Karlene A. Cimprich

17.7k total citations · 11 hit papers
66 papers, 13.1k citations indexed

About

Karlene A. Cimprich is a scholar working on Molecular Biology, Oncology and Cell Biology. According to data from OpenAlex, Karlene A. Cimprich has authored 66 papers receiving a total of 13.1k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Molecular Biology, 28 papers in Oncology and 17 papers in Cell Biology. Recurrent topics in Karlene A. Cimprich's work include DNA Repair Mechanisms (50 papers), Cancer-related Molecular Pathways (20 papers) and CRISPR and Genetic Engineering (16 papers). Karlene A. Cimprich is often cited by papers focused on DNA Repair Mechanisms (50 papers), Cancer-related Molecular Pathways (20 papers) and CRISPR and Genetic Engineering (16 papers). Karlene A. Cimprich collaborates with scholars based in United States, United Kingdom and Switzerland. Karlene A. Cimprich's co-authors include David Cortez, Michelle K. Zeman, Muh‐Ching Yee, M Bocek, Stephan Hamperl, Joshua C. Saldivar, Julie Sollier, Magdalena P. Crossley, Kazuyasu Sakaguchi and Yoichi Taya and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Karlene A. Cimprich

65 papers receiving 13.0k citations

Hit Papers

Activation of the ATM Kinase by Ionizing Radiation and Ph... 1998 2026 2007 2016 1998 2013 2008 2005 2017 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
    1998 1.7k citations Karlene A. Cimprich et al. Science profile →
  2. Causes and consequences of replication stress
    2013 1.4k citations Michelle K. Zeman, Karlene A. Cimprich Nature Cell Biology profile →
  3. ATR: an essential regulator of genome integrity
    2008 1.3k citations Karlene A. Cimprich, David Cortez Nature Reviews Molecular Cell Biology profile →
  4. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    2005 586 citations Tony Byun, Muh‐Ching Yee et al. Genes & Development profile →
  5. The essential kinase ATR: ensuring faithful duplication of a challenging genome
    2017 573 citations Joshua C. Saldivar, David Cortez et al. Nature Reviews Molecular Cell Biology profile →
  6. R-Loops as Cellular Regulators and Genomic Threats
    2019 493 citations Magdalena P. Crossley, M Bocek et al. Molecular Cell profile →
  7. Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability
    2014 435 citations Karlene A. Cimprich et al. Molecular Cell profile →
  8. Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses
    2017 434 citations Stephan Hamperl, M Bocek et al. profile →
  9. Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells
    2016 352 citations Gaelen T. Hess, Laure Frésard et al. Nature Methods profile →
  10. R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response
    2022 167 citations Magdalena P. Crossley, Chenlin Song et al. Nature profile →
  11. Walking a tightrope: The complex balancing act of R-loops in genome stability
    2022 140 citations Joshua R. Brickner, Karlene A. Cimprich et al. Molecular Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Karlene A. Cimprich United States 46 11.9k 4.2k 2.1k 2.0k 1.3k 66 13.1k
Claudia Lukas Denmark 46 13.3k 1.1× 5.9k 1.4× 2.3k 1.1× 2.6k 1.3× 1.1k 0.9× 54 14.7k
David Cortez United States 63 15.0k 1.3× 6.0k 1.4× 2.8k 1.3× 2.6k 1.3× 2.0k 1.5× 114 16.6k
Daniel Durocher Canada 58 13.1k 1.1× 4.1k 1.0× 1.4k 0.6× 1.6k 0.8× 1.5k 1.1× 105 14.3k
Niels Mailand Denmark 57 11.5k 1.0× 4.4k 1.0× 1.5k 0.7× 2.6k 1.3× 1.2k 0.9× 92 12.5k
Tanya T. Paull United States 61 13.3k 1.1× 4.3k 1.0× 2.9k 1.3× 1.3k 0.7× 1.3k 1.0× 111 14.7k
Marco Foiani Italy 58 12.3k 1.0× 2.3k 0.6× 2.2k 1.0× 2.5k 1.3× 1.2k 1.0× 124 13.3k
Lee Zou United States 63 14.3k 1.2× 5.1k 1.2× 3.2k 1.5× 2.0k 1.0× 1.2k 1.0× 127 16.1k
Simon Bekker‐Jensen Denmark 49 10.1k 0.8× 3.4k 0.8× 1.4k 0.6× 1.6k 0.8× 1.1k 0.8× 80 11.0k
Antony M. Carr United Kingdom 74 14.1k 1.2× 3.3k 0.8× 2.0k 0.9× 3.8k 1.9× 1.6k 1.2× 200 15.3k
Óscar Fernández-Capetillo Spain 52 10.7k 0.9× 3.9k 0.9× 1.9k 0.9× 1.2k 0.6× 1.2k 0.9× 108 12.7k

Countries citing papers authored by Karlene A. Cimprich

Since Specialization
Citations

This map shows the geographic impact of Karlene A. Cimprich's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karlene A. Cimprich with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karlene A. Cimprich more than expected).

