Igor Mochalkin

2.3k citations

26 papers · 1.0k · h-index 18

Impact in

Hematology top 10%
- Blood Coagulation and Thrombosis Mechanisms
Pulmonary and Respiratory Medicine top 10%
- Blood properties and coagulation

Papers in

Molecular Biology 14
Organic Chemistry 7
- Click Chemistry and Applications 2

Co-authors: Russell F. Doolittle (3 shared papers)Zhe Yang (3 shared papers)Sandra Lightle (6 shared papers)A. Tulinsky (6 shared papers)John D. Knafels (2 shared papers)J. Richard Miller (2 shared papers)C. Kendall Stover (2 shared papers)Beisong Cheng (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (6 papers)Protein Science (4 papers)Proceedings of the National Academy of Sciences (2 papers)Biochemistry (2 papers)Bioorganic & Medicinal Chemistry (2 papers)
Partner nations: United States Italy Switzerland

In The Last Decade

Igor Mochalkin

26 papers receiving 1.0k citations

Peers

Countries citing papers authored by Igor Mochalkin

Since Specialization

Citations

This map shows the geographic impact of Igor Mochalkin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Igor Mochalkin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Igor Mochalkin more than expected).

Fields of papers citing papers by Igor Mochalkin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Igor Mochalkin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Igor Mochalkin. The network helps show where Igor Mochalkin may publish in the future.

