Kathryn DeFea

5.7k total citations · 2 hit papers
52 papers, 4.8k citations indexed

About

Kathryn DeFea is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Hematology. According to data from OpenAlex, Kathryn DeFea has authored 52 papers receiving a total of 4.8k indexed citations (citations by other indexed papers that have themselves been cited), including 41 papers in Molecular Biology, 22 papers in Cellular and Molecular Neuroscience and 12 papers in Hematology. Recurrent topics in Kathryn DeFea's work include Receptor Mechanisms and Signaling (33 papers), Neuropeptides and Animal Physiology (19 papers) and Blood Coagulation and Thrombosis Mechanisms (12 papers). Kathryn DeFea is often cited by papers focused on Receptor Mechanisms and Signaling (33 papers), Neuropeptides and Animal Physiology (19 papers) and Blood Coagulation and Thrombosis Mechanisms (12 papers). Kathryn DeFea collaborates with scholars based in United States, Canada and Russia. Kathryn DeFea's co-authors include Nigel W. Bunnett, Olivier Déry, Morley D. Hollenberg, Jonathan Zalevsky, R. Dyche Mullins, Mark S. Thoma, Lan Ge, Rithwik Ramachandran, Marilyn Torchia and Stephen J. DeArmond and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Kathryn DeFea

51 papers receiving 4.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

2000 679 citations Kathryn DeFea, Jonathan Zalevsky et al. profile →
A Transmembrane Form of the Prion Protein in Neurodegenerative Disease

1998 572 citations Kathryn DeFea et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Kathryn DeFea United States	31	3.2k	1.3k	711	585	493	52	4.8k
Klaus Seuwen Switzerland	41	3.9k 1.2×	1.0k 0.8×	225 0.3×	679 1.2×	476 1.0×	97	5.9k
T. Voyno-Yasenetskaya United States	36	2.7k 0.8×	751 0.6×	485 0.7×	482 0.8×	447 0.9×	65	4.4k
Andrew J. H. Smith United Kingdom	33	3.4k 1.1×	701 0.5×	588 0.8×	668 1.1×	726 1.5×	57	5.7k
Jeanette N. McClintick United States	33	1.8k 0.6×	525 0.4×	791 1.1×	426 0.7×	1.3k 2.7×	65	4.3k
David R. Manning United States	45	4.1k 1.3×	1.2k 0.9×	613 0.9×	456 0.8×	318 0.6×	76	5.5k
Fernando A. González Spain	30	2.1k 0.7×	484 0.4×	236 0.3×	356 0.6×	336 0.7×	104	3.8k
Alastair D. Reith United Kingdom	35	4.6k 1.4×	936 0.7×	217 0.3×	832 1.4×	709 1.4×	52	7.1k
Matilde Caivano United Kingdom	12	5.0k 1.6×	837 0.6×	263 0.4×	791 1.4×	950 1.9×	16	7.3k
Shalom Avraham United States	45	3.4k 1.1×	564 0.4×	458 0.6×	346 0.6×	1.1k 2.3×	89	6.2k
Michael Gotthardt Germany	37	3.8k 1.2×	1.0k 0.8×	163 0.2×	1.0k 1.7×	418 0.8×	87	6.8k

Countries citing papers authored by Kathryn DeFea

Since Specialization

Citations

This map shows the geographic impact of Kathryn DeFea's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kathryn DeFea with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kathryn DeFea more than expected).

Fields of papers citing papers by Kathryn DeFea

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kathryn DeFea. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kathryn DeFea. The network helps show where Kathryn DeFea may publish in the future.

Co-authorship network of co-authors of Kathryn DeFea

This figure shows the co-authorship network connecting the top 25 collaborators of Kathryn DeFea. A scholar is included among the top collaborators of Kathryn DeFea based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kathryn DeFea. Kathryn DeFea is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Bunnett, Nigel W., Kathryn DeFea, Justin R. Hamilton, et al.. (2023). Proteinase-activated receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023(1).

