Mark K. Saville

3.9k total citations · 1 hit paper
33 papers, 3.2k citations indexed

About

Mark K. Saville is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, Mark K. Saville has authored 33 papers receiving a total of 3.2k indexed citations (citations by other indexed papers that have themselves been cited), including 30 papers in Molecular Biology, 22 papers in Oncology and 4 papers in Cell Biology. Recurrent topics in Mark K. Saville's work include Cancer-related Molecular Pathways (20 papers), Ubiquitin and proteasome pathways (16 papers) and Epigenetics and DNA Methylation (6 papers). Mark K. Saville is often cited by papers focused on Cancer-related Molecular Pathways (20 papers), Ubiquitin and proteasome pathways (16 papers) and Epigenetics and DNA Methylation (6 papers). Mark K. Saville collaborates with scholars based in United Kingdom, United States and Belgium. Mark K. Saville's co-authors include David P. Lane, Dimitris P. Xirodimas, Jean‐Christophe Bourdon, Alison Sparks, Nerea Allende-Vega, Ronald T. Hay, Kenneth Fernandes, Alexandra Diot, Geng Liu and Lauren Stevenson and has published in prestigious journals such as Cell, Journal of Biological Chemistry and Genes & Development.

In The Last Decade

Mark K. Saville

33 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

p53 isoforms can regulate p53 transcriptional activity

2005 631 citations Jean‐Christophe Bourdon, Kenneth Fernandes et al. Genes & Development profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Mark K. Saville United Kingdom	23	2.7k	1.9k	490	362	297	33	3.2k
Carl G. Maki United States	27	2.3k 0.9×	1.8k 1.0×	584 1.2×	328 0.9×	191 0.6×	62	2.9k
Robert L. Ludwig United States	18	3.3k 1.2×	2.4k 1.3×	693 1.4×	562 1.6×	249 0.8×	20	4.1k
David Dornan United States	20	2.5k 0.9×	1.4k 0.8×	816 1.7×	281 0.8×	203 0.7×	38	3.1k
Stewart Bates United States	16	2.2k 0.8×	2.2k 1.2×	438 0.9×	359 1.0×	166 0.6×	18	3.0k
Anne M. Theodoras United States	8	2.5k 0.9×	2.1k 1.1×	399 0.8×	622 1.7×	201 0.7×	8	3.2k
Mark A. Subler United States	32	2.0k 0.7×	1.5k 0.8×	412 0.8×	226 0.6×	183 0.6×	65	3.0k
Richard Tomasini France	28	2.1k 0.8×	1.8k 1.0×	1.1k 2.2×	294 0.8×	233 0.8×	49	3.3k
Mu‐Shui Dai United States	30	3.1k 1.2×	1.5k 0.8×	656 1.3×	240 0.7×	170 0.6×	62	3.6k
Rebecca Haffner Israel	12	1.8k 0.7×	1.4k 0.8×	336 0.7×	204 0.6×	128 0.4×	15	2.3k
Giulia Fontemaggi Italy	33	2.8k 1.0×	1.6k 0.9×	1.2k 2.5×	438 1.2×	161 0.5×	58	3.7k

Countries citing papers authored by Mark K. Saville

Since Specialization

Citations

This map shows the geographic impact of Mark K. Saville's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mark K. Saville with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mark K. Saville more than expected).

Fields of papers citing papers by Mark K. Saville

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mark K. Saville. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mark K. Saville. The network helps show where Mark K. Saville may publish in the future.

Co-authorship network of co-authors of Mark K. Saville

This figure shows the co-authorship network connecting the top 25 collaborators of Mark K. Saville. A scholar is included among the top collaborators of Mark K. Saville based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mark K. Saville. Mark K. Saville is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kidger, Andrew M., Mark K. Saville, Linda Rushworth, et al.. (2022). Suppression of mutant Kirsten-RAS (KRASG12D)-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene. 41(20). 2811–2823. 9 indexed citations

McHugh, Angela, Kenneth Fernandes, Adel F.M. Ibrahim, et al.. (2019). The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma. Journal of Investigative Dermatology. 140(6). 1154–1165.e5. 12 indexed citations

Sparks, Alison, et al.. (2013). The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene. 33(38). 4685–4696. 40 indexed citations

Allende-Vega, Nerea, et al.. (2012). p53 is activated in response to disruption of the pre-mRNA splicing machinery. Oncogene. 32(1). 1–14. 80 indexed citations

Allende-Vega, Nerea, Alison Sparks, David P. Lane, & Mark K. Saville. (2009). MdmX is a substrate for the deubiquitinating enzyme USP2a. Oncogene. 29(3). 432–441. 87 indexed citations

Marcar, Lynnette, Diane Milne, Mark K. Saville, et al.. (2008). Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma. Journal of Biological Chemistry. 283(26). 18012–18023. 71 indexed citations

Sparks, Alison, et al.. (2008). Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53. Journal of Biological Chemistry. 284(8). 5030–5041. 162 indexed citations

Stevenson, Lauren, Alison Sparks, Nerea Allende-Vega, et al.. (2007). The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. The EMBO Journal. 26(4). 976–986. 238 indexed citations

Allende-Vega, Nerea, Mark K. Saville, & David W. Meek. (2007). Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53. Oncogene. 26(29). 4234–4242. 21 indexed citations

10.

Duncan, Lidia M., Siân C. Piper, Roger B. Dodd, et al.. (2006). Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules. The EMBO Journal. 25(8). 1635–1645. 227 indexed citations

11.

Bourdon, Jean‐Christophe, Kenneth Fernandes, Geng Liu, et al.. (2005). p53 isoforms can regulate p53 transcriptional activity. Genes & Development. 19(18). 2122–2137. 631 indexed citations breakdown →

12.

Xirodimas, Dimitris P., Mark K. Saville, Jean‐Christophe Bourdon, Ronald T. Hay, & David P. Lane. (2004). Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity. Cell. 118(1). 83–97. 442 indexed citations

13.

Woods, Yvonne L., Dimitris P. Xirodimas, Alan R. Prescott, et al.. (2004). p14 Arf Promotes Small Ubiquitin-like Modifier Conjugation of Werners Helicase. Journal of Biological Chemistry. 279(48). 50157–50166. 48 indexed citations

14.

Saville, Mark K., Alison Sparks, Dimitris P. Xirodimas, et al.. (2004). Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo. Journal of Biological Chemistry. 279(40). 42169–42181. 124 indexed citations

15.

Joaquin, Manel, Maria João Bessa, Mark K. Saville, & Roger J. Watson. (2002). B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107. Oncogene. 21(52). 7923–7932. 19 indexed citations

16.

Bessa, Maria João, Manel Joaquin, Fiona Tavner, Mark K. Saville, & R J Watson. (2001). Regulation of the Cell Cycle by B-Myb. Blood Cells Molecules and Diseases. 27(2). 416–421. 22 indexed citations

17.

Bessa, Maria João, Mark K. Saville, & Roger J. Watson. (2001). Inhibition of cyclin A/Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator. Oncogene. 20(26). 3376–3386. 36 indexed citations

18.

Midgley, Carol, et al.. (2001). Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein. Journal of Molecular Biology. 313(4). 711–731. 34 indexed citations

19.

Xirodimas, Dimitris P., Mark K. Saville, Charlotte E. Edling, David P. Lane, & Sonia Laı́n. (2001). Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene. 20(36). 4972–4983. 145 indexed citations

20.

Midgley, Carol, Joana Desterro, Mark K. Saville, et al.. (2000). An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene. 19(19). 2312–2323. 212 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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