George F. Koob

112.8k total citations · 32 hit papers
749 papers, 84.1k citations indexed

About

George F. Koob is a scholar working on Cellular and Molecular Neuroscience, Molecular Biology and Behavioral Neuroscience. According to data from OpenAlex, George F. Koob has authored 749 papers receiving a total of 84.1k indexed citations (citations by other indexed papers that have themselves been cited), including 492 papers in Cellular and Molecular Neuroscience, 245 papers in Molecular Biology and 201 papers in Behavioral Neuroscience. Recurrent topics in George F. Koob's work include Neurotransmitter Receptor Influence on Behavior (411 papers), Stress Responses and Cortisol (201 papers) and Receptor Mechanisms and Signaling (183 papers). George F. Koob is often cited by papers focused on Neurotransmitter Receptor Influence on Behavior (411 papers), Stress Responses and Cortisol (201 papers) and Receptor Mechanisms and Signaling (183 papers). George F. Koob collaborates with scholars based in United States, France and Italy. George F. Koob's co-authors include Nora D. Volkow, Michel Le Moal, Floyd E. Bloom, Neal R. Swerdlow, Eric P. Zorrilla, Friedbert Weiss, Serge H. Ahmed, Lisa Gold, Wylie Vale and Luis Stinus and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

George F. Koob

744 papers receiving 82.1k citations

Hit Papers

Neurocircuitry of Addiction 1980 2026 1995 2010 2009 2016 1997 1988 2016 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Neurocircuitry of Addiction
    2009 3.8k citations George F. Koob, Nora D. Volkow Neuropsychopharmacology profile →
  2. Neurobiology of addiction: a neurocircuitry analysis
    2016 2.2k citations George F. Koob, Nora D. Volkow The Lancet Psychiatry profile →
  3. Drug Abuse: Hedonic Homeostatic Dysregulation
    1997 1.9k citations George F. Koob et al. profile →
  4. Cellular and Molecular Mechanisms of Drug Dependence
    1988 1.7k citations George F. Koob et al. profile →
  5. Neurobiologic Advances from the Brain Disease Model of Addiction
    2016 1.0k citations Nora D. Volkow, George F. Koob et al. profile →
  6. Addiction and the Brain Antireward System
    2007 947 citations George F. Koob et al. profile →
  7. Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point
    1998 863 citations George F. Koob et al. profile →
  8. Neuroscience of Addiction
    1998 825 citations George F. Koob et al. profile →
  9. A Role for Brain Stress Systems in Addiction
    2008 769 citations George F. Koob profile →
  10. Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development
    1998 709 citations Angelo Contarino, George F. Koob et al. profile →
  11. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction
    2005 708 citations George F. Koob et al. profile →
  12. Stress, Dysregulation of Drug Reward Pathways, and the Transition to Drug Dependence
    2007 647 citations George F. Koob et al. profile →
  13. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants.
    1993 633 citations George F. Koob et al. profile →
  14. Corticotropin releasing factor produces behavioural activation in rats
    1982 631 citations George F. Koob et al. profile →
  15. Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens
    1980 627 citations George F. Koob et al. Pharmacology Biochemistry and Behavior profile →
  16. Alcoholism: Allostasis and Beyond
    2003 586 citations George F. Koob Alcoholism Clinical and Experimental Research profile →
  17. Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function
    1987 566 citations George F. Koob et al. profile →
