Hiroyuki Mano

30.2k total citations · 6 hit papers
262 papers, 19.5k citations indexed

About

Hiroyuki Mano is a scholar working on Molecular Biology, Oncology and Pulmonary and Respiratory Medicine. According to data from OpenAlex, Hiroyuki Mano has authored 262 papers receiving a total of 19.5k indexed citations (citations by other indexed papers that have themselves been cited), including 133 papers in Molecular Biology, 94 papers in Oncology and 71 papers in Pulmonary and Respiratory Medicine. Recurrent topics in Hiroyuki Mano's work include Lung Cancer Treatments and Mutations (48 papers), Cancer Genomics and Diagnostics (37 papers) and Lung Cancer Research Studies (25 papers). Hiroyuki Mano is often cited by papers focused on Lung Cancer Treatments and Mutations (48 papers), Cancer Genomics and Diagnostics (37 papers) and Lung Cancer Research Studies (25 papers). Hiroyuki Mano collaborates with scholars based in Japan, United States and United Kingdom. Hiroyuki Mano's co-authors include Manabu Soda, Young Lim Choi, Yoshihiro Yamashita, Yuichi Ishikawa, Shuji Takada, Kengo Takeuchi, Munehiro Enomoto, Toshihide Ueno, Yukihiko Sugiyama and Hisashi Hatanaka and has published in prestigious journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Hiroyuki Mano

257 papers receiving 19.1k citations

Hit Papers

Identification of the tra... 1994 2026 2004 2015 2007 2012 2010 2008 1994 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
    2007 4.0k citations Manabu Soda, Young Lim Choi et al. Nature profile →
  2. RET, ROS1 and ALK fusions in lung cancer
    2012 963 citations Kengo Takeuchi, Manabu Soda et al. profile →
  3. EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
    2010 915 citations Young Lim Choi, Manabu Soda et al. profile →
  4. Oncogenic mutations of ALK kinase in neuroblastoma
    2008 640 citations Young Lim Choi, Manabu Soda et al. Nature profile →
  5. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.
    1994 582 citations Hiroyuki Mano et al. profile →
  6. KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer
    2009 557 citations Kengo Takeuchi, Young Lim Choi et al. Clinical Cancer Research profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Hiroyuki Mano Japan 66 9.4k 8.5k 8.4k 4.6k 2.3k 262 19.5k
Frank G. Haluska United States 51 7.9k 0.8× 8.0k 0.9× 10.9k 1.3× 3.0k 0.7× 2.8k 1.2× 138 18.7k
Joseph R. Testa United States 83 14.1k 1.5× 5.9k 0.7× 5.4k 0.6× 3.9k 0.8× 1.9k 0.8× 347 24.5k
Elisa de Stanchina United States 65 13.8k 1.5× 3.0k 0.4× 7.0k 0.8× 4.9k 1.1× 1.8k 0.8× 226 19.4k
Michael F. Berger United States 63 7.4k 0.8× 5.1k 0.6× 7.8k 0.9× 5.1k 1.1× 1.2k 0.5× 325 17.3k
Boris Reva United States 22 11.3k 1.2× 4.3k 0.5× 4.7k 0.6× 5.0k 1.1× 1.5k 0.7× 50 16.9k
Jonathan A. Fletcher United States 75 7.2k 0.8× 11.0k 1.3× 5.5k 0.7× 2.5k 0.5× 1.2k 0.5× 203 23.4k
Sabina Signoretti United States 69 11.5k 1.2× 8.2k 1.0× 6.9k 0.8× 6.2k 1.3× 2.7k 1.2× 296 20.4k
Sooryanarayana Varambally United States 63 19.1k 2.0× 9.7k 1.1× 5.2k 0.6× 8.5k 1.8× 2.2k 1.0× 158 27.0k
Marco A. Pierotti Italy 85 13.3k 1.4× 5.5k 0.6× 10.7k 1.3× 5.5k 1.2× 1.8k 0.8× 457 27.2k
Marileila Varella‐Garcia United States 70 7.2k 0.8× 11.1k 1.3× 10.0k 1.2× 4.0k 0.9× 555 0.2× 246 18.1k

Countries citing papers authored by Hiroyuki Mano

Since Specialization
Citations

This map shows the geographic impact of Hiroyuki Mano's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroyuki Mano with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroyuki Mano more than expected).

Fields of papers citing papers by Hiroyuki Mano

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroyuki Mano. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroyuki Mano. The network helps show where Hiroyuki Mano may publish in the future.

Co-authorship network of co-authors of Hiroyuki Mano

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroyuki Mano. A scholar is included among the top collaborators of Hiroyuki Mano based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroyuki Mano. Hiroyuki Mano is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Zhang, Fang, Yue Zhou, Satoru Yokoyama, et al.. (2025). Stress Response Kinase MK2 Induces Non-canonical Activation of EphA2 in <i>EML4-ALK</i> Lung Cancer Cells. Biological and Pharmaceutical Bulletin. 48(2). 172–176.
2.
Ikegami, Masachika, Rina Kitada, Kazuya Takamochi, et al.. (2025). Functional Analysis of Rare RAS Variants of Unknown Significance. Cancer Research Communications. 5(10). 1747–1757.
3.
Ueno, Toshihide, Masanaka Sugiyama, Shinya Kojima, et al.. (2023). Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia. npj Precision Oncology. 7(1). 132–132. 1 indexed citations
4.
Yagishita, Shigehiro, Ken Kato, Mami Takahashi, et al.. (2021). Characterization of the large‐scale Japanese patient‐derived xenograft (J‐PDX) library. Cancer Science. 112(6). 2454–2466. 13 indexed citations
5.
Yagishita, Shigehiro, Yoshiharu Hayashi, Mikiko Suzuki, et al.. (2021). Comparative Study on the Efficacy and Exposure of Molecular Target Agents in Non–small Cell Lung Cancer PDX Models with Driver Genetic Alterations. Molecular Cancer Therapeutics. 21(2). 359–370. 6 indexed citations
6.
Kawazoe, Akihito, Yasutoshi Kuboki, Eiji Shinozaki, et al.. (2020). Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial). Clinical Cancer Research. 26(22). 5887–5894. 66 indexed citations
7.
Nonaka, Satoru, Ichiro Oda, Seiichiro Abe, et al.. (2020). Safety and usefulness of endoscopic submucosal dissection for early esophageal cancers in elderly patients aged 80 years or older. Esophagus. 18(1). 81–89. 8 indexed citations
8.
Makise, Naohiro, Taisuke Mori, Hiroshi Kobayashi, et al.. (2020). Mesenchymal tumours with RREB1–MRTFB fusion involving the mediastinum: extra‐glossal ectomesenchymal chondromyxoid tumours?. Histopathology. 76(7). 1023–1031. 10 indexed citations
9.
Sato, Kazuhito, Masahito Kawazu, Yoko Yamamoto, et al.. (2018). Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers. Clinical Cancer Research. 25(1). 378–389. 44 indexed citations
10.
Yamada, Tadaaki, Shinji Takeuchi, Junya Nakade, et al.. (2012). Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells. Clinical Cancer Research. 18(13). 3592–3602. 93 indexed citations
11.
Soda, Manabu, Kazutoshi Isobe, Akira Inoue, et al.. (2012). A Prospective PCR-Based Screening for the EML4-ALK Oncogene in Non–Small Cell Lung Cancer. Clinical Cancer Research. 18(20). 5682–5689. 96 indexed citations
12.
Takeuchi, Kengo, Manabu Soda, Yuki Togashi, et al.. (2011). Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1–ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification. Clinical Cancer Research. 17(10). 3341–3348. 77 indexed citations
13.
Sakairi, Yuichi, Takahiro Nakajima, Kazuhiro Yasufuku, et al.. (2010). EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration. Clinical Cancer Research. 16(20). 4938–4945. 125 indexed citations
14.
Takeuchi, Kengo, Young Lim Choi, Yuki Togashi, et al.. (2009). KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer. Clinical Cancer Research. 15(9). 3143–3149. 557 indexed citations breakdown →
15.
Soda, Manabu, Shuji Takada, Kengo Takeuchi, et al.. (2008). A mouse model for EML4-ALK -positive lung cancer. Proceedings of the National Academy of Sciences. 105(50). 19893–19897. 396 indexed citations
16.
Takeuchi, Kengo, Young Lim Choi, Manabu Soda, et al.. (2008). Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts. Clinical Cancer Research. 14(20). 6618–6624. 397 indexed citations
17.
Choi, Young Lim, Kengo Takeuchi, Manabu Soda, et al.. (2008). Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer. Cancer Research. 68(13). 4971–4976. 346 indexed citations
18.
Soda, Manabu, Young Lim Choi, Munehiro Enomoto, et al.. (2007). Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer. Nature. 448(7153). 561–566. 4018 indexed citations breakdown →
19.
Suzuki, N., Susumu Nakamura, Hiroyuki Mano, & Tohru Kozasa. (2003). Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. Proceedings of the National Academy of Sciences. 100(2). 733–738. 175 indexed citations
20.
Tang, Bo, Hiroyuki Mano, Taolin Yi, & James N. Ihle. (1994). Tec Kinase Associates with c-kit and Is Tyrosine Phosphorylated and Activated following Stem Cell Factor Binding. Molecular and Cellular Biology. 14(12). 8432–8437. 91 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Frank G. Haluska Breakdown of academic impact, for papers by Joseph R. Testa Breakdown of academic impact, for papers by Elisa de Stanchina Breakdown of academic impact, for papers by Michael F. Berger Breakdown of academic impact, for papers by Boris Reva Breakdown of academic impact, for papers by Jonathan A. Fletcher Breakdown of academic impact, for papers by Sabina Signoretti Breakdown of academic impact, for papers by Sooryanarayana Varambally Breakdown of academic impact, for papers by Marco A. Pierotti Breakdown of academic impact, for papers by Marileila Varella‐Garcia
Rankless by CCL
2026