Patrick Berna

740 citations

18 papers · 505 indexed · h-index 12

Impact in

Pharmacology
- Cholinesterase and Neurodegenerative Diseases
Molecular Biology
- Phosphodiesterase function and regulation
- Enzyme Catalysis and Immobilization
- Mitochondrial Function and Pathology
- RNA modifications and cancer

Papers in ⓘ

Pharmacology 5
- Cholinesterase and Neurodegenerative Diseases 4
Spectroscopy 4
- Analytical Chemistry and Chromatography 2

Co-authors: Jean‐Louis Abitbol (3 shared papers)Thierry Bordet (2 shared papers)Rebecca M. Pruss (2 shared papers)Mireille Rivière (1 shared paper)Robert Verger (1 shared paper)Véronique Gruber (1 shared paper)Christian Cambillau (1 shared paper)Alain Roussel (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (4 papers)Biochemistry (2 papers)European Journal of Pharmacology (2 papers)Electrophoresis (1 paper)Journal of Translational Medicine (1 paper)
Partner nations: France United States Sweden

In The Last Decade

Patrick Berna

18 papers receiving 491 citations

Peers

Countries citing papers authored by Patrick Berna

Since Specialization

Citations

This map shows the geographic impact of Patrick Berna's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick Berna with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick Berna more than expected).

Fields of papers citing papers by Patrick Berna

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick Berna. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick Berna. The network helps show where Patrick Berna may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick Berna, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick Berna Line = papers co-authored together Patrick Berna links everyone, so they are left out of the graph.

