Rafael León
About
Rafael León is a scholar working on Molecular Biology, Pharmacology and Organic Chemistry.
According to data from OpenAlex, Rafael León has authored 83 papers receiving a total of 4.2k indexed citations (citations by other indexed papers that have themselves been cited), including 40 papers in Molecular Biology, 34 papers in Pharmacology and 32 papers in Organic Chemistry. Recurrent topics in Rafael León's work include Cholinesterase and Neurodegenerative Diseases (33 papers), Genomics, phytochemicals, and oxidative stress (16 papers) and Alzheimer's disease research and treatments (11 papers). Rafael León is often cited by papers focused on Cholinesterase and Neurodegenerative Diseases (33 papers), Genomics, phytochemicals, and oxidative stress (16 papers) and Alzheimer's disease research and treatments (11 papers). Rafael León collaborates with scholars based in Spain, United Kingdom and Brazil. Rafael León's co-authors include José Marco‐Contelles, Manuela G. López, Antonio G. Garcı́a, Javier Egea, Izaskun Buendía, Patrycja Michalska, Elisa Navarro, Isabel Gameiro‐Ros, Antonio Cuadrado and Mércedes Villarroya and has published in prestigious journals such as Journal of Biological Chemistry, Angewandte Chemie International Edition and Biochemistry.
In The Last Decade
Rafael León
82 papers receiving 4.1k citations
Hit Papers
Peers — A (Enhanced Table)
Peers by citation overlap · career bar shows stage (early→late) cites · hero ref
| Name | h | Career | Trend | Papers | Cites | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Rafael León Spain | 33 | 1.9k | 1.2k | 1.1k | 713 | 571 | 83 | 4.2k | ||
| С. О. Бачурин Russia | 35 | 1.5k 0.8× | 1.5k 1.2× | 1.2k 1.1× | 1.1k 1.6× | 767 1.3× | 220 | 4.2k | ||
| Andrea Tarozzi Italy | 35 | 1.3k 0.7× | 1.2k 1.0× | 836 0.8× | 698 1.0× | 651 1.1× | 83 | 3.4k | ||
| Tony Giordano United States | 30 | 1.3k 0.7× | 913 0.8× | 465 0.4× | 1.0k 1.5× | 472 0.8× | 45 | 3.2k | ||
| Harold W. Holloway United States | 40 | 1.6k 0.9× | 2.2k 1.9× | 968 0.9× | 1.2k 1.7× | 1.3k 2.2× | 78 | 5.7k | ||
| Hachiro Sugimoto Japan | 40 | 1.7k 0.9× | 1.8k 1.5× | 831 0.8× | 1.1k 1.6× | 831 1.5× | 104 | 4.6k | ||
| Javier Egea Spain | 41 | 2.6k 1.4× | 902 0.8× | 460 0.4× | 939 1.3× | 339 0.6× | 121 | 5.4k | ||
| Rongbiao Pi China | 40 | 1.7k 0.9× | 1.1k 0.9× | 586 0.5× | 901 1.3× | 330 0.6× | 119 | 4.5k | ||
| Mércedes Villarroya Spain | 33 | 1.4k 0.7× | 1.4k 1.2× | 1.2k 1.1× | 609 0.9× | 681 1.2× | 81 | 3.4k | ||
| Cristóbal de los Rı́os Spain | 28 | 704 0.4× | 1.1k 0.9× | 1.1k 1.0× | 415 0.6× | 623 1.1× | 91 | 2.4k | ||
| Rona R. Ramsay United States | 46 | 3.6k 1.9× | 1.2k 1.0× | 1.3k 1.2× | 1.0k 1.5× | 615 1.1× | 151 | 7.7k |
Countries citing papers authored by Rafael León
Since
Specialization
Citations
This map shows the geographic impact of Rafael León's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Rafael León with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Rafael León more than expected).
Fields of papers citing papers by Rafael León
Since
Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences
This network shows the impact of papers produced by Rafael León. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Rafael León. The network helps show where Rafael León may publish in the future.
Co-authorship network of co-authors of Rafael León
This figure shows the co-authorship network connecting the top 25 collaborators of Rafael León. A scholar is included among the top collaborators of Rafael León based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Rafael León. Rafael León is excluded from the visualization to improve readability, since they are connected to all nodes in the network.
All Works
1.
Domínguez, Cristina, et al.. (2024). Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment. Medicinal Research Reviews. 44(6). 2367–2419.
