Lei Chen

8.8k total citations · 2 hit papers
165 papers, 5.7k citations indexed

About

Lei Chen is a scholar working on Molecular Biology, Surgery and Cancer Research. According to data from OpenAlex, Lei Chen has authored 165 papers receiving a total of 5.7k indexed citations (citations by other indexed papers that have themselves been cited), including 114 papers in Molecular Biology, 34 papers in Surgery and 30 papers in Cancer Research. Recurrent topics in Lei Chen's work include MicroRNA in disease regulation (20 papers), Gut microbiota and health (16 papers) and Cancer-related gene regulation (15 papers). Lei Chen is often cited by papers focused on MicroRNA in disease regulation (20 papers), Gut microbiota and health (16 papers) and Cancer-related gene regulation (15 papers). Lei Chen collaborates with scholars based in China, United States and Italy. Lei Chen's co-authors include Robert H. Crabtree, Brett T. Staahl, Andrew S. Yoo, Guohua Xie, Yanhui Ma, Qin Luo, Peiming Zheng, Lisong Shen, Xiangliang Yuan and Luika Timmerman and has published in prestigious journals such as Nature, Science and Journal of Biological Chemistry.

In The Last Decade

Lei Chen

159 papers receiving 5.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 512 citations Lei Chen et al. profile →
Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

2017 504 citations Lei Chen et al. profile →

Peers

Countries citing papers authored by Lei Chen

Since Specialization

Citations

This map shows the geographic impact of Lei Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lei Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lei Chen more than expected).

Fields of papers citing papers by Lei Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lei Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lei Chen. The network helps show where Lei Chen may publish in the future.

Co-authorship network of co-authors of Lei Chen

This figure shows the co-authorship network connecting the top 25 collaborators of Lei Chen. A scholar is included among the top collaborators of Lei Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lei Chen. Lei Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Harnessing HDAC-targeted oleanolic acid derivatives for combined anti-cancer and hepatoprotective effects 2025 ·International Journal of Biological Macromolecules ·(unknown), Miao Deng, (unknown), (unknown), Junhui Yu, (unknown), Xingyu Wang, Lei Chen, Ting Liu, Yan Li, Bin He	2
2	TIGAR Suppresses ER Stress-Induced Neuronal Injury through Targeting ATF4 Signaling in Cerebral Ischemia/Reperfusion 2025 ·Journal of Neuroscience ·Lei Chen, Jie Tang, Xueqing Liu, Qiqi Li, Jiaying Li, Yanyan Li, Wen‐Hua Zheng, Zheng‐Hong Qin, Rui Sheng	1
3	Structural characteristics of a polysaccharide from Armillariella tabescens and its protective effect on colitis mice via regulating gut microbiota and intestinal barrier function 2024 ·International Journal of Biological Macromolecules ·Yuanyuan Li, Jingwen Sun, Lei Chen, Yongming Lu, Qing-Xi Wu, (unknown), Yan Chen, Mei Zhang, Wenna Zhang	10
4	Targeting SMAD3 Improves Response to Oxaliplatin in Esophageal Adenocarcinoma Models by Impeding DNA Repair 2024 ·Clinical Cancer Research ·Farah Ballout, Heng Lu, Nadeem S. Bhat, Lei Chen, Dunfa Peng, Zheng Chen, (unknown), (unknown), Silvia Giordano, Simona Corso, Alexander Zaika, Oliver G. McDonald, Alan S. Livingstone, Wael El‐Rifai	2
5	Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma 2023 ·Gut ·Heng Lu, (unknown), Farah Ballout, Abbes Belkhiri, Dunfa Peng, Lei Chen, Zheng Chen, Mohammed Soutto, Timothy C. Wang, Jianwen Que, Silvia Giordano, M. Kay Washington, Steven Chen, Oliver G. McDonald, (unknown), (unknown)	17
6	Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus 2023 ·Cancers ·Lei Chen, Farah Ballout, Heng Lu, (unknown), Shoumin Zhu, Zheng Chen, Dunfa Peng	5
7	A series of tuberculous cold abscesses at uncommon anatomic sites 2023 ·Quantitative Imaging in Medicine and Surgery ·Lei Chen, (unknown), (unknown), Zhengrong Zhou	0
8	Host-Specific Differences in Gut Microbiota Between Cricetulus barabensis and Phodopus sungorus 2023 ·Current Microbiology ·(unknown), (unknown), (unknown), Shuo Wang, (unknown), Lei Chen, (unknown)	1
9	Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma 2022 ·Gut ·Lei Chen, Heng Lu, Dunfa Peng, (unknown), Farah Ballout, (unknown), Zheng Chen, Ajaz A. Bhat, Timothy C. Wang, Anthony J. Capobianco, Jianwen Que, Oliver G. McDonald, (unknown), Shutian Zhang, (unknown)	19
10	Combined Mean Corpuscular Hemoglobin, Fibrinogen, and Albumin (MF-A) Is a Novel Prognostic Marker in Patients with Resectable Esophageal Squamous Cell Carcinoma 2022 ·Annals of Surgical Oncology ·Linlin Liang, Fangfang Liu, Wenlei Yang, (unknown), Lei Chen, Yu He, Zhen Liu, Liqun Zhang, Fan Zhang, (unknown), (unknown), (unknown), Mengfei Liu, Yaqi Pan, Ying Liu, Zhe Hu, Huanyu Chen, Zhisong He, Ke Yang	5
11	Prognostic and clinicopathological significance of NRF2 expression in non-small cell lung cancer: A meta-analysis 2020 ·PLoS ONE ·Qingsong Wang, (unknown), Gang Wang, Lei Chen, Changping Li, Xiangli Jiang, Hai Gao, Bing Yang, Weiping Tian	15
12	Strategy for initial en bloc resection of a giant mediastinal solitary fibrous tumor: Judicious usage of cardiopulmonary bypass 2020 ·Thoracic Cancer ·Lei Chen, Yonghua Sang, Zhiwei Zhang, Wentao Yang, Yongbing Chen	4
13	Comparison of Ivor Lewis and Sweet esophagectomy for middle and lower esophageal squamous cell carcinoma: A systematic review and pooled analysis 2020 ·EClinicalMedicine ·(unknown), Donglai Chen, Wei Wang, Wenjia Wang, Lei Chen, Yonghua Sang, Yongbing Chen, Weihua Xu	0
14	The role of thioredoxin system in cancer: strategy for cancer therapy 2019 ·Cancer Chemotherapy and Pharmacology ·Jing Jia, Wen-Shuo Geng, (unknown), Lei Chen, Xiansi Zeng	116
15	Transgenic Arabidopsis Plants Expressing Grape Glutathione S-Transferase Gene (VvGSTF13) Show Enhanced Tolerance to Abiotic Stress 2018 ·Biochemistry (Moscow) ·Jing Xu, (unknown), Xiaojuan Xing, Lei Chen, Xiaoyan Fu, Ri‐He Peng, Yong‐Sheng Tian, Quan‐Hong Yao	29
16	Selective COX-2 inhibitor versus non-selective COX-2 inhibitor for the prevention of heterotopic ossification after total hip arthroplasty 2018 ·Medicine ·(unknown), Lei Chen, Jianhua Lin	28
17	The clinicopathological features and prognosis of signet ring cell carcinoma of the esophagus: A 10-year retrospective study in China 2017 ·PLoS ONE ·Lei Chen, Xi Liu, Linggen Gao, Rong Wang, (unknown), (unknown)	12
18	The miR-7 Identified from Collagen Biomaterial-Based Three-Dimensional Cultured Cells Regulates Neural Stem Cell Differentiation 2013 ·Stem Cells and Development ·Yi Cui, Zhifeng Xiao, Tong Chen, Jianshu Wei, Lei Chen, Lijun Liu, Bing Chen, Xiu‐Jie Wang, Xiaoran Li, Jianwu Dai	30
19	SOX2 in Gastric Carcinoma, but not Hath1, is Related to Patients’ Clinicopathological Features and Prognosis 2010 ·Journal of Gastrointestinal Surgery ·Xin Zhang, Hao Yu, Yongtao Yang, Rong Zhu, Jianying Bai, Zhihong Peng, Yonghong He, Lei Chen, Wensheng Chen, Dian-Chun Fang, Xiu‐Wu Bian, Rongquan Wang	55
20	Activation of Protein Kinase C Induces Nuclear Translocation of RFX1 and Down-regulates c-myc via an Intron 1 X Box in Undifferentiated Leukemia HL-60 Cells 2000 ·Journal of Biological Chemistry ·Lei Chen, Lucinda Smith, Martin R. Johnson, Kangsheng Wang, Robert B. Diasio, Jeffrey B. Smith	36

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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