All Works

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18 of 18 papers shown

#	Work
1	Crystal Structure of the Open Form of Dog Gastric Lipase in Complex with a Phosphonate Inhibitor Journal of Biological Chemistry ·Alain Roussel, Nabil Miled, Liliane Berti-Dupuis, Mireille Rivière, Silvia Spinelli, Patrick Berna, Véronique Gruber, Robert Verger, Christian Cambillau	2002	105
2	Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound Pharmaceuticals ·Thierry Bordet, Patrick Berna, Jean‐Louis Abitbol, Rebecca M. Pruss	2010	92
3	Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: Design, synthesis and structure–activity relationship studies Bioorganic & Medicinal Chemistry Letters ·Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, Nga Pham, Emmanuelle Proust, Chrystelle Oliveira, Abdel‐Kader Mafroud, Frédérique Royer, Roger Wrigglesworth, Jennifer Schellhaas, Mark R. Barvian, F. Moreau, Moulay Idrissi, Anita Tertre, Bernadette Bertin, Magali Coupe, Patrick Berna, Patricia Soulard	2004	45
4	Analysis of the inflammatory response induced by rhMMP-12 catalytic domain instilled in mouse airways International Immunopharmacology ·Soazig Nénan, Jean‐Michel Planquois, Patrick Berna, Isabelle de Mendez, Simon Hitier, Steve D. Shapiro, Elisabeth Boichot, Vincent Lagente, Claude Bertrand	2004	38
5	Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1 Bioorganic & Medicinal Chemistry Letters ·Edwige Lorthiois, Patrick Bernardelli, Fabrice Vergne, Chrystelle Oliveira, Abdel‐Kader Mafroud, Emmanuelle Proust, Lamia Heuze, F. Moreau, Moulay Idrissi, Anita Tertre, Bernadette Bertin, Magali Coupe, Roger Wrigglesworth, Arnaud Descours, Patricia Soulard, Patrick Berna	2004	37
6	Residue Accessibility, Hydrogen Bonding, and Molecular Recognition: Metal−Chelate Probing of Active Site Histidines in Chymotrypsins Biochemistry ·Patrick Berna, Nadir T. Mrabet, Jozef Van Beeumen, Bart Devreese, Jerker Porath, M.A. Vijayalakshmi	1997	30
7	Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 2: Metabolism-directed optimization studies towards orally bioavailable derivatives Bioorganic & Medicinal Chemistry Letters ·Fabrice Vergne, Patrick Bernardelli, Edwige Lorthiois, Nga Pham, Emmanuelle Proust, Chrystelle Oliveira, Abdel‐Kader Mafroud, Pierre Ducrot, Roger Wrigglesworth, Françoise Berlioz-Seux, Francis Coleon, Éric Chevalier, F. Moreau, Moulay Idrissi, Anita Tertre, Arnaud Descours, Patrick Berna, Mei Li	2004	28
8	Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial Journal of Translational Medicine ·Sophie Le Lamer, Stéphanie Paradis, Hidayat Rahmouni, Corinne Chaimbault, Magali Michaud, Marcel Culcasi, Jean Afxantidis, Mathilde Latreille, Patrick Berna, Alain Berdeaux, Sylvia Pietri, Didier Morin, Yves Donazzolo, Jean‐Louis Abitbol, Rebacca M Pruss, Sophie Schaller	2014	28
9	Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives Bioorganic & Medicinal Chemistry Letters ·Patrick Bernardelli, Edwige Lorthiois, Fabrice Vergne, Chrystelle Oliveira, Abdel‐Kader Mafroud, Emmanuelle Proust, Nga Pham, Pierre Ducrot, F. Moreau, Moulay Idrissi, Anita Tertre, Bernadette Bertin, Magali Coupe, Éric Chevalier, Arnaud Descours, Françoise Berlioz-Seux, Patrick Berna, Mei Li	2004	24
10	Metalloelastase (MMP-12) induced inflammatory response in mice airways: Effects of dexamethasone, rolipram and marimastat European Journal of Pharmacology ·Soazig Nénan, Vincent Lagente, Jean‐Michel Planquois, Simon Hitier, Patrick Berna, Claude Bertrand, Elisabeth Boichot	2006	20
11	Drug Discovery and Development for Spinal Muscular Atrophy: Lessons from Screening Approaches and Future Challenges for Clinical Development Future Medicinal Chemistry ·Rebecca M. Pruss, Marc Giraudon‐Paoli, Svetlana Morozova, Patrick Berna, Jean‐Louis Abitbol, Thierry Bordet	2010	13
12	Substrate use and production of α- l -arabinofuranosidase during solid-state culture of Trichoderma reesei on sugar beet pulp Enzyme and Microbial Technology ·Nathalie Roche, Patrick Berna, C. Desgranges, Alain Durand	1995	11
13	Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma European Respiratory Journal ·É. Chevalier, Vincent Lagente, Mariana Dupont, Helene Fargeau, Xavier Palazzi, Vinitha Richard, M. Dassaud, Michal Fric, Magali Coupe, C. Carré, Sarah J Leduc, Patrick Bernardelli, Fabrice Vergne, Patrick Berna, Claude Bertrand	2011	10
14	Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways European Journal of Pharmacology ·Soazig Nénan, Elisabeth Boichot, Jean‐Michel Planquois, Patrick Berna, Simon Hitier, Tsiala Bénard, Vincent Lagente, Claude Bertrand	2007	9
15	Cosolvent-Induced Adsorption and Desorption of Serum Proteins on an Amphiphilic Mercaptomethylene Pyridine-Derivatized Agarose Gel Archives of Biochemistry and Biophysics ·Nathalie Berna, Patrick Berna, Sven Oscarsson	1996	6
16	Polyol-promoted adsorption of serum proteins to amphiphilic agarose-based adsorbents Journal of Chromatography A ·Nathalie Berna, Patrick Berna, Sven Oscarsson	1997	5
17	Resolution of 8‐aminonaphthalene‐1,3,6‐trisulfonic acid‐labeled glucose oligomers in polyacrylamide gel electrophoresis at low gel concentration Electrophoresis ·Marion Cabanes‐Macheteau, Andreas Chrambach, Myriam Taverna, Zsuzsanna Buzás, Patrick Berna	2004	2
18	Residue Accessibility, Hydrogen Bonding, and Molecular Recognition: Metal−Chelate Probing of Active Site Histidines in Chymotrypsins Biochemistry ·Patrick Berna, Nadir T. Mrabet, Jozef Van Beeumen, Bart Devreese, Jerker Porath, M.A. Vijayalakshmi	1997	2

About Patrick Berna

Patrick Berna is a scholar working on Pharmacology, Spectroscopy, Biotechnology, Molecular Medicine and Cancer Research, having authored 18 papers that have together received 505 indexed citations. Recurring topics across this work include Phosphodiesterase function and regulation (5 papers), Cholinesterase and Neurodegenerative Diseases (4 papers), Phenothiazines and Benzothiazines Synthesis and Activities (3 papers), Protease and Inhibitor Mechanisms (3 papers), Analytical Chemistry and Chromatography (2 papers), Asthma and respiratory diseases (2 papers), Microfluidic and Capillary Electrophoresis Applications (2 papers) and Neurogenetic and Muscular Disorders Research (2 papers). The work is most often cited by research in Pharmacology (77 citations), Molecular Biology (313 citations), Genetics (48 citations), Organic Chemistry (88 citations) and Biochemistry (21 citations). Patrick Berna has collaborated with scholars based in France, United States and Sweden. Frequent co-authors include Jean‐Louis Abitbol, Thierry Bordet, Rebecca M. Pruss, Mireille Rivière, Robert Verger, Véronique Gruber, Christian Cambillau, Alain Roussel, Silvia Spinelli and Nabil Miled. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Biochemistry, European Journal of Pharmacology, Electrophoresis and Journal of Translational Medicine.

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