Joep C. Defesche

16.9k total citations · 3 hit papers
128 papers, 5.9k citations indexed

About

Joep C. Defesche is a scholar working on Surgery, Endocrinology, Diabetes and Metabolism and Cancer Research. According to data from OpenAlex, Joep C. Defesche has authored 128 papers receiving a total of 5.9k indexed citations (citations by other indexed papers that have themselves been cited), including 111 papers in Surgery, 42 papers in Endocrinology, Diabetes and Metabolism and 36 papers in Cancer Research. Recurrent topics in Joep C. Defesche's work include Lipoproteins and Cardiovascular Health (107 papers), Cancer, Lipids, and Metabolism (35 papers) and Diabetes, Cardiovascular Risks, and Lipoproteins (34 papers). Joep C. Defesche is often cited by papers focused on Lipoproteins and Cardiovascular Health (107 papers), Cancer, Lipids, and Metabolism (35 papers) and Diabetes, Cardiovascular Risks, and Lipoproteins (34 papers). Joep C. Defesche collaborates with scholars based in Netherlands, United States and Canada. Joep C. Defesche's co-authors include John J.P. Kastelein, Eric J.G. Sijbrands, Sigrid W. Fouchier, G. Kees Hovingh, M.A.W. Umans-Eckenhausen, Barbara A. Hutten, Peter Lansberg, Samuel S. Gidding, Raúl D. Santos and Anthony S. Wierzbicki and has published in prestigious journals such as The Lancet, JAMA and Circulation.

In The Last Decade

Joep C. Defesche

127 papers receiving 5.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Efficacy of statins in familial hypercholesterolaemia: a long term cohort study

2008 524 citations Mojgan Yazdanpanah, Joep C. Defesche et al. profile →
The Agenda for Familial Hypercholesterolemia

2015 450 citations Samuel S. Gidding, Mary Ann Champagne et al. Circulation profile →
Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype–phenotype relationship, and clinical outcome

2014 308 citations Barbara Sjouke, Joep C. Defesche et al. European Heart Journal profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Joep C. Defesche Netherlands	38	4.7k	2.0k	1.6k	1.3k	709	128	5.9k
Marcello Arca Italy	43	2.9k 0.6×	2.1k 1.0×	1.1k 0.7×	2.1k 1.6×	360 0.5×	215	6.3k
Atsushi Nohara Japan	37	2.5k 0.5×	1.3k 0.7×	889 0.6×	1.1k 0.9×	223 0.3×	178	4.3k
Patrick M. Moriarty United States	35	3.1k 0.7×	1.3k 0.6×	829 0.5×	1.3k 0.9×	641 0.9×	109	4.8k
Robert Pordy United States	29	5.5k 1.2×	1.6k 0.8×	1.0k 0.6×	1.8k 1.3×	2.2k 3.1×	107	6.6k
Trond P. Leren Norway	38	2.6k 0.6×	770 0.4×	774 0.5×	1.6k 1.2×	294 0.4×	166	4.8k
Mieke D. Trip Netherlands	33	1.8k 0.4×	1.0k 0.5×	578 0.4×	1.2k 0.9×	172 0.2×	70	3.6k
S. Calandra Italy	39	3.0k 0.6×	1.6k 0.8×	978 0.6×	1.3k 1.0×	67 0.1×	187	5.2k
Narimon Honarpour United States	23	2.7k 0.6×	840 0.4×	518 0.3×	780 0.6×	931 1.3×	51	3.8k
Pia R. Kamstrup Denmark	22	3.0k 0.6×	1.2k 0.6×	840 0.5×	1.5k 1.1×	281 0.4×	48	3.7k
William J. Sasiela United States	21	2.9k 0.6×	1.0k 0.5×	716 0.4×	1.2k 0.9×	528 0.7×	61	3.9k

Countries citing papers authored by Joep C. Defesche

Since Specialization

Citations

This map shows the geographic impact of Joep C. Defesche's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Joep C. Defesche with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Joep C. Defesche more than expected).

Fields of papers citing papers by Joep C. Defesche

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Joep C. Defesche. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Joep C. Defesche. The network helps show where Joep C. Defesche may publish in the future.

Co-authorship network of co-authors of Joep C. Defesche

This figure shows the co-authorship network connecting the top 25 collaborators of Joep C. Defesche. A scholar is included among the top collaborators of Joep C. Defesche based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Joep C. Defesche. Joep C. Defesche is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hartgers, Merel L., Laurens F. Reeskamp, Linda Zuurbier, et al.. (2024). LDLR variant classification for improved cardiovascular risk prediction in familial hypercholesterolemia. Atherosclerosis. 397. 117610–117610. 2 indexed citations

Rooij, Jeroen van, Annemieke J.M.H. Verkerk, Linda Zuurbier, et al.. (2023). Low-Cost High-Throughput Genotyping for Diagnosing Familial Hypercholesterolemia. Circulation Genomic and Precision Medicine. 16(5). 462–469. 3 indexed citations

