James C. Whisstock

21.9k total citations · 4 hit papers
261 papers, 16.2k citations indexed

About

James C. Whisstock is a scholar working on Molecular Biology, Cancer Research and Hematology. According to data from OpenAlex, James C. Whisstock has authored 261 papers receiving a total of 16.2k indexed citations (citations by other indexed papers that have themselves been cited), including 121 papers in Molecular Biology, 70 papers in Cancer Research and 59 papers in Hematology. Recurrent topics in James C. Whisstock's work include Protease and Inhibitor Mechanisms (70 papers), Blood Coagulation and Thrombosis Mechanisms (35 papers) and Peptidase Inhibition and Analysis (24 papers). James C. Whisstock is often cited by papers focused on Protease and Inhibitor Mechanisms (70 papers), Blood Coagulation and Thrombosis Mechanisms (35 papers) and Peptidase Inhibition and Analysis (24 papers). James C. Whisstock collaborates with scholars based in Australia, United States and United Kingdom. James C. Whisstock's co-authors include Arthur M. Lesk, Joseph A. Trapani, Ilia Voskoboinik, Robert N. Pike, Phillip I. Bird, James A. Irving, Ruby H. P. Law, Stephen Bottomley, Michelle A. Dunstone and Ashley M. Buckle and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

James C. Whisstock

258 papers receiving 16.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins

2001 1.0k citations Gary A. Silverman, Phillip I. Bird et al. Journal of Biological Chemistry profile →
Perforin and granzymes: function, dysfunction and human pathology

2015 880 citations Ilia Voskoboinik, James C. Whisstock et al. profile →
MUSTANG: A multiple structural alignment algorithm

2006 563 citations James C. Whisstock et al. profile →
An overview of the serpin superfamily.

2006 527 citations Ruby H. P. Law, Qingwei Zhang et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James C. Whisstock Australia	68	7.6k	3.6k	2.7k	2.2k	2.1k	261	16.2k
Charles S. Craik United States	76	10.6k 1.4×	2.2k 0.6×	2.0k 0.7×	1.5k 0.7×	3.4k 1.6×	344	19.6k
Nissi Varki United States	73	8.7k 1.1×	5.0k 1.4×	1.3k 0.5×	1.3k 0.6×	2.9k 1.4×	173	15.7k
Eric J. Brown United States	80	9.2k 1.2×	7.3k 2.0×	1.9k 0.7×	1.4k 0.6×	3.5k 1.7×	205	20.0k
Eric Rubinstein France	62	6.0k 0.8×	2.6k 0.7×	1.4k 0.5×	1.5k 0.7×	1.2k 0.6×	239	13.9k
Phillip I. Bird Australia	50	4.2k 0.5×	3.1k 0.8×	2.0k 0.7×	1.6k 0.7×	1.1k 0.5×	189	9.2k
Robert Liddington United States	66	9.4k 1.2×	2.8k 0.8×	1.1k 0.4×	1.6k 0.7×	1.3k 0.6×	145	18.1k
Toshio Kitamura Japan	76	10.2k 1.3×	9.4k 2.6×	2.0k 0.8×	3.7k 1.7×	5.1k 2.4×	349	23.3k
Vito Türk Slovenia	85	12.8k 1.7×	2.5k 0.7×	7.1k 2.6×	1.6k 0.7×	4.3k 2.0×	424	25.3k
Matthew Bogyo United States	80	12.0k 1.6×	2.9k 0.8×	3.5k 1.3×	697 0.3×	4.7k 2.2×	300	21.5k
Christopher R. Parish Australia	64	7.4k 1.0×	7.7k 2.1×	1.2k 0.5×	1.4k 0.6×	2.2k 1.0×	330	18.5k

Countries citing papers authored by James C. Whisstock

Since Specialization

Citations

This map shows the geographic impact of James C. Whisstock's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James C. Whisstock with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James C. Whisstock more than expected).

Fields of papers citing papers by James C. Whisstock

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James C. Whisstock. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James C. Whisstock. The network helps show where James C. Whisstock may publish in the future.

