Florian Nachon

7.9k citations

139 papers · 6.1k indexed · 3 hit papers · h-index 43

Impact in

Pharmacology top 0.05%
- Cholinesterase and Neurodegenerative Diseases
Computational Theory and Mathematics top 0.1%
- Computational Drug Discovery Methods

Papers in

Pharmacology 110
- Cholinesterase and Neurodegenerative Diseases 110
Computational Theory and Mathematics 67
- Computational Drug Discovery Methods 67

Co-authors: Patrick Masson Oksana Lockridge Yvain Nicolet Pierre‐Yves Renard Ludovic Jean Juan C. Fontecilla‐Camps Xavier Brazzolotto E. Carletti
Journals: Chemico-Biological Interactions (17 papers)European Journal of Medicinal Chemistry (11 papers)Journal of Medicinal Chemistry (9 papers)Chemical Research in Toxicology (7 papers)Molecules (5 papers)
Partner nations: France United States Russia

In The Last Decade

Florian Nachon

136 papers receiving 6.1k citations

Hit Papers

align trajectories log scale

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase 2013 · 398 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2013 Biochemical Journal
2012 Accounts of Chemical Research
2003 Journal of Biological Chemistry

Peers

Countries citing papers authored by Florian Nachon

Since Specialization

Citations

This map shows the geographic impact of Florian Nachon's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Florian Nachon with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Florian Nachon more than expected).

Fields of papers citing papers by Florian Nachon

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Florian Nachon. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Florian Nachon. The network helps show where Florian Nachon may publish in the future.

