Melek C. Arkan

6.6k total citations · 3 hit papers
18 papers, 4.0k citations indexed

About

Melek C. Arkan is a scholar working on Molecular Biology, Oncology and Immunology. According to data from OpenAlex, Melek C. Arkan has authored 18 papers receiving a total of 4.0k indexed citations (citations by other indexed papers that have themselves been cited), including 7 papers in Molecular Biology, 7 papers in Oncology and 7 papers in Immunology. Recurrent topics in Melek C. Arkan's work include NF-κB Signaling Pathways (7 papers), Immune Response and Inflammation (4 papers) and Cytokine Signaling Pathways and Interactions (4 papers). Melek C. Arkan is often cited by papers focused on NF-κB Signaling Pathways (7 papers), Immune Response and Inflammation (4 papers) and Cytokine Signaling Pathways and Interactions (4 papers). Melek C. Arkan collaborates with scholars based in Germany, United States and Türkiye. Melek C. Arkan's co-authors include Florian R. Greten, Michael Karin, Giuseppe Poli, Anthony Wynshaw‐Boris, Jerrold M. Olefsky, Zhi-Wei Li, Andrea L. Hevener, Shin Maeda, Jeffrey M. Long and Roland M. Schmid and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Melek C. Arkan

18 papers receiving 3.9k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IKK-β links inflammation to obesity-induced insulin resistance

2005 1.5k citations Melek C. Arkan, Andrea L. Hevener et al. Nature Medicine profile →
gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

2009 780 citations Julia Bollrath, Toby J. Phesse et al. Cancer Cell profile →
NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

2007 503 citations Florian R. Greten, Melek C. Arkan et al. Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Melek C. Arkan Germany	16	1.7k	1.2k	1.1k	964	823	18	4.0k
Paloma Martı́n-Sanz Spain	37	2.1k 1.2×	1.4k 1.1×	1.3k 1.2×	398 0.4×	606 0.7×	119	5.0k
Dipak P. Ramji United Kingdom	36	2.4k 1.4×	1.9k 1.6×	797 0.7×	756 0.8×	610 0.7×	101	5.8k
Hidemi Yoshida Japan	39	1.4k 0.8×	1.6k 1.4×	559 0.5×	725 0.8×	505 0.6×	183	4.6k
Guobin He United States	15	1.7k 1.0×	811 0.7×	1.1k 1.0×	1.1k 1.1×	264 0.3×	25	4.0k
Cynthia Ju United States	36	1.4k 0.8×	1.5k 1.2×	1.7k 1.5×	631 0.7×	308 0.4×	80	5.8k
Xiaoni Kong China	32	1.7k 1.0×	952 0.8×	1.3k 1.1×	645 0.7×	298 0.4×	114	4.4k
Shuichi Kaneko Japan	42	3.2k 1.9×	760 0.6×	2.3k 2.1×	885 0.9×	1.0k 1.2×	191	7.1k
Arshad Rahman United States	43	2.3k 1.4×	1.6k 1.4×	514 0.5×	609 0.6×	618 0.8×	77	5.0k
Tian Lan China	38	2.3k 1.4×	630 0.5×	920 0.8×	587 0.6×	333 0.4×	134	4.5k
Christian Liedtke Germany	40	2.0k 1.2×	632 0.5×	1.5k 1.3×	553 0.6×	268 0.3×	108	4.6k

Countries citing papers authored by Melek C. Arkan

Since Specialization

Citations

This map shows the geographic impact of Melek C. Arkan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Melek C. Arkan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Melek C. Arkan more than expected).

Fields of papers citing papers by Melek C. Arkan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Melek C. Arkan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Melek C. Arkan. The network helps show where Melek C. Arkan may publish in the future.

