Randall J. Brezski

2.7k citations

32 papers · 2.0k indexed · h-index 23

Radiology, Nuclear Medicine and Imaging top 1%
Immunology top 5%
Molecular Biology top 10%
Oncology top 5%
Pulmonary and Respiratory Medicine

Co-authors: Robert E. Jordan Xinhua Wang Mary Mathieu John G. Monroe William R. Strohl George Georgiou Allison R. Greenplate Omid Vafa
Topics: Monoclonal and Polyclonal Antibodies Research (21 papers)T-cell and B-cell Immunology (12 papers)Glycosylation and Glycoproteins Research (10 papers)
Cited by: Immunology Radiology, Nuclear Medicine and Imaging Oncology
Journals: Proceedings of the National Academy of Sciences Journal of Biological Chemistry Nature Immunology
Partner nations: United States Belgium France

In The Last Decade

Randall J. Brezski

32 papers receiving 1.9k citations

Peers

Countries citing papers authored by Randall J. Brezski

Since Specialization

Citations

This map shows the geographic impact of Randall J. Brezski's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Randall J. Brezski with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Randall J. Brezski more than expected).

Fields of papers citing papers by Randall J. Brezski

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Randall J. Brezski. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Randall J. Brezski. The network helps show where Randall J. Brezski may publish in the future.

