John N. Philoppes

515 citations

16 papers · 408 indexed · h-index 12

Organic Chemistry top 5%
- Synthesis and biological activity 13
- Synthesis and Biological Evaluation 5
- Synthesis of Tetrazole Derivatives 2
- Synthesis and Characterization of Heterocyclic Compounds 2
- Quinazolinone synthesis and applications 2
Toxicology
Computational Theory and Mathematics top 10%
- Computational Drug Discovery Methods 4
Pharmacology
- Inflammatory mediators and NSAID effects 4
Oncology
Molecular Biology
- Cancer therapeutics and mechanisms 2

Co-authors: Phoebe F. Lamie Madlen B. Labib Amany A. Azouz Eman K. A. Abdelall Lucie Rárová Laila A. Rashed N. LATIF Marwa H. A. Hassan
Cited by: Organic Chemistry Toxicology Computational Theory and Mathematics
Journals: European Journal of Medicinal Chemistry (1 paper)Journal of Molecular Structure (1 paper)Bioorganic Chemistry (7 papers)
Partner nations: Egypt Saudi Arabia Czechia

In The Last Decade

John N. Philoppes

15 papers receiving 395 citations

Peers

Countries citing papers authored by John N. Philoppes

Since Specialization

Citations

This map shows the geographic impact of John N. Philoppes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John N. Philoppes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John N. Philoppes more than expected).

Fields of papers citing papers by John N. Philoppes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John N. Philoppes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John N. Philoppes. The network helps show where John N. Philoppes may publish in the future.

Co-authorship network

The 18 scholars most cited alongside John N. Philoppes, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John N. Philoppes Line = papers co-authored together John N. Philoppes links everyone, so they are left out of the graph.

All Works

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16 of 16 papers shown

#	Work
1	Synthesis of new selective agents with dual anti-inflammatory and SARS-CoV-2 Mpro inhibitory activity: Antipyrine-celecoxib hybrid analogues; COX-2, COVID-19 cytokine storm and replication inhibitory activities. Bioorganic Chemistry ·Eman K. A. Abdelall,Heba A.H. Elshemy,Madlen B. Labib,John N. Philoppes,Fares E.M. Ali,Amira K.M. Ahmed	2025	0
2	Molecular docking, ADME study, Cardiovascular biomarkers and gastric safety of new pyrazoles as selective anti-inflammatory agents Journal of Molecular Structure ·Eman K. A. Abdelall,Sameh S. Zaghlool,Joseph Z.F. Saad,John N. Philoppes	2025	1
3	Development of safe and antioxidant COX-2 inhibitors; Synthesis, molecular docking analysis and biological evaluation of novel pyrrolizine 5-carboxamides Bioorganic Chemistry ·Eman K. A. Abdelall,Heba A.H. Elshemy,John N. Philoppes,Maha M. Abdel‐Fattah,El-Shaymaa El-Nahaas,Raefa Mahmoud Mohamed Mahmoud	2024	2
4	Novel N -methylsulfonyl-indole derivatives: biological activity and COX-2/5-LOX inhibitory effect with improved gastro protective profile and reduced cardio vascular risks Journal of Enzyme Inhibition and Medicinal Chemistry ·John N. Philoppes,Mohamed A. Abdelgawad,Mohammed A. S. Abourehab,Mohamed Sebak,Mostafa A. Darwish,Phoebe F. Lamie	2022	19
5	Design and synthesis of new indole drug candidates to treat Alzheimer’s disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) strategy Journal of Enzyme Inhibition and Medicinal Chemistry ·Phoebe F. Lamie,Maha M. Abdel‐Fattah,John N. Philoppes	2022	17
6	Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure–activity relationship and biological activity as potential antitumor and anticonvulsant agents European Journal of Medicinal Chemistry ·Phoebe F. Lamie,Asmaa M. El-Kalaawy,N. LATIF,Laila A. Rashed,John N. Philoppes	2021	41
7	Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies Bioorganic Chemistry ·Khaled R.A. Abdellatif,Eman K. A. Abdelall,Heba A.H. Elshemy,John N. Philoppes,Emad H. M. Hassanein,Nesma M. Kahk	2021	39
8	Design, synthesis, stereochemical determination, molecular docking study, in silico pre-ADMET prediction and anti-proliferative activities of indole-pyrimidine derivatives as Mcl-1 inhibitors Bioorganic Chemistry ·Phoebe F. Lamie,John N. Philoppes	2021	18
9	New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics Bioorganic Chemistry ·John N. Philoppes,Mohammed A. Khedr,Marwa H. A. Hassan,Gehan M. Kamel,Phoebe F. Lamie	2020	33
10	2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors Journal of Enzyme Inhibition and Medicinal Chemistry ·Phoebe F. Lamie,John N. Philoppes	2020	27
11	Design and synthesis of new benzoxazole/benzothiazole-phthalimide hybrids as antitumor-apoptotic agents Bioorganic Chemistry ·John N. Philoppes,Phoebe F. Lamie	2019	46
12	Design, synthesis, and biological evaluation of novel 1,2‐diaryl‐4‐substituted‐benzylidene‐5(4H)‐imidazolone derivatives as cytotoxic agents and COX‐2/LOX inhibitors Archiv der Pharmazie ·Phoebe F. Lamie,John N. Philoppes,Lucie Rárová	2018	23
13	Azole-hydrazone derivatives: Design, synthesis, in vitro biological evaluation, dual EGFR/HER2 inhibitory activity, cell cycle analysis and molecular docking study as anticancer agents Bioorganic Chemistry ·Madlen B. Labib,John N. Philoppes,Phoebe F. Lamie,Esam R. Ahmed	2017	71
14	Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study Journal of Enzyme Inhibition and Medicinal Chemistry ·Phoebe F. Lamie,John N. Philoppes,Amany A. Azouz,Nesreen M. Safwat	2017	51
15	Design and synthesis of three series of novel antitumor–azo derivatives Medicinal Chemistry Research ·Phoebe F. Lamie,John N. Philoppes	2017	9
16	Synthesis and cytotoxic activity of new pyrazolo[1,5-a]pyrimidines and determination of pyrimidine regiospecific ring formation with 2D NMR ARKIVOC ·Eman K. A. Abdelall,John N. Philoppes	2016	11

About John N. Philoppes

John N. Philoppes is a scholar working on Organic Chemistry, Pharmacology and Toxicology, having authored 16 papers that have together received 408 indexed citations. Recurring topics across this work include Synthesis and biological activity (13 papers), Synthesis and Biological Evaluation (5 papers), Computational Drug Discovery Methods (4 papers), Inflammatory mediators and NSAID effects (4 papers), Cancer therapeutics and mechanisms (2 papers), Synthesis of Tetrazole Derivatives (2 papers), Synthesis and Characterization of Heterocyclic Compounds (2 papers) and Quinazolinone synthesis and applications (2 papers). The work is most often cited by research in Organic Chemistry (326 citations), Toxicology (18 citations) and Computational Theory and Mathematics (68 citations). John N. Philoppes has collaborated with scholars based in Egypt, Saudi Arabia and Czechia. Frequent co-authors include Phoebe F. Lamie, Madlen B. Labib, Amany A. Azouz, Eman K. A. Abdelall, Lucie Rárová, Laila A. Rashed, N. LATIF, Marwa H. A. Hassan, Mohammed A. Khedr and Khaled R.A. Abdellatif. Their work appears in journals such as European Journal of Medicinal Chemistry, Journal of Molecular Structure and Bioorganic Chemistry.

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