Ignacio Moraleda

1.8k citations

36 papers · 1.4k indexed · h-index 24

Impact in

Pharmacology top 0.5%
- Cholinesterase and Neurodegenerative Diseases
Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods

Papers in ⓘ

Pharmacology 31
- Cholinesterase and Neurodegenerative Diseases 31
- Synthesis of Organic Compounds 3
Organic Chemistry 19
- Chemical synthesis and alkaloids 9
- Synthesis and biological activity 8

Co-authors: Isabel Iriepa (35 shared papers)José Marco‐Contelles (27 shared papers)Abdelouahid Samadi (13 shared papers)Mourad Chioua (15 shared papers)Mercedes Unzeta (5 shared papers)Gerard Esteban (4 shared papers)Enrique J. Galvez (7 shared papers)Óscar M. Bautista‐Aguilera (4 shared papers)
Journals: European Journal of Medicinal Chemistry (13 papers)Molecules (3 papers)Journal of Enzyme Inhibition and Medicinal Chemistry (2 papers)Bioorganic Chemistry (2 papers)Future Medicinal Chemistry (2 papers)
Partner nations: Spain Italy France

In The Last Decade

Ignacio Moraleda

36 papers receiving 1.4k citations

Peers

Countries citing papers authored by Ignacio Moraleda

Since Specialization

Citations

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Fields of papers citing papers by Ignacio Moraleda

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ignacio Moraleda. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ignacio Moraleda. The network helps show where Ignacio Moraleda may publish in the future.

