Gerald Koelsch

4.7k total citations · 2 hit papers
53 papers, 3.5k citations indexed

About

Gerald Koelsch is a scholar working on Molecular Biology, Physiology and Computational Theory and Mathematics. According to data from OpenAlex, Gerald Koelsch has authored 53 papers receiving a total of 3.5k indexed citations (citations by other indexed papers that have themselves been cited), including 39 papers in Molecular Biology, 20 papers in Physiology and 11 papers in Computational Theory and Mathematics. Recurrent topics in Gerald Koelsch's work include Alzheimer's disease research and treatments (19 papers), Computational Drug Discovery Methods (11 papers) and Protein Structure and Dynamics (9 papers). Gerald Koelsch is often cited by papers focused on Alzheimer's disease research and treatments (19 papers), Computational Drug Discovery Methods (11 papers) and Protein Structure and Dynamics (9 papers). Gerald Koelsch collaborates with scholars based in United States, Japan and Czechia. Gerald Koelsch's co-authors include Jordan Tang, Arun K. Ghosh, Xinli Lin, Shili Wu, Hong Lin, Azar Dashti, Robert T. Turner, Jacques Ermolieff, S. Terzyan and Jeffrey A. Loy and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Gerald Koelsch

51 papers receiving 3.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

2000 641 citations Xinli Lin, Gerald Koelsch et al. Proceedings of the National Academy of Sciences profile →
Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

2000 566 citations Hong Lin, Gerald Koelsch et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Gerald Koelsch United States	27	2.0k	1.7k	1.3k	1.2k	422	53	3.5k
Alfredo G. Tomasselli United States	32	1.2k 0.6×	2.3k 1.3×	670 0.5×	621 0.5×	503 1.2×	72	4.1k
Ming‐Tain Lai United States	24	1.3k 0.7×	1.1k 0.7×	493 0.4×	555 0.5×	227 0.5×	55	2.6k
Avlin Barlow United States	9	2.6k 1.3×	1.8k 1.1×	488 0.4×	629 0.5×	335 0.8×	11	4.5k
Brian Austen United Kingdom	31	1.1k 0.6×	1.5k 0.9×	275 0.2×	284 0.2×	239 0.6×	113	2.7k
Urs Brodbeck Switzerland	33	513 0.3×	1.8k 1.1×	473 0.4×	1.1k 0.9×	109 0.3×	107	3.4k
John R. Brashler United States	22	1.8k 0.9×	933 0.6×	328 0.3×	606 0.5×	210 0.5×	59	2.8k
Marina Kirkitadze Canada	18	2.0k 1.0×	1.9k 1.1×	490 0.4×	307 0.3×	178 0.4×	37	3.1k
Kirk A. Findlay United States	11	1.0k 0.5×	716 0.4×	292 0.2×	532 0.5×	189 0.4×	12	2.2k
Delia Picone Italy	31	1.1k 0.5×	2.4k 1.4×	319 0.2×	223 0.2×	214 0.5×	115	3.6k
Gerald W. Becker United States	30	658 0.3×	1.6k 0.9×	96 0.1×	916 0.8×	341 0.8×	53	4.0k

Countries citing papers authored by Gerald Koelsch

Since Specialization

Citations

This map shows the geographic impact of Gerald Koelsch's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gerald Koelsch with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gerald Koelsch more than expected).

Fields of papers citing papers by Gerald Koelsch

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gerald Koelsch. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gerald Koelsch. The network helps show where Gerald Koelsch may publish in the future.

Co-authorship network of co-authors of Gerald Koelsch

This figure shows the co-authorship network connecting the top 25 collaborators of Gerald Koelsch. A scholar is included among the top collaborators of Gerald Koelsch based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gerald Koelsch. Gerald Koelsch is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Olson, Daniel G., Afshin Dowlati, Jason J. Luke, et al.. (2024). 1004P Phase I/II trial of ASP1570, a novel diacylglycerol kinase ζ inhibitor, in patients with advanced solid tumors. Annals of Oncology. 35. S683–S683.