Ahmad, Ayesha, Kathryn DeFea, Josef Vágner, et al.. (2023). Protease-Activated Receptor 2 (PAR2) Expressed in Sensory Neurons Contributes to Signs of Pain and Neuropathy in Paclitaxel Treated Mice. Journal of Pain. 24(11). 1980–1993. 8 indexed citations

Mason, Bianca N., Shayne Hassler, Kathryn DeFea, et al.. (2023). PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model. The Journal of Headache and Pain. 24(1). 42–42. 11 indexed citations

Ahmad, Ayesha, Stephanie Shiers, Michael D. Burton, et al.. (2022). C781, a β-Arrestin Biased Antagonist at Protease-Activated Receptor-2 (PAR2), Displays in vivo Efficacy Against Protease-Induced Pain in Mice. Journal of Pain. 24(4). 605–616. 6 indexed citations

Miyazaki, Takahiro, Laurie A. VanderVeen, Jonathan Zalevsky, et al.. (2021). In vivo and in vitro Characterization of a Partial Mu Opioid Receptor Agonist, NKTR-181, Supports Future Therapeutic Development. SHILAP Revista de lepidopterología. 2. 695962–695962. 4 indexed citations

Walker, Julia K. L. & Kathryn DeFea. (2014). Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma. Current Opinion in Pharmacology. 16. 142–147. 39 indexed citations

McGovern, Kathryn E. & Kathryn DeFea. (2013). Molecular Mechanisms Underlying Beta-Arrestin-Dependent Chemotaxis and Actin-Cytoskeletal Reorganization. Handbook of experimental pharmacology. 219. 341–359. 19 indexed citations

Mittal, Nitish, Kasturi Pal, Laurent A. Bentolila, et al.. (2013). Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway. Cell Reports. 5(4). 1010–1021. 43 indexed citations

DeFea, Kathryn. (2013). Arrestins in Actin Reorganization and Cell Migration. Progress in molecular biology and translational science. 118. 205–222. 22 indexed citations

10.

Pal, Kasturi, et al.. (2012). Divergent β-Arrestin-dependent Signaling Events Are Dependent upon Sequences within G-protein-coupled Receptor C Termini. Journal of Biological Chemistry. 288(5). 3265–3274. 18 indexed citations

11.

Ramachandran, Rithwik, Koichiro Mihara, Hyunjae Chung, et al.. (2011). Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2). Journal of Biological Chemistry. 286(28). 24638–24648. 134 indexed citations

12.

DeFea, Kathryn, et al.. (2011). β-Arrestin-Dependent Actin Reorganization: Bringing the Right Players Together at the Leading Edge. Molecular Pharmacology. 80(5). 760–768. 53 indexed citations

13.

Wang, Ping, et al.. (2010). Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. BMC Biochemistry. 11(1). 36–36. 27 indexed citations

14.

Zoudilova, Maria, et al.. (2010). β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2. Journal of Biological Chemistry. 285(19). 14318–14329. 60 indexed citations

15.

Shi, Yang, Crystal Pontrello, Kathryn DeFea, Louis F. Reichardt, & Iryna M. Ethell. (2009). Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity. Journal of Neuroscience. 29(25). 8129–8142. 134 indexed citations

16.

Ramachandran, Rithwik, Koichiro Mihara, Moulay Driss Rochdi, et al.. (2009). Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways. Molecular Pharmacology. 76(4). 791–801. 86 indexed citations

17.

Kumar, Puneet, et al.. (2007). Differential effects of β-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2. American Journal of Physiology-Cell Physiology. 293(1). C346–C357. 43 indexed citations

18.

Petreaca, Melissa, Min Yao, Yan Liu, Kathryn DeFea, & Manuela Martins‐Green. (2007). Transactivation of Vascular Endothelial Growth Factor Receptor-2 by Interleukin-8 (IL-8/CXCL8) Is Required for IL-8/CXCL8-induced Endothelial Permeability. Molecular Biology of the Cell. 18(12). 5014–5023. 170 indexed citations

19.

Ge, Lan, Sudha K. Shenoy, Robert J. Lefkowitz, & Kathryn DeFea. (2004). Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2. Journal of Biological Chemistry. 279(53). 55419–55424. 154 indexed citations

20.

Ge, Lan, et al.. (2003). A β-Arrestin-dependent Scaffold Is Associated with Prolonged MAPK Activation in Pseudopodia during Protease-activated Receptor-2-induced Chemotaxis. Journal of Biological Chemistry. 278(36). 34418–34426. 171 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact