Ian M. Copple

3.3k total citations · 1 hit paper
37 papers, 2.2k citations indexed

About

Ian M. Copple is a scholar working on Molecular Biology, Pharmacology and Biochemistry. According to data from OpenAlex, Ian M. Copple has authored 37 papers receiving a total of 2.2k indexed citations (citations by other indexed papers that have themselves been cited), including 28 papers in Molecular Biology, 8 papers in Pharmacology and 5 papers in Biochemistry. Recurrent topics in Ian M. Copple's work include Genomics, phytochemicals, and oxidative stress (25 papers), Glutathione Transferases and Polymorphisms (15 papers) and Drug-Induced Hepatotoxicity and Protection (7 papers). Ian M. Copple is often cited by papers focused on Genomics, phytochemicals, and oxidative stress (25 papers), Glutathione Transferases and Polymorphisms (15 papers) and Drug-Induced Hepatotoxicity and Protection (7 papers). Ian M. Copple collaborates with scholars based in United Kingdom, United States and Switzerland. Ian M. Copple's co-authors include Christopher E. Goldring, Neil R. Kitteringham, Albena T. Dinkova‐Kostova, Luke M. Shelton, B. Kevin Park, Rosalind E. Jenkins, Paul M. O’Neill, B. Kevin Park, Adam Lister and Robert Layfield and has published in prestigious journals such as Journal of Biological Chemistry, Hepatology and Scientific Reports.

In The Last Decade

Ian M. Copple

37 papers receiving 2.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Advances and challenges in therapeutic targeting of NRF2

2023 149 citations Albena T. Dinkova‐Kostova, Ian M. Copple Trends in Pharmacological Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Ian M. Copple United Kingdom	22	1.5k	248	209	172	167	37	2.2k
Lin Luo China	16	1.1k 0.7×	195 0.8×	188 0.9×	119 0.7×	129 0.8×	32	2.1k
Yen‐Chou Chen Taiwan	24	1.5k 0.9×	169 0.7×	114 0.5×	114 0.7×	213 1.3×	44	2.5k
Heyao Wang China	30	1.2k 0.8×	191 0.8×	250 1.2×	176 1.0×	163 1.0×	111	2.4k
Keon Wook Kang South Korea	30	1.7k 1.1×	226 0.9×	292 1.4×	139 0.8×	295 1.8×	87	2.7k
Philip J. Sherratt United Kingdom	14	2.1k 1.3×	168 0.7×	129 0.6×	190 1.1×	198 1.2×	16	2.6k
Qi Jia China	29	973 0.6×	257 1.0×	148 0.7×	88 0.5×	205 1.2×	146	2.5k
Sujit Nair India	25	1.7k 1.1×	159 0.6×	112 0.5×	277 1.6×	246 1.5×	65	2.7k
Chia-Wen Tsai Taiwan	25	920 0.6×	128 0.5×	133 0.6×	124 0.7×	221 1.3×	125	1.9k
Pengfei Gong China	24	2.3k 1.5×	165 0.7×	271 1.3×	163 0.9×	191 1.1×	48	3.3k

Countries citing papers authored by Ian M. Copple

Since Specialization

Citations

This map shows the geographic impact of Ian M. Copple's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ian M. Copple with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ian M. Copple more than expected).

Fields of papers citing papers by Ian M. Copple

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ian M. Copple. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ian M. Copple. The network helps show where Ian M. Copple may publish in the future.

Co-authorship network of co-authors of Ian M. Copple

This figure shows the co-authorship network connecting the top 25 collaborators of Ian M. Copple. A scholar is included among the top collaborators of Ian M. Copple based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ian M. Copple. Ian M. Copple is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Jakubowska, Monika A., Vera Marisa Costa, Wojciech Krzeptowski, et al.. (2025). Altered NRF2 signalling in systemic redox imbalance: Insights from non-communicable diseases. Redox Biology. 87. 103891–103891. 3 indexed citations

Livoti, Lucia A, Rowena Sison‐Young, Ciarán Fisher, et al.. (2024). Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models. Toxicological Sciences. 203(1). 35–40. 1 indexed citations

Dinkova‐Kostova, Albena T. & Ian M. Copple. (2023). Advances and challenges in therapeutic targeting of NRF2. Trends in Pharmacological Sciences. 44(3). 137–149. 149 indexed citations breakdown →

Copple, Ian M., et al.. (2022). Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer. Molecular Therapy — Nucleic Acids. 31. 211–223. 24 indexed citations

Copple, Ian M., B. Kevin Park, & Christopher E. Goldring. (2021). Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening. Hepatology. 74(1). 513–515. 3 indexed citations

Colley, Helen, Craig Murdoch, Steven D. Webb, et al.. (2019). Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway. Biomedicine & Pharmacotherapy. 112. 108637–108637. 21 indexed citations

Lister, Adam, Soline Bourgeois, Pedro Henrique Imenez Silva, et al.. (2018). NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis. Scientific Reports. 8(1). 5629–5629. 23 indexed citations

Copple, Ian M., Wouter den Hollander, James L. Maggs, et al.. (2018). Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury. Archives of Toxicology. 93(2). 385–399. 22 indexed citations

Oni, Louise, Daniel B. Hawcutt, MW Beresford, et al.. (2017). Optimising the use of medicines to reduce acute kidney injury in children and babies. Pharmacology & Therapeutics. 174. 55–62. 8 indexed citations

10.

Forootan, Shiva S., Anja Kipar, Takao Iwawaki, et al.. (2017). Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity. Scientific Reports. 7(1). 16084–16084. 12 indexed citations

11.

Clarke, Jessica, et al.. (2016). Roles of Nrf2 in drug and chemical toxicity. Current Opinion in Toxicology. 1. 104–110. 20 indexed citations

12.

Shelton, Luke M., Adam Lister, Joanne Walsh, et al.. (2015). Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney. Kidney International. 88(6). 1261–1273. 44 indexed citations

13.

Copple, Ian M., Luke M. Shelton, Joanne Walsh, et al.. (2014). Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids. Toxicological Sciences. 140(2). 462–469. 20 indexed citations

14.

Shelton, Luke M., et al.. (2013). Role of Nrf2 in protection against acute kidney injury. Kidney International. 84(6). 1090–1095. 170 indexed citations

15.

Copple, Ian M.. (2012). The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?. Advances in pharmacology. 63. 43–79. 146 indexed citations

16.

Nedjadi, Taoufik, Neil R. Kitteringham, Fiona Campbell, et al.. (2011). Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Molecular Cancer. 10(1). 37–37. 205 indexed citations

17.

Mercer, Amy E., Ian M. Copple, James L. Maggs, Paul M. O’Neill, & B. Kevin Park. (2010). The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials. Journal of Biological Chemistry. 286(2). 987–996. 127 indexed citations

18.

Copple, Ian M., Adam Lister, Neil R. Kitteringham, et al.. (2010). Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway. Journal of Biological Chemistry. 285(22). 16782–16788. 225 indexed citations

19.

Copple, Ian M., Christopher E. Goldring, Neil R. Kitteringham, & B. Kevin Park. (2009). The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity. Handbook of experimental pharmacology. 233–266. 77 indexed citations

20.

Copple, Ian M., Christopher E. Goldring, Rosalind E. Jenkins, et al.. (2008). The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system†. Hepatology. 48(4). 1292–1301. 104 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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