Fields of papers citing papers by Karlene A. Cimprich

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karlene A. Cimprich. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karlene A. Cimprich. The network helps show where Karlene A. Cimprich may publish in the future.

Co-authorship network of co-authors of Karlene A. Cimprich

This figure shows the co-authorship network connecting the top 25 collaborators of Karlene A. Cimprich. A scholar is included among the top collaborators of Karlene A. Cimprich based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karlene A. Cimprich. Karlene A. Cimprich is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Endres, Theresa, Matthew D. Newton, Magdalena P. Crossley, et al.. (2024). HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability. Molecular Cell. 84(16). 3044–3060.e11. 10 indexed citations
2.
Cimprich, Karlene A., Guo‐Min Li, Sandra Demaria, et al.. (2023). The crosstalk between DNA repair and immune responses. Molecular Cell. 83(20). 3582–3587. 4 indexed citations
3.
Stoy, Henriette, Katharina Zwicky, Kevin S. Lang, et al.. (2023). Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids. Nature Structural & Molecular Biology. 30(3). 348–359. 40 indexed citations
4.
Salvi, Jayesh S., Jengmin Kang, Soochi Kim, et al.. (2022). ATR activity controls stem cell quiescence via the cyclin F–SCF complex. Proceedings of the National Academy of Sciences. 119(18). e2115638119–e2115638119. 9 indexed citations
5.
Crossley, Magdalena P., Chenlin Song, M Bocek, et al.. (2022). R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response. Nature. 613(7942). 187–194. 167 indexed citations breakdown →
6.
Crossley, Magdalena P., Joshua R. Brickner, Chenlin Song, et al.. (2021). Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA–DNA hybrid imaging. The Journal of Cell Biology. 220(9). 45 indexed citations
7.
Xu, Yu, Caiyun G. Li, Eui Jung Moon, et al.. (2021). Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination–deficient cancer models. Journal of Clinical Investigation. 131(11). 22 indexed citations
8.
Saldivar, Joshua C., Stephan Hamperl, M Bocek, et al.. (2018). An intrinsic S/G 2 checkpoint enforced by ATR. Science. 361(6404). 806–810. 203 indexed citations
9.
Saldivar, Joshua C., David Cortez, & Karlene A. Cimprich. (2017). The essential kinase ATR: ensuring faithful duplication of a challenging genome. Nature Reviews Molecular Cell Biology. 18(10). 622–636. 573 indexed citations breakdown →
10.
Hess, Gaelen T., Laure Frésard, Kyuho Han, et al.. (2016). Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nature Methods. 13(12). 1036–1042. 352 indexed citations breakdown →
11.
Slaats, Gisela G., Joshua C. Saldivar, Julien Bacal, et al.. (2015). DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. Journal of Clinical Investigation. 125(9). 3657–3666. 46 indexed citations
12.
Pérez, Vinicio A. de Jesús, Ke Yuan, Frederick E. Dewey, et al.. (2014). Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 189(10). 1260–1272. 62 indexed citations
13.
Zeman, Michelle K. & Karlene A. Cimprich. (2013). Causes and consequences of replication stress. Nature Cell Biology. 16(1). 2–9. 1441 indexed citations breakdown →
14.
Lin, Jia‐Ren, Michelle K. Zeman, Jia-Yun Chen, Muh‐Ching Yee, & Karlene A. Cimprich. (2011). SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis. Molecular Cell. 42(2). 237–249. 152 indexed citations
15.
Chen, Jia-Yun, Jia‐Ren Lin, Karlene A. Cimprich, & Tobias Meyer. (2011). A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision. Molecular Cell. 45(2). 196–209. 97 indexed citations
16.
Van, Christopher, Shan Yan, W. Matthew Michael, S Waga, & Karlene A. Cimprich. (2010). Continued primer synthesis at stalled replication forks contributes to checkpoint activation. The Journal of Cell Biology. 189(2). 233–246. 77 indexed citations
17.
Byun, Tony, et al.. (2007). The structural determinants of checkpoint activation. Genes & Development. 21(8). 898–903. 185 indexed citations
18.
O’Connell, Matthew J. & Karlene A. Cimprich. (2004). G2 damage checkpoints: what is the turn-on?. Journal of Cell Science. 118(1). 1–6. 74 indexed citations
19.
Lupardus, Patrick J., Tony Byun, Muh‐Ching Yee, Mohammad Hekmat-Nejad, & Karlene A. Cimprich. (2002). A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes & Development. 16(18). 2327–2332. 141 indexed citations
20.
Hekmat-Nejad, Mohammad, Zhongsheng You, Muh‐Ching Yee, John W. Newport, & Karlene A. Cimprich. (2000). Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Current Biology. 10(24). 1565–1573. 168 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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