David R. Spring

20.4k total citations · 10 hit papers
293 papers, 16.8k citations indexed

About

David R. Spring is a scholar working on Molecular Biology, Organic Chemistry and Pharmacology. According to data from OpenAlex, David R. Spring has authored 293 papers receiving a total of 16.8k indexed citations (citations by other indexed papers that have themselves been cited), including 203 papers in Molecular Biology, 134 papers in Organic Chemistry and 38 papers in Pharmacology. Recurrent topics in David R. Spring's work include Chemical Synthesis and Analysis (101 papers), Click Chemistry and Applications (59 papers) and Bacterial biofilms and quorum sensing (33 papers). David R. Spring is often cited by papers focused on Chemical Synthesis and Analysis (101 papers), Click Chemistry and Applications (59 papers) and Bacterial biofilms and quorum sensing (33 papers). David R. Spring collaborates with scholars based in United Kingdom, United States and China. David R. Spring's co-authors include Warren R. J. D. Galloway, Zhaochao Xu, Juyoung Yoon, Martin Welch, Albert Isidro‐Llobet, Hannah F. Sore, James T. Hodgkinson, Fengzhi Zhang, Jingnan Cui and Yu Heng Lau and has published in prestigious journals such as Nature, Chemical Reviews and Proceedings of the National Academy of Sciences.

In The Last Decade

David R. Spring

284 papers receiving 16.5k citations

Hit Papers

Fluorescent chemosensors for Zn2+ 2009 2026 2014 2020 2010 2010 2009 2014 2010 250 500 750
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Fluorescent chemosensors for Zn2+
    2010 922 citations David R. Spring et al. Chemical Society Reviews profile →
  2. Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules
    2010 723 citations Warren R. J. D. Galloway, Albert Isidro‐Llobet et al. profile →
  3. Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor
    2009 665 citations David R. Spring et al. profile →
  4. Arene C–H functionalisation using a removable/modifiable or a traceless directing group strategy
    2014 583 citations David R. Spring et al. Chemical Society Reviews profile →
  5. Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways
    2010 512 citations Warren R. J. D. Galloway, James T. Hodgkinson et al. profile →
  6. Peptide stapling techniques based on different macrocyclisation chemistries
    2014 470 citations Yuteng Wu, David R. Spring et al. Chemical Society Reviews profile →
  7. Cleavable linkers in antibody–drug conjugates
    2019 443 citations Jonathan D. Bargh, Albert Isidro‐Llobet et al. Chemical Society Reviews profile →
  8. The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
    2021 338 citations Josephine Gaynord, Sam M. Rowe et al. Chemical Society Reviews profile →
  9. Site-selective modification strategies in antibody–drug conjugates
    2020 315 citations Stephen J. Walsh, Jonathan D. Bargh et al. Chemical Society Reviews profile →
  10. Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)
    2020 293 citations Jessica Iegre, David R. Spring et al. Chemical Society Reviews profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David R. Spring United Kingdom 62 8.8k 7.3k 2.9k 2.3k 1.4k 293 16.8k
Rob M. J. Liskamp Netherlands 58 10.2k 1.2× 6.6k 0.9× 1.5k 0.5× 888 0.4× 1.4k 1.0× 338 15.1k
Donald Hilvert Switzerland 74 13.1k 1.5× 3.9k 0.5× 887 0.3× 3.5k 1.5× 852 0.6× 323 17.0k
Luc Brunsveld Netherlands 56 6.7k 0.8× 6.9k 0.9× 1.7k 0.6× 3.5k 1.5× 820 0.6× 246 15.3k
Fernando Alberício Spain 85 20.0k 2.3× 14.9k 2.1× 1.1k 0.4× 1.7k 0.7× 2.6k 1.8× 935 30.7k
Jonathan A. Ellman United States 96 10.0k 1.1× 27.7k 3.8× 1.0k 0.3× 865 0.4× 1.4k 1.0× 354 33.9k
Benjamin G. Davis United Kingdom 76 13.4k 1.5× 10.7k 1.5× 1.1k 0.4× 1.5k 0.6× 1.7k 1.2× 324 19.5k
Carlo Pedone Italy 56 8.8k 1.0× 3.8k 0.5× 926 0.3× 1.1k 0.5× 1.0k 0.7× 401 11.9k
Barbara Imperiali United States 62 8.3k 0.9× 4.0k 0.6× 2.1k 0.7× 2.6k 1.1× 903 0.6× 239 12.0k
Tom W. Muir United States 79 20.9k 2.4× 5.3k 0.7× 914 0.3× 941 0.4× 2.8k 1.9× 273 23.7k
Morten Meldal Denmark 50 13.0k 1.5× 14.4k 2.0× 782 0.3× 1.6k 0.7× 1.7k 1.2× 292 20.3k

Countries citing papers authored by David R. Spring

Since Specialization
Citations

This map shows the geographic impact of David R. Spring's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David R. Spring with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David R. Spring more than expected).