Tromp, Tycho R., M. Doortje Reijman, Albert Wiegman, et al.. (2022). Counseling couples at risk of having a child with homozygous familial hypercholesterolemia – Clinical experience and recommendations. Journal of clinical lipidology. 17(2). 291–296. 2 indexed citations

Tromp, Tycho R., Nick S. Nurmohamed, Jorge Peter, et al.. (2022). Use of Lipoprotein(a) to improve diagnosis and management in clinical familial hypercholesterolemia. Atherosclerosis. 365. 27–33. 8 indexed citations

Reeskamp, Laurens F., Jorge Peter, M. Mahdi Motazacker, et al.. (2021). Intronic variant screening with targeted next-generation sequencing reveals first pseudoexon in LDLR in familial hypercholesterolemia. Atherosclerosis. 321. 14–20. 10 indexed citations

Reeskamp, Laurens F., Andrea Venema, João Pereira, et al.. (2020). Differential DNA methylation in familial hypercholesterolemia. EBioMedicine. 61. 103079–103079. 16 indexed citations

Reeskamp, Laurens F., et al.. (2020). ABCG5 and ABCG8 genetic variants in familial hypercholesterolemia. Journal of clinical lipidology. 14(2). 207–217.e7. 25 indexed citations

Kastelein, John J.P., Gisle Langslet, Paul N. Hopkins, et al.. (2016). EFFICACY OF ALIROCUMAB IN 1,191 PATIENTS WITH A WIDE SPECTRUM OF MUTATIONS IN GENES CAUSATIVE FOR FAMILIAL HYPERCHOLESTEROLEMIA. Journal of the American College of Cardiology. 67(13). 1864–1864. 1 indexed citations

Sjouke, Barbara, Joep C. Defesche, Merel L. Hartgers, et al.. (2016). Double-heterozygous autosomal dominant hypercholesterolemia: Clinical characterization of an underreported disease. Journal of clinical lipidology. 10(6). 1462–1469. 19 indexed citations

10.

Gidding, Samuel S., Mary Ann Champagne, Sarah D. de Ferranti, et al.. (2015). The Agenda for Familial Hypercholesterolemia. Circulation. 132(22). 2167–2192. 450 indexed citations breakdown →

11.

Fouchier, Sigrid W. & Joep C. Defesche. (2013). Lysosomal acid lipase A and the hypercholesterolaemic phenotype. Current Opinion in Lipidology. 24(4). 332–338. 52 indexed citations

12.

Stef, Marianne, et al.. (2013). A DNA Microarray for the Detection of Point Mutations and Copy Number Variation Causing Familial Hypercholesterolemia in Europe. Journal of Molecular Diagnostics. 15(3). 362–372. 18 indexed citations

13.

Net, Jeroen B. van der, A. Cecile J.W. Janssens, Joep C. Defesche, et al.. (2008). Usefulness of Genetic Polymorphisms and Conventional Risk Factors to Predict Coronary Heart Disease in Patients With Familial Hypercholesterolemia. The American Journal of Cardiology. 103(3). 375–380. 20 indexed citations

14.

Net, Jeroen B. van der, Mojgan Yazdanpanah, Geesje M. Dallinga‐Thie, et al.. (2008). Gene-load score of the renin–angiotensin–aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia. European Heart Journal. 29(11). 1370–1376. 14 indexed citations

15.

Defesche, Joep C., et al.. (2003). Identification of a New Mutation, S305C, in Exon 7 of the Low-Density Lipoprotein Receptor Gene in a Brazilian Family with Homozygous Familial Hypercholesterolemia. Genetic Testing. 7(1). 77–79. 3 indexed citations

16.

Jansen, Angelique C.M., Sanne van Wissen, Joep C. Defesche, & John J.P. Kastelein. (2002). Phenotypic variability in familial hypercholesterolaemia: an update. Current Opinion in Lipidology. 13(2). 165–171. 79 indexed citations

17.

Defesche, Joep C., et al.. (2001). Review of first 5 years of screening for familial hypercholesterolaemia in the Netherlands. The Lancet. 357(9251). 165–168. 346 indexed citations

18.

Lombardi, Maria, Joep C. Defesche, Sylvia W.A. Kamerling, et al.. (2000). Molecular genetic testing for familial hypercholesterolemia: spectrum of LDL receptor gene mutations in the Netherlands. Clinical Genetics. 57(2). 116–124. 47 indexed citations

19.

Hoek, Ytje Y. van der, Arno Lingenhel, H.G. Kraft, et al.. (1997). Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB.. Journal of Clinical Investigation. 99(9). 2269–2273. 13 indexed citations

20.

Lombardi, Pietro, Sylvia W.A. Kamerling, Joep C. Defesche, John J.P. Kastelein, & Louis M. Havekes. (1996). Identification of a double mutation in the low‐density lipoprotein receptor gene causing familial hypercholesterolemia. Clinical Genetics. 50(6). 525–526. 6 indexed citations

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