Co-authors

The 25 scholars most cited alongside Igor Mochalkin, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Igor Mochalkin Line = papers co-authored together Igor Mochalkin links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides Proceedings of the National Academy of Sciences ·Zhe Yang, Igor Mochalkin, Russell F. Doolittle	2000	168
2	Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120 Cancer Discovery ·Shih-Hsun Chen, Youyan Zhang, Robert D. Van Horn, Tinggui Yin, Sean G. Buchanan, Vipin Yadav, Igor Mochalkin, Swee Seong Wong, Yong Yue, Lysiane Huber, Ilaria Conti, James R. Henry, James J. Starling, Gregory D. Plowman, Sheng-Bin Peng	2016	119
3	Structure and Ligand Binding Determinants of the Recombinant Kringle 5 Domain of Human Plasminogen^, Biochemistry ·(unknown), Igor Mochalkin, Stephen G. McCance, Beisong Cheng, A. Tulinsky, Francis Castellino	1998	77
4	Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches ACS Chemical Biology ·Igor Mochalkin, J. Richard Miller, Lakshmi Narasimhan, V. Thanabal, Paul Erdman, Philip B. Cox, J. V. N. Vara Prasad, Sandra Lightle, Michael D. Huband, C. Kendall Stover	2009	75
5	Structural evidence for substrate‐induced synergism and half‐sites reactivity in biotin carboxylase Protein Science ·Igor Mochalkin, J. Richard Miller, A.G. Evdokimov, Sandra Lightle, Chunhong Yan, C. Kendall Stover, Grover L. Waldrop	2008	67
6	Crystal structure of native chicken fibrinogen at 5.5-Å resolution Proceedings of the National Academy of Sciences ·Zhe Yang, Igor Mochalkin, L. Veerapandian, Marcia Riley, Russell F. Doolittle	2000	64
7	Structure and binding determinants of the recombinant kringle-2 domain of human plasminogen to an internal peptide from a group A Streptococcal surface protein 1 1Edited by R. Huber Journal of Molecular Biology ·Jorge L. Ríos-Steiner, Mónica Schenone, Igor Mochalkin, A. Tulinsky, Francis J. Castellino	2001	53
8	Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB‐78485 inhibitor Protein Science ·Igor Mochalkin, John D. Knafels, Sandra Lightle	2008	48
9	Structure of a small‐molecule inhibitor complexed with GlmU from Haemophilus influenzae reveals an allosteric binding site Protein Science ·Igor Mochalkin, Sandra Lightle, Lakshmi Narasimhan, Dirk A. Bornemeier, Michael Melnick, Steven VanderRoest, Laura McDowell	2008	44
10	Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors Bioorganic & Medicinal Chemistry ·Noel A. Powell, Fred L. Ciske, Cuiman Cai, Daniel D. Holsworth, Ken Mennen, Chad A. Van Huis, Mehran Jalaie, Jacqueline E. Day, Michelle Mastronardi, Pat McConnell, Igor Mochalkin, Erli Zhang, Michael J. Ryan, John W. Bryant, Wendy T. Collard, Suzie A. Ferreira, Chungang Gu, Roxane Collins, Jeremy J. Edmunds	2007	43
11	Characterization of substrate binding and catalysis in the potential antibacterial target N‐acetylglucosamine‐1‐phosphate uridyltransferase (GlmU) Protein Science ·Igor Mochalkin, Sandra Lightle, Yaqi Zhu, Jeffrey F. Ohren, Cindy Spessard, Nickolay Y. Chirgadze, Craig Banotai, Michael Melnick, Laura McDowell	2007	38
12	Crystal Structure Studies on Fibrinogen and Fibrin Annals of the New York Academy of Sciences ·Russell F. Doolittle, Zhe Yang, Igor Mochalkin	2001	34
13	Binding thermodynamics of substituted diaminopyrimidine renin inhibitors Analytical Biochemistry ·Ronald W. Sarver, Jeanette Peevers, Wayne L. Cody, Fred L. Ciske, Jim Dyer, S. Donald Emerson, Jeanne C. Hagadorn, Daniel D. Holsworth, Mehran Jalaie, Michael D. Kaufman, Michelle Mastronardi, Patrick McConnell, Noel A. Powell, John Quin, Chad A. Van Huis, Erli Zhang, Igor Mochalkin	2006	34
14	Recent progress towards clinically relevant ATP-competitive Akt inhibitors Bioorganic & Medicinal Chemistry Letters ·Bayard R. Huck, Igor Mochalkin	2017	29
15	Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC Bioorganic & Medicinal Chemistry Letters ·Joseph S. Warmus, Cheryl L. Quinn, Clarke Taylor, Sean T. Murphy, Timothy A. Johnson, Chris Limberakis, Daniel F. Ortwine, Joel C. Bronstein, Paul Pagano, John D. Knafels, Sandra Lightle, Igor Mochalkin, Roger J. Brideau, Terry Podoll	2012	28
16	Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors Bioorganic & Medicinal Chemistry Letters ·Daniel D. Holsworth, Mehran Jalaie, Thomas R. Belliotti, Cuiman Cai, Wendy T. Collard, Suzie A. Ferreira, Noel A. Powell, Michael A. Stier, Erli Zhang, Pat McConnell, Igor Mochalkin, Michael J. Ryan, John W. Bryant, Tingsheng Li, Aparna Kasani, Rajendra Subedi, Samarendra N. Maiti, Jeremy J. Edmunds	2007	19
17	Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit Bioorganic & Medicinal Chemistry Letters ·Hui Qiu, Lesley Liu‐Bujalski, Richard D. Caldwell, Ariele Viacava Follis, A.S. Gardberg, Andreas Goutopoulos, Roland Grenningloh, Jared Head, Theresa Johnson, Reinaldo Jones, Igor Mochalkin, Federica Morandi, Constantin Neagu, Brian Sherer	2018	19
18	Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action Bioorganic & Medicinal Chemistry ·Chad A. Van Huis, Agustin Casimiro‐Garcia, Christopher F. Bigge, Wayne L. Cody, Danette A. Dudley, Kevin J. Filipski, Ronald J. Heemstra, Jeffrey T. Kohrt, Robert J. Leadley, Lakshmi Narasimhan, Thomas B. McClanahan, Igor Mochalkin, Michael Pamment, Janet T. Peterson, Vaishali Sahasrabudhe, Robert Schaum, Jeremy J. Edmunds	2009	17
19	Recombinant Kringle IV-10 Modules of Human Apolipoprotein(a): Structure, Ligand Binding Modes, and Biological Relevance Biochemistry ·Igor Mochalkin, Beisong Cheng, Olga Klezovitch, Angelo M. Scanu, A. Tulinsky	1999	17
20	Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk Bioorganic & Medicinal Chemistry Letters ·Richard D. Caldwell, Lesley Liu‐Bujalski, Hui Qiu, Igor Mochalkin, Reinaldo Jones, Constantin Neagu, Andreas Goutopoulos, Roland Grenningloh, Theresa Johnson, Brian Sherer, A.S. Gardberg, Ariele Viacava Follis, Federica Morandi, Jared Head	2018	15

About Igor Mochalkin

Igor Mochalkin is a scholar working on Molecular Biology, Organic Chemistry, Genetics, Hematology and Materials Chemistry, having authored 26 papers that have together received 1.0k indexed citations. Recurring topics across this work include Enzyme Structure and Function (5 papers), Chronic Lymphocytic Leukemia Research (5 papers), Protease and Inhibitor Mechanisms (4 papers), Lymphoma Diagnosis and Treatment (4 papers), Monoclonal and Polyclonal Antibodies Research (3 papers), Blood properties and coagulation (3 papers), Blood Coagulation and Thrombosis Mechanisms (3 papers) and Click Chemistry and Applications (2 papers). The work is most often cited by research in Hematology (114 citations), Pulmonary and Respiratory Medicine (230 citations), Cancer Research (105 citations), Molecular Medicine (37 citations) and Molecular Biology (498 citations). Igor Mochalkin has collaborated with scholars based in United States, Italy and Switzerland. Frequent co-authors include Russell F. Doolittle, Zhe Yang, Sandra Lightle, A. Tulinsky, John D. Knafels, J. Richard Miller, C. Kendall Stover, Beisong Cheng, Bayard R. Huck and Lakshmi Narasimhan. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Protein Science, Proceedings of the National Academy of Sciences, Biochemistry and Bioorganic & Medicinal Chemistry.

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Igor Mochalkin

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