  18. Effects of Moderate Alcohol Consumption on the Central Nervous System*
    1998 540 citations George F. Koob et al. Alcoholism Clinical and Experimental Research profile →
  19. Sex Differences in Animal Models: Focus on Addiction
    2016 539 citations George F. Koob et al. profile →
  20. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats
    1984 532 citations George F. Koob et al. Psychopharmacology profile →
  21. Neural Mechanisms of Drug Reinforcementa
    1992 512 citations George F. Koob Annals of the New York Academy of Sciences profile →
  22. Drug dependence: stress and dysregulation of brain reward pathways
    1998 505 citations George F. Koob et al. profile →
  23. Corticotropin-releasing factor, norepinephrine, and stress
    1999 500 citations George F. Koob profile →
  24. Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems
    1982 480 citations George F. Koob et al. Psychopharmacology profile →
  25. The Development and Maintenance of Drug Addiction
    2013 368 citations George F. Koob et al. Neuropsychopharmacology profile →
  26. Opioid use disorder
    2020 354 citations Nora D. Volkow, George F. Koob et al. profile →
  27. Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement
    2019 294 citations George F. Koob profile →
  28. Alcohol-Related Deaths During the COVID-19 Pandemic
    2022 222 citations George F. Koob et al. profile →
  29. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission
    2023 114 citations Mehdi Farokhnia, Sophia Khom et al. JCI Insight profile →
  30. Defining Recovery From Alcohol Use Disorder: Development of an NIAAA Research Definition
    2022 98 citations George F. Koob et al. profile →
  31. Alcohol Use Disorder Treatment: Problems and Solutions
    2024 39 citations George F. Koob profile →
  32. Glucagon-like peptide-1 receptor agonists, but not dipeptidyl peptidase-4 inhibitors, reduce alcohol intake
    2025 17 citations Mehdi Farokhnia, George F. Koob et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
George F. Koob United States 149 50.9k 24.2k 18.2k 16.5k 12.5k 749 84.1k
Eric J. Nestler United States 157 47.0k 0.9× 35.6k 1.5× 16.2k 0.9× 15.0k 0.9× 11.0k 0.9× 667 92.0k
Kjell Fuxé Sweden 126 52.1k 1.0× 35.8k 1.5× 6.3k 0.3× 9.6k 0.6× 8.4k 0.7× 1.4k 83.2k
Miklós Palkovits Hungary 95 33.4k 0.7× 17.1k 0.7× 9.5k 0.5× 10.9k 0.7× 9.8k 0.8× 692 62.5k
Trevor W. Robbins United Kingdom 213 60.6k 1.2× 19.9k 0.8× 10.7k 0.6× 74.4k 4.5× 14.6k 1.2× 1.1k 140.3k
Ronald S. Duman United States 128 28.9k 0.6× 13.9k 0.6× 15.6k 0.9× 8.5k 0.5× 4.6k 0.4× 365 61.7k
Charles B. Nemeroff United States 137 15.9k 0.3× 11.1k 0.5× 24.5k 1.3× 7.5k 0.5× 14.6k 1.2× 974 77.0k
René Hen United States 116 23.6k 0.5× 14.5k 0.6× 7.8k 0.4× 10.6k 0.6× 5.5k 0.4× 326 49.2k
Huda Akil United States 107 21.6k 0.4× 15.1k 0.6× 8.9k 0.5× 5.8k 0.4× 6.9k 0.6× 498 40.5k
Klaus‐Peter Lesch Germany 101 18.0k 0.4× 10.4k 0.4× 6.5k 0.4× 8.1k 0.5× 6.7k 0.5× 635 42.3k
Nora D. Volkow United States 146 35.1k 0.7× 14.0k 0.6× 2.5k 0.1× 27.3k 1.7× 3.8k 0.3× 902 91.3k

Countries citing papers authored by George F. Koob

Since Specialization
Citations

This map shows the geographic impact of George F. Koob's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by George F. Koob with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites George F. Koob more than expected).

Fields of papers citing papers by George F. Koob

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by George F. Koob. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by George F. Koob. The network helps show where George F. Koob may publish in the future.