Co-authors

The 25 scholars most cited alongside Florian Nachon, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Florian Nachon Line = papers co-authored together Florian Nachon links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Role of paraoxonase 1 in organophosphate G-series nerve agent poisoning and future therapeutic strategies Archives of Toxicology ·Andrew Je, J Michel, Janek Bzdrenga, Florian Nachon, Xavier Brazzolotto, Abhay H. Pande	2024	0
2	Warfare Nerve Agents and Paraoxonase-1 as a Potential ProphylacticTherapy against Intoxication Protein and Peptide Letters ·Hamed Moradikia, J Michel, Janek Bzdrenga, Florian Nachon, Xavier Brazzolotto, Abhay H. Pande	2024	2
3	Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies European Journal of Medicinal Chemistry ·Dawid Panek, Anna Pasieka, Gniewomir Latacz, Paula Zaręba, Filippino Lippi, Justyna Godyń, F Tsukaya, Florian Nachon, Xavier Brazzolotto, T Y Liow, Maria Walczak, Miryan Baez Osorio, Kinga Sałat, Georg Höfner, Klaus T. Wanner, Anna Więckowska, Barbara Malawska	2023	9
4	Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases Antioxidants ·Daniel Chavarria, G. Hommel, Sofia Benfeito, 刘广军, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges	2021	10
5	Impact of Sucrose as Osmolyte on Molecular Dynamics of Mouse Acetylcholinesterase Biomolecules ·Sofya V. Lushchekina, 威夫飯田, Nicolás Martínez, Patrick Masson, M. Zavanella, Florian Nachon, Michael Marek Koza, Tilo Seydel, Judith Peters	2020	11
6	New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease Neuropharmacology ·Irina V. Zueva, José Dias, Sofya V. Lushchekina, Vyacheslav E. Semenov, Marat A. Mukhamedyarov, Tatiana N. Pashirova, Vasily M. Babaev, Florian Nachon, Н. В. Петрова, Л. Ф. Нуруллин, L. Ya. Zakharova, Victor I. Ilyin, Patrick Masson, K. A. PETROV	2019	79
7	Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase European Journal of Medicinal Chemistry ·耕三朽津, Gianluca Santoni, Delphine Karila, Cédric Lecoutey, Audrey Davis, Florian Nachon, Israel Silman, Joel L. Sussman, Martin H. Weik, Tangui Maurice, Patrick Dallemagne, Christophe Rochais	2018	39
8	Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents Journal of Medicinal Chemistry ·Gianluca Santoni, Nicholas Owen, E. De la Mora, José Dias, Ludovic Jean, Joel L. Sussman, Israel Silman, Pierre‐Yves Renard, Richard C. D. Brown, Martin H. Weik, Rachid Baati, Florian Nachon	2018	46
9	Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration Chemistry - A European Journal ·Tamara Zorbaz, Abhishek Rastogi, 二郎岡田, Julien Renou, (unknown), Nikolina Maček Hrvat, Maja Katalinić, Israel Silman, Joel L. Sussman, Guillaume Mercey, Shreya Shukla, Taban Baghfalaki, Belén Pérez, Rachid Baati, Florian Nachon, Martin H. Weik, Ludovic Jean, Zrinka Kovarik, Pierre‐Yves Renard	2018	56
10	Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase Journal of Medicinal Chemistry ·Martijn C. de Koning, Marloes J.A. Joosen, Franz Worek, Florian Nachon, Marco van Grol, Mohamed El Kassem Mohamed Hassouna, Batygina Gz, Timo Wille, NV Dolgushina	2017	15
11	Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development Molecules ·Xavier Brazzolotto, Janua, Virginia Guillon, Gianluca Santoni, Florian Nachon	2017	25
12	Progress in the development of enzyme-based nerve agent bioscavengers Chemico-Biological Interactions ·Florian Nachon, Xavier Brazzolotto, Marie Trovaslet, Patrick Masson	2013	135
13	Correction: Evolution of Acetylcholinesterase and Butyrylcholinesterase in the Vertebrates: An Atypical Butyrylcholinesterase from the Medaka Oryzias latipes PLoS ONE ·Leo Pezzementi, Florian Nachon, Arnaud Chatonnet	2011	14
14	Evolution of Acetylcholinesterase and Butyrylcholinesterase in the Vertebrates: An Atypical Butyrylcholinesterase from the Medaka Oryzias latipes PLoS ONE ·Leo Pezzementi, Florian Nachon, Arnaud Chatonnet	2011	47
15	Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran Chemico-Biological Interactions ·Ellen G. Duysen, John R. Cashman, Lawrence M. Schopfer, Florian Nachon, Patrick Masson, Oksana Lockridge	2011	27
16	Application of laccase-mediator system (LMS) for the degradation of organophosphorus compounds Chemico-Biological Interactions ·M. Zavanella, Claude Jolivalt, Marie‐Thérèse Froment, F.L. Sayles, Bertrand Lefèbvre, Denis Daveloose, Florian Nachon, Patrick Masson	2010	22
17	Structural Evidence That Human Acetylcholinesterase Inhibited by Tabun Ages through O-Dealkylation Journal of Medicinal Chemistry ·E. Carletti, Jacques‐Philippe Colletier, Florine Dupeux, Marie Trovaslet, Patrick Masson, Florian Nachon	2010	85
18	Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: Characteristic mass fragments and a new binding motif for organophosphates Journal of Chromatography B ·Lawrence M. Schopfer, Hasmik Grigoryan, Bin Li, Florian Nachon, Patrick Masson, Oksana Lockridge	2009	41
19	Kinetic analysis of effector modulation of butyrylcholinesterase‐catalysed hydrolysis of acetanilides and homologous esters FEBS Journal ·Patrick Masson, Marie‐Thérèse Froment, Émilie Gillon, Florian Nachon, Oksana Lockridge, Lawrence M. Schopfer	2008	20
20	Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ·Thomas Poyot, Florian Nachon, Marie-Thérèse Froment, Mélanie Loiodice, Guozhen Liu (6429), Lawrence M. Schopfer, Oksana Lockridge, Patrick Masson	2006	23

About Florian Nachon

Florian Nachon is a scholar working on Pharmacology, Computational Theory and Mathematics, Plant Science, Pollution and Health, Toxicology and Mutagenesis, having authored 139 papers that have together received 6.1k indexed citations. Recurring topics across this work include Cholinesterase and Neurodegenerative Diseases (110 papers), Pesticide Exposure and Toxicity (74 papers), Computational Drug Discovery Methods (67 papers), Environmental Toxicology and Ecotoxicology (20 papers), Pesticide and Herbicide Environmental Studies (20 papers), Chemical synthesis and alkaloids (19 papers), Insect and Pesticide Research (13 papers) and Enzyme function and inhibition (8 papers). The work is most often cited by research in Pharmacology (4.2k citations), Computational Theory and Mathematics (2.3k citations), Plant Science (2.6k citations), Organic Chemistry (1.7k citations) and Pollution (609 citations). Florian Nachon has collaborated with scholars based in France, United States and Russia. Frequent co-authors include Patrick Masson, Oksana Lockridge, Yvain Nicolet, Pierre‐Yves Renard, Ludovic Jean, Juan C. Fontecilla‐Camps, Xavier Brazzolotto, E. Carletti, Marie Trovaslet and Lawrence M. Schopfer. Their work appears in journals such as Chemico-Biological Interactions, European Journal of Medicinal Chemistry, Journal of Medicinal Chemistry, Chemical Research in Toxicology and Molecules.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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