Gang Lu

4.0k total citations · 1 hit paper
18 papers, 1.9k citations indexed

About

Gang Lu is a scholar working on Molecular Biology, Hematology and Oncology. According to data from OpenAlex, Gang Lu has authored 18 papers receiving a total of 1.9k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Molecular Biology, 9 papers in Hematology and 3 papers in Oncology. Recurrent topics in Gang Lu's work include Protein Degradation and Inhibitors (14 papers), Ubiquitin and proteasome pathways (9 papers) and Multiple Myeloma Research and Treatments (9 papers). Gang Lu is often cited by papers focused on Protein Degradation and Inhibitors (14 papers), Ubiquitin and proteasome pathways (9 papers) and Multiple Myeloma Research and Treatments (9 papers). Gang Lu collaborates with scholars based in United States, Switzerland and Germany. Gang Lu's co-authors include Richard E. Middleton, Kwok‐Kin Wong, Christopher J. Ott, Huahang Sun, William G. Kaelin, Constantine S. Mitsiades, James E. Bradner, Brian E. Cathers, Chin-Chun Lu and Laurie A. LeBrun and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Blood.

In The Last Decade

Gang Lu

18 papers receiving 1.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

2013 1.1k citations Gang Lu, Richard E. Middleton et al. Science profile →

Peers

Gang Lu

HEMAT

ONCOL

IMMUN

GENET

Christine R. Klaus Germany

Sabrina Manni Italy

Michael F. Emmons United States

Erik Kupperman United States

James T. Lynch United Kingdom

Christine M. Stellrecht United States

Jennifer M. Atkinson United States

Cédric Leroy France

Andrea Basile Italy

Erica O’Bryan United States

Christine R. Klaus Germany

Gang Lu

1.6k ×1.0

252 ×0.3

HEMAT

188 ×0.4

ONCOL

173 ×1.4

IMMUN

51 ×0.7

GENET

Citations per year, relative to Gang Lu Gang Lu (= 1×) peers Christine R. Klaus

Countries citing papers authored by Gang Lu

Since Specialization

Citations

This map shows the geographic impact of Gang Lu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gang Lu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gang Lu more than expected).

Fields of papers citing papers by Gang Lu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gang Lu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gang Lu. The network helps show where Gang Lu may publish in the future.

Co-authorship network of co-authors of Gang Lu

This figure shows the co-authorship network connecting the top 25 collaborators of Gang Lu. A scholar is included among the top collaborators of Gang Lu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gang Lu. Gang Lu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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18 of 18 papers shown

Xia, Yifeng, Ji X, In Sock Jang, et al.. (2021). Genetic and pharmacological interrogation of cancer vulnerability using a multiplexed cell line screening platform. Communications Biology. 4(1). 834–834. 4 indexed citations

Mo, Zhongying, Scott Wood, In Sock Jang, et al.. (2021). Deciphering the mechanisms of CC-122 resistance in DLBCL via a genome-wide CRISPR screen. Blood Advances. 5(7). 2027–2039. 15 indexed citations

Hansen, Joshua D., Matthew Correa, Mark A. Nagy, et al.. (2021). CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. Journal of Medicinal Chemistry. 64(4). 1835–1843. 100 indexed citations

Belair, David G., et al.. (2020). Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4. Scientific Reports. 10(1). 2864–2864. 23 indexed citations

Matyskiela, Mary E., Thomas Clayton, Xinde Zheng, et al.. (2020). Crystal structure of the SALL4–pomalidomide–cereblon–DDB1 complex. Nature Structural & Molecular Biology. 27(4). 319–322. 65 indexed citations

Matyskiela, Mary E., J. Zhu, Joshua M. Baughman, et al.. (2020). Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chemical Biology. 15(12). 3149–3158. 30 indexed citations

Dai, Yumin, Carla Guarinós, Manuel Sanchez, et al.. (2020). Abstract 2048: Discovery of induction and release of IL-1b are unique and on-target effects of GSPT1 degradation that provide potential mitigation strategies to hypotension in the CC-90009-AML-001 phase 1 trial. Cancer Research. 80(16_Supplement). 2048–2048. 3 indexed citations

Lopez‐Girona, Antonia, Gang Lu, Emily Rychak, et al.. (2019). CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML). Blood. 134(Supplement_1). 2703–2703. 16 indexed citations

Lopez‐Girona, Antonia, Courtney G. Havens, Gang Lu, et al.. (2019). CC-92480 Is a Novel Cereblon E3 Ligase Modulator with Enhanced Tumoricidal and Immunomodulatory Activity Against Sensitive and Resistant Multiple Myeloma Cells. Blood. 134(Supplement_1). 1812–1812. 18 indexed citations

10.

Lu, Gang, Christine Surka, Chin-Chun Lu, et al.. (2019). Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen. Blood. 134(Supplement_1). 405–405. 7 indexed citations

11.

Lu, Gang, Mary E. Matyskiela, Xinde Zheng, et al.. (2018). UBE2G1 governs the destruction of cereblon neomorphic substrates. eLife. 7. 56 indexed citations

12.

Nguyen, Thang Van, Jing Li, Chin-Chun Lu, et al.. (2017). p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proceedings of the National Academy of Sciences. 114(14). 3565–3571. 68 indexed citations

13.

Matyskiela, Mary E., Weihong Zhang, Hon‐Wah Man, et al.. (2017). A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. Journal of Medicinal Chemistry. 61(2). 535–542. 203 indexed citations

14.

Hansen, Joshua D., Kevin R. Condroski, Matthew Correa, et al.. (2017). Protein Degradation via CRL4^CRBN Ubiquitin Ligase: Discovery and Structure–Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1. Journal of Medicinal Chemistry. 61(2). 492–503. 60 indexed citations

15.

Lu, Gang, Richard E. Middleton, Huahang Sun, et al.. (2013). The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins. Science. 343(6168). 305–309. 1108 indexed citations breakdown →

16.

Lu, Gang, et al.. (2005). TRPV1b, a Functional Human Vanilloid Receptor Splice Variant. Molecular Pharmacology. 67(4). 1119–1127. 59 indexed citations

17.

Lu, Gang, Haikun Shi, Carol Asher, et al.. (2001). In vitro phosphorylation of COOH termini of the epithelial Na⁺channel and its effects on channel activity inXenopusoocytes. American Journal of Physiology-Renal Physiology. 280(6). F1030–F1036. 31 indexed citations

18.

Narayanan, Ramaswamy, Margaret S. Hibbs, Peter Benn, et al.. (1993). Altered Epidermal Growth Factor Signal Transduction in Activated Ha-ras-Transformed Human Keratinocytes. Biochemical and Biophysical Research Communications. 193(1). 167–174. 20 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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