Co-authorship network of co-authors of Randall J. Brezski

This figure shows the co-authorship network connecting the top 25 collaborators of Randall J. Brezski. A scholar is included among the top collaborators of Randall J. Brezski based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Randall J. Brezski. Randall J. Brezski is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells 2017 ·Journal of Biological Chemistry ·Tao Huang,Mary Mathieu,Sophia Lee,Xinhua Wang,(unknown),Jack Bevers,Claudio Ciferri,(unknown),Manda Wong,Nancy Chiang,Gerald Nakamura,Randall J. Brezski	8
2	IgG Fc engineering to modulate antibody effector functions 2017 ·Protein & Cell ·Xinhua Wang,Mary Mathieu,Randall J. Brezski	243
3	Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice 2017 ·Journal of Biological Chemistry ·Megan Lo,Hok Seon Kim,Raymond K. Tong,Travis W. Bainbridge,Jean-Michel Vernes,Yin Zhang,Yuwen Linda Lin,Shan Chung,Mark S. Dennis,Y. Joy Yu Zuchero,Ryan J. Watts,Jessica A. Couch,Y. Gloria Meng,Jasvinder K. Atwal,Randall J. Brezski,Christoph Spiess,James A. Ernst	184
4	A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors 2016 ·Cancer Research ·Sheri L. Moores,Mark L. Chiu,Barbara S. Bushey,Kristen Chevalier,Leopoldo Luistro,(unknown),Randall J. Brezski,Peter Haytko,Thomas J. Kelly,Sheng‐Jiun Wu,Pauline L. Martin,Joost Neijssen,Paul W.H.I. Parren,Janine Schuurman,Ricardo M. Attar,Sylvie Laquerre,Matthew V. Lorenzi,Geoffrey M. Anderson	188
5	Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity 2015 ·Clinical Cancer Research ·Ningyan Zhang,Hui Deng,Xuejun Fan,Anneliese Gonzalez,Songlin Zhang,Randall J. Brezski,Byung‐Kwon Choi,Michael A. Rycyzyn,William R. Strohl,Robert Jordan,Zhiqiang An	18
6	Proteolytic Cleavage and Loss of Function of Biologic Agents That Neutralize Tumor Necrosis Factor in the Mucosa of Patients With Inflammatory Bowel Disease 2015 ·Gastroenterology ·Paolo Biancheri,Randall J. Brezski,Antonio Di Sabatino,Allison R. Greenplate,(unknown),Gino Roberto Corazza,Klaartje Kok,L. Rovedatti,Anna Vossenkämper,(unknown),Susanne A. Snoek,Séverine Vermeire,Paul Rutgeerts,Robert E. Jordan,Thomas T. MacDonald	104
7	An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions 2015 ·mAbs ·Michelle Kinder,Allison R. Greenplate,William R. Strohl,Robert E. Jordan,Randall J. Brezski	34
8	9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland 2014 ·mAbs ·Janice M. Reichert,Alain Beck,Alexey A. Lugovskoy,Thierry Wurch,Steven Coats,Randall J. Brezski	15
9	A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo 2014 ·mAbs ·Randall J. Brezski,Michelle Kinder,Katharine D. Grugan,(unknown),Jill M. Carton,Allison R. Greenplate,(unknown),(unknown),(unknown),Eva Emmell,(unknown),Robert E. Jordan	24
10	A Novel Therapeutic Strategy to Rescue the Immune Effector Function of Proteolytically Inactivated Cancer Therapeutic Antibodies 2014 ·Molecular Cancer Therapeutics ·Xuejun Fan,Randall J. Brezski,Hui Deng,(unknown),Yun Shi,Anneliese Gonzalez,Songlin Zhang,Michael A. Rycyzyn,William R. Strohl,Robert E. Jordan,Ningyan Zhang,Zhiqiang An	18
11	Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge 2014 ·Proteins Structure Function and Bioinformatics ·T. Malia,A. Teplyakov,Randall J. Brezski,Jinquan Luo,Michelle Kinder,Raymond W. Sweet,Juan C. Almagro,Robert E. Jordan,Gary L. Gilliland	15
12	Engineered Protease-resistant Antibodies with Selectable Cell-killing Functions 2013 ·Journal of Biological Chemistry ·Michelle Kinder,Allison R. Greenplate,Katharine D. Grugan,(unknown),Katharine Heeringa,Stephen G. McCarthy,Gregory Bannish,(unknown),(unknown),Robert E. Jordan,William R. Strohl,Randall J. Brezski	31
13	An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations 2013 ·Methods ·Omid Vafa,Gary L. Gilliland,Randall J. Brezski,Brandy Strake,(unknown),Eilyn R. Lacy,Bernard J. Scallon,A. Teplyakov,T. Malia,William R. Strohl	117
14	A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy 2012 ·Breast Cancer Research ·Xuejun Fan,Randall J. Brezski,(unknown),Hui Deng,(unknown),Anneliese Gonzalez,William P. Dubinsky,William R. Strohl,Robert E. Jordan,Ningyan Zhang,Zhiqiang An	51
15	The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge 2011 ·mAbs ·Randall J. Brezski,(unknown),Brandy Strake,Robert E. Jordan	35
16	Cleavage of IgGs by proteases associated with invasive diseases 2010 ·mAbs ·Randall J. Brezski,Robert E. Jordan	117
17	Human Anti-IgG1 Hinge Autoantibodies Reconstitute the Effector Functions of Proteolytically Inactivated IgGs 2008 ·The Journal of Immunology ·Randall J. Brezski,Jennifer L. Luongo,(unknown),Mary Ryan,Degang Zhong,Susan H. Tam,(unknown),Marian Kruszynski,Brian Whitaker,David Knight,Robert E. Jordan	38
18	Tonic B cell antigen receptor signals supply an NF-κB substrate for prosurvival BLyS signaling 2008 ·Nature Immunology ·Jason Stadanlick,Mary Kaileh,Fredrick G. Karnell,Jean L. Scholz,Juli P. Miller,William J. Quinn,Randall J. Brezski,Laura S. Treml,Kimberly A. Jordan,John G. Monroe,Ranjan Sen,Michael P. Cancro	161
19	B Cell Antigen Receptor-Induced Rac1 Activation and Rac1-Dependent Spreading Are Impaired in Transitional Immature B Cells Due to Levels of Membrane Cholesterol 2007 ·The Journal of Immunology ·Randall J. Brezski,John G. Monroe	24
20	Membrane Cholesterol Content Accounts for Developmental Differences inSurface B Cell Receptor Compartmentalization andSignaling 2005 ·Journal of Biological Chemistry ·Fredrick G. Karnell,Randall J. Brezski,Leslie B. King,Michael A. Silverman,John G. Monroe	53

About Randall J. Brezski

Randall J. Brezski is a scholar working on Immunology and Allergy, Radiology, Nuclear Medicine and Imaging and Immunology, having authored 32 papers that have together received 2.0k indexed citations. Recurring topics across this work include Monoclonal and Polyclonal Antibodies Research (21 papers), T-cell and B-cell Immunology (12 papers) and Glycosylation and Glycoproteins Research (10 papers). The work is most often cited by research in Immunology (917 citations), Radiology, Nuclear Medicine and Imaging (963 citations) and Oncology (551 citations). Randall J. Brezski has collaborated with scholars based in United States, Belgium and France. Frequent co-authors include Robert E. Jordan, Xinhua Wang, Mary Mathieu, John G. Monroe, William R. Strohl, George Georgiou, Allison R. Greenplate, Omid Vafa, Fredrick G. Karnell and Xuejun Fan. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Nature Immunology.

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