Shirasuna, Kenna, Gerald Koelsch, Cynthia Seidel‐Dugan, et al.. (2021). Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody. Cancer Treatment and Research Communications. 28. 100433–100433. 10 indexed citations

Koelsch, Gerald. (2017). BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology. Molecules. 22(10). 1723–1723. 95 indexed citations

Ghosh, Arun K., Margherita Brindisi, Xiaoming Xu, et al.. (2014). Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. Bioorganic & Medicinal Chemistry Letters. 25(3). 668–672. 18 indexed citations

Ghosh, Arun K., Geoffrey Bilcer, Hong Lin, Gerald Koelsch, & Jordan Tang. (2007). Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality. Current Alzheimer Research. 4(4). 418–422. 20 indexed citations

Ghosh, Arun K., Nagaswamy Kumaragurubaran, Hong Lin, et al.. (2007). Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Bioorganic & Medicinal Chemistry Letters. 18(3). 1031–1036. 74 indexed citations

Ghosh, Arun K., Thippeswamy Devasamudram, Hong Lin, et al.. (2004). Structure-based design of cycloamide–urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase). Bioorganic & Medicinal Chemistry Letters. 15(1). 15–20. 59 indexed citations

Chang, Wan‐Pin, Gerald Koelsch, Stephen T.C. Wong, et al.. (2004). In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors. Journal of Neurochemistry. 89(6). 1409–1416. 74 indexed citations

Tang, Jordan, Arun K. Ghosh, Hong Lin, et al.. (2003). Study of Memapsin 2 (β-Secretase) and Strategy of Inhibitor Design. Journal of Molecular Neuroscience. 20(3). 299–304. 12 indexed citations

10.

Beneš, Petr, Gerald Koelsch, Bohuslav Dvořák, Martin Fusek, & Václav Větvička. (2002). Detection of procathepsin D in rat milk. Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology. 133(1). 113–118. 15 indexed citations

11.

He, Xiangyuan, Wan‐Pin Chang, Gerald Koelsch, & Jordan Tang. (2002). Memapsin 2 (β‐secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. FEBS Letters. 524(1-3). 183–187. 98 indexed citations

12.

Sun, Anyang, Gerald Koelsch, Jordan Tang, & Guoying Bing. (2002). Localization of β-Secretase Memapsin 2 in the Brain of Alzheimer's Patients and Normal Aged Controls. Experimental Neurology. 175(1). 10–22. 37 indexed citations

13.

Koelsch, Gerald, Jordan Tang, Michel Monod, Stephen I. Foundling, & Xinli Lin. (1998). Primary Substrate Specificities of Secreted Aspartic Proteases of Candida albicans. Advances in experimental medicine and biology. 436. 335–338. 3 indexed citations

14.

Koelsch, Gerald, Peter Metcalf, Václav Větvička, & Martin Fusek. (1995). Human Procathepsin D: Three-Dimensional Model and Isolation. Advances in experimental medicine and biology. 362. 273–278. 10 indexed citations

15.

Lin, Xinli, Gerald Koelsch, Jeffrey A. Loy, & Jordan Tang. (1995). Rearranging the domains of pepsinogen. Protein Science. 4(2). 159–166. 9 indexed citations

16.

Koelsch, Gerald, Michael A. Mares, Peter Metcalf, & Martin Fusek. (1994). Multiple functions of pro‐parts of aspartic proteinase zymogens. FEBS Letters. 343(1). 6–10. 82 indexed citations

17.

Koelsch, Gerald, et al.. (1994). Proteolytic Processing Mechanisms of a Miniprecursor of the Aspartic Protease of Human Immunodeficiency Virus Type 1. Biochemistry. 33(5). 1248–1254. 22 indexed citations

18.

Scofield, R. Hal, W. Louise Warren, Gerald Koelsch, & J B Harley. (1993). A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution.. Proceedings of the National Academy of Sciences. 90(20). 9330–9334. 80 indexed citations

19.

Hartsuck, Jean A., Gerald Koelsch, & S. James Remington. (1992). The high‐resolution crystal structure of porcine pepsinogen. Proteins Structure Function and Bioinformatics. 13(1). 1–25. 77 indexed citations

20.

Lin, Xinli, Martin Fusek, Gerald Koelsch, et al.. (1991). Studies on Pepsin Mutagenesis and Recombinant Rhizopuspepsinogen. Advances in experimental medicine and biology. 306. 1–8. 2 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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