Mark E. B. Smith

8.6k citations

98 papers · 6.8k · 1 hit paper · h-index 39

Impact in

Biochemistry top 1%
Organic Chemistry top 1%
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis

Papers in

Biochemistry 13
- Biochemical Acid Research Studies 11
Organic Chemistry 27
- Click Chemistry and Applications 11

Co-authors: Stephen Caddick (24 shared papers)James R. Baker (19 shared papers)Vijay Chudasama (17 shared papers)John M. Ward (9 shared papers)Felix F. Schumacher (7 shared papers)Antoine Maruani (9 shared papers)Chris P. Ryan (6 shared papers)Ursula Kaulmann (4 shared papers)
Journals: Organic & Biomolecular Chemistry (9 papers)Chemical Communications (7 papers)Tetrahedron Letters (5 papers)Journal of the American Chemical Society (4 papers)Tetrahedron Asymmetry (3 papers)
Partner nations: United Kingdom United States India

In The Last Decade

Mark E. B. Smith

94 papers receiving 6.5k citations

Mark E. B. Smith's Hit Papers

align trajectories log scale

Accurate whole human genome sequencing using reversible terminator chemistry 2008 · 2.7k citations

What are hit papers?

Paper score: A paper's citations measured against the top-1% bar of its own field and year: the square root of citations ÷ bar, so 1 means right at the bar and 2 means four times its citations. The bar blends the citation counts that enter the top 1% of the paper's subfields in its year (weighted 89.5%), of those subfields over all years (0.5%) and of its year across all fields (10%); a subfield and year with fewer than 400 papers takes its year's bar. Papers from 2026 are not scored yet: in an unfinished year, when a paper appeared matters more than how it is cited.

Hit paper: A paper cited at least 1.5× the top-1% bar of its field and year: a paper score of at least √1.5.

2008 Nature

Peers

Countries citing papers authored by Mark E. B. Smith

Since Specialization

Citations

This map shows the geographic impact of Mark E. B. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mark E. B. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mark E. B. Smith more than expected).

Fields of papers citing papers by Mark E. B. Smith

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mark E. B. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mark E. B. Smith. The network helps show where Mark E. B. Smith may publish in the future.