Co-authors

The 25 scholars most cited alongside Ignacio Moraleda, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ignacio Moraleda Line = papers co-authored together Ignacio Moraleda links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 36 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease European Journal of Medicinal Chemistry ·Li Wang, Gerard Esteban, Masaki Ojima, Óscar M. Bautista‐Aguilera, Tsutomu Inokuchi, Ignacio Moraleda, Isabel Iriepa, Abdelouahid Samadi, Moussa B. H. Youdim, Alejandro Romero, Elena Soriano, Raquel Herrero-Labrador, Ana Patricia Fernández, Ricardo-Martínez-Murillo, José Marco‐Contelles, Mercedes Unzeta	2014	127
2	Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease European Journal of Medicinal Chemistry ·Óscar M. Bautista‐Aguilera, Gerard Esteban, Irene Bolea, Katarina Nikolić, Danica Agbaba, Ignacio Moraleda, Isabel Iriepa, Abdelouahid Samadi, Elena Soriano, Mercedes Unzeta, José Marco‐Contelles	2014	116
3	Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase European Journal of Medicinal Chemistry ·Ehab D. AlFadly, Perihan A. Elzahhar, Anna Tramarin, Salwa Elkazaz, Hossam A. Shaltout, Marwa M. Abu‐Serie, Jana Janočková, Ondřej Soukup, Doaa A. Ghareeb, Ahmed F. El‐Yazbi, Rim W. Rafeh, Nour‐Mounira Z. Bakkar, Firas Kobeissy, Isabel Iriepa, Ignacio Moraleda, Manal N. Saudi, Manuela Bartolini, Ahmed S.F. Belal	2019	83
4	Synthesis, Inhibitory Activity of Cholinesterases, and Neuroprotective Profile of Novel 1,8-Naphthyridine Derivatives Journal of Medicinal Chemistry ·Cristóbal de los Rı́os, Javier Egea, José Marco‐Contelles, Rafael León, Abdelouahid Samadi, Isabel Iriepa, Ignacio Moraleda, Enrique J. Galvez, Antonio G. Garcı́a, Manuela G. López, Mércedes Villarroya, Alejandro Romero	2010	74
5	Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease European Journal of Medicinal Chemistry ·Emna Maalej, Fakher Chabchoub, María Jesús Oset‐Gasque, Mario Esquivias-Pérez, María Pilar González, Leticia Monjas, Concepción Pérez, Cristóbal de los Rı́os, Marı́a Isabel Rodrı́guez-Franco, Isabel Iriepa, Ignacio Moraleda, Mourad Chioua, Alejandro Romero, José Marco‐Contelles, Abdelouahid Samadi	2012	67
6	Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification Proceedings of the National Academy of Sciences ·Ricardo Caballero, Pablo Dolz-Gaitón, Ricardo Gómez, Irene Amorós, Adriana Barana, Marta González de la Fuente, Lourdes Osuna Almagro, Juan Duarte, Angélica López-Izquierdo, Ignacio Moraleda, Enrique J. Galvez, José A. Sánchez‐Chapula, Juan Tamargo, Eva Delpón	2010	64
7	Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine European Journal of Medicinal Chemistry ·Abdelouahid Samadi, Cristóbal de los Rı́os, Irene Bolea, Mourad Chioua, Isabel Iriepa, Ignacio Moraleda, Manuela Bartolini, Vincenza Andrisano, Enrique J. Galvez, Carolina Valderas, Mercedes Unzeta, José Marco‐Contelles	2012	62
8	Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease European Journal of Medicinal Chemistry ·Abdelouahid Samadi, Mourad Chioua, Irene Bolea, Cristóbal de los Rı́os, Isabel Iriepa, Ignacio Moraleda, Ágatha Bastida, Gerard Esteban, Mercedes Unzeta, Enrique J. Galvez, José Marco‐Contelles	2011	61
9	Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling European Journal of Medicinal Chemistry ·Abdelouahid Samadi, Martín Estrada, Concepción Pérez, Marı́a Isabel Rodrı́guez-Franco, Isabel Iriepa, Ignacio Moraleda, Mourad Chioua, José Marco‐Contelles	2012	56
10	Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids Drug Design Development and Therapy ·José Marco-Contelles, Óscar M. Bautista‐Aguilera, Gerard Esteban, Mourad Chioua, Katarina Nikolić, Danica Agbaba, Ignacio Moraleda, Isabel Iriepa, Elena Soriano, Abdelouahid Samadi, Mercedes Unzeta	2014	51
11	Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity ACS Chemical Neuroscience ·Daniel Silva, Mourad Chioua, Abdelouahid Samadi, Paula Agostinho, Pedro Garção, Rocío Lajarín-Cuesta, Cristóbal de los Rı́os, Isabel Iriepa, Ignacio Moraleda, Laura González‐Lafuente, Eduarda Mendes, Concepción Pérez, Marı́a Isabel Rodrı́guez-Franco, José Marco‐Contelles, M. Carmo Carreiras	2013	50
12	Harmaline and hispidin from Peganum harmala and Inonotus hispidus with binding affinity to Candida rugosa lipase: In silico and in vitro studies Bioorganic Chemistry ·Khedidja Benarous, Isabelle Bombarda, Isabel Iriepa, Ignacio Moraleda, Gaëtan Herbette, Abderahmane Linani, Djilali Tahri, M. Sebaa, Mohamed Yousfi	2015	49
13	Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy Journal of Enzyme Inhibition and Medicinal Chemistry ·Irène Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Hélène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez‐Iriepa, María Jesús Oset‐Gasque, José Marco‐Contelles, Kamil Musílek, Lhassane Ismaïli	2019	48
14	Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease European Journal of Medicinal Chemistry ·Nuria García-Font, H. Hayour, Ali Belfaitah, Jorge Pedraz, Ignacio Moraleda, Isabel Iriepa, Abdelmalek Bouraiou, Mourad Chioua, José Marco‐Contelles, María Jesús Oset‐Gasque	2016	46
15	Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile Journal of Medicinal Chemistry ·Óscar M. Bautista‐Aguilera, Josiane Budni, Francielle Mina, Eduarda Behenck Medeiros, Winnie Deuther‐Conrad, José Manuel Entrena, Ignacio Moraleda, Isabel Iriepa, Francisco López‐Muñoz, José Marco‐Contelles	2018	46
16	Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease European Journal of Medicinal Chemistry ·Mourad Chioua, Eleonora Buzzi, Ignacio Moraleda, Isabel Iriepa, Maciej Maj, Artur Wnorowski, Catia Giovannini, Anna Tramarin, Federica Portali, Lhassane Ismaïli, Pilar López‐Alvarado, María Laura Bolognesi, Krzysztof Jóźwiak, J. Carlos Menéndez, José Marco‐Contelles, Manuela Bartolini	2018	43
17	Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment European Journal of Medicinal Chemistry ·Serena Montanari, Alì Mokhtar Mahmoud, Letizia Pruccoli, Alessandro Rabbito, Marina Naldi, Sabrina Petralla, Ignacio Moraleda, Manuela Bartolini, Barbara Monti, Isabel Iriepa, Federica Belluti, Silvia Gobbi, Vincenzo Di Marzo, Alessandra Bisi, Andrea Tarozzi, Alessia Ligresti, Angela Rampa	2019	41
18	Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues European Journal of Medicinal Chemistry ·Carla P. Martins, M. Carmo Carreiras, Rafael León, Cristóbal de los Rı́os, Manuela Bartolini, Vincenza Andrisano, Isabel Iriepa, Ignacio Moraleda, Enrique J. Galvez, Manuela E. García, Javier Egea, Abdelouahid Samadi, Mourad Chioua, José Marco‐Contelles	2011	41
19	Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy European Journal of Medicinal Chemistry ·Youssef Dgachi, Olga Sokolov, Vincent Luzet, Justyna Godyń, Dawid Panek, Alexandre Bonet, Hélène Martin, Isabel Iriepa, Ignacio Moraleda, Cristina García‐Iriepa, Jana Janočková, Lysiane Richert, Ondřej Soukup, Barbara Malawska, Fakher Chabchoub, José Marco‐Contelles, Lhassane Ismaïli	2016	34
20	Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease European Journal of Medicinal Chemistry ·Abdelouahid Samadi, Mario de la Fuente Revenga, Concepción Pérez, Isabel Iriepa, Ignacio Moraleda, Marı́a Isabel Rodrı́guez-Franco, José Marco‐Contelles	2013	33

About Ignacio Moraleda

Ignacio Moraleda is a scholar working on Pharmacology, Organic Chemistry, Computational Theory and Mathematics, Molecular Biology and Physiology, having authored 36 papers that have together received 1.4k indexed citations. Recurring topics across this work include Cholinesterase and Neurodegenerative Diseases (31 papers), Computational Drug Discovery Methods (18 papers), Nicotinic Acetylcholine Receptors Study (11 papers), Chemical synthesis and alkaloids (9 papers), Synthesis and biological activity (8 papers), Alzheimer's disease research and treatments (4 papers), Synthesis of Organic Compounds (3 papers) and Cardiac electrophysiology and arrhythmias (2 papers). The work is most often cited by research in Pharmacology (922 citations), Computational Theory and Mathematics (614 citations), Organic Chemistry (655 citations), Complementary and alternative medicine (152 citations) and Physiology (257 citations). Ignacio Moraleda has collaborated with scholars based in Spain, Italy and France. Frequent co-authors include Isabel Iriepa, José Marco‐Contelles, Abdelouahid Samadi, Mourad Chioua, Mercedes Unzeta, Gerard Esteban, Enrique J. Galvez, Óscar M. Bautista‐Aguilera, Cristóbal de los Rı́os and Manuela Bartolini. Their work appears in journals such as European Journal of Medicinal Chemistry, Molecules, Journal of Enzyme Inhibition and Medicinal Chemistry, Bioorganic Chemistry and Future Medicinal Chemistry.

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