Francis G. Spinale

24.7k total citations · 4 hit papers
380 papers, 19.0k citations indexed

About

Francis G. Spinale is a scholar working on Cardiology and Cardiovascular Medicine, Surgery and Oncology. According to data from OpenAlex, Francis G. Spinale has authored 380 papers receiving a total of 19.0k indexed citations (citations by other indexed papers that have themselves been cited), including 282 papers in Cardiology and Cardiovascular Medicine, 96 papers in Surgery and 75 papers in Oncology. Recurrent topics in Francis G. Spinale's work include Cardiac Fibrosis and Remodeling (136 papers), Peptidase Inhibition and Analysis (73 papers) and Cardiovascular Function and Risk Factors (71 papers). Francis G. Spinale is often cited by papers focused on Cardiac Fibrosis and Remodeling (136 papers), Peptidase Inhibition and Analysis (73 papers) and Cardiovascular Function and Risk Factors (71 papers). Francis G. Spinale collaborates with scholars based in United States, United Kingdom and Canada. Francis G. Spinale's co-authors include Rupak Mukherjee, Michael R. Zile, Mytsi L. Coker, Fred A. Crawford, Robert E. Stroud, John S. Ikonomidis, Douglas L. Mann, James L. Zellner, Jeffrey A. Jones and Chadwick V. Thomas and has published in prestigious journals such as Journal of Biological Chemistry, Circulation and Journal of Clinical Investigation.

In The Last Decade

Francis G. Spinale

375 papers receiving 18.6k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function

2007 856 citations Francis G. Spinale profile →
Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 667 citations Francis G. Spinale et al. Circulation profile →
Matrix Metalloproteinases

2002 596 citations Francis G. Spinale Circulation Research profile →
Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

2014 409 citations Kia N. Zellars, Christina B. Logdon et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Francis G. Spinale United States	75	12.3k	5.3k	4.2k	3.7k	2.9k	380	19.0k
Mat J.A.P. Daemen Netherlands	83	8.0k 0.7×	6.3k 1.2×	4.5k 1.1×	2.6k 0.7×	1.7k 0.6×	308	23.1k
Nikolaos G. Frangogiannis United States	88	17.7k 1.4×	13.6k 2.5×	6.9k 1.6×	3.0k 0.8×	3.8k 1.3×	178	30.9k
Elena Aïkawa United States	78	7.4k 0.6×	6.5k 1.2×	4.6k 1.1×	2.4k 0.6×	1.6k 0.5×	261	22.1k
Alain Tedgui France	95	5.9k 0.5×	12.7k 2.4×	5.8k 1.4×	3.7k 1.0×	2.9k 1.0×	294	31.4k
Mark L. Entman United States	88	10.0k 0.8×	10.4k 1.9×	6.0k 1.4×	1.6k 0.4×	1.9k 0.7×	295	23.9k
Tsutomu Imaizumi Japan	76	7.3k 0.6×	6.8k 1.3×	4.8k 1.1×	1.3k 0.4×	1.5k 0.5×	350	21.1k
Merry L. Lindsey United States	67	7.3k 0.6×	6.0k 1.1×	2.7k 0.6×	2.4k 0.6×	2.3k 0.8×	240	14.3k
Kensuke Egashira Japan	77	6.0k 0.5×	5.9k 1.1×	3.5k 0.8×	1.4k 0.4×	1.7k 0.6×	247	17.5k
Ziad Mallat France	84	4.5k 0.4×	9.5k 1.8×	4.4k 1.0×	2.6k 0.7×	2.4k 0.9×	279	25.8k
Gianluigi Condorelli Italy	76	5.4k 0.4×	11.6k 2.2×	2.5k 0.6×	5.0k 1.3×	2.0k 0.7×	290	19.0k

Countries citing papers authored by Francis G. Spinale

Since Specialization

Citations

This map shows the geographic impact of Francis G. Spinale's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Francis G. Spinale with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Francis G. Spinale more than expected).

Fields of papers citing papers by Francis G. Spinale

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Francis G. Spinale. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Francis G. Spinale. The network helps show where Francis G. Spinale may publish in the future.

Co-authorship network of co-authors of Francis G. Spinale

This figure shows the co-authorship network connecting the top 25 collaborators of Francis G. Spinale. A scholar is included among the top collaborators of Francis G. Spinale based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Francis G. Spinale. Francis G. Spinale is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Thorn, Stephanie, Selen Uman, James S. Duncan, et al.. (2025). Intramyocardial Hydrogel Delivery Decreases Left Ventricular Remodeling and Increases Angiogenesis Post Myocardial Infarction. Circulation Cardiovascular Imaging. 18(10). e018357–e018357.

Barlow, Shayne C., et al.. (2024). Left ventricle function and post-transcriptional events with exercise training in pigs. PLoS ONE. 19(2). e0292243–e0292243. 1 indexed citations

Shazly, Tarek, John F. Eberth, Mark J. Uline, et al.. (2024). Hydrophilic Coating Microstructure Mediates Acute Drug Transfer in Drug-Coated Balloon Therapy. ACS Applied Bio Materials. 7(5). 3041–3049. 2 indexed citations

Barlow, Shayne C., Diego Altomare, Hao Ji, et al.. (2024). Heart failure with preserved ejection fraction in pigs causes shifts in posttranscriptional checkpoints. American Journal of Physiology-Heart and Circulatory Physiology. 327(5). H1272–H1285. 1 indexed citations

Goldsmith, Edie C., et al.. (2022). Tissue inhibitor of metalloproteinase-4 deletion in mice impacts maternal cardiac function during pregnancy and postpartum. American Journal of Physiology-Heart and Circulatory Physiology. 324(1). H85–H99. 2 indexed citations

Barber, Jacob L., Kia N. Zellars, Kurt G. Barringhaus, et al.. (2019). The Effects of Regular Exercise on Circulating Cardiovascular-related MicroRNAs. Scientific Reports. 9(1). 7527–7527. 53 indexed citations

Zavadzkas, Juozas A., Robert E. Stroud, Shenikqua Bouges, et al.. (2014). Targeted Overexpression of Tissue Inhibitor of Matrix Metalloproteinase-4 Modifies Post–Myocardial Infarction Remodeling in Mice. Circulation Research. 114(9). 1435–1445. 40 indexed citations

Goldsmith, Edie C., Amy D. Bradshaw, Michael R. Zile, & Francis G. Spinale. (2014). Myocardial fibroblast–matrix interactions and potential therapeutic targets. Journal of Molecular and Cellular Cardiology. 70. 92–99. 75 indexed citations

Eckhouse, Shaina R., Adam W. Akerman, Christina B. Logdon, et al.. (2012). Differential membrane type 1 matrix metalloproteinase substrate processing with ischemia–reperfusion: Relationship to interstitial microRNA dynamics and myocardial function. Journal of Thoracic and Cardiovascular Surgery. 145(1). 267–277.e4. 8 indexed citations

10.

DeSantis, Stacia M., John M. Toole, John M. Kratz, et al.. (2011). Early Postoperative Outcomes and Blood Product Utilization in Adult Cardiac Surgery. Circulation. 124(11_suppl_1). S62–9. 18 indexed citations

11.

Yarbrough, William M., Rupak Mukherjee, Robert E. Stroud, et al.. (2011). Progressive induction of left ventricular pressure overload in a large animal model elicits myocardial remodeling and a unique matrix signature. Journal of Thoracic and Cardiovascular Surgery. 143(1). 215–223. 45 indexed citations

12.

Warters, R. David, et al.. (2011). The effect of neuromuscular blockade on mask ventilation. Anaesthesia. 66(3). 163–167. 75 indexed citations

13.

Stroud, Robert E., et al.. (2009). Abstract 3472: Relationship Between the Temporal Profile of Plasma microRNA and Left Ventricular Remodeling in Patients Following Myocardial Infarction. Circulation. 120. 2 indexed citations

14.

Yan, Andrew T., Raymond T. Yan, Francis G. Spinale, et al.. (2008). Relationships Between Plasma Levels of Matrix Metalloproteinases and Neurohormonal Profile in Patients with Heart Failure. European Journal of Heart Failure. 10(2). 125–128. 28 indexed citations

15.

Stroud, Robert E., et al.. (2004). The Effects of Leukocyte Reduction on Matrix Metalloproteinase Release in Cardiopulmonary Bypass. Journal of ExtraCorporeal Technology. 36(2). 185–190. 4 indexed citations

16.

Gunasinghe, Himali R., et al.. (2003). Effects of Leukocyte Depletion Filters on Matrix Metalloproteinase Activation in an Extracorporeal Circulation Circuit. Journal of ExtraCorporeal Technology. 35(2). 139–142. 6 indexed citations

17.

Wilson, Eric & Francis G. Spinale. (2001). Myocardial remodelling and matrix metallotxoteinases in heart failure: turmoil within the interstitium. Annals of Medicine. 33(9). 623–634. 43 indexed citations

18.

Hebbar, Latha, et al.. (1997). Protective Effects of Adenosine on Myocyte Contractility During Cardioplegic Arrest. The Annals of Thoracic Surgery. 63(4). 981–987. 4 indexed citations

19.

McMahon, William, Henry H. Holzgrefe, Jennifer Walker, et al.. (1996). Cellular basis for improved left ventricular pump function after digoxin therapy in experimental left ventricular failure. Journal of the American College of Cardiology. 28(2). 495–505. 11 indexed citations

20.

Mukherjee, Rupak, Henry H. Holzgrefe, J.R. Powell, William H. Koster, & Francis G. Spinale. (1995). 727-4 Differential Effects of Chronic Angiotensin Converting Enzyme (ACE) Inhibition and Angiotensin II (AT-II) Receptor (AT 1 AT-II) Blockade on Myocyte Excitation and Contraction in Dilated Cardiomyopathy. Journal of the American College of Cardiology. 25(2). 133A–133A. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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