Michael W. Heartlein

4.0k citations

37 papers · 3.3k indexed · 1 hit paper · h-index 25

Co-authors: Frank DeRosa Daniel G. Anderson Kevin Kauffman Owen S. Fenton James C. Kaczmarek Faryal F. Mir J. Robert Dorkin Asha K. Patel
Topics: RNA Interference and Gene Delivery (15 papers)Advanced biosensing and bioanalysis techniques (11 papers)DNA and Nucleic Acid Chemistry (6 papers)
Cited by: Molecular Biology Genetics Immunology
Journals: Nature Proceedings of the National Academy of Sciences Nucleic Acids Research
Partner nations: United States United Kingdom Sweden

In The Last Decade

Michael W. Heartlein

37 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

2015 611 citations Kevin Kauffman, J. Robert Dorkin et al. Nano Letters profile →

Peers

Countries citing papers authored by Michael W. Heartlein

Since Specialization

Citations

This map shows the geographic impact of Michael W. Heartlein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael W. Heartlein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael W. Heartlein more than expected).

Fields of papers citing papers by Michael W. Heartlein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael W. Heartlein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael W. Heartlein. The network helps show where Michael W. Heartlein may publish in the future.

Co-authorship network of co-authors of Michael W. Heartlein

This figure shows the co-authorship network connecting the top 25 collaborators of Michael W. Heartlein. A scholar is included among the top collaborators of Michael W. Heartlein based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael W. Heartlein. Michael W. Heartlein is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles 2021 ·Biomaterials ·James C. Kaczmarek,Asha K. Patel,Luke H. Rhym,Umberto Capasso Palmiero,Balkrishen Bhat,Michael W. Heartlein,Frank DeRosa,Daniel G. Anderson	94
2	mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo 2019 ·Molecular Therapy ·Yulia Rybakova,Piotr S. Kowalski,Yuxuan Huang,John Gonzalez,Michael W. Heartlein,Frank DeRosa,Derfogail Delcassian,Daniel G. Anderson	161
3	Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy 2019 ·Molecular Therapy ·Frank DeRosa,(unknown),Yinghua Shen,Yan Huang,Jing Pan,Hongsheng Xie,Barak Yahalom,Michael W. Heartlein	84
4	Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system 2016 ·Nature ·Frank DeRosa,Braydon C. Guild,Shrirang Karve,(unknown),(unknown),Barak Yahalom,Michael W. Heartlein,Kerry R. Love,J. Robert Dorkin,Kevin Kauffman,Daniel G. Anderson	1
5	Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery 2016 ·Advanced Materials ·Owen S. Fenton,Kevin Kauffman,Rebecca L. McClellan,Eric A. Appel,J. Robert Dorkin,Mark W. Tibbitt,Michael W. Heartlein,Frank DeRosa,Róbert Langer,Daniel G. Anderson	199
6	Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system 2016 ·Gene Therapy ·Frank DeRosa,Braydon C. Guild,Shrirang Karve,(unknown),Kevin T. Love,J. Robert Dorkin,Kevin Kauffman,(unknown),Barak Yahalom,Daniel G. Anderson,Michael W. Heartlein	138
7	Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo 2016 ·Nano Letters ·Yizhou Dong,J. Robert Dorkin,Weiheng Wang,Philip Chang,Matthew J. Webber,Benjamin C. Tang,(unknown),Inbal Abutbul‐Ionita,Dganit Danino,Frank DeRosa,Michael W. Heartlein,Róbert Langer,Daniel G. Anderson	97
8	Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designsbreakdown → 2015 ·Nano Letters ·Kevin Kauffman,J. Robert Dorkin,Jung Hoon Yang,Michael W. Heartlein,Frank DeRosa,Faryal F. Mir,Owen S. Fenton,Daniel G. Anderson	611
9	CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder 2012 ·PLoS ONE ·Pericles Calias,Mikhail Papisov,Jing Pan,(unknown),Vasily Belov,Yan Huang,(unknown),(unknown),Nan Liu,Alan J. Fischman,Jan Powell,Michael W. Heartlein	104
10	Safety evaluation of chronic intrathecal administration of heparan N-sulfatase in juvenile cynomolgus monkeys 2011 ·Drug Delivery and Translational Research ·Richard W. Pfeifer,(unknown),Robert B. Boyd,Mark T. Butt,Juan Ruiz,Michael W. Heartlein,Pericles Calias	10
11	Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts 2010 ·BMC Cancer ·Sarah Peterson,(unknown),(unknown),(unknown),(unknown),Michael A. Jones,(unknown),(unknown),Michael W. Heartlein,Michael F. Concino,Lucy Liaw,Paolo G.V. Martini	29
12	Long-term production and delivery of human growth hormone in vivo. 1994 ·Proceedings of the National Academy of Sciences ·Michael W. Heartlein,(unknown),Jian‐Li Jiang,(unknown),(unknown),Douglas A. Treco,Richard F. Selden	40
13	Amplified inverted duplications within and adjacent to heterologous selectable DNAS 1989 ·Nucleic Acids Research ·Michael W. Heartlein,S.A. Latt	13
14	Breakage of the human Y-chromosome short arm between two blocks of tandemly repeated DNA sequences 1989 ·Genomics ·Ulrich Müller,Marc Lalande,Timothy A. Donlon,Michael W. Heartlein	11
15	Disparate effects of 5-bromodeoxyuridine on sister-chromatid exchanges and chromosomal aberrations in Bloom syndrome fibroblasts 1988 ·Mutation research. Fundamental and molecular mechanisms of mutagenesis ·Hideo Tsuji,Michael W. Heartlein,S.A. Latt	11
16	The effect of 3-aminobenzamide on the frequency of X-ray- or neutron-induced chromosome aberrations in cycling or non-cycling human lymphocytes 1985 ·Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ·Michael W. Heartlein,R. Julian Preston	24
17	An explanation of interspecific differences in sensitivity to X-ray-induced chromosome aberrations and a consideration of dose-response curves 1985 ·Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ·Michael W. Heartlein,R. Julian Preston	6
18	Sister-chromatid exchanges and gene mutations are induced by the replication of 5-bromo- and 5-chloro-deoxyuridine substituted DNA 1983 ·Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ·John P. O’Neill,Michael W. Heartlein,R. Julian Preston	52
19	SCE induction is proportional to substitution in DNA for thymidine by CldU and BrdU 1983 ·Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ·Michael W. Heartlein,John P. O’Neill,R. Julian Preston	43
20	The induction of specific-locus mutations and sister-chromatid exchanges by 5-bromo- and 5-chloro-deoxyuridine 1982 ·Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ·Michael W. Heartlein,John P. O’Neill,Buddhadeb Pal,R. Julian Preston	42

About Michael W. Heartlein

Michael W. Heartlein is a scholar working on Cancer Research, Molecular Biology and Genetics, having authored 37 papers that have together received 3.3k indexed citations. Recurring topics across this work include RNA Interference and Gene Delivery (15 papers), Advanced biosensing and bioanalysis techniques (11 papers) and DNA and Nucleic Acid Chemistry (6 papers). The work is most often cited by research in Molecular Biology (2.8k citations), Genetics (724 citations) and Immunology (462 citations). Michael W. Heartlein has collaborated with scholars based in United States, United Kingdom and Sweden. Frequent co-authors include Frank DeRosa, Daniel G. Anderson, Kevin Kauffman, Owen S. Fenton, James C. Kaczmarek, Faryal F. Mir, J. Robert Dorkin, Asha K. Patel, Jung Hoon Yang and Matthew J. Webber. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact