Hiroyuki Mano

30.2k citations

262 papers · 19.5k indexed · 6 hit papers · h-index 66

Molecular Biology top 0.5%
Pulmonary and Respiratory Medicine top 0.05%
Oncology top 0.1%
Cancer Research top 0.1%
Immunology top 1%

Co-authors: Manabu Soda Young Lim Choi Yoshihiro Yamashita Yuichi Ishikawa Shuji Takada Kengo Takeuchi Munehiro Enomoto Toshihide Ueno
Topics: Lung Cancer Treatments and Mutations (48 papers)Cancer Genomics and Diagnostics (37 papers)Lung Cancer Research Studies (25 papers)
Cited by: Oncology Cancer Research Pulmonary and Respiratory Medicine
Journals: Nature New England Journal of Medicine Proceedings of the National Academy of Sciences
Partner nations: Japan United States United Kingdom

In The Last Decade

Hiroyuki Mano

257 papers receiving 19.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

2007 4.0k citations Manabu Soda, Young Lim Choi et al. profile →
RET, ROS1 and ALK fusions in lung cancer

2012 963 citations Kengo Takeuchi, Manabu Soda et al. profile →
EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors

2010 915 citations Young Lim Choi, Manabu Soda et al. profile →
Oncogenic mutations of ALK kinase in neuroblastoma

2008 640 citations Young Lim Choi, Manabu Soda et al. profile →
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 582 citations Hiroyuki Mano et al. profile →
KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer

2009 557 citations Kengo Takeuchi, Young Lim Choi et al. Clinical Cancer Research profile →

Peers

Countries citing papers authored by Hiroyuki Mano

Since Specialization

Citations

This map shows the geographic impact of Hiroyuki Mano's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroyuki Mano with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroyuki Mano more than expected).

Fields of papers citing papers by Hiroyuki Mano

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroyuki Mano. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroyuki Mano. The network helps show where Hiroyuki Mano may publish in the future.