Co-authors

The 25 scholars most cited alongside Mark E. B. Smith, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Mark E. B. Smith Line = papers co-authored together Mark E. B. Smith links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 98 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Accurate whole human genome sequencing using reversible terminator chemistry Nature ·David Bentley, Shankar Balasubramanian, Harold Swerdlow, Geoff Smith, John Milton, Clive G. Brown, Kevin P. Hall, Dirk J. Evers Hit paper breakdown →	2008	2717
2	Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides Journal of the American Chemical Society ·Mark E. B. Smith, Felix F. Schumacher, Chris P. Ryan, Lauren M. Tedaldi, Danai Papaioannou, Gabriel Waksman, Stephen Caddick, James R. Baker	2010	336
3	Substrate spectrum of ω-transaminase from Chromobacterium violaceum DSM30191 and its potential for biocatalysis Enzyme and Microbial Technology ·Ursula Kaulmann, Kirsty Smithies, Mark E. B. Smith, John M. Ward +1 other	2007	278
4	A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy Nature Communications ·Antoine Maruani, Mark E. B. Smith, Enrique Miranda, Kerry Ann Chester, Vijay Chudasama, Stephen Caddick	2015	217
5	Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging Organic & Biomolecular Chemistry ·Felix F. Schumacher, João P. M. Nunes, Antoine Maruani, Vijay Chudasama, Mark E. B. Smith, Kerry Ann Chester, James R. Baker, Stephen Caddick	2014	144
6	In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation Bioconjugate Chemistry ·Felix F. Schumacher, Muriel Nobles, Chris P. Ryan, Mark E. B. Smith, Andrew J. Tinker, Stephen Caddick, James R. Baker	2011	123
7	One‐pot synthesis of amino‐alcohols using a de‐novo transketolase and β‐alanine: Pyruvate transaminase pathway in Escherichia coli Biotechnology and Bioengineering ·Christine Ursula Ingram, Martin Bommer, Mark E. B. Smith, Paul A. Dalby, John M. Ward, Gary J. Lye +1 other	2006	122
8	Iron versus Ruthenium: Dramatic Changes in Electronic Structure Result from Replacement of One Fe by Ru in [{Cp(dppe)Fe}-CC-CC-{Fe(dppe)Cp}]n+(n= 0, 1, 2) Organometallics ·Michael I. Bruce, Karine Costuas, Thomas J. Davin, Benjamin George Ellis, Jean‐François Halet, Claude Lapinte, Paul J. Low, Mark E. B. Smith	2005	110
9	Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC) Chemical Communications ·João P. M. Nunes, Maurício Morais, Vessela Vassileva, Eifion Robinson, Vineeth S. Rajkumar, Mark E. B. Smith, R. Barbara Pedley, Stephen Caddick	2015	107
10	Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues Molecules ·Mieke Guinan, Caecilie M. M. Benckendorff, Mark E. B. Smith, Gavin John Miller	2020	103
11	Bromopyridazinedione-mediated protein and peptide bioconjugation Chemical Communications ·Vijay Chudasama, Mark E. B. Smith, Felix F. Schumacher, Danai Papaioannou, Gabriel Waksman, James R. Baker, Stephen Caddick	2011	99
12	Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis Chemical Communications ·Chris P. Ryan, Mark E. B. Smith, Felix F. Schumacher, Dina Grohmann, Danai Papaioannou, Gabriel Waksman, Finn Werner, James R. Baker	2011	97
13	Parallel Sheet Secondary Structure in γ-Peptides Journal of the American Chemical Society ·Matthew G. Woll, Jonathan R. Lai, Ilia A. Guzei, Stephen J. Taylor, Mark E. B. Smith, Samuel H. Gellman	2001	93
14	Bromomaleimides: new reagents for the selective and reversible modification of cysteine Chemical Communications ·Lauren M. Tedaldi, Mark E. B. Smith, Ramiz I. Nathani, James R. Baker	2009	91
15	A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/ω-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol Organic Process Research & Development ·Mark E. B. Smith, Binghui Chen, Edward G. Hibbert, Ursula Kaulmann, Kirsty Smithies, James L. Galman, Frank Baganz, Paul A. Dalby	2009	77
16	Directed evolution of transketolase activity on non-phosphorylated substrates Journal of Biotechnology ·Edward G. Hibbert, Tarik Senussi, Seán J. Costelloe, Wenling Lei, Mark E. B. Smith, John M. Ward, Paul A. Dalby +1 other	2007	70
17	Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody RSC Advances ·Eifion Robinson, João P. M. Nunes, Vessela Vassileva, Antoine Maruani, João C. F. Nogueira, Mark E. B. Smith, R. Barbara Pedley, Stephen Caddick	2017	69
18	Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment Bioconjugate Chemistry ·Francesca Bryden, Antoine Maruani, Huguette Savoie, Vijay Chudasama, Mark E. B. Smith, Stephen Caddick, Ross W. Boyle	2014	68
19	Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis Organic & Biomolecular Chemistry ·Maurício Morais, João P. M. Nunes, Kersti Karu, Nafsika Forte, Irene Benni, Mark E. B. Smith, Stephen Caddick, Vijay Chudasama	2017	66
20	Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation Chemical Communications ·Lourdes Castañeda, Antoine Maruani, Felix F. Schumacher, Enrique Miranda, Vijay Chudasama, Kerry Ann Chester, James R. Baker, Mark E. B. Smith	2013	64

About Mark E. B. Smith

Mark E. B. Smith is a scholar working on Biochemistry, Organic Chemistry, Oncology, Molecular Biology and Radiology, Nuclear Medicine and Imaging, having authored 98 papers that have together received 6.8k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (17 papers), Monoclonal and Polyclonal Antibodies Research (12 papers), Peptidase Inhibition and Analysis (12 papers), Biochemical Acid Research Studies (11 papers), Click Chemistry and Applications (11 papers), Microbial Metabolic Engineering and Bioproduction (10 papers), Enzyme Catalysis and Immobilization (10 papers) and HER2/EGFR in Cancer Research (9 papers). The work is most often cited by research in Biochemistry (482 citations), Organic Chemistry (1.8k citations), Molecular Biology (4.0k citations), Radiology, Nuclear Medicine and Imaging (1.0k citations) and Oncology (995 citations). Mark E. B. Smith has collaborated with scholars based in United Kingdom, United States and India. Frequent co-authors include Stephen Caddick, James R. Baker, Vijay Chudasama, John M. Ward, Felix F. Schumacher, Antoine Maruani, Chris P. Ryan, Ursula Kaulmann, Kerry Ann Chester and Kirsty Smithies. Their work appears in journals such as Organic & Biomolecular Chemistry, Chemical Communications, Tetrahedron Letters, Journal of the American Chemical Society and Tetrahedron Asymmetry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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Mark E. B. Smith

Mark E. B. Smith's Hit Papers

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