John P. O’Bryan

5.1k total citations · 1 hit paper
77 papers, 3.9k citations indexed

About

John P. O’Bryan is a scholar working on Molecular Biology, Cell Biology and Immunology. According to data from OpenAlex, John P. O’Bryan has authored 77 papers receiving a total of 3.9k indexed citations (citations by other indexed papers that have themselves been cited), including 56 papers in Molecular Biology, 21 papers in Cell Biology and 13 papers in Immunology. Recurrent topics in John P. O’Bryan's work include Protein Kinase Regulation and GTPase Signaling (23 papers), Ubiquitin and proteasome pathways (19 papers) and Cellular transport and secretion (13 papers). John P. O’Bryan is often cited by papers focused on Protein Kinase Regulation and GTPase Signaling (23 papers), Ubiquitin and proteasome pathways (19 papers) and Cellular transport and secretion (13 papers). John P. O’Bryan collaborates with scholars based in United States, United Kingdom and Canada. John P. O’Bryan's co-authors include Andreas Neubauer, Channing J. Der, Rafael Espinosa, Roy A. Frye, Patricia C. Cogswell, Carol Prokop, Michelle M. Le Beau, H. Shelton Earp, Imran Khan and Stephanie L. Miller and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Nature Communications.

In The Last Decade

John P. O’Bryan

73 papers receiving 3.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

1991 632 citations John P. O’Bryan, Roy A. Frye et al. Molecular and Cellular Biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John P. O’Bryan United States	35	2.3k	1.0k	968	708	397	77	3.9k
Judy Pawling Canada	22	4.5k 1.9×	1.5k 1.4×	790 0.8×	779 1.1×	243 0.6×	37	5.8k
Pablo Rodriguez‐Viciana United States	24	5.2k 2.2×	731 0.7×	1.1k 1.2×	1.5k 2.1×	225 0.6×	31	6.3k
Kurt R. Auger United States	22	4.1k 1.8×	661 0.6×	1.0k 1.1×	1.3k 1.8×	211 0.5×	33	5.4k
Patricia H. Warne United Kingdom	25	5.8k 2.5×	938 0.9×	1.2k 1.3×	1.8k 2.6×	279 0.7×	30	7.3k
Yoko Aoki Japan	36	2.9k 1.3×	891 0.9×	562 0.6×	581 0.8×	254 0.6×	170	4.8k
Shi‐Yuan Cheng United States	43	4.2k 1.8×	577 0.6×	474 0.5×	1.5k 2.1×	211 0.5×	96	6.1k
Andrea Morrione United States	40	3.2k 1.4×	307 0.3×	590 0.6×	924 1.3×	262 0.7×	92	4.7k
Reiner Lammers Germany	39	4.6k 2.0×	1.3k 1.2×	981 1.0×	1.1k 1.5×	412 1.0×	75	6.1k
Bart Vanhaesebroeck United Kingdom	16	2.7k 1.2×	652 0.6×	588 0.6×	682 1.0×	298 0.8×	17	3.8k
Mariona Graupera Spain	35	2.4k 1.0×	493 0.5×	419 0.4×	978 1.4×	331 0.8×	59	4.6k

Countries citing papers authored by John P. O’Bryan

Since Specialization

Citations

This map shows the geographic impact of John P. O’Bryan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John P. O’Bryan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John P. O’Bryan more than expected).

Fields of papers citing papers by John P. O’Bryan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John P. O’Bryan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John P. O’Bryan. The network helps show where John P. O’Bryan may publish in the future.

Co-authorship network of co-authors of John P. O’Bryan

This figure shows the co-authorship network connecting the top 25 collaborators of John P. O’Bryan. A scholar is included among the top collaborators of John P. O’Bryan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John P. O’Bryan. John P. O’Bryan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Ferretti, Giulia D. S., Irene Bertolini, Özge Saatci, et al.. (2024). HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer. Cell Death and Differentiation. 31(7). 881–896. 18 indexed citations

Koide, Akiko, Mubashir J. Mintoo, Matthew J. Sale, et al.. (2024). Inhibition and degradation of NRAS with a pan-NRAS monobody. Oncogene. 43(48). 3489–3497. 3 indexed citations