Fields of papers citing papers by David R. Spring

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David R. Spring. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David R. Spring. The network helps show where David R. Spring may publish in the future.

Co-authorship network of co-authors of David R. Spring

This figure shows the co-authorship network connecting the top 25 collaborators of David R. Spring. A scholar is included among the top collaborators of David R. Spring based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David R. Spring. David R. Spring is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Counsell, Andrew J., Stephen J. Walsh, Nicola Ashman, et al.. (2025). MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody–drug conjugates. Chemical Science. 17(5). 2722–2731.
2.
King, Thomas A., et al.. (2025). A platform for SpyCatcher conjugation to native antibodies. Chemical Science. 16(23). 10602–10609.
3.
Seki, Hikaru, et al.. (2025). Pseudomonas aeruginosa PfpI is a methylglyoxalase. Journal of Biological Chemistry. 301(4). 108374–108374.
4.
Ashman, Nicola, Jonathan D. Bargh, Stephen J. Walsh, et al.. (2023). Peroxide-cleavable linkers for antibody–drug conjugates. Chemical Communications. 59(13). 1841–1844. 17 indexed citations
5.
Walther, Raoul, et al.. (2023). Identification of macrocyclic peptides which activate bacterial cylindrical proteases. RSC Medicinal Chemistry. 14(6). 1186–1191. 1 indexed citations
6.
Zuazua‐Villar, Pedro, Andrew J. Counsell, Stephen J. Walsh, et al.. (2023). A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chemical Science. 14(47). 13915–13923. 3 indexed citations
7.
Iegre, Jessica, Anders Gunnarsson, Lisa Wissler, et al.. (2023). A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction. Chemical Science. 14(39). 10800–10805. 8 indexed citations
8.
Ashman, Nicola, et al.. (2023). Red-light modulated ortho -chloro azobenzene photoswitch for peptide stapling via aromatic substitution. RSC Chemical Biology. 5(1). 49–54. 11 indexed citations
9.
Iegre, Jessica, Claudio D’Amore, P. Brear, et al.. (2022). Development of small cyclic peptides targeting the CK2α/β interface. Chemical Communications. 58(30). 4791–4794. 3 indexed citations
10.
Iegre, Jessica, et al.. (2022). Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance. ChemMedChem. 18(2). e202200548–e202200548. 6 indexed citations
11.
Hanby, Abigail R., Stephen J. Walsh, Andrew J. Counsell, et al.. (2022). Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy. Chemical Communications. 58(67). 9401–9404. 12 indexed citations
12.
Walsh, Stephen J., Jonathan D. Bargh, Abigail R. Hanby, et al.. (2020). Site-selective modification strategies in antibody–drug conjugates. Chemical Society Reviews. 50(2). 1305–1353. 315 indexed citations breakdown →
13.
Walsh, Stephen J., et al.. (2020). Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics. Angewandte Chemie International Edition. 59(51). 23045–23050. 15 indexed citations
14.
Robertson, Naomi, Stephen J. Walsh, Elaine Fowler, et al.. (2019). Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling. Chemical Communications. 55(64). 9499–9502. 20 indexed citations
15.
Iegre, Jessica, Josephine Gaynord, Naomi Robertson, et al.. (2018). Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future. Advanced Therapeutics. 1(7). 40 indexed citations
16.
Osberger, Thomas J., et al.. (2018). Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections. Frontiers in Chemistry. 6. 460–460. 56 indexed citations
17.
Cole, Daniel J., M. Janecek, Maxim Rossmann, et al.. (2017). Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction. Chemical Communications. 53(67). 9372–9375. 12 indexed citations
18.
Isidro‐Llobet, Albert, Agostino Cilibrizzi, James T. Hodgkinson, et al.. (2011). Diversity-oriented synthesis of macrocyclic peptidomimetics. Proceedings of the National Academy of Sciences. 108(17). 6793–6798. 96 indexed citations
19.
Ramsay, Joshua P., Neil R. Williamson, David R. Spring, & George P. C. Salmond. (2011). A quorum-sensing molecule acts as a morphogen controlling gas vesicle organelle biogenesis and adaptive flotation in an enterobacterium. Proceedings of the National Academy of Sciences. 108(36). 14932–14937. 52 indexed citations
20.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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