H.T. Claude Chan

4.9k total citations
54 papers, 3.5k citations indexed

About

H.T. Claude Chan is a scholar working on Radiology, Nuclear Medicine and Imaging, Immunology and Oncology. According to data from OpenAlex, H.T. Claude Chan has authored 54 papers receiving a total of 3.5k indexed citations (citations by other indexed papers that have themselves been cited), including 41 papers in Radiology, Nuclear Medicine and Imaging, 33 papers in Immunology and 19 papers in Oncology. Recurrent topics in H.T. Claude Chan's work include Monoclonal and Polyclonal Antibodies Research (40 papers), T-cell and B-cell Immunology (18 papers) and CAR-T cell therapy research (13 papers). H.T. Claude Chan is often cited by papers focused on Monoclonal and Polyclonal Antibodies Research (40 papers), T-cell and B-cell Immunology (18 papers) and CAR-T cell therapy research (13 papers). H.T. Claude Chan collaborates with scholars based in United Kingdom, Netherlands and United States. H.T. Claude Chan's co-authors include Martin J. Glennie, Ruth R. French, Mark S. Cragg, Stephen A. Beers, Alison L. Tutt, Peter Johnson, C. Ian Mockridge, Sean H. Lim, Kerry L. Cox and J. Sjef Verbeek and has published in prestigious journals such as Nature, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

H.T. Claude Chan

53 papers receiving 3.4k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
H.T. Claude Chan United Kingdom 29 2.1k 1.8k 1.2k 869 807 54 3.5k
Ruth R. French United Kingdom 32 2.7k 1.3× 2.3k 1.3× 1.5k 1.2× 1.1k 1.3× 1.0k 1.3× 58 4.5k
Pablo Umaña Switzerland 32 2.3k 1.1× 2.7k 1.5× 1.8k 1.6× 2.4k 2.8× 678 0.8× 119 5.2k
C. Ian Mockridge United Kingdom 28 1.3k 0.6× 874 0.5× 523 0.4× 590 0.7× 756 0.9× 43 2.1k
Thomas M. Cardillo United States 38 818 0.4× 2.0k 1.1× 2.4k 2.0× 1.3k 1.5× 256 0.3× 94 4.1k
Dana A. Kennedy United States 24 887 0.4× 891 0.5× 2.8k 2.4× 437 0.5× 761 0.9× 50 4.5k
Craig Okada United States 20 1.7k 0.8× 407 0.2× 749 0.6× 760 0.9× 249 0.3× 49 2.6k
Kerry Klussman United States 19 1.8k 0.9× 938 0.5× 1.4k 1.2× 792 0.9× 201 0.2× 37 3.4k
Fumiko Arakawa Japan 23 603 0.3× 468 0.3× 1.2k 1.0× 572 0.7× 373 0.5× 98 2.3k
Paul V. Beum United States 17 970 0.5× 809 0.5× 337 0.3× 322 0.4× 587 0.7× 29 1.6k
R. Katherine Alpaugh United States 37 1.1k 0.5× 996 0.6× 2.6k 2.2× 1.7k 1.9× 145 0.2× 112 4.5k

Countries citing papers authored by H.T. Claude Chan

Since Specialization
Citations

This map shows the geographic impact of H.T. Claude Chan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by H.T. Claude Chan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites H.T. Claude Chan more than expected).

Fields of papers citing papers by H.T. Claude Chan

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by H.T. Claude Chan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by H.T. Claude Chan. The network helps show where H.T. Claude Chan may publish in the future.

Co-authorship network of co-authors of H.T. Claude Chan

This figure shows the co-authorship network connecting the top 25 collaborators of H.T. Claude Chan. A scholar is included among the top collaborators of H.T. Claude Chan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with H.T. Claude Chan. H.T. Claude Chan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Chan, H.T. Claude, Tatyana Inzhelevskaya, C. Ian Mockridge, et al.. (2025). Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nature Communications. 16(1). 3495–3495. 1 indexed citations
2.
Yu, Xiaojie, Christian M. Orr, H.T. Claude Chan, et al.. (2023). Reducing affinity as a strategy to boost immunomodulatory antibody agonism. Nature. 614(7948). 539–547. 71 indexed citations
3.
Allen, Joel D., Sarah L. Buchan, Jinny Kim, et al.. (2023). Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc. Frontiers in Immunology. 14. 1252274–1252274. 1 indexed citations
4.
Orr, Christian M., Xiaojie Yu, H.T. Claude Chan, et al.. (2022). Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility. Science Immunology. 7(73). eabm3723–eabm3723. 30 indexed citations
5.
Roghanian, Ali, Robert Oldham, H.T. Claude Chan, et al.. (2022). FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms. Cell Reports. 40(3). 111099–111099. 16 indexed citations
6.
Chan, H.T. Claude, Michael J. Marshall, Christine A. Penfold, et al.. (2022). Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering. Communications Biology. 5(1). 229–229. 12 indexed citations
7.
Yu, Xiaojie, Sonya James, James H. Felce, et al.. (2021). TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity. Communications Biology. 4(1). 772–772. 35 indexed citations
8.
Yu, Xiaojie, H.T. Claude Chan, Christine A. Penfold, et al.. (2020). Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity. Cancer Cell. 37(6). 850–866.e7. 48 indexed citations
9.
Oldham, Robert, Alison L. Tutt, Patrick J. Duriez, et al.. (2018). Detection of Experimental and Clinical Immune Complexes by Measuring SHIP-1 Recruitment to the Inhibitory FcγRIIB. The Journal of Immunology. 200(5). 1937–1950. 6 indexed citations
10.
Cleary, Kirstie L.S., et al.. (2017). Antibody Distance from the Cell Membrane Regulates Antibody Effector Mechanisms. The Journal of Immunology. 198(10). 3999–4011. 92 indexed citations
11.
White, Ann L., H.T. Claude Chan, Ruth R. French, et al.. (2013). FcγRΙΙB controls the potency of agonistic anti-TNFR mAbs. Cancer Immunology Immunotherapy. 62(5). 941–948. 34 indexed citations
12.
Alduaij, Waleed, Andrei Ivanov, Jamie Honeychurch, et al.. (2011). Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood. 117(17). 4519–4529. 222 indexed citations
13.
Beers, Stephen A., Ruth R. French, H.T. Claude Chan, et al.. (2010). Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Blood. 115(25). 5191–5201. 241 indexed citations
14.
Beers, Stephen A., H.T. Claude Chan, Ruth R. French, Mark S. Cragg, & Martin J. Glennie. (2010). CD20 as a Target for Therapeutic Type I and II Monoclonal Antibodies. Seminars in Hematology. 47(2). 107–114. 167 indexed citations
15.
Иванов, А. В., Stephen A. Beers, Claire A. Walshe, et al.. (2009). Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. Journal of Clinical Investigation. 119(8). 2143–59. 142 indexed citations
16.
Walshe, Claire A., Stephen A. Beers, Ruth R. French, et al.. (2008). Induction of Cytosolic Calcium Flux by CD20 Is Dependent upon B Cell Antigen Receptor Signaling. Journal of Biological Chemistry. 283(25). 16971–16984. 117 indexed citations
17.
Savage, Philip, Julian Dyson, Ben C. King, et al.. (2007). Immunotherapy with Antibody-Targeted HLA Class I Complexes: Results of in vivo Tumour Cell Killing and Therapeutic Vaccination. Tumor Biology. 28(4). 205–211. 4 indexed citations
18.
Taraban, Vadim Y., Tania F. Rowley, Lyn M. O’Brien, et al.. (2002). Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses. European Journal of Immunology. 32(12). 3617–3627. 120 indexed citations
19.
French, Ruth R., H.T. Claude Chan, Alison L. Tutt, & Martin J. Glennie. (1999). CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nature Medicine. 5(5). 548–553. 348 indexed citations
20.
Chan, H.T. Claude. (1992). The mechanism of inhibition by EDTA and EGTA of methanol oxidation by methylotrophic bacteria. FEMS Microbiology Letters. 96(2-3). 231–234. 16 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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