2.
Estrada, Martín, Concepción Pérez, Rafael León, et al.. (2024). Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties. European Journal of Medicinal Chemistry. 277. 116763–116763.
3.
Estrada, Martín, Concepción Pérez, José Á. Morales-García, et al.. (2022). Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. Journal of Medicinal Chemistry. 65(6). 4727–4751.
4.
Estrada, Martín, Concepción Pérez, Laura Lagartera, et al.. (2020). Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties. European Journal of Medicinal Chemistry. 190. 112090–112090.
5.
Duarte, Pablo, Antonio Cuadrado, & Rafael León. (2020). Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches. Handbook of experimental pharmacology. 264. 229–259.
6.
Paredes, Antonio, et al.. (2020). Large scale use of SARS-CoV-2 antigen-based detection tests: a three-month experience in Guatemala, June-August 2020. Revista Panamericana de Salud Pública. 44. 1–6.
7.
Rubio‐Navarro, Alfonso, Cristina Vázquez‐Carballo, Melania Guerrero‐Hue, et al.. (2019). Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury. Frontiers in Pharmacology. 10. 740–740.
8.
Martin‐de‐Saavedra, María Dolores, Elisa Navarro, Maurício P. Cunha, et al.. (2018). The APP swe/PS 1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities. Journal of Neurochemistry. 145(2). 170–182.
9.
Vera, Olga, Carlos Rodríguez‐Antolín, Patrycja Michalska, et al.. (2018). MAFG is a potential therapeutic target to restore chemosensitivity in cisplatin-resistant cancer cells by increasing reactive oxygen species. Translational research. 200. 1–17.
10.
Monjas, Leticia, Mariana P. Arce, Rafael León, et al.. (2017). Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia. European Journal of Medicinal Chemistry. 130. 60–72.
11.
Efentakis, Panagiotis, Anna Rizakou, Eirini Christodoulou, et al.. (2017). Saffron ( Crocus sativus ) intake provides nutritional preconditioning against myocardial ischemia–reperfusion injury in Wild Type and ApoE (−/−) mice: Involvement of Nrf2 activation. Nutrition Metabolism and Cardiovascular Diseases. 27(10). 919–929.
12.
Michalska, Patrycja, Izaskun Buendía, Laura Barrio, & Rafael León. (2016). Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer’s Disease. Current Topics in Medicinal Chemistry. 17(9). 1027–1043.
13.
Buendía, Izaskun, Patrycja Michalska, Elisa Navarro, et al.. (2015). Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacology & Therapeutics. 157. 84–104.
14.
Egea, Javier, Alejandro Romero, E. Parada, et al.. (2014). Neuroprotective effect of dimebon against ischemic neuronal damage. Neuroscience. 267. 11–21.
15.
León, Rafael & José Marco‐Contelles. (2011). A Step Further Towards Multitarget Drugs for Alzheimer and Neuronal Vascular Diseases: Targeting the Cholinergic System, Amyloid-β Aggregation and Ca2++ Dyshomeostasis. Current Medicinal Chemistry. 18(4). 552–576.
16.
Caricati‐Neto, Afonso, Soraya S. Smaili, Rosely Oliveira Godinho, et al.. (2011). Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity. European Journal of Pharmacology. 660(2-3). 411–419.
17.
Martins, Carla P., M. Carmo Carreiras, Abdelouahid Samadi, et al.. (2009). A reinvestigation of the acid-promoted heterocyclization of 2-(2-oxo-2-arylethyl)malononitriles in the presence of amines. Molecular Diversity. 13(4). 459–468.
18.
León, Rafael, Cristóbal de los Rı́os, José Marco‐Contelles, et al.. (2008). New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties. Bioorganic & Medicinal Chemistry. 16(16). 7759–7769.
19.
Orozco, Camilo Madariaga, Cristóbal de los Rı́os, Esperanza Arias, et al.. (2004). ITH4012 (Ethyl 5-Amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a Novel Acetylcholinesterase Inhibitor with “Calcium Promotor” and Neuroprotective Properties. Journal of Pharmacology and Experimental Therapeutics. 310(3). 987–994.
20.
León, Rafael, José Marco‐Contelles, Antonio G. Garcı́a, & Mércedes Villarroya. (2004). Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues. Bioorganic & Medicinal Chemistry. 13(4). 1167–1175.
Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.
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