Co-authorship network of co-authors of Melek C. Arkan

This figure shows the co-authorship network connecting the top 25 collaborators of Melek C. Arkan. A scholar is included among the top collaborators of Melek C. Arkan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Melek C. Arkan. Melek C. Arkan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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18 of 18 papers shown

Denk, Dominic, Mallika Ramakrishnan, Claire Conche, et al.. (2025). IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis. Immunity. 58(3). 701–715.e8. 7 indexed citations

Greten, Florian R. & Melek C. Arkan. (2024). Gut microbial carcinogen metabolism: another avenue to cancer. Signal Transduction and Targeted Therapy. 9(1). 297–297. 3 indexed citations

Schmitt, Mark R., Fatih Ceteci, J. R. P. Gupta, et al.. (2022). Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Nature. 612(7939). 347–353. 53 indexed citations

Arkan, Melek C.. (2017). The intricate connection between diet, microbiota, and cancer: A jigsaw puzzle. Seminars in Immunology. 32. 35–42. 16 indexed citations

Göktuna, Serkan İsmail, Özge Canli, Julia Bollrath, et al.. (2014). IKKα Promotes Intestinal Tumorigenesis by Limiting Recruitment of M1-like Polarized Myeloid Cells. Cell Reports. 7(6). 1914–1925. 18 indexed citations

Atay, Çiğdem, Sarah Schwitalla, Begüm Aydın, et al.. (2014). High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity. Nature. 514(7523). 508–512. 343 indexed citations

Kriegl, Lydia, Monther Bajbouj, Sylvie Robine, et al.. (2010). Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis. Cancer Cell. 18(2). 135–146. 144 indexed citations

Arkan, Melek C. & Florian R. Greten. (2010). IKK- and NF-κB-Mediated Functions in Carcinogenesis. Current topics in microbiology and immunology. 349. 159–169. 42 indexed citations

Fritsch, Ralph, et al.. (2010). IκBβ is an essential co-activator for LPS-induced IL-1β transcription in vivo. The Journal of Experimental Medicine. 207(12). 2621–2630. 85 indexed citations

10.

Walch, Axel, Jan Rozman, Martin Hrabě de Angelis, et al.. (2009). Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion. Proceedings of the National Academy of Sciences. 106(9). 3354–3359. 143 indexed citations

11.

Bollrath, Julia, Toby J. Phesse, Tracy L. Putoczki, et al.. (2009). gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis. Cancer Cell. 15(2). 91–102. 780 indexed citations breakdown →

12.

Eckmann, Lars, Tim Nebelsiek, Alexander A. Fingerle, et al.. (2008). Opposing functions of IKKβ during acute and chronic intestinal inflammation. Proceedings of the National Academy of Sciences. 105(39). 15058–15063. 139 indexed citations

13.

Greten, Florian R., Melek C. Arkan, Julia Bollrath, et al.. (2007). NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ. Cell. 130(5). 918–931. 503 indexed citations breakdown →

14.

Lickteig, Andrew J., Angela L. Slitt, Melek C. Arkan, Michael Karin, & Nathan J. Cherrington. (2006). Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor-α, Interleukin-1β, Interleukin-6, and Nuclear Factor-κB in Two Models of Cholestasis. Drug Metabolism and Disposition. 35(3). 402–409. 37 indexed citations

15.

Arkan, Melek C., Andrea L. Hevener, Florian R. Greten, et al.. (2005). IKK-β links inflammation to obesity-induced insulin resistance. Nature Medicine. 11(2). 191–198. 1456 indexed citations breakdown →

16.

Arkan, Melek C., Gabriella Leonarduzzi, Fiorella Biasi, Hüveyda Başağa, & Giuseppe Poli. (2001). Physiological amounts of ascorbate potentiate phorbol ester-induced nuclear-binding of AP-1 transcription factor in cells of macrophagic lineage. Free Radical Biology and Medicine. 31(3). 374–382. 21 indexed citations

17.

Leonarduzzi, Gabriella, Alex Sevanian, Barbara Sottero, et al.. (2001). Up‐regulation of the fibrogenic cytokine TGF‐β1 by oxysterols: a mechanistic link between cholesterol and atherosclerosis. The FASEB Journal. 15(9). 1619–1621. 59 indexed citations

18.

Leonarduzzi, Gabriella, Melek C. Arkan, Hüveyda Başağa, et al.. (2000). Lipid oxidation products in cell signaling. Free Radical Biology and Medicine. 28(9). 1370–1378. 174 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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