Paul Modrich

29.2k total citations · 25 hit papers
183 papers, 23.7k citations indexed

About

Paul Modrich is a scholar working on Molecular Biology, Pathology and Forensic Medicine and Cancer Research. According to data from OpenAlex, Paul Modrich has authored 183 papers receiving a total of 23.7k indexed citations (citations by other indexed papers that have themselves been cited), including 167 papers in Molecular Biology, 91 papers in Pathology and Forensic Medicine and 33 papers in Cancer Research. Recurrent topics in Paul Modrich's work include DNA Repair Mechanisms (108 papers), Genetic factors in colorectal cancer (91 papers) and RNA and protein synthesis mechanisms (57 papers). Paul Modrich is often cited by papers focused on DNA Repair Mechanisms (108 papers), Genetic factors in colorectal cancer (91 papers) and RNA and protein synthesis mechanisms (57 papers). Paul Modrich collaborates with scholars based in United States, United Kingdom and Canada. Paul Modrich's co-authors include Robert S. Lahue, Guo‐Min Li, Jochen Genschel, James T. Drummond, Karin G. Au, Suzanne Clark, Matthew J. Longley, S S Su, Ravi R. Iyer and Farid A. Kadyrov and has published in prestigious journals such as Science, Cell and Chemical Reviews.

In The Last Decade

Paul Modrich

182 papers receiving 23.0k citations

Hit Papers

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC REC... 1976 2026 1992 2009 1996 1993 1991 2005 2011 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY
    1996 1.3k citations Paul Modrich et al. profile →
  2. Hypermutability and mismatch repair deficiency in RER+ tumor cells
    1993 871 citations Matthew J. Longley, Kenneth W. Kinzler et al. Cell profile →
  3. MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR
    1991 748 citations Paul Modrich profile →
  4. DNA Mismatch Repair:  Functions and Mechanisms
    2005 694 citations Ravi R. Iyer, Anna Pluciennik et al. profile →
  5. BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair
    2011 576 citations Jochen Genschel, Paul Modrich et al. profile →
  6. Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
    1998 507 citations Paul Modrich et al. Proceedings of the National Academy of Sciences profile →
  7. Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
    1995 492 citations Matthew J. Longley, Paul Modrich et al. profile →
  8. Endonucleolytic Function of MutLα in Human Mismatch Repair
    2006 484 citations Farid A. Kadyrov, Leonid Dzantiev et al. Cell profile →
  9. DNA Mismatch Correction in a Defined System
    1989 447 citations Paul Modrich et al. profile →
  10. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
    1993 390 citations Matthew J. Longley, Paul Modrich et al. Proceedings of the National Academy of Sciences profile →
  11. DNA MISMATCH CORRECTION
    1987 375 citations Paul Modrich profile →
  12. Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
    1996 354 citations Aziz Sancar, Paul Modrich et al. Proceedings of the National Academy of Sciences profile →
  13. Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα
    1998 339 citations Jochen Genschel, Susan J. Littman et al. Journal of Biological Chemistry profile →
  14. Mismatch Repair, Genetic Stability, and Cancer
    1994 335 citations Paul Modrich profile →
  15. Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.
    1990 334 citations Paul Modrich et al. Proceedings of the National Academy of Sciences profile →
  16. Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
    1995 328 citations Paul Modrich et al. Proceedings of the National Academy of Sciences profile →
  17. Mechanisms in Eukaryotic Mismatch Repair
    2006 325 citations Paul Modrich Journal of Biological Chemistry profile →
  18. Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.
    1986 298 citations S S Su, Paul Modrich Proceedings of the National Academy of Sciences profile →
  19. Mispair specificity of methyl-directed DNA mismatch correction in vitro.
    1988 293 citations S S Su, Paul Modrich et al. Journal of Biological Chemistry profile →
  20. Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease.
    1979 285 citations Paul Modrich et al. Journal of Biological Chemistry profile →
  21. Methyl-directed repair of DNA base-pair mismatches in vitro.
    1983 281 citations Paul Modrich et al. Proceedings of the National Academy of Sciences profile →
  22. Structure of the Human MutSα DNA Lesion Recognition Complex
    2007 279 citations J.J. Warren, Anita Changela et al. Molecular Cell profile →
  23. Isolation and Characterization of the Escherichia coli mutL Gene Product
    1989 248 citations S S Su, Paul Modrich et al. Journal of Biological Chemistry profile →
  24. EFFECTS OF HIGH LEVELS OF DNA ADENINE METHYLATION ON METHYL-DIRECTED MISMATCH REPAIR IN ESCHERICHIA COLI
    1983 245 citations Paul Modrich et al. profile →
  25. EcoRI endonuclease. Physical and catalytic properties of the homogenous enzyme.
    1976 242 citations Paul Modrich et al. Journal of Biological Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Paul Modrich United States 86 20.1k 10.6k 5.2k 4.4k 3.4k 183 23.7k
Richard D. Kolodner United States 95 25.5k 1.3× 13.5k 1.3× 7.7k 1.5× 5.4k 1.2× 6.9k 2.0× 271 34.2k
Josef Jiricny Switzerland 68 12.2k 0.6× 5.3k 0.5× 3.6k 0.7× 2.3k 0.5× 3.0k 0.9× 199 15.4k
Julian Adams United States 69 14.2k 0.7× 1.6k 0.2× 2.4k 0.5× 2.3k 0.5× 6.2k 1.8× 168 21.4k
Anton Berns Netherlands 80 13.5k 0.7× 3.1k 0.3× 2.0k 0.4× 3.1k 0.7× 9.6k 2.8× 211 23.7k
Peter K. Vogt United States 87 17.7k 0.9× 1.3k 0.1× 2.8k 0.5× 5.8k 1.3× 4.5k 1.3× 382 27.3k
Wei Yang United States 60 12.6k 0.6× 1.5k 0.1× 1.4k 0.3× 2.4k 0.5× 1.1k 0.3× 225 14.9k
Errol C. Friedberg United States 61 13.1k 0.7× 861 0.1× 3.3k 0.6× 2.3k 0.5× 1.9k 0.6× 233 14.6k
George F. Vande Woude United States 82 17.2k 0.9× 2.2k 0.2× 2.8k 0.5× 3.5k 0.8× 6.3k 1.8× 247 27.8k
Geoffrey M. Wahl United States 80 21.7k 1.1× 1.1k 0.1× 4.8k 0.9× 4.3k 1.0× 11.1k 3.2× 178 30.1k
Eric J. Stanbridge United States 65 12.4k 0.6× 1.2k 0.1× 4.7k 0.9× 2.0k 0.5× 4.6k 1.3× 275 18.3k

Countries citing papers authored by Paul Modrich

Since Specialization
Citations

This map shows the geographic impact of Paul Modrich's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Paul Modrich with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Paul Modrich more than expected).

Fields of papers citing papers by Paul Modrich

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Paul Modrich. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Paul Modrich. The network helps show where Paul Modrich may publish in the future.

Co-authorship network of co-authors of Paul Modrich

This figure shows the co-authorship network connecting the top 25 collaborators of Paul Modrich. A scholar is included among the top collaborators of Paul Modrich based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Paul Modrich. Paul Modrich is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Sherrer, Shanen M., et al.. (2018). The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease. Proceedings of the National Academy of Sciences. 115(28). 7314–7319. 21 indexed citations
2.
Lindahl, Tomas, Paul Modrich, & Aziz Sancar. (2016). The 2015 Nobel Prize in Chemistry The Discovery of Essential Mechanisms that Repair DNA Damage.. PubMed. 42(1). 37–41. 10 indexed citations
3.
Qiu, Ruoyi, Miho Sakato, Elizabeth J. Sacho, et al.. (2015). MutL traps MutS at a DNA mismatch. Proceedings of the National Academy of Sciences. 112(35). 10914–10919. 45 indexed citations
4.
Orans, Jillian, Ravi Iyer, Michael A. Hast, et al.. (2011). Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family. Cell. 145(2). 212–223. 130 indexed citations
5.
Pluciennik, Anna, Leonid Dzantiev, Ravi R. Iyer, et al.. (2010). PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair. Proceedings of the National Academy of Sciences. 107(37). 16066–16071. 209 indexed citations
6.
Kadyrov, Farid A., et al.. (2009). A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. Proceedings of the National Academy of Sciences. 106(21). 8495–8500. 112 indexed citations
7.
Zhao, Junhua, Aklank Jain, Ravi R. Iyer, Paul Modrich, & Karen M. Vásquez. (2009). Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. Nucleic Acids Research. 37(13). 4420–4429. 70 indexed citations
8.
Warren, J.J., et al.. (2007). Structure of the Human MutSα DNA Lesion Recognition Complex. Molecular Cell. 26(4). 579–592. 279 indexed citations breakdown →
9.
Pluciennik, Anna & Paul Modrich. (2007). Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair. Proceedings of the National Academy of Sciences. 104(31). 12709–12713. 55 indexed citations
10.
Kadyrov, Farid A., Shannon F. Holmes, Mercedes E. Arana, et al.. (2007). Saccharomyces cerevisiae MutLα Is a Mismatch Repair Endonuclease. Journal of Biological Chemistry. 282(51). 37181–37190. 199 indexed citations
11.
Yang, Qin, Ran Zhang, Xin Wei Wang, et al.. (2004). The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. Oncogene. 23(21). 3749–3756. 62 indexed citations
12.
Burdett, Vickers, Celia Baitinger, Mohan Viswanathan, Susan T. Lovett, & Paul Modrich. (2001). In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair. Proceedings of the National Academy of Sciences. 98(12). 6765–6770. 175 indexed citations
13.
Hoyt, Peter R., Mitchel J. Doktycz, Paul Modrich, R. J. Warmack, & David P. Allison. (2000). Identifying sequence similarities between DNA molecules. Ultramicroscopy. 82(1-4). 237–244. 3 indexed citations
14.
Blackwell, Leonard J., et al.. (1998). Nucleotide-promoted Release of hMutSα from Heteroduplex DNA Is Consistent with an ATP-dependent Translocation Mechanism. Journal of Biological Chemistry. 273(48). 32055–32062. 160 indexed citations
15.
Nicolaides, Nicholas C., Susan J. Littman, Paul Modrich, Kenneth W. Kinzler, & Bert Vogelstein. (1998). A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype. Molecular and Cellular Biology. 18(3). 1635–1641. 82 indexed citations
16.
Longley, Matthew J., Andrew J. Pierce, & Paul Modrich. (1997). DNA Polymerase δ Is Required for Human Mismatch Repair in Vitro. Journal of Biological Chemistry. 272(16). 10917–10921. 175 indexed citations
17.
Modrich, Paul. (1995). Mismatch repair, genetic stability and tumour avoidance. Philosophical Transactions of the Royal Society B Biological Sciences. 347(1319). 89–95. 41 indexed citations
18.
Jiricny, Josef, S S Su, Steven G. Wood, & Paul Modrich. (1988). Mismatch-containing oligonucleotide duplexes bound by theE.coli mutS-encoded protein. Nucleic Acids Research. 16(16). 7843–7853. 81 indexed citations
19.
Modrich, Paul & Richard J. Roberts. (1982). Type-II Restriction and Modification Enzymes. Cold Spring Harbor Monograph Archive. 14. 109–154. 32 indexed citations
20.
Rubin, Robert A. & Paul Modrich. (1980). [12] Purification and properties of EcoRI endonuclease. Methods in enzymology on CD-ROM/Methods in enzymology. 65(1). 96–104. 21 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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