Michael W. Heartlein

4.0k total citations · 1 hit paper
37 papers, 3.3k citations indexed

About

Michael W. Heartlein is a scholar working on Molecular Biology, Genetics and Cancer Research. According to data from OpenAlex, Michael W. Heartlein has authored 37 papers receiving a total of 3.3k indexed citations (citations by other indexed papers that have themselves been cited), including 28 papers in Molecular Biology, 7 papers in Genetics and 7 papers in Cancer Research. Recurrent topics in Michael W. Heartlein's work include RNA Interference and Gene Delivery (15 papers), Advanced biosensing and bioanalysis techniques (11 papers) and DNA and Nucleic Acid Chemistry (6 papers). Michael W. Heartlein is often cited by papers focused on RNA Interference and Gene Delivery (15 papers), Advanced biosensing and bioanalysis techniques (11 papers) and DNA and Nucleic Acid Chemistry (6 papers). Michael W. Heartlein collaborates with scholars based in United States, United Kingdom and Sweden. Michael W. Heartlein's co-authors include Frank DeRosa, Daniel G. Anderson, Kevin Kauffman, Owen S. Fenton, James C. Kaczmarek, Faryal F. Mir, J. Robert Dorkin, Asha K. Patel, Jung Hoon Yang and Matthew J. Webber and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Michael W. Heartlein

37 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

2015 611 citations Kevin Kauffman, J. Robert Dorkin et al. Nano Letters profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Michael W. Heartlein United States	25	2.8k	724	462	359	263	37	3.3k
Virginie Escriou France	30	1.9k 0.7×	685 0.9×	474 1.0×	118 0.3×	230 0.9×	81	2.7k
Fabrice Le Bœuf Canada	25	1.6k 0.6×	1.2k 1.6×	502 1.1×	202 0.6×	295 1.1×	38	3.0k
Ronald K. Scheule United States	38	2.4k 0.9×	1.2k 1.7×	518 1.1×	347 1.0×	100 0.4×	100	4.0k
Xinyao Du United States	6	2.3k 0.8×	284 0.4×	411 0.9×	275 0.8×	244 0.9×	6	2.7k
Regina Heidenreich Germany	26	1.7k 0.6×	315 0.4×	956 2.1×	316 0.9×	516 2.0×	44	2.7k
Sean A. Dilliard United States	8	2.2k 0.8×	377 0.5×	422 0.9×	241 0.7×	151 0.6×	9	2.8k
Daniela Castanotto United States	23	2.7k 1.0×	435 0.6×	234 0.5×	116 0.3×	626 2.4×	44	3.1k
Hans Herweijer United States	24	1.9k 0.7×	823 1.1×	211 0.5×	254 0.7×	191 0.7×	39	2.7k
Scott Barros United States	14	1.8k 0.7×	244 0.3×	291 0.6×	181 0.5×	223 0.8×	20	2.4k
Georges Vassaux France	30	1.3k 0.5×	1.1k 1.5×	246 0.5×	168 0.5×	210 0.8×	94	2.7k

Countries citing papers authored by Michael W. Heartlein

Since Specialization

Citations

This map shows the geographic impact of Michael W. Heartlein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael W. Heartlein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael W. Heartlein more than expected).

Fields of papers citing papers by Michael W. Heartlein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael W. Heartlein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael W. Heartlein. The network helps show where Michael W. Heartlein may publish in the future.

Co-authorship network of co-authors of Michael W. Heartlein

This figure shows the co-authorship network connecting the top 25 collaborators of Michael W. Heartlein. A scholar is included among the top collaborators of Michael W. Heartlein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael W. Heartlein. Michael W. Heartlein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kaczmarek, James C., Asha K. Patel, Luke H. Rhym, et al.. (2021). Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles. Biomaterials. 275. 120966–120966. 94 indexed citations

Rybakova, Yulia, Piotr S. Kowalski, Yuxuan Huang, et al.. (2019). mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo. Molecular Therapy. 27(8). 1415–1423. 161 indexed citations

