Karen E. Christensen

1.2k total citations
32 papers, 844 citations indexed

About

Karen E. Christensen is a scholar working on Rheumatology, Molecular Biology and Clinical Biochemistry. According to data from OpenAlex, Karen E. Christensen has authored 32 papers receiving a total of 844 indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Rheumatology, 16 papers in Molecular Biology and 9 papers in Clinical Biochemistry. Recurrent topics in Karen E. Christensen's work include Folate and B Vitamins Research (23 papers), RNA modifications and cancer (10 papers) and Metabolism and Genetic Disorders (9 papers). Karen E. Christensen is often cited by papers focused on Folate and B Vitamins Research (23 papers), RNA modifications and cancer (10 papers) and Metabolism and Genetic Disorders (9 papers). Karen E. Christensen collaborates with scholars based in Canada, United States and Denmark. Karen E. Christensen's co-authors include Robert E. MacKenzie, Marie A. Caudill, Liyuan Deng, Rima Rozen, Rima Rozen, Qing Wu, Olga Malysheva, Xiaoling Wang, Grégor Andelfinger and Charles Rohlicek and has published in prestigious journals such as Journal of Biological Chemistry, American Journal of Clinical Nutrition and Journal of Nutrition.

In The Last Decade

Karen E. Christensen

31 papers receiving 835 citations

Peers

Karen E. Christensen

RHEUM

PPCH

EPIDE

Lourdes L. Gruca United States

S J James United States

Jitka Sokolová Czechia

Antoinette Sakaris United States

Susan Marczewski United States

Eva Greibe Denmark

A. Joan Levine United States

Marion Bodis Germany

J. Schaub Germany

Patrice Clément France

Lourdes L. Gruca United States

Karen E. Christensen

153 ×0.3

RHEUM

191 ×0.5

206 ×1.0

PPCH

101 ×0.8

EPIDE

131 ×1.1

Citations per year, relative to Karen E. Christensen Karen E. Christensen (= 1×) peers Lourdes L. Gruca

Countries citing papers authored by Karen E. Christensen

Since Specialization

Citations

This map shows the geographic impact of Karen E. Christensen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karen E. Christensen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karen E. Christensen more than expected).

Fields of papers citing papers by Karen E. Christensen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karen E. Christensen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karen E. Christensen. The network helps show where Karen E. Christensen may publish in the future.

Co-authorship network of co-authors of Karen E. Christensen

This figure shows the co-authorship network connecting the top 25 collaborators of Karen E. Christensen. A scholar is included among the top collaborators of Karen E. Christensen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karen E. Christensen. Karen E. Christensen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Chan, Donovan, Karen E. Christensen, Alaina M. Reagan, et al.. (2024). Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation. Molecular Human Reproduction. 30(4). 3 indexed citations

Christensen, Karen E., Daniel Leclerc, Vafa Keser, et al.. (2024). Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr677C>T Mouse Model with Hepatic Steatosis. Nutrients. 17(1). 82–82.

Leclerc, Daniel, Karen E. Christensen, Alaina M. Reagan, et al.. (2024). Folate Deficiency and/or the Genetic Variant Mthfr^{677C >T} Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex‐Specific Manner. Molecular Nutrition & Food Research. 68(5). e2300355–e2300355. 5 indexed citations

Reagan, Alaina M., Karen E. Christensen, Leah Graham, et al.. (2022). The 677C > T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice. Journal of Cerebral Blood Flow & Metabolism. 42(12). 2333–2350. 9 indexed citations

Leclerc, Daniel, Jaroslav Jelı́nek, Karen E. Christensen, Jean‐Pierre J. Issa, & Rima Rozen. (2020). High folic acid intake increases methylation-dependent expression of Lsr and dysregulates hepatic cholesterol homeostasis. The Journal of Nutritional Biochemistry. 88. 108554–108554. 12 indexed citations

Bidla, Gawa, David Watkins, Céline Chéry, et al.. (2020). Biochemical analysis of patients with mutations in MTHFD1 and a diagnosis of methylenetetrahydrofolate dehydrogenase 1 deficiency. Molecular Genetics and Metabolism. 130(3). 179–182. 7 indexed citations

Christensen, Karen E., Liyuan Deng, Olga Malysheva, et al.. (2018). Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects. Journal of Nutrition. 148(4). 501–509. 9 indexed citations

Christensen, Karen E., Liyuan Deng, Olga Malysheva, et al.. (2016). Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. American Journal of Clinical Nutrition. 104(5). 1459–1469. 21 indexed citations

Christensen, Karen E., Leonie G. Mikael, Kit‐Yi Leung, et al.. (2015). High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. American Journal of Clinical Nutrition. 101(3). 646–658. 124 indexed citations

10.

Christensen, Karen E., Lin Deng, Kit‐Yi Leung, et al.. (2013). A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development. Human Molecular Genetics. 22(18). 3705–3719. 36 indexed citations

11.

Christensen, Karen E., Yassamin Feroz Zada, Charles Rohlicek, et al.. (2012). Risk of congenital heart defects is influenced by genetic variation in folate metabolism. Cardiology in the Young. 23(1). 89–98. 24 indexed citations

12.

Christensen, Karen E., Qing Wu, Xiaoling Wang, et al.. (2010). Steatosis in Mice Is Associated with Gender, Folate Intake, and Expression of Genes of One-Carbon Metabolism. Journal of Nutrition. 140(10). 1736–1741. 88 indexed citations

13.

Christensen, Karen E. & Robert E. MacKenzie. (2008). Chapter 14 Mitochondrial Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase, and Formyltetrahydrofolate Synthetases. Vitamins and hormones. 79. 393–410. 53 indexed citations

14.

Christensen, Karen E., Charles Rohlicek, Grégor Andelfinger, et al.. (2008). The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects. Human Mutation. 30(2). 212–220. 88 indexed citations

15.

Christensen, Karen E. & Robert E. MacKenzie. (2006). Mitochondrial one‐carbon metabolism is adapted to the specific needs of yeast, plants and mammals. BioEssays. 28(6). 595–605. 98 indexed citations

16.

Christensen, Karen E., I.A. Mirza, Albert M. Berghuis, & Robert E. MacKenzie. (2005). Magnesium and Phosphate Ions Enable NAD Binding to Methylenetetrahydrofolate Dehydrogenase-Methenyltetrahydrofolate Cyclohydrolase. Journal of Biological Chemistry. 280(40). 34316–34323. 32 indexed citations

17.

Christensen, Karen E., et al.. (2004). Disruption of the Mthfd1 Gene Reveals a Monofunctional 10-Formyltetrahydrofolate Synthetase in Mammalian Mitochondria. Journal of Biological Chemistry. 280(9). 7597–7602. 41 indexed citations

18.

Hilton, John, Karen E. Christensen, David Watkins, et al.. (2003). The molecular basis of glutamate formiminotransferase deficiency. Human Mutation. 22(1). 67–73. 40 indexed citations

19.

Christensen, Karen E., et al.. (2002). Mammalian mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase derived from a trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase. Archives of Biochemistry and Biophysics. 403(1). 145–148. 19 indexed citations

20.

Christensen, Karen E. & R. Manthorpe. (1983). Alkaptonuria and Ochronosis. Human Heredity. 33(2). 140–144. 2 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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