Co-authorship network of co-authors of Hiroyuki Mano

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroyuki Mano. A scholar is included among the top collaborators of Hiroyuki Mano based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroyuki Mano. Hiroyuki Mano is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Functional Analysis of Rare RAS Variants of Unknown Significance 2025 ·Cancer Research Communications ·(unknown),Masachika Ikegami,Rina Kitada,Kazuya Takamochi,Kenji Suzuki,Hiroyuki Mano,Shinji Kohsaka	0
2	The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma 2024 ·Journal of Neuro-Oncology ·(unknown),Toshihide Ueno,Shinya Kojima,Hiroshi Ikeuchi,Rina Kitada,Takafumi Koyama,Fumiyuki Takahashi,Kazuhisa Takahashi,Koichi Ichimura,Akihiko Yoshida,(unknown),Hiroyuki Mano,Yoshitaka Narita,Masamichi Takahashi,Shinji Kohsaka	2
3	GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway 2024 ·Oncogene ·Hiroshi Ikeuchi,(unknown),Rika Kusumoto‐Matsuo,Shinya Kojima,Toshihide Ueno,Masachika Ikegami,Rina Kitada,Hitomi Sumiyoshi Okuma,Yuki Kojima,Kan Yonemori,Yasushi Yatabe,Kazuya Takamochi,Kenji Suzuki,Kenichi Yoshioka,Hiroyuki Mano,Shinji Kohsaka	2
4	Extensive analysis of 59 sarcoma‐related fusion genes identified pazopanib as a potential inhibitor to COL1A1‐PDGFB fusion gene 2023 ·Cancer Science ·Takeshi Hirose,Masachika Ikegami,Shinya Kojima,Akihiko Yoshida,Makoto Endo,(unknown),(unknown),(unknown),Yoshihiro Matsumoto,Yasuharu Nakashima,Akira Kawai,Hiroyuki Mano,Shinji Kohsaka	3
5	Molecular pathology quality control in Southeast Asia: Results of a multiregional quality assurance study from MASTER KEY Asia 2023 ·Cancer Science ·Hitomi Sumiyoshi Okuma,Hiroshi Yoshida,Yoshihisa Kobayashi,(unknown),(unknown),Lina Inagaki,(unknown),(unknown),Hwoei Fen Soo Hoo,(unknown),(unknown),(unknown),(unknown),Shinji Kohsaka,Hiroyuki Mano,Kan Yonemori,Kenichi Nakamura,Yasushi Yatabe	4
6	Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial) 2023 ·Clinical Cancer Research ·Hitomi Sumiyoshi Okuma,(unknown),Kenji Tsuchihashi,Ryunosuke Machida,Ryo Sadachi,Akihiro Hirakawa,Hiroshi Ariyama,Masashi Kanai,(unknown),(unknown),(unknown),Shigeki Sekine,Natsuko Okita,Hiroyuki Mano,Hiroyoshi Nishikawa,Kenichi Nakamura,Kan Yonemori	7
7	High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer 2022 ·Molecular Cancer Therapeutics ·(unknown),Masachika Ikegami,Takafumi Koyama,Kuniko Sunami,Dai Ogata,Hidenori Kage,Mitsuru Yanagaki,Hiroshi Ikeuchi,Toshihide Ueno,Michihiro Tanikawa,Katsutoshi Oda,Yutaka Osuga,Hiroyuki Mano,Shinji Kohsaka	15
8	Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities 2021 ·Nature Cancer ·Yosuke Tanaka,Fumiko Chiwaki,Shinya Kojima,Masahito Kawazu,Masayuki Komatsu,Toshihide Ueno,Satoshi Inoue,Shigeki Sekine,Keisuke Matsusaki,Hiromichi Matsushita,Narikazu Boku,Yae Kanai,Yasushi Yatabe,Hiroki Sasaki,Hiroyuki Mano	61
9	MicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples 2021 ·Communications Biology ·Masachika Ikegami,Shinji Kohsaka,Takeshi Hirose,Toshihide Ueno,Satoshi Inoue,Naoki Kanomata,Hideko Yamauchi,Taisuke Mori,Shigeki Sekine,Yoshihiro Inamoto,Yasushi Yatabe,Hiroshi Kobayashi,Sakae Tanaka,Hiroyuki Mano	5
10	Mesenchymal tumours with RREB1–MRTFB fusion involving the mediastinum: extra‐glossal ectomesenchymal chondromyxoid tumours? 2020 ·Histopathology ·Naohiro Makise,Taisuke Mori,Hiroshi Kobayashi,Kazuo Nakagawa,Eijitsu Ryo,Jun Nakajima,Shinji Kohsaka,Hiroyuki Mano,Hiroyuki Aburatani,Akihiko Yoshida,Tetsuo Ushiku	10
11	Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability–High Colorectal Cancers 2018 ·Clinical Cancer Research ·Kazuhito Sato,Masahito Kawazu,Yoko Yamamoto,Toshihide Ueno,Shinya Kojima,Genta Nagae,(unknown),Manabu Soda,(unknown),Shinji Kohsaka,Eirin Sai,Yoshihiro Yamashita,Hisae Iinuma,Masashi Fukayama,Hiroyuki Aburatani,Toshiaki Watanabe,Hiroyuki Mano	44
12	Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells 2012 ·Clinical Cancer Research ·Tadaaki Yamada,Shinji Takeuchi,Junya Nakade,Kenji Kita,Takayuki Nakagawa,Shigeki Nanjo,Takahiro Nakamura,Kunio Matsumoto,Manabu Soda,Hiroyuki Mano,Toshimitsu Uenaka,Seiji Yano	93
13	A Prospective PCR-Based Screening for the EML4-ALK Oncogene in Non–Small Cell Lung Cancer 2012 ·Clinical Cancer Research ·Manabu Soda,Kazutoshi Isobe,Akira Inoue,Makoto Maemondo,Satoshi Oizumi,Yuka Fujita,Akihiko Gemma,Yoshihiro Yamashita,Toshihide Ueno,Kengo Takeuchi,Young Lim Choi,Hitoshi Miyazawa,Tomoaki Tanaka,Koichi Hagiwara,Hiroyuki Mano,(unknown)	96
14	Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1–ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification 2011 ·Clinical Cancer Research ·Kengo Takeuchi,Manabu Soda,Yuki Togashi,Emiko Sugawara,Satoko Hatano,Reimi Asaka,Sakae Okumura,Ken Nakagawa,Hiroyuki Mano,Yuichi Ishikawa	77
15	EML4-ALK Fusion Gene Assessment Using Metastatic Lymph Node Samples Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration 2010 ·Clinical Cancer Research ·Yuichi Sakairi,Takahiro Nakajima,Kazuhiro Yasufuku,Dai Ikebe,Hajime Kageyama,Manabu Soda,Kengo Takeuchi,Makiko Itami,Toshihiko Iizasa,Ichiro Yoshino,Hiroyuki Mano,Hideki Kimura	125
16	KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancerbreakdown → 2009 ·Clinical Cancer Research ·Kengo Takeuchi,Young Lim Choi,Yuki Togashi,Manabu Soda,Satoko Hatano,Kentaro Inamura,Shuji Takada,Toshihide Ueno,Yoshihiro Yamashita,Yukitoshi Satoh,Sakae Okumura,Ken Nakagawa,Yuichi Ishikawa,Hiroyuki Mano	557
17	Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer 2008 ·Cancer Research ·Young Lim Choi,Kengo Takeuchi,Manabu Soda,Kentaro Inamura,Yuki Togashi,Satoko Hatano,Munehiro Enomoto,Toru Hamada,Hidenori Haruta,Hideki Watanabe,Kentaro Kurashina,Hisashi Hatanaka,Toshihide Ueno,Shuji Takada,Yoshihiro Yamashita,Yukihiko Sugiyama,Yuichi Ishikawa,Hiroyuki Mano	346
18	A mouse model for EML4-ALK -positive lung cancer 2008 ·Proceedings of the National Academy of Sciences ·Manabu Soda,Shuji Takada,Kengo Takeuchi,Young Lim Choi,Munehiro Enomoto,Toshihide Ueno,Hidenori Haruta,Toru Hamada,Yoshihiro Yamashita,Yuichi Ishikawa,Yukihiko Sugiyama,Hiroyuki Mano	396
19	Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts 2008 ·Clinical Cancer Research ·Kengo Takeuchi,Young Lim Choi,Manabu Soda,Kentaro Inamura,Yuki Togashi,Satoko Hatano,Munehiro Enomoto,Shuji Takada,Yoshihiro Yamashita,Yukitoshi Satoh,Sakae Okumura,Ken Nakagawa,Yuichi Ishikawa,Hiroyuki Mano	397
20	Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF 2003 ·Proceedings of the National Academy of Sciences ·N. Suzuki,Susumu Nakamura,Hiroyuki Mano,Tohru Kozasa	175

About Hiroyuki Mano

Hiroyuki Mano is a scholar working on Cancer Research, Oncology and Hematology, having authored 262 papers that have together received 19.5k indexed citations. Recurring topics across this work include Lung Cancer Treatments and Mutations (48 papers), Cancer Genomics and Diagnostics (37 papers) and Lung Cancer Research Studies (25 papers). The work is most often cited by research in Oncology (8.4k citations), Cancer Research (4.6k citations) and Pulmonary and Respiratory Medicine (8.5k citations). Hiroyuki Mano has collaborated with scholars based in Japan, United States and United Kingdom. Frequent co-authors include Manabu Soda, Young Lim Choi, Yoshihiro Yamashita, Yuichi Ishikawa, Shuji Takada, Kengo Takeuchi, Munehiro Enomoto, Toshihide Ueno, Yukihiko Sugiyama and Hisashi Hatanaka. Their work appears in journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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