P. Brear

1.0k citations

41 papers · 648 indexed · h-index 16

Impact in

Molecular Biology
- Protein Kinase Regulation and GTPase Signaling
- Biochemical and Molecular Research
- Protein Structure and Dynamics
- Chemical Synthesis and Analysis
Computational Theory and Mathematics top 10%
- Computational Drug Discovery Methods

Papers in ⓘ

Molecular Biology 34
- Protein Kinase Regulation and GTPase Signaling 15
- Protein Structure and Dynamics 5
- Chemical Synthesis and Analysis 5
- Biochemical and Molecular Research 3
Oncology 8

Co-authors: Marko Hyvönen (20 shared papers)David R. Spring (14 shared papers)Jessica Iegre (8 shared papers)Hannah F. Sore (5 shared papers)Claudia De Fusco (4 shared papers)Martin Welch (7 shared papers)Stephen K. Dolan (3 shared papers)Nicholas J. Westwood (3 shared papers)
Journals: Journal of Biological Chemistry (5 papers)Journal of Medicinal Chemistry (4 papers)Chemical Science (3 papers)Nature Chemical Biology (3 papers)European Journal of Medicinal Chemistry (2 papers)
Partner nations: United Kingdom United States Germany

In The Last Decade

P. Brear

39 papers receiving 646 citations

Peers

Countries citing papers authored by P. Brear

Since Specialization

Citations

This map shows the geographic impact of P. Brear's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by P. Brear with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites P. Brear more than expected).

Fields of papers citing papers by P. Brear

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by P. Brear. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by P. Brear. The network helps show where P. Brear may publish in the future.

