A. Negro‐Vilar, Lin Zhi	2007	27
12	5(Z)-Benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators Bioorganic & Medicinal Chemistry Letters ·Robert Ardecky, Andrew R. Hudson, Dean P. Phillips, John Tyhonas, Primitivo III Cabanes Ragandang, Jose R. Reyna, Yongkai Li, Esther Martinborough, Steven L. Roach, Robert I. Higuchi, Francisco J. López, Keith B. Marschke, Jeffrey N. Miner, Donald S. Karanewsky, A. Negro‐Vilar, Zhi Lin	2007	9
13	Synthesis and Characterization of Nonsteroidal Glucocorticoid Receptor Modulators for Multiple Myeloma Journal of Medicinal Chemistry ·Andrew R. Hudson, Steven L. Roach, Robert I. Higuchi, Dean P. Phillips, Reid P. Bissonnette, William W. Lamph, Rick Battarbee, Yongkai Li, Mark E. Adams, Prof. Dr. Johannes Ibrahim Kosasih, N. Tsopelas, Rafael Jacinto Muñoz Rodríguez, E. Adam Kallel, Vasil Balev, Dale E. Mais, Jeffrey N. Miner, Keith B. Marschke, Deepa Rungta, A. Negro‐Vilar, Zhi Lin	2007	28
14	Novel Series of Potent, Nonsteroidal, Selective Androgen Receptor Modulators Based on 7H-[1,4]Oxazino[3,2-g]quinolin-7-ones Journal of Medicinal Chemistry ·Robert I. Higuchi, Kristen L. Arienti, Francisco J. López, 蕨雄大, Dale E. Mais, Thomas R. Caferro, Yun Oliver Long, Todd K. Jones, James P. Edwards, Zhi Lin, William T. Schrader, A. Negro‐Vilar, Keith B. Marschke	2007	34
15	Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one Bioorganic & Medicinal Chemistry Letters ·James P. Edwards, Robert I. Higuchi, David T. Winn, J. Gote-Schniering, Thomas R. Caferro, Lawrence G. Hamann, I. Pytlowa, Keith B. Marschke, Mark E. Goldman, Todd K. Jones	1999	42
16	4-Alkyl- and 3,4-dialkyl-1,2,3,4,-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, nonsteroidal androgen receptor agonists Bioorganic & Medicinal Chemistry Letters ·Robert I. Higuchi, James P. Edwards, Thomas R. Caferro, Νικόλαος Ζηνιέρης, Théophile Dolmaire, Lawrence G. Hamann, Kristen L. Arienti, Keith B. Marschke, Robert L. Davis, Luc J. Farmer, Todd K. Jones	1999	45
17	Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines Journal of Medicinal Chemistry ·Lawrence G. Hamann, Robert I. Higuchi, Lin Zhi, James P. Edwards, Xiaoning Wang, Keith B. Marschke, Théophile Dolmaire, Luc J. Farmer, Todd K. Jones	1998	118
18	On the Diastereoselectivity of Intramolecular Pd-Catalyzed TMM Cycloadditions. An Asymmetric Synthesis of the Perhydroazulene (−)-Isoclavukerin A Journal of the American Chemical Society ·Barry M. Trost, Robert I. Higuchi	1996	39

About Robert I. Higuchi

Robert I. Higuchi is a scholar working on Genetics, Endocrinology, Diabetes and Metabolism, Pharmacology, Pharmacology and Molecular Medicine, having authored 18 papers that have together received 446 indexed citations. Recurring topics across this work include Estrogen and related hormone effects (13 papers), Hormonal and reproductive studies (7 papers), Inflammatory mediators and NSAID effects (4 papers), Protein Kinase Regulation and GTPase Signaling (2 papers), Receptor Mechanisms and Signaling (2 papers), Pharmacogenetics and Drug Metabolism (2 papers), Prostate Cancer Treatment and Research (2 papers) and Synthesis and pharmacology of benzodiazepine derivatives (1 paper). The work is most often cited by research in Endocrinology, Diabetes and Metabolism (143 citations), Organic Chemistry (218 citations), Genetics (164 citations), Pharmacology (59 citations) and Pharmacology (27 citations). Robert I. Higuchi has collaborated with scholars based in United States and China. Frequent co-authors include Keith B. Marschke, Todd K. Jones, James P. Edwards, Lawrence G. Hamann, Lin Zhi, Barry M. Trost, Luc J. Farmer, Andrew R. Hudson, Xiaoning Wang and Thomas R. Caferro. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Current Topics in Medicinal Chemistry, Tetrahedron Letters and ACS Medicinal Chemistry Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact