Hiroaki Okae

4.1k total citations · 3 hit papers
49 papers, 2.3k citations indexed

About

Hiroaki Okae is a scholar working on Molecular Biology, Pediatrics, Perinatology and Child Health and Obstetrics and Gynecology. According to data from OpenAlex, Hiroaki Okae has authored 49 papers receiving a total of 2.3k indexed citations (citations by other indexed papers that have themselves been cited), including 35 papers in Molecular Biology, 30 papers in Pediatrics, Perinatology and Child Health and 19 papers in Obstetrics and Gynecology. Recurrent topics in Hiroaki Okae's work include Epigenetics and DNA Methylation (23 papers), Prenatal Screening and Diagnostics (23 papers) and Pregnancy and preeclampsia studies (18 papers). Hiroaki Okae is often cited by papers focused on Epigenetics and DNA Methylation (23 papers), Prenatal Screening and Diagnostics (23 papers) and Pregnancy and preeclampsia studies (18 papers). Hiroaki Okae collaborates with scholars based in Japan, United States and United Kingdom. Hiroaki Okae's co-authors include Takahiro Arima, Hitoshi Hiura, Mikita Suyama, Hiroyuki Sasaki, Hidehiro Toh, Kenjiro Shirane, Tetsuya Sato, Sota Takahashi, Hatsune Chiba and Yuka Kabayama and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Nature Communications and Genes & Development.

In The Last Decade

Hiroaki Okae

45 papers receiving 2.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Derivation of Human Trophoblast Stem Cells

2017 631 citations Hiroaki Okae, Hidehiro Toh et al. profile →
Modeling embryo-endometrial interface recapitulating human embryo implantation

2024 51 citations Shun Shibata, Luís Augusto Eijy Nagai et al. Science Advances profile →
Trophoblast stem cell-based organoid models of the human placental barrier

2024 40 citations Takeshi Hori, Hiroaki Okae et al. Nature Communications profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hiroaki Okae Japan	26	1.5k	1.1k	690	546	410	49	2.3k
Hitoshi Hiura Japan	23	1.9k 1.3×	1.3k 1.2×	414 0.6×	1.1k 2.0×	634 1.5×	39	2.7k
Paulina A. Latos Austria	17	1.2k 0.8×	336 0.3×	446 0.6×	261 0.5×	118 0.3×	24	1.7k
Monica Mainigi United States	23	391 0.3×	890 0.8×	352 0.5×	160 0.3×	640 1.6×	53	1.6k
David Blesa Spain	22	516 0.3×	325 0.3×	347 0.5×	339 0.6×	476 1.2×	40	1.9k
G. Harton United States	30	616 0.4×	2.4k 2.3×	106 0.2×	1.1k 2.0×	790 1.9×	55	3.1k
Mark B. Harvey Australia	19	666 0.4×	281 0.3×	145 0.2×	339 0.6×	787 1.9×	27	1.5k
Mark D. Pertile Australia	23	383 0.3×	826 0.8×	110 0.2×	564 1.0×	171 0.4×	51	1.4k
Yukiyasu Sato Japan	23	268 0.2×	253 0.2×	549 0.8×	103 0.2×	269 0.7×	73	1.4k
L. Wilton Australia	29	731 0.5×	2.5k 2.3×	113 0.2×	1.2k 2.2×	1.1k 2.7×	50	3.4k
S.J. Fisher United States	10	320 0.2×	308 0.3×	777 1.1×	91 0.2×	291 0.7×	15	1.7k

Countries citing papers authored by Hiroaki Okae

Since Specialization

Citations

This map shows the geographic impact of Hiroaki Okae's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroaki Okae with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroaki Okae more than expected).

Fields of papers citing papers by Hiroaki Okae

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroaki Okae. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroaki Okae. The network helps show where Hiroaki Okae may publish in the future.

Co-authorship network of co-authors of Hiroaki Okae

This figure shows the co-authorship network connecting the top 25 collaborators of Hiroaki Okae. A scholar is included among the top collaborators of Hiroaki Okae based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hiroaki Okae. Hiroaki Okae is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Rai, Alin, Qi Hui Poh, Hiroaki Okae, et al.. (2025). Dynamic Proteome Landscape During Preimplantation Human Embryo Development and Trophectoderm Stem Cell‐Differentiation. PROTEOMICS. 25(15). 72–89.

Chappell‐Maor, Louise, Philippe Arnaúd, Isabel Iglesias‐Platas, et al.. (2025). Non-canonical imprinting, manifesting as post-fertilization placenta-specific parent-of-origin dependent methylation, is not conserved in humans. Human Molecular Genetics. 34(7). 626–638. 3 indexed citations

Varberg, Kaela M., Joseph M. Varberg, Irfan Saadi, et al.. (2025). Leveraging chorionic villus biopsies for the derivation of patient-specific trophoblast stem cells. Communications Biology. 8(1). 964–964.

Shibata, Shun, Luís Augusto Eijy Nagai, Eri Kobayashi, et al.. (2024). Modeling embryo-endometrial interface recapitulating human embryo implantation. Science Advances. 10(8). eadi4819–eadi4819. 51 indexed citations breakdown →

Varberg, Kaela M., Khursheed Iqbal, John Aplin, et al.. (2024). NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development. Proceedings of the National Academy of Sciences. 121(40). e2403003121–e2403003121. 9 indexed citations

Okae, Hiroaki, et al.. (2024). Human trophoblast stem cells restrict human cytomegalovirus replication. Journal of Virology. 98(4). e0193523–e0193523. 6 indexed citations

Toh, Hidehiro, Hiroaki Okae, Kenjiro Shirane, et al.. (2024). Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells. BMC Genomics. 25(1). 1050–1050. 3 indexed citations

Oike, Akira, Eri Kobayashi, Norio Kobayashi, et al.. (2023). CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development. Proceedings of the National Academy of Sciences. 120(51). e2311372120–e2311372120. 18 indexed citations

Dhakal, Pramod, Khursheed Iqbal, Lindsey N. Kent, et al.. (2023). CITED2 is a conserved regulator of the uterine–placental interface. Proceedings of the National Academy of Sciences. 120(3). e2213622120–e2213622120. 17 indexed citations

10.

Varberg, Kaela M., Joseph M. Varberg, Khursheed Iqbal, et al.. (2023). Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape. Nature Communications. 14(1). 4826–4826. 27 indexed citations

11.

Kobayashi, Norio, Hiroaki Okae, Hitoshi Hiura, et al.. (2022). The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells. Nature Communications. 13(1). 40 indexed citations

12.

Hada, Masashi, Hisashi Miura, Akie Tanigawa, et al.. (2022). Highly rigid H3.1/H3.2–H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells. Genes & Development. 36(1-2). 84–102. 11 indexed citations

13.

Muto, Masanaga, Damayanti Chakraborty, Kaela M. Varberg, et al.. (2021). Intersection of regulatory pathways controlling hemostasis and hemochorial placentation. Proceedings of the National Academy of Sciences. 118(50). 21 indexed citations

14.

Okada, Mai, et al.. (2021). Abnormal cleavage is involved in the self-correction of bovine preimplantation embryos. Biochemical and Biophysical Research Communications. 562. 76–82. 6 indexed citations

15.

Bhattacharya, Bhaswati, Pratik Home, Avishek Ganguly, et al.. (2020). Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal–fetal exchange interface. Proceedings of the National Academy of Sciences. 117(25). 14280–14291. 16 indexed citations

16.

Jeyarajah, Mariyan J., Megan McGill, Vanessa Dumeaux, et al.. (2020). Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts. Cell Death and Disease. 11(5). 311–311. 36 indexed citations

17.

Hattori, Hiromitsu, Hitoshi Hiura, Akane Kitamura, et al.. (2019). Association of four imprinting disorders and ART. Clinical Epigenetics. 11(1). 21–21. 109 indexed citations

18.

Kobayashi, Norio, Hiroaki Okae, Hitoshi Hiura, et al.. (2016). Genome-Scale Assessment of Age-Related DNA Methylation Changes in Mouse Spermatozoa. PLoS ONE. 11(11). e0167127–e0167127. 11 indexed citations

19.

Hiura, Hitoshi, Hiroaki Okae, Naoko Miyauchi, et al.. (2012). High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method. BMC Medical Genomics. 5(1). 8–8. 5 indexed citations

20.

Satô, Akiko, Hitoshi Hiura, Hiroaki Okae, et al.. (2010). Assessing loss of imprint methylation in sperm from subfertile men using novel methylation polymerase chain reaction Luminex analysis. Fertility and Sterility. 95(1). 129–134.e4. 50 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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