Sofi, M. Hanief, Linlu Tian, Steven Schutt, et al.. (2022). Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. Leukemia. 36(7). 1907–1915. 13 indexed citations

Khan, Imran, Akiko Koide, Mariyam Zuberi, et al.. (2022). Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Reports. 38(6). 110322–110322. 14 indexed citations

Ash, Dipankar, Sudhahar Varadarajan, Seock‐Won Youn, et al.. (2021). The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2. Nature Communications. 12(1). 3091–3091. 67 indexed citations

Naiche, L.A., et al.. (2021). Neuroblastoma differentiation in vivo excludes cranial tumors. Developmental Cell. 56(19). 2752–2764.e6. 3 indexed citations

Spencer-Smith, Russell & John P. O’Bryan. (2017). Direct inhibition of RAS: Quest for the Holy Grail?. Seminars in Cancer Biology. 54. 138–148. 65 indexed citations

Russo, Angela, Mustafa Nazir Okur, Maarten C. Bosland, & John P. O’Bryan. (2015). Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2β) isoform contributes to neuroblastoma tumorigenesis. Cancer Letters. 359(2). 262–268. 23 indexed citations

Wang, Li, et al.. (2015). Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. Journal of Biological Chemistry. 290(19). 12058–12067. 15 indexed citations

10.

Wong, Katy A., Jessica Wilson, Angela Russo, et al.. (2012). Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks. PLoS ONE. 7(4). e36023–e36023. 44 indexed citations

11.

Russo, Angela & John P. O’Bryan. (2012). Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene. 31(46). 4828–4834. 33 indexed citations

12.

Place, Aaron T., Zhenlong Chen, Farnaz R. Bakhshi, et al.. (2011). Cooperative Role of Caveolin-1 and C-Terminal Src Kinase Binding Protein in C-Terminal Src Kinase-Mediated Negative Regulation of c-Src. Molecular Pharmacology. 80(4). 665–672. 33 indexed citations

13.

Martin, Negin P., et al.. (2006). Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling. Molecular Pharmacology. 70(5). 1643–1653. 54 indexed citations

14.

Mohney, Robert P., et al.. (2003). Intersectin Activates Ras but Stimulates Transcription through an Independent Pathway Involving JNK. Journal of Biological Chemistry. 278(47). 47038–47045. 56 indexed citations

15.

Storey, Nina M., John P. O’Bryan, & David L. Armstrong. (2002). Rac and Rho Mediate Opposing Hormonal Regulation of the Ether-A-Go-Go-Related Potassium Channel. Current Biology. 12(1). 27–33. 67 indexed citations

16.

Sakai, Ryuichi, Jeffrey T. Henderson, John P. O’Bryan, et al.. (2000). The Mammalian ShcB and ShcC Phosphotyrosine Docking Proteins Function in the Maturation of Sensory and Sympathetic Neurons. Neuron. 28(3). 819–833. 89 indexed citations

17.

O’Bryan, John P., Que T. Lambert, & Channing J. Der. (1998). The Src Homology 2 and Phosphotyrosine Binding Domains of the ShcC Adaptor Protein Function as Inhibitors of Mitogenic Signaling by the Epidermal Growth Factor Receptor. Journal of Biological Chemistry. 273(32). 20431–20437. 26 indexed citations

18.

O’Bryan, John P., Carol B. Martin, Zhou Songyang, Lewis C. Cantley, & Channing J. Der. (1996). Binding Specificity and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-specific Adaptor Protein ShcC. Journal of Biological Chemistry. 271(20). 11787–11791. 17 indexed citations

19.

O’Bryan, John P., Yih-Woei C. Fridell, R. K. Koski, Brian Varnum, & Edison T. Liu. (1995). The Transforming Receptor Tyrosine Kinase, Axl, Is Post-translationally Regulated by Proteolytic Cleavage. Journal of Biological Chemistry. 270(2). 551–557. 140 indexed citations

20.

O’Bryan, John P., Roy A. Frye, Patricia C. Cogswell, et al.. (1991). axl , a Transforming Gene Isolated from Primary Human Myeloid Leukemia Cells, Encodes a Novel Receptor Tyrosine Kinase. Molecular and Cellular Biology. 11(10). 5016–5031. 214 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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