Co-authorship network of co-authors of James C. Whisstock

This figure shows the co-authorship network connecting the top 25 collaborators of James C. Whisstock. A scholar is included among the top collaborators of James C. Whisstock based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James C. Whisstock. James C. Whisstock is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Talaulikar, Dipti, Sarah M. Hicks, Sidra Ali, et al.. (2024). Patients with Waldenström macroglobulinemia have impaired platelet and coagulation function. Blood Advances. 8(21). 5542–5555. 2 indexed citations

Yin, Victor, Tomislav Čaval, Vojtěch Franc, et al.. (2023). Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site. Molecular & Cellular Proteomics. 23(1). 100696–100696. 1 indexed citations

Wu, Guojie, et al.. (2023). Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors. ChemMedChem. 18(6). e202200632–e202200632. 1 indexed citations

Bayly-Jones, Charles, Hariprasad Venugopal, Michael Wermann, et al.. (2022). Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor. Nature Communications. 13(1). 6178–6178. 8 indexed citations

Dickeson, S. Kent, Mao-fu Sun, Bassem M. Mohammed, et al.. (2022). A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen. Blood. 139(18). 2816–2829. 21 indexed citations

Whisstock, James C., et al.. (2022). Macrophage self‐renewal is regulated by transient expression of PDGF‐ and VEGF‐related factor 2. FEBS Journal. 289(13). 3735–3751. 2 indexed citations

Bird, Catherina H., Cody C. Allison, Daniel Enosi Tuipulotu, et al.. (2022). Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation. Immunology and Cell Biology. 100(7). 529–546. 5 indexed citations

Rudloff, Ina, Jennifer K. Dowling, Ashley Mansell, et al.. (2020). Parsing the IL-37-Mediated Suppression of Inflammasome Function. Cells. 9(1). 178–178. 25 indexed citations

Pang, Siew Siew, Charles Bayly-Jones, Mazdak Radjainia, et al.. (2019). The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1. Nature Communications. 10(1). 4288–4288. 62 indexed citations

10.

Yuan, Yue, Damini Singh, Adam J. Quek, et al.. (2019). Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes. Journal of Structural Biology. 208(1). 18–29. 7 indexed citations

11.

Koyama, Takashi, Travis K. Johnson, James C. Whisstock, et al.. (2018). Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway in Drosophila. Genetics. 208(4). 1523–1533. 8 indexed citations

12.

House, Imran G., Colin M. House, A. J. Brennan, et al.. (2017). Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation. EMBO Reports. 18(10). 1775–1785. 28 indexed citations

13.

Ellisdon, Andrew M., Cyril F. Reboul, Santosh Panjikar, et al.. (2015). Stonefish toxin defines an ancient branch of the perforin-like superfamily. Proceedings of the National Academy of Sciences. 112(50). 15360–15365. 50 indexed citations

14.

Ellisdon, Andrew M., Qingwei Zhang, Travis K. Johnson, et al.. (2014). High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster. BMC Structural Biology. 14(1). 14–14. 14 indexed citations

15.

Bernal, Jamie Lopez, Olivia Susanto, Misty R. Jenkins, et al.. (2013). Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack. Blood. 121(14). 2659–2668. 190 indexed citations

16.

Chia, Jenny, Kim Pin Yeo, James C. Whisstock, et al.. (2009). Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer. Proceedings of the National Academy of Sciences. 106(24). 9809–9814. 94 indexed citations

17.

McGowan, Sheena, Corrine J. Porter, Jonathan Lowther, et al.. (2009). Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proceedings of the National Academy of Sciences. 106(8). 2537–2542. 121 indexed citations

18.

McGowan, Sheena, Mary C. Pearce, James A. Irving, et al.. (2007). DNA Accelerates the Inhibition of Human Cathepsin V by Serpins. Journal of Biological Chemistry. 282(51). 36980–36986. 40 indexed citations

19.

Quinsey, Noelene S., et al.. (2002). Molecular Determinants of the Mechanism Underlying Acceleration of the Interaction between Antithrombin and Factor Xa by Heparin Pentasaccharide. Journal of Biological Chemistry. 277(18). 15971–15978. 25 indexed citations

20.

Whisstock, James C., et al.. (2002). The Structure and Function of Catalytic Domains Within Inositol Polyphosphate 5‐Phosphatases. IUBMB Life. 53(1). 15–23. 44 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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