DeRosa, Frank, Yinghua Shen, Yan Huang, et al.. (2019). Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy. Molecular Therapy. 27(4). 878–889. 84 indexed citations

DeRosa, Frank, Braydon C. Guild, Shrirang Karve, et al.. (2016). Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system. Nature. 1 indexed citations

Fenton, Owen S., Kevin Kauffman, Rebecca L. McClellan, et al.. (2016). Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery. Advanced Materials. 28(15). 2939–2943. 199 indexed citations

DeRosa, Frank, Braydon C. Guild, Shrirang Karve, et al.. (2016). Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system. Gene Therapy. 23(10). 699–707. 138 indexed citations

Dong, Yizhou, J. Robert Dorkin, Weiheng Wang, et al.. (2016). Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo. Nano Letters. 16(2). 842–848. 97 indexed citations

Kauffman, Kevin, J. Robert Dorkin, Jung Hoon Yang, et al.. (2015). Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs. Nano Letters. 15(11). 7300–7306. 611 indexed citations breakdown →

Calias, Pericles, Mikhail Papisov, Jing Pan, et al.. (2012). CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder. PLoS ONE. 7(1). e30341–e30341. 104 indexed citations

10.

Pfeifer, Richard W., Robert B. Boyd, Mark T. Butt, et al.. (2011). Safety evaluation of chronic intrathecal administration of heparan N-sulfatase in juvenile cynomolgus monkeys. Drug Delivery and Translational Research. 2(3). 187–200. 10 indexed citations

11.

Peterson, Sarah, Michael A. Jones, Michael W. Heartlein, et al.. (2010). Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts. BMC Cancer. 10(1). 427–427. 29 indexed citations

12.

Heartlein, Michael W., et al.. (1994). Long-term production and delivery of human growth hormone in vivo.. Proceedings of the National Academy of Sciences. 91(23). 10967–10971. 40 indexed citations

13.

Heartlein, Michael W. & S.A. Latt. (1989). Amplified inverted duplications within and adjacent to heterologous selectable DNAS. Nucleic Acids Research. 17(4). 1697–1716. 13 indexed citations

14.

Müller, Ulrich, Marc Lalande, Timothy A. Donlon, & Michael W. Heartlein. (1989). Breakage of the human Y-chromosome short arm between two blocks of tandemly repeated DNA sequences. Genomics. 5(1). 153–156. 11 indexed citations

15.

Tsuji, Hideo, Michael W. Heartlein, & S.A. Latt. (1988). Disparate effects of 5-bromodeoxyuridine on sister-chromatid exchanges and chromosomal aberrations in Bloom syndrome fibroblasts. Mutation research. Fundamental and molecular mechanisms of mutagenesis. 198(1). 241–253. 11 indexed citations

16.

Heartlein, Michael W. & R. Julian Preston. (1985). The effect of 3-aminobenzamide on the frequency of X-ray- or neutron-induced chromosome aberrations in cycling or non-cycling human lymphocytes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 148(1-2). 91–97. 24 indexed citations

17.

Heartlein, Michael W. & R. Julian Preston. (1985). An explanation of interspecific differences in sensitivity to X-ray-induced chromosome aberrations and a consideration of dose-response curves. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 150(1-2). 299–305. 6 indexed citations

18.

O’Neill, John P., Michael W. Heartlein, & R. Julian Preston. (1983). Sister-chromatid exchanges and gene mutations are induced by the replication of 5-bromo- and 5-chloro-deoxyuridine substituted DNA. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 109(2). 259–270. 52 indexed citations

19.

Heartlein, Michael W., John P. O’Neill, & R. Julian Preston. (1983). SCE induction is proportional to substitution in DNA for thymidine by CldU and BrdU. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 107(1). 103–109. 43 indexed citations

20.

Heartlein, Michael W., John P. O’Neill, Buddhadeb Pal, & R. Julian Preston. (1982). The induction of specific-locus mutations and sister-chromatid exchanges by 5-bromo- and 5-chloro-deoxyuridine. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 92(1-2). 411–416. 42 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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