John Xi Chen

2.6k total citations · 1 hit paper
17 papers, 2.2k citations indexed

About

John Xi Chen is a scholar working on Physiology, Molecular Biology and Clinical Biochemistry. According to data from OpenAlex, John Xi Chen has authored 17 papers receiving a total of 2.2k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Physiology, 15 papers in Molecular Biology and 4 papers in Clinical Biochemistry. Recurrent topics in John Xi Chen's work include Alzheimer's disease research and treatments (16 papers), Mitochondrial Function and Pathology (11 papers) and Metabolism and Genetic Disorders (3 papers). John Xi Chen is often cited by papers focused on Alzheimer's disease research and treatments (16 papers), Mitochondrial Function and Pathology (11 papers) and Metabolism and Genetic Disorders (3 papers). John Xi Chen collaborates with scholars based in United States, China and United Kingdom. John Xi Chen's co-authors include Shirley ShiDu Yan, Shi Du Yan, Lan Guo, Heng Du, Ottavio Arancio, Guy M. McKhann, Fang Fang, Frank J. Gunn‐Moore, Doris Chen and Alexander A. Sosunov and has published in prestigious journals such as Journal of Biological Chemistry, Nature Medicine and Journal of Neuroscience.

In The Last Decade

John Xi Chen

17 papers receiving 2.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

2008 785 citations Heng Du, Lan Guo et al. Nature Medicine profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John Xi Chen United States	17	1.4k	1.4k	377	376	257	17	2.2k
Shaharyar M. Khan United States	19	1.7k 1.2×	1.5k 1.1×	394 1.0×	391 1.0×	281 1.1×	29	2.8k
Virginie Rhein Switzerland	16	1.1k 0.8×	1.2k 0.8×	279 0.7×	298 0.8×	203 0.8×	19	1.8k
Michela Guglielmotto Italy	26	922 0.7×	1.5k 1.1×	347 0.9×	511 1.4×	381 1.5×	43	2.5k
Lan Guo United States	22	2.0k 1.4×	1.8k 1.3×	607 1.6×	457 1.2×	329 1.3×	48	3.1k
Ulziibat Shirendeb United States	12	1.7k 1.2×	1.1k 0.8×	721 1.9×	236 0.6×	213 0.8×	13	2.5k
Zhong Zhao United States	13	654 0.5×	1.3k 0.9×	370 1.0×	253 0.7×	350 1.4×	19	2.3k
Birgitta Wiehager Sweden	23	1.6k 1.2×	1.4k 1.0×	746 2.0×	454 1.2×	147 0.6×	37	2.5k
Isabel Scherping Germany	11	986 0.7×	1.3k 0.9×	310 0.8×	380 1.0×	333 1.3×	13	1.9k
Wesley Farris United States	10	987 0.7×	1.9k 1.4×	416 1.1×	485 1.3×	414 1.6×	11	2.7k
Laura Canevari United Kingdom	20	1.5k 1.0×	1.6k 1.2×	723 1.9×	339 0.9×	660 2.6×	32	2.9k

Countries citing papers authored by John Xi Chen

Since Specialization

Citations

This map shows the geographic impact of John Xi Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Xi Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Xi Chen more than expected).

Fields of papers citing papers by John Xi Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Xi Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Xi Chen. The network helps show where John Xi Chen may publish in the future.

Co-authorship network of co-authors of John Xi Chen

This figure shows the co-authorship network connecting the top 25 collaborators of John Xi Chen. A scholar is included among the top collaborators of John Xi Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Xi Chen. John Xi Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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17 of 17 papers shown

Yu, Qing, Fang Du, Russell H. Swerdlow, et al.. (2016). Antioxidants Rescue Mitochondrial Transport in Differentiated Alzheimer’s Disease Trans-Mitochondrial Cybrid Cells. Journal of Alzheimer s Disease. 54(2). 679–690. 36 indexed citations

Du, Fang, Yongfu Wang, Heng Du, et al.. (2015). Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model. Human Molecular Genetics. 24(18). 5198–5210. 76 indexed citations

Gan, Xueqi, Long Wu, Shengbin Huang, et al.. (2014). Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction. Free Radical Biology and Medicine. 75. 230–240. 55 indexed citations

Wang, Yongfu, Long Wu, Jianping Li, et al.. (2014). Synergistic Exacerbation of Mitochondrial and Synaptic Dysfunction and Resultant Learning and Memory Deficit in a Mouse Model of Diabetic Alzheimer's Disease. Journal of Alzheimer s Disease. 43(2). 451–463. 34 indexed citations

Guo, Lan, Heng Du, Shiqiang Yan, et al.. (2013). Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons. PLoS ONE. 8(1). e54914–e54914. 104 indexed citations

Gan, Xueqi, Shengbin Huang, Long Wu, et al.. (2013). Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1842(2). 220–231. 159 indexed citations

Du, Heng, Lan Guo, Xiaoping Wu, et al.. (2013). Cyclophilin D deficiency rescues Aβ-impaired PKA/CREB signaling and alleviates synaptic degeneration. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1842(12). 2517–2527. 74 indexed citations

Yao, Jun, Heng Du, Shiqiang Yan, et al.. (2011). Inhibition of Amyloid-β (Aβ) Peptide-Binding Alcohol Dehydrogenase-Aβ Interaction Reduces Aβ Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Journal of Neuroscience. 31(6). 2313–2320. 152 indexed citations

Alikhani, Nyosha, Lan Guo, Shiqiang Yan, et al.. (2011). Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria. Journal of Alzheimer s Disease. 27(1). 75–87. 95 indexed citations

10.

Chen, John Xi & Shirley ShiDu Yan. (2010). Role of Mitochondrial Amyloid-β in Alzheimer's Disease. Journal of Alzheimer s Disease. 20(s2). S569–S578. 156 indexed citations

11.

Xu, Hongwei, Fang Fang, Lan Guo, et al.. (2010). Genetic deficiency of Irgm1 (LRG‐47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4 ⁺ T cells. The FASEB Journal. 24(5). 1583–1592. 32 indexed citations

12.

Ren, Yimin, Hongwei Xu, Fleur Davey, et al.. (2008). Endophilin I Expression Is Increased in the Brains of Alzheimer Disease Patients. Journal of Biological Chemistry. 283(9). 5685–5691. 52 indexed citations

13.

Du, Heng, Lan Guo, Fang Fang, et al.. (2008). Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nature Medicine. 14(10). 1097–1105. 785 indexed citations breakdown →

14.

Origlia, Nicola, Massimo Righi, Simona Capsoni, et al.. (2008). Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid-β-Mediated Cortical Synaptic Dysfunction. Journal of Neuroscience. 28(13). 3521–3530. 186 indexed citations

15.

Yao, Jun, Margaret Taylor, Fleur Davey, et al.. (2007). Interaction of amyloid binding alcohol dehydrogenase/Aβ mediates up-regulation of peroxiredoxin II in the brains of Alzheimer’s disease patients and a transgenic Alzheimer’s disease mouse model. Molecular and Cellular Neuroscience. 35(2). 377–382. 70 indexed citations

16.

Chen, John Xi & Shi Du Yan. (2007). Pathogenic role of mitochondrial amyloid-β peptide. Expert Review of Neurotherapeutics. 7(11). 1517–1525. 23 indexed citations

17.

Chen, John Xi & Shi Du Yan. (2007). Amyloid-β-Induced Mitochondrial Dysfunction. Journal of Alzheimer s Disease. 12(2). 177–184. 138 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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