Co-authors

The 25 scholars most cited alongside P. Brear, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with P. Brear Line = papers co-authored together P. Brear links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 41 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Specific inhibition of CK2α from an anchor outside the active site Chemical Science ·P. Brear, Claudia De Fusco, Kathy Hadje Georgiou, Nicola J. Francis-Newton, Christopher J. Stubbs, Hannah F. Sore, Ashok R. Venkitaraman, Chris Abell, David R. Spring, Marko Hyvönen	2016	56
2	A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066 Bioorganic & Medicinal Chemistry ·Claudia De Fusco, P. Brear, Jessica Iegre, Kathy Hadje Georgiou, Hannah F. Sore, Marko Hyvönen, David R. Spring	2017	48
3	ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species Chemistry & Biology ·Linna Zhou, Hironori Ishizaki, Michaela Spitzer, Kerrie L. Taylor, Nicholas D. Temperley, Stephen L. Johnson, P. Brear, Philippe Gautier, Zhiqiang Zeng, Amy Mitchell, Vikram Narayan, Ewan M. McNeil, David W. Melton, Terry Smith, Mike Tyers, Nicholas J. Westwood, E. Elizabeth Patton	2012	40
4	Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa Journal of Biological Chemistry ·Audrey Crousilles, Stephen K. Dolan, P. Brear, Dimitri Y. Chirgadze, Martin Welch	2018	38
5	Novel non-ATP competitive small molecules targeting the CK2 α/β interface Bioorganic & Medicinal Chemistry ·P. Brear, Andrew J. P. North, Jessica Iegre, Kathy Hadje Georgiou, Alexandra Lubin, L. Carro, William H. Green, Hannah F. Sore, Marko Hyvönen, David R. Spring	2018	36
6	Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors Nature Chemical Biology ·Maria Reinecke, P. Brear, Larsen Vornholz, Benedict‐Tilman Berger, Florian Seefried, Stephanie Wilhelm, Patroklos Samaras, Laszlo Gyenis, David W. Litchfield, Guillaume Médard, Susanne Müller, Jürgen Ruland, Marko Hyvönen, Mathias Wilhelm, Bernhard Küster	2023	35
7	Second-generation CK2α inhibitors targeting the αD pocket Chemical Science ·Jessica Iegre, P. Brear, Claudia De Fusco, Masao Yoshida, Sophie L. Mitchell, Maxim Rossmann, L. Carro, Hannah F. Sore, Marko Hyvönen, David R. Spring	2018	33
8	Chain alignment of collagen I deciphered using computationally designed heterotrimers Nature Chemical Biology ·Abhishek A. Jalan, Douglas Sammon, Jeffrey D. Hartgerink, P. Brear, Katherine Stott, Samir W. Hamaia, Emma J. Hunter, Douglas R. Walker, Birgit Leitinger, Richard W. Farndale	2020	32
9	Functional metagenomic screening identifies an unexpected β-glucuronidase Nature Chemical Biology ·Stefanie Neun, P. Brear, E.C. Campbell, Theodora Tryfona, Kamel El Omari, Armin Wagner, Paul Dupree, Marko Hyvönen, Florian Hollfelder	2022	31
10	Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction Chemical Science ·Jessica Iegre, P. Brear, David Baker, Yaw Sing Tan, Eleanor L. Atkinson, Hannah F. Sore, Daniel H. O’Donovan, Chandra Verma, Marko Hyvönen, David R. Spring	2019	30
11	A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins Molecular Informatics ·Ava S.‐Y. Chen, Nicholas J. Westwood, P. Brear, Graeme W. Rogers, Lazaros Mavridis, John B. O. Mitchell	2016	28
12	Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors Scientific Reports ·Irina Kufareva, Benoît Bestgen, P. Brear, Renaud Prudent, Béatrice Laudet, Virginie Moucadel, Mohamed Ettaoussi, Céline F Sautel, Isabelle Krimm, Matthias Engel, Odile Filhol, Marc Le Borgne, Thierry Lomberget, Claude Cochet, Ruben Abagyan	2019	24
13	Chemical probes targeting the kinase CK2: a journey outside the catalytic box Organic & Biomolecular Chemistry ·Jessica Iegre, Eleanor L. Atkinson, P. Brear, Bethany Cooper, Marko Hyvönen, David R. Spring	2021	21
14	Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study Molecules ·Eleanor L. Atkinson, Jessica Iegre, P. Brear, Elizabeth A. Zhabina, Marko Hyvönen, David R. Spring	2021	19
15	Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α Journal of Medicinal Chemistry ·P. Brear, Darby Ball, Katherine Stott, Sheena D’Arcy, Marko Hyvönen	2020	16
16	Aqueous methods for the preparation of 5′-substituted guanosine derivatives Chemical Communications ·P. Brear, Gemma R. Freeman, Mark C. Shankey, Milena Trmčić, David R. W. Hodgson	2009	16
17	Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa Journal of Biological Chemistry ·Yassmin Abdelhamid, P. Brear, Jack Greenhalgh, Xavier Chee Wezen, Taufiq Rahman, Martin Welch	2019	14
18	Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism mBio ·Stephen K. Dolan, Andre J. Wijaya, Michael Kohlstedt, Lars Gläser, P. Brear, Rafael Silva‐Rocha, Christoph Wittmann, Martin Welch	2022	14
19	Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase European Journal of Medicinal Chemistry ·Amalyn Nain‐Perez, Anders Foller Füchtbauer, Liliana Håversen, Aleksei Lulla, Chunxia Gao, Josipa Matić, Leticia Monjas, Alexandra Rodríguez, P. Brear, Woonghee Kim, Marko Hyvönen, Jan Borén, Adil Mardinoğlu, Mathias Uhlén, Morten Grøtli	2022	14
20	Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells Nature Biotechnology ·Katrin Fischer, Aleksei Lulla, Tsz Y. So, Pehuén Pereyra-Gerber, Matthew I. J. Raybould, Timo N. Kohler, Juan Carlos Yam‐Puc, Tomasz S. Kamiński, Robert M. Hughes, Gwendolyn L. Pyeatt, Florian Leiss-Maier, P. Brear, Nicholas J. Matheson, Charlotte M. Deane, Marko Hyvönen, James Thaventhiran, Florian Hollfelder	2024	10

About P. Brear

P. Brear is a scholar working on Molecular Biology, Oncology, Genetics, Materials Chemistry and Organic Chemistry, having authored 41 papers that have together received 648 indexed citations. Recurring topics across this work include Protein Kinase Regulation and GTPase Signaling (15 papers), Bacterial Genetics and Biotechnology (7 papers), Enzyme Structure and Function (7 papers), Protein Structure and Dynamics (5 papers), Chemical Synthesis and Analysis (5 papers), Monoclonal and Polyclonal Antibodies Research (4 papers), Coagulation, Bradykinin, Polyphosphates, and Angioedema (3 papers) and Biochemical and Molecular Research (3 papers). The work is most often cited by research in Molecular Biology (483 citations), Computational Theory and Mathematics (76 citations), Biotechnology (29 citations), Molecular Medicine (16 citations) and Oncology (85 citations). P. Brear has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include Marko Hyvönen, David R. Spring, Jessica Iegre, Hannah F. Sore, Claudia De Fusco, Martin Welch, Stephen K. Dolan, Nicholas J. Westwood, Dimitri Y. Chirgadze and L. Carro. Their work appears in journals such as Journal of Biological Chemistry, Journal of Medicinal Chemistry, Chemical Science, Nature Chemical Biology and European Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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