Co-authorship network of co-authors of George F. Koob

This figure shows the co-authorship network connecting the top 25 collaborators of George F. Koob. A scholar is included among the top collaborators of George F. Koob based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with George F. Koob. George F. Koob is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Koob, George F., et al.. (2023). Cold nociception as a measure of hyperalgesia during spontaneous heroin withdrawal in mice. Pharmacology Biochemistry and Behavior. 235. 173694–173694. 4 indexed citations
2.
Farokhnia, Mehdi, Sophia Khom, Sophie K. Elvig, et al.. (2023). The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI Insight. 8(12). 114 indexed citations breakdown →
3.
Farokhnia, Mehdi, Lia J. Zallar, Zhi‐Bing You, et al.. (2021). A closer look at alcohol‐induced changes in the ghrelin system: novel insights from preclinical and clinical data. Addiction Biology. 27(1). e13033–e13033. 23 indexed citations
4.
Tyler, Ryan E., Sung Won Kim, Min Guo, et al.. (2019). Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding. European Journal of Neuroscience. 50(1). 1831–1842. 25 indexed citations
5.
Guglielmo, Giordano de, Marsida Kallupi, Matthew B. Pomrenze, et al.. (2019). Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nature Communications. 10(1). 1238–1238. 98 indexed citations
6.
Koob, George F. & Nora D. Volkow. (2016). Neurobiology of addiction: a neurocircuitry analysis. The Lancet Psychiatry. 3(8). 760–773. 2211 indexed citations breakdown →
7.
Koob, George F.. (2015). The dark side of emotion: The addiction perspective. European Journal of Pharmacology. 753. 73–87. 277 indexed citations
8.
López, Alan D, Thomas N. Williams, Adeera Levin, et al.. (2014). Remembering the forgotten non-communicable diseases. BMC Medicine. 12(1). 200–200. 75 indexed citations
9.
Herman, Melissa A., Marsida Kallupi, George Luu, et al.. (2012). Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: Alcohol and CRF effects. Neuropharmacology. 67. 337–348. 49 indexed citations
10.
George, Olivier & George F. Koob. (2010). Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience & Biobehavioral Reviews. 35(2). 232–247. 237 indexed citations
11.
Cottone, Pietro, Valentina Sabino, Marisa Roberto, et al.. (2009). CRF system recruitment mediates dark side of compulsive eating. Proceedings of the National Academy of Sciences. 106(47). 20016–20020. 153 indexed citations
12.
Koob, George F.. (2008). Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology. 56. 18–31. 337 indexed citations
13.
Papaleo, Francesco, et al.. (2008). Disruption of the CRF2 Receptor Pathway Decreases the Somatic Expression of Opiate Withdrawal. Neuropsychopharmacology. 33(12). 2878–2887. 36 indexed citations
14.
Carrera, M. Rocı́o A., Gunnar F. Kaufmann, Jenny M. Mee, et al.. (2004). Treating cocaine addiction with viruses. Proceedings of the National Academy of Sciences. 101(28). 10416–10421. 80 indexed citations
15.
Bevins, Rick A., Michael T. Bardo, & George F. Koob. (2004). Motivational factors in the etiology of drug abuse. University of Nebraska Press eBooks. 53 indexed citations
16.
17.
Roberts, Amanda J., Maury Cole, & George F. Koob. (1996). Intra‐amygdala Muscimol Decreases Operant Ethanol Self‐administration in Dependent Rats. Alcoholism Clinical and Experimental Research. 20(7). 1289–1298. 293 indexed citations
18.
Pulvirenti, Luigi, Diana Smith, & George F. Koob. (1994). SDZ 208-911, an amino-ergoline with partial dopamine agonist properties, dose dependently increases cocaine self-administration in the rat. Psychopharmacology. 113(3-4). 518–520. 12 indexed citations
19.
Koob, George F.. (1992). Neural Mechanisms of Drug Reinforcementa. Annals of the New York Academy of Sciences. 654(1). 171–191. 512 indexed citations breakdown →
20.
Markou, Athina, Richard L. Hauger, & George F. Koob. (1992). Desmethylimipramine attenuates cocaine withdrawal in rats. Psychopharmacology. 109(3). 305–314. 84 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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